Cops5 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Cops5
Entrez Gene ID	312916
Full Name	COP9 signalosome subunit 5
General protein information	Preferred Names COP9 signalosome subunit 5 Names COP9 signalosome complex subunit 5 COP9 (constitutive photomorphogenic) homolog, subunit 5
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 5 Map Location: 5q11

mRNA and Protein(s)

mRNA	Protein	Name
XM_006237758.3	XP_006237820.1	COP9 signalosome complex subunit 5 isoform X1
NM_001025695.1	NP_001020866.1	COP9 signalosome complex subunit 5

Pathways from BioSystems

Homologies

Homo sapiens (human)	COPS5	NP_006828.2
Bos taurus (cattle)	COPS5	NP_001179068.1
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP002880	XP_312032.5
Mus musculus (house mouse)	Cops5	NP_038743.1
Arabidopsis thaliana (thale cress)	CSN5B	NP_177279.1
Oryza sativa (rice)	Os04g0654700	NP_001054112.1
Xenopus tropicalis (tropical clawed frog)	cops5	NP_989109.1
Pan troglodytes (chimpanzee)	COPS5	XP_001162723.1
Canis lupus familiaris (dog)	COPS5	XP_005638087.1
Gallus gallus (chicken)	COPS5	NP_001034400.1
Drosophila melanogaster (fruit fly)	CSN5	NP_477442.1
Caenorhabditis elegans (roundworm)	csn-5	NP_500841.1
Magnaporthe oryzae (rice blast fungus)	MGG_05274	XP_003712833.1
Neurospora crassa	NCU00467	XP_956786.1
	COPS5	XP_001097856.1
Rattus norvegicus (Norway rat)	Cops5	NP_001020866.1
Danio rerio (zebrafish)	cops5	NP_957019.1
Arabidopsis thaliana (thale cress)	CSN5A	NP_173705.1

Gene Ontology
Bibliography

Related articles in PubMed

Porcine JAB1 significantly enhances apoptosis induced by staurosporine.
Jiang P, Wang J, Kang Z, Li D, Zhang D
Cell death & disease4e823(2013 Oct)

The D-dopachrome tautomerase (DDT) gene product is a cytokine and functional homolog of macrophage migration inhibitory factor (MIF).
Merk M, Zierow S, Leng L, Das R, Du X, Schulte W, Fan J, Lue H, Chen Y, Xiong H, Chagnon F, Bernhagen J, Lolis E, Mor G, Lesur O, Bucala R
Proceedings of the National Academy of Sciences of the United States of America108(34)E577-85(2011 Aug)

Fank1 interacts with Jab1 and regulates cell apoptosis via the AP-1 pathway.
Wang H, Song W, Hu T, Zhang N, Miao S, Zong S, Wang L
Cellular and molecular life sciences : CMLS68(12)2129-39(2011 Jun)

CSN complex controls the stability of selected synaptic proteins via a torsinA-dependent process.
Granata A, Koo SJ, Haucke V, Schiavo G, Warner TT
The EMBO journal30(1)181-93(2011 Jan)

Physical interaction of Jab1 with human serotonin 6 G-protein-coupled receptor and their possible roles in cell survival.
Yun HM, Baik JH, Kang I, Jin C, Rhim H
The Journal of biological chemistry285(13)10016-29(2010 Mar)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Jab1 provides a novel signal transduction pathway for 5-HT(6)R and may play an important role in 5-HT(6)R-mediated behavior changes in the brain
Title: Physical interaction of Jab1 with human serotonin 6 G-protein-coupled receptor and their possible roles in cell survival.

The following Cops5 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Cops5 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa07567	NM_001025695.1 Latest version!	Rattus norvegicus COP9 signalosome subunit 5 (Cops5), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$188.30 $269.00
ORa27978	XM_006237758.3 Latest version!	Rattus norvegicus COP9 signalosome subunit 5 (Cops5), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$139.30 $199.00

ORF Online Only Promotion

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Cops5 ( NM_001025695.1 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_001020866.1 Rattus norvegicus COP9 signalosome subunit 5 (Cops5), mRNA.

Price & Availability↑

CloneID	ORa07567
Clone ID Related Accession (Same CDS sequence)	NM_001025695.1
Accession Version	NM_001025695.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1005bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-10-09
Organism	Rattus norvegicus(Norway rat)
Product	COP9 signalosome complex subunit 5
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC098736.1. On Jul 22, 2005 this sequence version replaced XM_232615.3. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC098736.1, FQ215612.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMD00052296, SAMD00052297 [ECO:0000348] ##Evidence-Data-END##

ATGACAGCTT CCGGGAGTGG TATGGCCCAG AAGACCTGGG AATTGGCCAA CAACATGCAG 
GAAGCGCAGA GTATCGATGA AATCTACAAA TATGACAAAA AACAACAACA AGAAATCCTG 
GCGGCGAAAC CCTGGACTAA GGATCACCAC TACTTTAAAT ACTGCAAAAT CTCTGCGTTG 
GCACTGCTGA AAATGGTGAT GCATGCCAGG TCAGGAGGCA ACCTGGAGGT GATGGGTTTG 
ATGCTCGGGA AAGTGGATGG AGAGACCATG ATCATCATGG ACAGCTTTGC TTTGCCTGTA 
GAGGGCACTG AAACCCGAGT AAATGCCCAG GCTGCTGCAT ACGAGTACAT GGCTGCATAC 
ATAGAAAATG CCAAACAGGT TGGCCGCCTT GAGAATGCAA TTGGTTGGTA TCACAGCCAC 
CCTGGTTATG GCTGCTGGCT CTCCGGAATT GATGTTAGTA CACAGATGCT TAACCAGCAG 
TTTCAGGAAC CATTTGTAGC AGTGGTGATT GACCCAACCA GAACAATATC TGCAGGGAAG 
GTGAATCTTG GCGCCTTTAG GACATATCCA AAGGGCTATA AGCCTCCTGA TGAAGGACCT 
TCAGAGTACC AGACTATCCC ACTCAATAAA ATAGAAGATT TTGGCGTGCA CTGCAAACAA 
TATTATGCCT TAGAAGTCTC ATATTTCAAA TCCTCTTTGG ATCGTAAACT ACTTGAGCTC 
TTGTGGAATA AATACTGGGT GAACACCCTG AGTTCCTCTA GCTTGCTTAC CAATGCTGAC 
TATACCACAG GCCAGGTGTT TGATCTGTCT GAGAAGTTAG AGCAGTCGGA AGCCCAGCTG 
GGGCGTGGGA GTTTCATGTT GGGTTTAGAA ACACATGACC GCAAGTCAGA AGACAAACTT 
GCCAAAGCTA CGAGAGACAG CTGTAAAACC ACCATAGAAG CCATCCATGG ACTGATGTCT 
CAGGTTATTA AGGATAAACT GTTTAATCAA ATTAACGTTG CTTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001020866.1
CDS	119..1123
Translation	MTASGSGMAQKTWELANNMQEAQSIDEIYKYDKKQQQEILAAKPWTKDHHYFKYCKISALALLKMVMHARSGGNLEVMGLMLGKVDGETMIIMDSFALPVEGTETRVNAQAAAYEYMAAYIENAKQVGRLENAIGWYHSHPGYGCWLSGIDVSTQMLNQQFQEPFVAVVIDPTRTISAGKVNLGAFRTYPKGYKPPDEGPSEYQTIPLNKIEDFGVHCKQYYALEVSYFKSSLDRKLLELLWNKYWVNTLSSSSLLTNADYTTGQVFDLSEKLEQSEAQLGRGSFMLGLETHDRKSEDKLAKATRDSCKTTIEAIHGLMSQVIKDKLFNQINVA

Target ORF information:

RefSeq Version	NM_001025695.1
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus COP9 signalosome subunit 5 (Cops5), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001025695.1

ORF Insert Sequence:

ATGACAGCTT CCGGGAGTGG TATGGCCCAG AAGACCTGGG AATTGGCCAA CAACATGCAG 
GAAGCGCAGA GTATCGATGA AATCTACAAA TATGACAAAA AACAACAACA AGAAATCCTG 
GCGGCGAAAC CCTGGACTAA GGATCACCAC TACTTTAAAT ACTGCAAAAT CTCTGCGTTG 
GCACTGCTGA AAATGGTGAT GCATGCCAGG TCAGGAGGCA ACCTGGAGGT GATGGGTTTG 
ATGCTCGGGA AAGTGGATGG AGAGACCATG ATCATCATGG ACAGCTTTGC TTTGCCTGTA 
GAGGGCACTG AAACCCGAGT AAATGCCCAG GCTGCTGCAT ACGAGTACAT GGCTGCATAC 
ATAGAAAATG CCAAACAGGT TGGCCGCCTT GAGAATGCAA TTGGTTGGTA TCACAGCCAC 
CCTGGTTATG GCTGCTGGCT CTCCGGAATT GATGTTAGTA CACAGATGCT TAACCAGCAG 
TTTCAGGAAC CATTTGTAGC AGTGGTGATT GACCCAACCA GAACAATATC TGCAGGGAAG 
GTGAATCTTG GCGCCTTTAG GACATATCCA AAGGGCTATA AGCCTCCTGA TGAAGGACCT 
TCAGAGTACC AGACTATCCC ACTCAATAAA ATAGAAGATT TTGGCGTGCA CTGCAAACAA 
TATTATGCCT TAGAAGTCTC ATATTTCAAA TCCTCTTTGG ATCGTAAACT ACTTGAGCTC 
TTGTGGAATA AATACTGGGT GAACACCCTG AGTTCCTCTA GCTTGCTTAC CAATGCTGAC 
TATACCACAG GCCAGGTGTT TGATCTGTCT GAGAAGTTAG AGCAGTCGGA AGCCCAGCTG 
GGGCGTGGGA GTTTCATGTT GGGTTTAGAA ACACATGACC GCAAGTCAGA AGACAAACTT 
GCCAAAGCTA CGAGAGACAG CTGTAAAACC ACCATAGAAG CCATCCATGG ACTGATGTCT 
CAGGTTATTA AGGATAAACT GTTTAATCAA ATTAACGTTG CTTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Cops5 ( XM_006237758.3 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> XP_006237820.1 Rattus norvegicus COP9 signalosome subunit 5 (Cops5), transcript variant X1, mRNA.

Price & Availability↑

CloneID	ORa27978
Clone ID Related Accession (Same CDS sequence)	XM_006237758.3
Accession Version	XM_006237758.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 954bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2016-07-25
Organism	Rattus norvegicus(Norway rat)
Product	COP9 signalosome complex subunit 5 isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_005104.4) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On Jul 26, 2016 this sequence version replaced XM_006237758.2. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Rattus norvegicus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGTCGCTAC GCCGCCGCCG CGCCCCGACG CGCGAATGGT CTGGACCAAC GTCACCTCCG 
GTCTCAAGTG TCATGGCTGC CTTGAGAGTC TATCACCACT ACTTTAAATA CTGCAAAATC 
TCTGCGTTGG CACTGCTGAA AATGGTGATG CATGCCAGGT CAGGAGGCAA CCTGGAGGTG 
ATGGGTTTGA TGCTCGGGAA AGTGGATGGA GAGACCATGA TCATCATGGA CAGCTTTGCT 
TTGCCTGTAG AGGGCACTGA AACCCGAGTA AATGCCCAGG CTGCTGCATA CGAGTACATG 
GCTGCATACA TAGAAAATGC CAAACAGGTT GGCCGCCTTG AGAATGCAAT TGGTTGGTAT 
CACAGCCACC CTGGTTATGG CTGCTGGCTC TCCGGAATTG ATGTTAGTAC ACAGATGCTT 
AACCAGCAGT TTCAGGAACC ATTTGTAGCA GTGGTGATTG ACCCAACCAG AACAATATCT 
GCAGGGAAGG TGAATCTTGG CGCCTTTAGG ACATATCCAA AGGGCTATAA GCCTCCTGAT 
GAAGGACCTT CAGAGTACCA GACTATCCCA CTCAATAAAA TAGAAGATTT TGGCGTGCAC 
TGCAAACAAT ATTATGCCTT AGAAGTCTCA TATTTCAAAT CCTCTTTGGA TCGTAAACTA 
CTTGAGCTCT TGTGGAATAA ATACTGGGTG AACACCCTGA GTTCCTCTAG CTTGCTTACC 
AATGCTGACT ATACCACAGG CCAGGTGTTT GATCTGTCTG AGAAGTTAGA GCAGTCGGAA 
GCCCAGCTGG GGCGTGGGAG TTTCATGTTG GGTTTAGAAA CACATGACCG CAAGTCAGAA 
GACAAACTTG CCAAAGCTAC GAGAGACAGC TGTAAAACCA CCATAGAAGC CATCCATGGA 
CTGATGTCTC AGGTTATTAA GGATAAACTG TTTAATCAAA TTAACGTTGC TTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_006237820.1
CDS	110..1063
Translation	MSLRRRRAPTREWSGPTSPPVSSVMAALRVYHHYFKYCKISALALLKMVMHARSGGNLEVMGLMLGKVDGETMIIMDSFALPVEGTETRVNAQAAAYEYMAAYIENAKQVGRLENAIGWYHSHPGYGCWLSGIDVSTQMLNQQFQEPFVAVVIDPTRTISAGKVNLGAFRTYPKGYKPPDEGPSEYQTIPLNKIEDFGVHCKQYYALEVSYFKSSLDRKLLELLWNKYWVNTLSSSSLLTNADYTTGQVFDLSEKLEQSEAQLGRGSFMLGLETHDRKSEDKLAKATRDSCKTTIEAIHGLMSQVIKDKLFNQINVA

Target ORF information:

RefSeq Version	XM_006237758.3
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus COP9 signalosome subunit 5 (Cops5), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_006237758.3

ORF Insert Sequence:

ATGTCGCTAC GCCGCCGCCG CGCCCCGACG CGCGAATGGT CTGGACCAAC GTCACCTCCG 
GTCTCAAGTG TCATGGCTGC CTTGAGAGTC TATCACCACT ACTTTAAATA CTGCAAAATC 
TCTGCGTTGG CACTGCTGAA AATGGTGATG CATGCCAGGT CAGGAGGCAA CCTGGAGGTG 
ATGGGTTTGA TGCTCGGGAA AGTGGATGGA GAGACCATGA TCATCATGGA CAGCTTTGCT 
TTGCCTGTAG AGGGCACTGA AACCCGAGTA AATGCCCAGG CTGCTGCATA CGAGTACATG 
GCTGCATACA TAGAAAATGC CAAACAGGTT GGCCGCCTTG AGAATGCAAT TGGTTGGTAT 
CACAGCCACC CTGGTTATGG CTGCTGGCTC TCCGGAATTG ATGTTAGTAC ACAGATGCTT 
AACCAGCAGT TTCAGGAACC ATTTGTAGCA GTGGTGATTG ACCCAACCAG AACAATATCT 
GCAGGGAAGG TGAATCTTGG CGCCTTTAGG ACATATCCAA AGGGCTATAA GCCTCCTGAT 
GAAGGACCTT CAGAGTACCA GACTATCCCA CTCAATAAAA TAGAAGATTT TGGCGTGCAC 
TGCAAACAAT ATTATGCCTT AGAAGTCTCA TATTTCAAAT CCTCTTTGGA TCGTAAACTA 
CTTGAGCTCT TGTGGAATAA ATACTGGGTG AACACCCTGA GTTCCTCTAG CTTGCTTACC 
AATGCTGACT ATACCACAGG CCAGGTGTTT GATCTGTCTG AGAAGTTAGA GCAGTCGGAA 
GCCCAGCTGG GGCGTGGGAG TTTCATGTTG GGTTTAGAAA CACATGACCG CAAGTCAGAA 
GACAAACTTG CCAAAGCTAC GAGAGACAGC TGTAAAACCA CCATAGAAGC CATCCATGGA 
CTGATGTCTC AGGTTATTAA GGATAAACTG TTTAATCAAA TTAACGTTGC TTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Porcine JAB1 significantly enhances apoptosis induced by staurosporine.
Cell death & disease4e823(2013 Oct)
Jiang P,Wang J,Kang Z,Li D,Zhang D

The D-dopachrome tautomerase (DDT) gene product is a cytokine and functional homolog of macrophage migration inhibitory factor (MIF).
Proceedings of the National Academy of Sciences of the United States of America108(34)E577-85(2011 Aug)
Merk M,Zierow S,Leng L,Das R,Du X,Schulte W,Fan J,Lue H,Chen Y,Xiong H,Chagnon F,Bernhagen J,Lolis E,Mor G,Lesur O,Bucala R

Fank1 interacts with Jab1 and regulates cell apoptosis via the AP-1 pathway.
Cellular and molecular life sciences : CMLS68(12)2129-39(2011 Jun)
Wang H,Song W,Hu T,Zhang N,Miao S,Zong S,Wang L

CSN complex controls the stability of selected synaptic proteins via a torsinA-dependent process.
The EMBO journal30(1)181-93(2011 Jan)
Granata A,Koo SJ,Haucke V,Schiavo G,Warner TT

Physical interaction of Jab1 with human serotonin 6 G-protein-coupled receptor and their possible roles in cell survival.
The Journal of biological chemistry285(13)10016-29(2010 Mar)
Yun HM,Baik JH,Kang I,Jin C,Rhim H