非対称型フォーマットは別個の2つの抗原結合ドメインが特徴で、それぞれの抗原に対して異なる特異性や親和性、機能を持つように設計することができます。これらの抗体は多様な抗原を柔軟に標的とすることができ、特定の生物学的パスウェイやシグナル伝達機構を調節する目的で使用することができます。
1 CrossMabCH1-CL

Manufacturability Score 1-5 according to bsAb’s expression
level and
purification difficulty defined by GenScript
(e.g. score 1 represents the most difficult) |
2 |
Recommend purification step(s) | 2 steps |
Typical yield Low: <50mg /L
Moderate: 50 – 200mg/L High: >200mg/L |
High |
2 scFv/BiTE-Fc

Manufacturability Score 1-5 according to bsAb’s expression
level and
purification difficulty defined by GenScript
(e.g. score 1 represents the most difficult) |
3 |
Recommend purification step(s) | 1 step |
Typical yield Low: <50mg /L
Moderate: 50 – 200mg/L High: >200mg/L |
High |
3 Fab/scFv-Fc

Manufacturability Score 1-5 according to bsAb’s expression
level and
purification difficulty defined by GenScript
(e.g. score 1 represents the most difficult) |
3 |
Recommend purification step(s) | 1 step |
Typical yield Low: <50mg /L
Moderate: 50 – 200mg/L High: >200mg/L |
High |
4 Fab-Fc/scFv-Fc-scFv

Manufacturability Score 1-5 according to bsAb’s expression
level and
purification difficulty defined by GenScript
(e.g. score 1 represents the most difficult) |
3 |
Recommend purification step(s) | 2 steps |
Typical yield Low: <50mg /L
Moderate: 50 – 200mg/L High: >200mg/L |
High |
5 scFab/BiTE-Fc

Manufacturability Score 1-5 according to bsAb’s expression
level and
purification difficulty defined by GenScript
(e.g. score 1 represents the most difficult) |
3 |
Recommend purification step(s) | 1 step |
Typical yield Low: <50mg /L
Moderate: 50 – 200mg/L High: >200mg/L |
High |
6 Heterodimeric IgG(KiH assembly)

Manufacturability Score 1-5 according to bsAb’s expression
level and
purification difficulty defined by GenScript
(e.g. score 1 represents the most difficult) |
3 |
Recommend purification step(s) | 2 steps |
Typical yield Low: <50mg /L
Moderate: 50 – 200mg/L High: >200mg/L |
Moderate |
7 Duobody (FAE)

Manufacturability Score 1-5 according to bsAb’s expression
level and
purification difficulty defined by GenScript
(e.g. score 1 represents the most difficult) |
3 |
Recommend purification step(s) | 1 step |
Typical yield Low: <50mg /L
Moderate: 50 – 200mg/L High: >200mg/L |
Moderate |
8 Heterodimeric IgG(Common LC)

Manufacturability Score 1-5 according to bsAb’s expression
level and
purification difficulty defined by GenScript
(e.g. score 1 represents the most difficult) |
4 |
Recommend purification step(s) | 2 steps |
Typical yield Low: <50mg /L
Moderate: 50 – 200mg/L High: >200mg/L |
Moderate |
9 Heterodimeric scFv-Fc

Manufacturability Score 1-5 according to bsAb’s expression
level and
purification difficulty defined by GenScript
(e.g. score 1 represents the most difficult) |
2 |
Recommend purification step(s) | 1 step |
Typical yield Low: <50mg /L
Moderate: 50 – 200mg/L High: >200mg/L |
Moderate |
10 Heterodimeric scFab-Fc

Manufacturability Score 1-5 according to bsAb’s expression
level and
purification difficulty defined by GenScript
(e.g. score 1 represents the most difficult) |
2 |
Recommend purification step(s) | 1 step |
Typical yield Low: <50mg /L
Moderate: 50 – 200mg/L High: >200mg/L |
Moderate |
11 Heterodimeric IgG-protein

Manufacturability Score 1-5 according to bsAb’s expression
level and
purification difficulty defined by GenScript
(e.g. score 1 represents the most difficult) |
2 |
Recommend purification step(s) | 1 step |
Typical yield Low: <50mg /L
Moderate: 50 – 200mg/L High: >200mg/L |
Moderate |
12 Fab/Diabody-Fc

Manufacturability Score 1-5 according to bsAb’s expression
level and
purification difficulty defined by GenScript
(e.g. score 1 represents the most difficult) |
3 |
Recommend purification step(s) | 2 steps |
Typical yield Low: <50mg /L
Moderate: 50 – 200mg/L High: >200mg/L |
Moderate |
13 Fab-Fc/scFv-VHH-Fc

Manufacturability Score 1-5 according to bsAb’s expression
level and
purification difficulty defined by GenScript
(e.g. score 1 represents the most difficult) |
3 |
Recommend purification step(s) | 2 steps |
Typical yield Low: <50mg /L
Moderate: 50 – 200mg/L High: >200mg/L |
Moderate |
14 Fab/VHH-Fc

Manufacturability Score 1-5 according to bsAb’s expression
level and
purification difficulty defined by GenScript
(e.g. score 1 represents the most difficult) |
3 |
Recommend purification step(s) | 1 step |
Typical yield Low: <50mg /L
Moderate: 50 – 200mg/L High: >200mg/L |
Moderate |
15 CrossMabVH-VL

Manufacturability Score 1-5 according to bsAb’s expression
level and
purification difficulty defined by GenScript
(e.g. score 1 represents the most difficult) |
2 |
Recommend purification step(s) | 2 steps |
Typical yield Low: <50mg /L
Moderate: 50 – 200mg/L High: >200mg/L |
Low |
16 Fab-IgG (CrossMabVH-VL)

Manufacturability Score 1-5 according to bsAb’s expression
level and
purification difficulty defined by GenScript
(e.g. score 1 represents the most difficult) |
2 |
Recommend purification step(s) | 2 steps |
Typical yield Low: <50mg /L
Moderate: 50 – 200mg/L High: >200mg/L |
Low |
17 IgG-Fab (CrossMabCH1-CL)

Manufacturability Score 1-5 according to bsAb’s expression
level and
purification difficulty defined by GenScript
(e.g. score 1 represents the most difficult) |
2 |
Recommend purification step(s) | 2 steps |
Typical yield Low: <50mg /L
Moderate: 50 – 200mg/L High: >200mg/L |
Low |
18 BiTE-Fc (KiH)

Manufacturability Score 1-5 according to bsAb’s expression
level and
purification difficulty defined by GenScript
(e.g. score 1 represents the most difficult) |
2 |
Recommend purification step(s) | 1 step |
Typical yield Low: <50mg /L
Moderate: 50 – 200mg/L High: >200mg/L |
Low |
19 Fab/BiTE-Fc

Manufacturability Score 1-5 according to bsAb’s expression
level and
purification difficulty defined by GenScript
(e.g. score 1 represents the most difficult) |
2 |
Recommend purification step(s) | 2 steps |
Typical yield Low: <50mg /L
Moderate: 50 – 200mg/L High: >200mg/L |
Low |
20 scFv-Fab/scFv-Fc

Manufacturability Score 1-5 according to bsAb’s expression
level and
purification difficulty defined by GenScript
(e.g. score 1 represents the most difficult) |
3 |
Recommend purification step(s) | 2 steps |
Typical yield Low: <50mg /L
Moderate: 50 – 200mg/L High: >200mg/L |
Low |
21 Fab-Fc-scFv/scFv-Fc

Manufacturability Score 1-5 according to bsAb’s expression
level and
purification difficulty defined by GenScript
(e.g. score 1 represents the most difficult) |
3 |
Recommend purification step(s) | 3 steps |
Typical yield Low: <50mg /L
Moderate: 50 – 200mg/L High: >200mg/L |
Low |
22 Heterodimeric VHH-Fc

Manufacturability Score 1-5 according to bsAb’s expression
level and
purification difficulty defined by GenScript
(e.g. score 1 represents the most difficult) |
2 |
Recommend purification step(s) | 2 steps |
Typical yield Low: <50mg /L
Moderate: 50 – 200mg/L High: >200mg/L |
Low |
23 Heterodimeric IgG-VHH (HC)

Manufacturability Score 1-5 according to bsAb’s expression
level and
purification difficulty defined by GenScript
(e.g. score 1 represents the most difficult) |
2 |
Recommend purification step(s) | 2 steps |
Typical yield Low: <50mg /L
Moderate: 50 – 200mg/L High: >200mg/L |
Low |
24 Heterodimeric IgG

Manufacturability Score 1-5 according to bsAb’s expression
level and
purification difficulty defined by GenScript
(e.g. score 1 represents the most difficult) |
Data to be collected |
Recommend purification step(s) | |
Typical yield Low: <50mg /L
Moderate: 50 – 200mg/L High: >200mg/L |
25 Fab/scFab-Fc

Manufacturability Score 1-5 according to bsAb’s expression
level and
purification difficulty defined by GenScript
(e.g. score 1 represents the most difficult) |
Data to be collected |
Recommend purification step(s) | |
Typical yield Low: <50mg /L
Moderate: 50 – 200mg/L High: >200mg/L |
26 DART-Fc (KiH)

Manufacturability Score 1-5 according to bsAb’s expression
level and
purification difficulty defined by GenScript
(e.g. score 1 represents the most difficult) |
Data to be collected |
Recommend purification step(s) | |
Typical yield Low: <50mg /L
Moderate: 50 – 200mg/L High: >200mg/L |
27 Fab/protein-Fc

Manufacturability Score 1-5 according to bsAb’s expression
level and
purification difficulty defined by GenScript
(e.g. score 1 represents the most difficult) |
Data to be collected |
Recommend purification step(s) | |
Typical yield Low: <50mg /L
Moderate: 50 – 200mg/L High: >200mg/L |
28 Heterodimeric IgG-protein complex

Manufacturability Score 1-5 according to bsAb’s expression
level and
purification difficulty defined by GenScript
(e.g. score 1 represents the most difficult) |
Data to be collected |
Recommend purification step(s) | |
Typical yield Low: <50mg /L
Moderate: 50 – 200mg/L High: >200mg/L |
29 Heterodimeric VHH-IgG (HC)

Manufacturability Score 1-5 according to bsAb’s expression
level and
purification difficulty defined by GenScript
(e.g. score 1 represents the most difficult) |
Data to be collected |
Recommend purification step(s) | |
Typical yield Low: <50mg /L
Moderate: 50 – 200mg/L High: >200mg/L |
30 Fab-Fc-scFv/VHH-Fc

Manufacturability Score 1-5 according to bsAb’s expression
level and
purification difficulty defined by GenScript
(e.g. score 1 represents the most difficult) |
Data to be collected |
Recommend purification step(s) | |
Typical yield Low: <50mg /L
Moderate: 50 – 200mg/L High: >200mg/L |
31 Fab/VHH2-Fc

Manufacturability Score 1-5 according to bsAb’s expression
level and
purification difficulty defined by GenScript
(e.g. score 1 represents the most difficult) |
Data to be collected |
Recommend purification step(s) | |
Typical yield Low: <50mg /L
Moderate: 50 – 200mg/L High: >200mg/L |