Dynlt3 cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Dynlt3
Entrez Gene ID	67117
Full Name	dynein light chain Tctex-type 3
Synonyms	2310075M16Rik,AU042796,Tcte1l
General protein information	Preferred Names dynein light chain Tctex-type 3 Names dynein light chain Tctex-type 3 protein 91/23
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: X Map Location: X\|X A1.1

mRNA and Protein(s)

mRNA	Protein	Name
NM_025975.5	NP_080251.3	dynein light chain Tctex-type 3

Pathways from BioSystems

Homologies

	DYNLT3	XP_001083869.1
Danio rerio (zebrafish)	dynlt3	NP_991171.1
Xenopus tropicalis (tropical clawed frog)	dynlt3	XP_004911807.1
Bos taurus (cattle)	DYNLT3	NP_001094690.1
Mus musculus (house mouse)	Dynlt3	NP_080251.3
Rattus norvegicus (Norway rat)	Dynlt3	NP_001013246.1
Pan troglodytes (chimpanzee)	DYNLT3	XP_003954015.1
Canis lupus familiaris (dog)	DYNLT3	NP_001003001.1
Bos taurus (cattle)	LOC101902009	XP_005221683.1
Homo sapiens (human)	DYNLT3	NP_006511.1
Gallus gallus (chicken)	DYNLT3	NP_001264663.1

Gene Ontology
Bibliography

Related articles in PubMed

C-terminal interactors of the AMPA receptor auxiliary subunit Shisa9.
Karataeva AR, Klaassen RV, Str?der J, Ruiperez-Alonso M, Hjorth JJ, van Nierop P, Spijker S, Mansvelder HD, Smit AB
PloS one9(2)e87360(2014)

DYNLT3 is required for chromosome alignment during mouse oocyte meiotic maturation.
Huang X, Wang HL, Qi ST, Wang ZB, Tong JS, Zhang QH, Ouyang YC, Hou Y, Schatten H, Qi ZQ, Sun QY
Reproductive sciences (Thousand Oaks, Calif.)18(10)983-9(2011 Oct)

Behavioral and other phenotypes in a cytoplasmic Dynein light intermediate chain 1 mutant mouse.
Banks GT, Haas MA, Line S, Shepherd HL, Alqatari M, Stewart S, Rishal I, Philpott A, Kalmar B, Kuta A, Groves M, Parkinson N, Acevedo-Arozena A, Brandner S, Bannerman D, Greensmith L, Hafezparast M, Koltzenburg M, Deacon R, Fainzilber M, Fisher EM
The Journal of neuroscience : the official journal of the Society for Neuroscience31(14)5483-94(2011 Apr)

Dynein light chain Tctex-type 1 modulates orexin signaling through its interaction with orexin 1 receptor.
Duguay D, B?langer-Nelson E, Mongrain V, Beben A, Khatchadourian A, Cermakian N
PloS one6(10)e26430(2011)

The DYNLT3 light chain directly links cytoplasmic dynein to a spindle checkpoint protein, Bub3.
Lo KW, Kogoy JM, Pfister KK
The Journal of biological chemistry282(15)11205-12(2007 Apr)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Data suggest that DNYLT3 is required for chromosome alignment and homologous segregation during mouse oocyte meiosis.
Title: DYNLT3 is required for chromosome alignment during mouse oocyte meiotic maturation.

subpopulation of dynein, containing the DYNLT3 light chain, may be important for chromosome congression, in addition to having a role in the transport of checkpoint proteins from the kinetochore to the spindle pole
Title: The DYNLT3 light chain directly links cytoplasmic dynein to a spindle checkpoint protein, Bub3.

The following Dynlt3 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Dynlt3 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OMu01349	NM_025975.5 Latest version!	Mus musculus dynein light chain Tctex-type 3 (Dynlt3), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$69.30 $99.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Dynlt3 ( NM_025975.5 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_080251.3 Mus musculus dynein light chain Tctex-type 3 (Dynlt3), mRNA.

Price & Availability↑

CloneID	OMu01349
Clone ID Related Accession (Same CDS sequence)	NM_025975.5
Accession Version	NM_025975.5 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 351bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-09-20
Organism	Mus musculus(house mouse)
Product	dynein light chain Tctex-type 3
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AL671118.30. On Apr 29, 2007 this sequence version replaced NM_025975.4. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. ##Evidence-Data-START## Transcript exon combination :: AK088277.1, SRR1660813.9179.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849381, SAMN01164131 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGAGGGGT ACCAACGGCC CTGCGATGAG GTTGGCTTCA ATGCTGATGA AGCCCATAAT 
ATAGTCAAAG AGTGTGTTGA TGGAGTTTTG GGTGGTAACG ATTATAATGA GAATAACATC 
AACCAATGGA CTGCAAGCAT AGTGGAACAG TCTATAACAC ATTTGGTCAA ACTGGGGAAA 
GCTTACAAGT ACATTGTGAC CTGTGCAGTG GTCCAGAGGA GCCCGTATGG ATTTCACACA 
GCCAGCTCCT GTTTTTGGGA TACAACATCT GATGGAACCT GTACCATCAG ATGGGAGAAC 
CGTACCATGA ACTGCATCGT GAATGTTTTT GCAGTTGCGA TTGTCCTGTA G

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_080251.3
CDS	86..436
Translation	MEGYQRPCDEVGFNADEAHNIVKECVDGVLGGNDYNENNINQWTASIVEQSITHLVKLGKAYKYIVTCAVVQRSPYGFHTASSCFWDTTSDGTCTIRWENRTMNCIVNVFAVAIVL

Target ORF information:

RefSeq Version	NM_025975.5
Organism	Mus musculus(house mouse)
Definition	Mus musculus dynein light chain Tctex-type 3 (Dynlt3), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_025975.5

ORF Insert Sequence:

ATGGAGGGGT ACCAACGGCC CTGCGATGAG GTTGGCTTCA ATGCTGATGA AGCCCATAAT 
ATAGTCAAAG AGTGTGTTGA TGGAGTTTTG GGTGGTAACG ATTATAATGA GAATAACATC 
AACCAATGGA CTGCAAGCAT AGTGGAACAG TCTATAACAC ATTTGGTCAA ACTGGGGAAA 
GCTTACAAGT ACATTGTGAC CTGTGCAGTG GTCCAGAGGA GCCCGTATGG ATTTCACACA 
GCCAGCTCCT GTTTTTGGGA TACAACATCT GATGGAACCT GTACCATCAG ATGGGAGAAC 
CGTACCATGA ACTGCATCGT GAATGTTTTT GCAGTTGCGA TTGTCCTGTA G

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

C-terminal interactors of the AMPA receptor auxiliary subunit Shisa9.
PloS one9(2)e87360(2014)
Karataeva AR,Klaassen RV,Str?der J,Ruiperez-Alonso M,Hjorth JJ,van Nierop P,Spijker S,Mansvelder HD,Smit AB

DYNLT3 is required for chromosome alignment during mouse oocyte meiotic maturation.
Reproductive sciences (Thousand Oaks, Calif.)18(10)983-9(2011 Oct)
Huang X,Wang HL,Qi ST,Wang ZB,Tong JS,Zhang QH,Ouyang YC,Hou Y,Schatten H,Qi ZQ,Sun QY

Behavioral and other phenotypes in a cytoplasmic Dynein light intermediate chain 1 mutant mouse.
The Journal of neuroscience : the official journal of the Society for Neuroscience31(14)5483-94(2011 Apr)
Banks GT,Haas MA,Line S,Shepherd HL,Alqatari M,Stewart S,Rishal I,Philpott A,Kalmar B,Kuta A,Groves M,Parkinson N,Acevedo-Arozena A,Brandner S,Bannerman D,Greensmith L,Hafezparast M,Koltzenburg M,Deacon R,Fainzilber M,Fisher EM

Dynein light chain Tctex-type 1 modulates orexin signaling through its interaction with orexin 1 receptor.
PloS one6(10)e26430(2011)
Duguay D,B?langer-Nelson E,Mongrain V,Beben A,Khatchadourian A,Cermakian N

The DYNLT3 light chain directly links cytoplasmic dynein to a spindle checkpoint protein, Bub3.
The Journal of biological chemistry282(15)11205-12(2007 Apr)
Lo KW,Kogoy JM,Pfister KK