Slc22a2 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Slc22a2
Entrez Gene ID	29503
Full Name	solute carrier family 22 member 2
Synonyms	OCT2,OCT2r,rOCT2
General protein information	Preferred Names solute carrier family 22 member 2 Names solute carrier family 22 member 2 organic cation transporter 2 solute carrier family 22 (organic cation transporter), member 2
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 1 Map Location: 1q11
Summary	acts as a transporter for organic cations and non-neuronal monoamines; may play a role in organic cation/H+ antiport function in renal brush border membrane vesicles [RGD, Feb 2006].

mRNA and Protein(s)

mRNA	Protein	Name
NM_031584.2	NP_113772.1	solute carrier family 22 member 2

Pathways from BioSystems

Homologies

Bos taurus (cattle)	SLC22A2	XP_002690417.1
Mus musculus (house mouse)	Slc22a2	NP_038695.1
Homo sapiens (human)	SLC22A2	NP_003049.2
	LOC708988	XP_002804005.1
Danio rerio (zebrafish)	slc22a2	NP_998315.1
Pan troglodytes (chimpanzee)	SLC22A2	XP_003311617.1
Canis lupus familiaris (dog)	SLC22A2	XP_533466.2
Gallus gallus (chicken)	LOC421584	XP_419622.2
Xenopus tropicalis (tropical clawed frog)	LOC100487774	XP_002933908.1
Rattus norvegicus (Norway rat)	Slc22a2	NP_113772.1
Gallus gallus (chicken)	SLC22A2	XP_419621.3

Gene Ontology
Bibliography

Related articles in PubMed

Targeting Oct2 and P53: Formononetin prevents cisplatin-induced acute kidney injury.
Huang D, Wang C, Duan Y, Meng Q, Liu Z, Huo X, Sun H, Ma X, Liu K
Toxicology and applied pharmacology32615-24(2017 07)

Pharmacological characterization of a high-affinity p-tyramine transporter in rat brain synaptosomes.
Berry MD, Hart S, Pryor AR, Hunter S, Gardiner D
Scientific reports638006(2016 Nov)

Gender-Related Differences in the Expression of Organic Cation Transporter 2 and its Role in Urinary Excretion of Metformin in Rats.
Ma YR, Qin HY, Jin YW, Huang J, Han M, Wang XD, Zhang GQ, Zhou Y, Rao Z, Wu XA
European journal of drug metabolism and pharmacokinetics41(5)559-65(2016 Oct)

Sex and age differences related to renal OCT2 gene expression in cisplatin-induced nephrotoxicity.
El-Arabey AA
Iranian journal of kidney diseases9(4)335-6(2015 Jul)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Formononetin prevents cisplatin-induced acute kidney injury by targeting Oct2/TP53 in the kidney.
Title: Targeting Oct2 and P53: Formononetin prevents cisplatin-induced acute kidney injury.

Renal rOCT2 levels, but not rOCT1 and rMATE1, were significantly lowered in female rats.
Title: Gender-Related Differences in the Expression of Organic Cation Transporter 2 and its Role in Urinary Excretion of Metformin in Rats.

A significant age-related decrease in rOCT2 protein expression was observed.
Title: Role of age-related decrease of renal organic cation transporter 2 in the effect of atenolol on renal excretion of metformin in rats.

cisplatin uptake was increased by OCT2 overexpression in male, but not female rats and associated with increased cellular sensitivity to cisplatin toxicity
Title: Sex and age differences related to renal OCT2 gene expression in cisplatin-induced nephrotoxicity.

Data show that lycopene upregulated the organic anion transporters (OAT1 and OAT3) and organic cation transporters (OCT1 and OCT2) in cisplatin-induced acute renal injury.
Title: Effect of lycopene against cisplatin-induced acute renal injury in rats: organic anion and cation transporters evaluation.

The following Slc22a2 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Slc22a2 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa08169	NM_031584.2 Latest version!	Rattus norvegicus solute carrier family 22 member 2 (Slc22a2), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$307.30 $439.00

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Slc22a2 ( NM_031584.2 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_113772.1 Rattus norvegicus solute carrier family 22 member 2 (Slc22a2), mRNA.

Price & Availability↑

CloneID	ORa08169
Clone ID Related Accession (Same CDS sequence)	NM_031584.2
Accession Version	NM_031584.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1782bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-08-03
Organism	Rattus norvegicus(Norway rat)
Product	solute carrier family 22 member 2
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from D83044.1. On Aug 30, 2012 this sequence version replaced NM_031584.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: D83044.1, X98334.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMD00052296, SAMEA2689597 [ECO:0000350] ##Evidence-Data-END##

ATGTCGACCG TGGATGATAT TCTAGAACAT ATAGGGGAAT TCCACCTTTT TCAGAAACAA 
ACATTTTTCC TCTTAGCTCT GCTGTCTGGT GCCTTCACCC CCATCTACGT GGGCATCGTT 
TTCCTAGGAT TTACCCCTGA CCACCACTGC TGGAGTCCTG GGGCAGCCAA GCTGAGCCAG 
CGGTGTGGCT GGAGCCAGGC AGAGGAGCTG AACTACACCG TGCCGGGTCT GGGACCTTCG 
GACGAGGCCT CCTTCCTCAG CCAGTGCATG AGGTATGAAG TGGACTGGAA CCAGAGCACC 
CTTGACTGTG TGGACCCACT GTCCAGCCTG GCTGCGGACA GGAACCAGTT GCCATTGGGC 
CCCTGCGAGC ATGGCTGGGT ATACAACACT CCCGGCTCCT CCATTGTCAC TGAGTTTAAC 
CTGGTGTGTG CTCACTCCTG GATGCTGGAC CTGTTTCAGT CAGTAGTGAA CGTGGGGTTT 
TTCATCGGTG CTATGATGAT TGGCTACCTA GCGGACAGGT TTGGCCGGAA GTTCTGCCTC 
TTGGTCACCA TCCTCATCAA TGCTATCTCT GGGGCTCTCA TGGCGATTTC TCCCAACTAT 
GCCTGGATGT TGGTGTTTCG CTTTCTCCAG GGACTGGTCA GCAAAGCAGG CTGGTTAATT 
GGCTACATCC TGATTACAGA ATTTGTTGGG CTGGGCTATC GCAGAATGGT GGGGATTTGC 
TATCAAATCG CCTTCACCGT TGGCCTCCTG ATCCTGGCTG GAGTGGCCTA TGTGATTCCC 
AACTGGAGAT GGCTACAATT TGCTGTGACT CTGCCCAACT TCTGCTTCCT GCTCTATTTC 
TGGTGCATAC CGGAATCTCC AAGATGGCTG ATCTCCCAGA ACAAAATCGT AAAAGCCATG 
AAGATAATTA AACATATTGC TAAGAAAAAT GGAAAGTCGG TGCCGGTCTC TCTTCAGAAC 
CTGACACCAG ATGAGGACGC TGGCAAGAAA TTGAAACCTT CAATCCTGGA CTTGGTCAGA 
ACCCCTCAGA TAAGGAAACA CACGTTGATC TTGATGTACA ATTGGTTCAC GAGCTCTGTT 
CTCTACCAGG GCCTCATCAT GCACATGGGC CTTGCAGGGG ACAACATCTA CCTGGATTTC 
TTCTACTCCG CCCTGGTGGA GTTTCCAGCC GCCTTCATCA TCATCCTCAC CATCGACCGG 
GTTGGTCGCC GCTATCCCTG GGCTGTGTCA AATATGGTGG CAGGAGCAGC CTGTCTAGCC 
TCTGTTTTTA TCCCTGATGA TCTACAGTGG CTGAAAATTA CCATTGCATG CTTGGGTAGA 
ATGGGCATCA CCATGGCCTA TGAAATGGTC TGCCTGGTCA ATGCTGAGCT GTACCCCACA 
TACATCAGGA ATCTTGGTGT CCTTGTCTGC TCCTCCATGT GTGACATTGG CGGCATCATC 
ACGCCTTTCC TCGTCTACCG TCTCACGGAC ATCTGGATGG AGTTCCCACT GGTTGTATTT 
GCTGTGGTTG GCCTTGTCGC TGGGGCACTT GTGCTGTTGC TACCTGAGAC CAAAGGGAAG 
GCTCTGCCTG AGACCATCGA GGATGCCGAG AATATGCAGA GGCCAAGAAA AAAAGAAAGA 
AAAGAGAATT TACCTCCAAG TCAAGCAAGC AGACCGTCCG CTAAGCTAAA AAGAAAGGGC 
ATCATTGCTG CTGGAGCTGA CTTTGCTCTC TCTGAGGCCA GAGATGGAGC TTCTCTCTCC 
CCTCCCCCCA AACCCACACA AACCAACCTC ACTTACCCCT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_113772.1
CDS	89..1870
Translation	MSTVDDILEHIGEFHLFQKQTFFLLALLSGAFTPIYVGIVFLGFTPDHHCWSPGAAKLSQRCGWSQAEELNYTVPGLGPSDEASFLSQCMRYEVDWNQSTLDCVDPLSSLAADRNQLPLGPCEHGWVYNTPGSSIVTEFNLVCAHSWMLDLFQSVVNVGFFIGAMMIGYLADRFGRKFCLLVTILINAISGALMAISPNYAWMLVFRFLQGLVSKAGWLIGYILITEFVGLGYRRMVGICYQIAFTVGLLILAGVAYVIPNWRWLQFAVTLPNFCFLLYFWCIPESPRWLISQNKIVKAMKIIKHIAKKNGKSVPVSLQNLTPDEDAGKKLKPSILDLVRTPQIRKHTLILMYNWFTSSVLYQGLIMHMGLAGDNIYLDFFYSALVEFPAAFIIILTIDRVGRRYPWAVSNMVAGAACLASVFIPDDLQWLKITIACLGRMGITMAYEMVCLVNAELYPTYIRNLGVLVCSSMCDIGGIITPFLVYRLTDIWMEFPLVVFAVVGLVAGALVLLLPETKGKALPETIEDAENMQRPRKKERKENLPPSQASRPSAKLKRKGIIAAGADFALSEARDGASLSPPPKPTQTNLTYP

Target ORF information:

RefSeq Version	NM_031584.2
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus solute carrier family 22 member 2 (Slc22a2), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_031584.2

ORF Insert Sequence:

ATGTCGACCG TGGATGATAT TCTAGAACAT ATAGGGGAAT TCCACCTTTT TCAGAAACAA 
ACATTTTTCC TCTTAGCTCT GCTGTCTGGT GCCTTCACCC CCATCTACGT GGGCATCGTT 
TTCCTAGGAT TTACCCCTGA CCACCACTGC TGGAGTCCTG GGGCAGCCAA GCTGAGCCAG 
CGGTGTGGCT GGAGCCAGGC AGAGGAGCTG AACTACACCG TGCCGGGTCT GGGACCTTCG 
GACGAGGCCT CCTTCCTCAG CCAGTGCATG AGGTATGAAG TGGACTGGAA CCAGAGCACC 
CTTGACTGTG TGGACCCACT GTCCAGCCTG GCTGCGGACA GGAACCAGTT GCCATTGGGC 
CCCTGCGAGC ATGGCTGGGT ATACAACACT CCCGGCTCCT CCATTGTCAC TGAGTTTAAC 
CTGGTGTGTG CTCACTCCTG GATGCTGGAC CTGTTTCAGT CAGTAGTGAA CGTGGGGTTT 
TTCATCGGTG CTATGATGAT TGGCTACCTA GCGGACAGGT TTGGCCGGAA GTTCTGCCTC 
TTGGTCACCA TCCTCATCAA TGCTATCTCT GGGGCTCTCA TGGCGATTTC TCCCAACTAT 
GCCTGGATGT TGGTGTTTCG CTTTCTCCAG GGACTGGTCA GCAAAGCAGG CTGGTTAATT 
GGCTACATCC TGATTACAGA ATTTGTTGGG CTGGGCTATC GCAGAATGGT GGGGATTTGC 
TATCAAATCG CCTTCACCGT TGGCCTCCTG ATCCTGGCTG GAGTGGCCTA TGTGATTCCC 
AACTGGAGAT GGCTACAATT TGCTGTGACT CTGCCCAACT TCTGCTTCCT GCTCTATTTC 
TGGTGCATAC CGGAATCTCC AAGATGGCTG ATCTCCCAGA ACAAAATCGT AAAAGCCATG 
AAGATAATTA AACATATTGC TAAGAAAAAT GGAAAGTCGG TGCCGGTCTC TCTTCAGAAC 
CTGACACCAG ATGAGGACGC TGGCAAGAAA TTGAAACCTT CAATCCTGGA CTTGGTCAGA 
ACCCCTCAGA TAAGGAAACA CACGTTGATC TTGATGTACA ATTGGTTCAC GAGCTCTGTT 
CTCTACCAGG GCCTCATCAT GCACATGGGC CTTGCAGGGG ACAACATCTA CCTGGATTTC 
TTCTACTCCG CCCTGGTGGA GTTTCCAGCC GCCTTCATCA TCATCCTCAC CATCGACCGG 
GTTGGTCGCC GCTATCCCTG GGCTGTGTCA AATATGGTGG CAGGAGCAGC CTGTCTAGCC 
TCTGTTTTTA TCCCTGATGA TCTACAGTGG CTGAAAATTA CCATTGCATG CTTGGGTAGA 
ATGGGCATCA CCATGGCCTA TGAAATGGTC TGCCTGGTCA ATGCTGAGCT GTACCCCACA 
TACATCAGGA ATCTTGGTGT CCTTGTCTGC TCCTCCATGT GTGACATTGG CGGCATCATC 
ACGCCTTTCC TCGTCTACCG TCTCACGGAC ATCTGGATGG AGTTCCCACT GGTTGTATTT 
GCTGTGGTTG GCCTTGTCGC TGGGGCACTT GTGCTGTTGC TACCTGAGAC CAAAGGGAAG 
GCTCTGCCTG AGACCATCGA GGATGCCGAG AATATGCAGA GGCCAAGAAA AAAAGAAAGA 
AAAGAGAATT TACCTCCAAG TCAAGCAAGC AGACCGTCCG CTAAGCTAAA AAGAAAGGGC 
ATCATTGCTG CTGGAGCTGA CTTTGCTCTC TCTGAGGCCA GAGATGGAGC TTCTCTCTCC 
CCTCCCCCCA AACCCACACA AACCAACCTC ACTTACCCCT GA