Cxcl2 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Cxcl2
Entrez Gene ID	114105
Full Name	C-X-C motif chemokine ligand 2
Synonyms	Mip-2,Scyb2
General protein information	Preferred Names C-X-C motif chemokine ligand 2 Names C-X-C motif chemokine 2 CINC-3 MIP2 chemokine (C-X-C motif) ligand 2 cytokine-induced neutrophil chemoattractant 3 macrophage inflammatory protein 2 small inducible cytokine subfamily, member 2
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 14 Map Location: 14p22
Summary	chemokine involved in the pulmonary inflammatory response [RGD, Feb 2006].

mRNA and Protein(s)

mRNA	Protein	Name
NM_053647.1	NP_446099.1	C-X-C motif chemokine 2 precursor

Pathways from BioSystems

Homologies

Pan troglodytes (chimpanzee)	CXCL3	XP_517228.2
Mus musculus (house mouse)	Cxcl2	NP_033166.1
Rattus norvegicus (Norway rat)	Cxcl2	NP_446099.1
Homo sapiens (human)	CXCL3	NP_002081.2
	CXCL3	NP_001028051.1
	LOC100424064	XP_002804334.1

Gene Ontology
Bibliography

Related articles in PubMed

Chemokine (C-X-C motif) ligand 1 (CXCL1) and chemokine (C-X-C motif) ligand 2 (CXCL2) modulate the activity of TRPV1+/IB4+ cultured rat dorsal root ganglia neurons upon short-term and acute application.
Deftu AF, Filippi A, Shibsaki K, Gheorghe RO, Chiritoiu M, Ristoiu V
Journal of physiology and pharmacology : an official journal of the Polish Physiological Society68(3)385-395(2017 Jun)

Local and Systemic Profiles of Inflammatory Cytokines in Carrageenan-induced Paw Inflammation in Rats.
Annamalai P, Thangam EB
Immunological investigations46(3)274-283(2017 Apr)

Protective effect of quercetin on acute lung injury in rats with sepsis and its influence on ICAM-1 and MIP-2 expression.
Meng L, Lv Z, Yu ZZ, Xu D, Yan X
Genetics and molecular research : GMR15(3)(2016 Jul)

Effect of rutin on spinal cord injury through inhibition of the expression of MIP-2 and activation of MMP-9, and downregulation of Akt phosphorylation.
Zhang P, Ma X
Molecular medicine reports12(5)7554-60(2015 Nov)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

this study shows elevated expression of CINC-3 at the site of inflammation as well as their significant reflection in the circulation, thereby suggesting their frontline role in carrageenan-induced acute inflammation
Title: Local and Systemic Profiles of Inflammatory Cytokines in Carrageenan-induced Paw Inflammation in Rats.

Quercetin might protect against acute lung injury in rats with sepsis by suppressing ICAM-1 and MIP-2 expression.
Title: Protective effect of quercetin on acute lung injury in rats with sepsis and its influence on ICAM-1 and MIP-2 expression.

rutin is a potential protective agent in spinal cord injury enhancing the neurotrophic effect by inhibiting the expression of MIP-2 and activation of MMP-9, and downregulating the expression of p-Akt.
Title: Effect of rutin on spinal cord injury through inhibition of the expression of MIP-2 and activation of MMP-9, and downregulation of Akt phosphorylation.

IL-1beta-mediated regulation of the CXCL1 and CXCL2 genes in pancreatic beta-cells requires stimulus-induced changes in histone chemical modifications, recruitment of the NF-kappaB and STAT1 transcription factors to genomic regulatory sequences within the proximal gene promoters, and increases in phosphorylated forms of RNA polymerase II.
Title: NF-?B and STAT1 control CXCL1 and CXCL2 gene transcription.

The rat spiral ligament fibrocytes were found to release CXCL2 in response to nontypeable H. influenzae via activation of c-Jun, leading to the recruitment of polymorphonuclear cells to the cochlea.
Title: ERK2-dependent activation of c-Jun is required for nontypeable Haemophilus influenzae-induced CXCL2 upregulation in inner ear fibrocytes.

The following Cxcl2 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Cxcl2 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa13016	NM_053647.1 Latest version!	Rattus norvegicus C-X-C motif chemokine ligand 2 (Cxcl2), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$69.30 $99.00

ORF Online Only Promotion

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Cxcl2 ( NM_053647.1 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_446099.1 Rattus norvegicus C-X-C motif chemokine ligand 2 (Cxcl2), mRNA.

Price & Availability↑

CloneID	ORa13016
Clone ID Related Accession (Same CDS sequence)	NM_053647.1
Accession Version	NM_053647.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 303bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-24
Organism	Rattus norvegicus(Norway rat)
Product	C-X-C motif chemokine 2 precursor
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from AB060092.1. On Dec 17, 2003 this sequence version replaced XM_346458.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AB060092.1, CF115385.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN01906356, SAMN02642791 [ECO:0000348] ##Evidence-Data-END##

ATGGCCCCTC CCACTCGCCA GCTCCTCAAT GCTGTACTGG TCCTGCTCCT CCTGCTGGCC 
ACCAACCATC AGGGTACAGG GGTTGTTGTG GCCAGTGAGC TGCGCTGTCA ATGCCTGACG 
ACCCTACCAA GGGTTGACTT CAAGAACATC CAGAGCTTGA CGGTGACCCC TCCAGGACCC 
CACTGCGCCC AGACAGAAGT CATAGCCACT CTTAAGGATG GTCATGAAGT TTGTCTCAAC 
CCTGAAGCCC CCTTGGTTCA GAGGATCGTC CAAAAGATAC TGAACAAAGG CAAGGCTAAC 
TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_446099.1
CDS	71..373
Translation	MAPPTRQLLNAVLVLLLLLATNHQGTGVVVASELRCQCLTTLPRVDFKNIQSLTVTPPGPHCAQTEVIATLKDGHEVCLNPEAPLVQRIVQKILNKGKAN

Target ORF information:

RefSeq Version	NM_053647.1
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus C-X-C motif chemokine ligand 2 (Cxcl2), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_053647.1

ORF Insert Sequence:

ATGGCCCCTC CCACTCGCCA GCTCCTCAAT GCTGTACTGG TCCTGCTCCT CCTGCTGGCC 
ACCAACCATC AGGGTACAGG GGTTGTTGTG GCCAGTGAGC TGCGCTGTCA ATGCCTGACG 
ACCCTACCAA GGGTTGACTT CAAGAACATC CAGAGCTTGA CGGTGACCCC TCCAGGACCC 
CACTGCGCCC AGACAGAAGT CATAGCCACT CTTAAGGATG GTCATGAAGT TTGTCTCAAC 
CCTGAAGCCC CCTTGGTTCA GAGGATCGTC CAAAAGATAC TGAACAAAGG CAAGGCTAAC 
TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Chemokine (C-X-C motif) ligand 1 (CXCL1) and chemokine (C-X-C motif) ligand 2 (CXCL2) modulate the activity of TRPV1+/IB4+ cultured rat dorsal root ganglia neurons upon short-term and acute application.
Journal of physiology and pharmacology : an official journal of the Polish Physiological Society68(3)385-395(2017 Jun)
Deftu AF,Filippi A,Shibsaki K,Gheorghe RO,Chiritoiu M,Ristoiu V

Local and Systemic Profiles of Inflammatory Cytokines in Carrageenan-induced Paw Inflammation in Rats.
Immunological investigations46(3)274-283(2017 Apr)
Annamalai P,Thangam EB

Protective effect of quercetin on acute lung injury in rats with sepsis and its influence on ICAM-1 and MIP-2 expression.
Genetics and molecular research : GMR15(3)(2016 Jul)
Meng L,Lv Z,Yu ZZ,Xu D,Yan X

Effect of rutin on spinal cord injury through inhibition of the expression of MIP-2 and activation of MMP-9, and downregulation of Akt phosphorylation.
Molecular medicine reports12(5)7554-60(2015 Nov)
Zhang P,Ma X