CXCL3 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	CXCL3
Entrez Gene ID	2921
Full Name	C-X-C motif chemokine ligand 3
Synonyms	CINC-2b,GRO3,GROg,MIP-2b,MIP2B,SCYB3
General protein information	Preferred Names C-X-C motif chemokine ligand 3 Names C-X-C motif chemokine 3 GRO-gamma GRO-gamma(1-73) GRO3 oncogene MGSA gamma MIP2-beta chemokine (C-X-C motif) ligand 3 growth-regulated protein gamma macrophage inflammatory protein 2-beta melanoma growth stimulatory activity gamma
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 4 Map Location: 4q13.3
Summary	This antimicrobial gene encodes a member of the CXC subfamily of chemokines. The encoded protein is a secreted growth factor that signals through the G-protein coupled receptor, CXC receptor 2. This protein plays a role in inflammation and as a chemoattractant for neutrophils. [provided by RefSeq, Sep 2014].
Disorder MIM:	139111

mRNA and Protein(s)

mRNA	Protein	Name
NM_002090.3	NP_002081.2	C-X-C motif chemokine 3 precursor
NM_002090.2	NP_002081.2	C-X-C motif chemokine 3 precursor

Pathways from BioSystems

Homologies

Pan troglodytes (chimpanzee)	CXCL3	XP_517228.2
Mus musculus (house mouse)	Cxcl2	NP_033166.1
Rattus norvegicus (Norway rat)	Cxcl2	NP_446099.1
Homo sapiens (human)	CXCL3	NP_002081.2
	CXCL3	NP_001028051.1
	LOC100424064	XP_002804334.1

Gene Ontology
Bibliography

Related articles in PubMed

Molecular cloning and biophysical characterization of CXCL3 chemokine.
Gulati K, Gangele K, Agarwal N, Jamsandekar M, Kumar D, Poluri KM
International journal of biological macromolecules107(Pt A)575-584(2018 Feb)

Suppression of Medulloblastoma Lesions by Forced Migration of Preneoplastic Precursor Cells with Intracerebellar Administration of the Chemokine Cxcl3.
Ceccarelli M, Micheli L, Tirone F
Frontiers in pharmacology7484(2016)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Our findings suggest that CXCL3 and its receptor CXCR2 are overexpressed in prostate cancer cells, prostate epithelial cells and prostate cancer tissues, which may play multiple roles in prostate cancer progression and metastasis.
Title: Overexpression of CXCL3 can enhance the oncogenic potential of prostate cancer.

results support a functional role of CXCL3 in breast cancer metastasis and as a viable target for cancer therapy
Title: CXCL3 is a potential target for breast cancer metastasis.

our results demonstrate the diverse mechanisms by which CXCL2 and CXCL3 mediate normal and asthmatic airway smooth muscle cell migration
Title: Differential roles of CXCL2 and CXCL3 and their receptors in regulating normal and asthmatic airway smooth muscle cell migration.

secreted growth-regulated oncogene chemokines, specifically GRO-gamma, in human Mesenchymal stromal cell-conditioned media have an effect on the differentiation and the function of human monocyte-derived dendritic cells.
Title: Mesenchymal stem cells tune the development of monocyte-derived dendritic cells toward a myeloid-derived suppressive phenotype through growth-regulated oncogene chemokines.

This study demonistrated that CXCL1, CXCL2, CXCL3, CXCL8, and CXCL11, absent from normal muscle fibers, were induced in DMD myofibers.
Title: Upregulation of chemokines and their receptors in Duchenne muscular dystrophy: potential for attenuation of myofiber necrosis.

The following CXCL3 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the CXCL3 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu03827	NM_002090.3 Latest version!	Homo sapiens C-X-C motif chemokine ligand 3 (CXCL3), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
View Old Accession Versions >>
OHu03827	NM_002090.2	Homo sapiens C-X-C motif chemokine ligand 3 (CXCL3), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
Hide Old Accession Versions >>

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

CXCL3 ( NM_002090.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_002081.2 Homo sapiens C-X-C motif chemokine ligand 3 (CXCL3), mRNA.

Price & Availability↑

CloneID	OHu03827
Clone ID Related Accession (Same CDS sequence)	NM_002090.3 , NM_002090.2
Accession Version	NM_002090.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 324bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-15
Organism	Homo sapiens(human)
Product	C-X-C motif chemokine 3 precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BC065743.1 and AW079760.1. On May 17, 2019 this sequence version replaced NM_002090.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR5189658.25158.1, SRR5189667.233906.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN02400288 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000296026.4/ ENSP00000296026.4 Protein has antimicrobial activity :: PMID: 12949249 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGGCCCACG CCACGCTCTC CGCCGCCCCC AGCAATCCCC GGCTCCTGCG GGTGGCGCTG 
CTGCTCCTGC TCCTGGTGGC CGCCAGCCGG CGCGCAGCAG GAGCGTCCGT GGTCACTGAA 
CTGCGCTGCC AGTGCTTGCA GACACTGCAG GGAATTCACC TCAAGAACAT CCAAAGTGTG 
AATGTAAGGT CCCCCGGACC CCACTGCGCC CAAACCGAAG TCATAGCCAC ACTCAAGAAT 
GGGAAGAAAG CTTGTCTCAA CCCCGCATCC CCCATGGTTC AGAAAATCAT CGAAAAGATA 
CTGAACAAGG GGAGCACCAA CTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_002081.2
CDS	79..402
Translation	MAHATLSAAPSNPRLLRVALLLLLLVAASRRAAGASVVTELRCQCLQTLQGIHLKNIQSVNVRSPGPHCAQTEVIATLKNGKKACLNPASPMVQKIIEKILNKGSTN

Target ORF information:

RefSeq Version	NM_002090.3
Organism	Homo sapiens(human)
Definition	Homo sapiens C-X-C motif chemokine ligand 3 (CXCL3), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_002090.3

ORF Insert Sequence:

ATGGCCCACG CCACGCTCTC CGCCGCCCCC AGCAATCCCC GGCTCCTGCG GGTGGCGCTG 
CTGCTCCTGC TCCTGGTGGC CGCCAGCCGG CGCGCAGCAG GAGCGTCCGT GGTCACTGAA 
CTGCGCTGCC AGTGCTTGCA GACACTGCAG GGAATTCACC TCAAGAACAT CCAAAGTGTG 
AATGTAAGGT CCCCCGGACC CCACTGCGCC CAAACCGAAG TCATAGCCAC ACTCAAGAAT 
GGGAAGAAAG CTTGTCTCAA CCCCGCATCC CCCATGGTTC AGAAAATCAT CGAAAAGATA 
CTGAACAAGG GGAGCACCAA CTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

CXCL3 ( NM_002090.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_002081.2 Homo sapiens C-X-C motif chemokine ligand 3 (CXCL3), mRNA.

Price & Availability↑

CloneID	OHu03827
Clone ID Related Accession (Same CDS sequence)	NM_002090.3 , NM_002090.2
Accession Version	NM_002090.2	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 324bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-03-06
Organism	Homo sapiens(human)
Product	C-X-C motif chemokine 3 precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BM828712.1, BC065743.1 and AW079760.1. On Oct 15, 2004 this sequence version replaced NM_002090.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: CN263767.1, BC065743.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN02400288 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## Protein has antimicrobial activity :: PMID: 12949249 ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGGCCCACG CCACGCTCTC CGCCGCCCCC AGCAATCCCC GGCTCCTGCG GGTGGCGCTG 
CTGCTCCTGC TCCTGGTGGC CGCCAGCCGG CGCGCAGCAG GAGCGTCCGT GGTCACTGAA 
CTGCGCTGCC AGTGCTTGCA GACACTGCAG GGAATTCACC TCAAGAACAT CCAAAGTGTG 
AATGTAAGGT CCCCCGGACC CCACTGCGCC CAAACCGAAG TCATAGCCAC ACTCAAGAAT 
GGGAAGAAAG CTTGTCTCAA CCCCGCATCC CCCATGGTTC AGAAAATCAT CGAAAAGATA 
CTGAACAAGG GGAGCACCAA CTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_002081.2
CDS	163..486
Translation	MAHATLSAAPSNPRLLRVALLLLLLVAASRRAAGASVVTELRCQCLQTLQGIHLKNIQSVNVRSPGPHCAQTEVIATLKNGKKACLNPASPMVQKIIEKILNKGSTN

Target ORF information:

RefSeq Version	NM_002090.2
Organism	Homo sapiens(human)
Definition	Homo sapiens C-X-C motif chemokine ligand 3 (CXCL3), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_002090.2

ORF Insert Sequence:

ATGGCCCACG CCACGCTCTC CGCCGCCCCC AGCAATCCCC GGCTCCTGCG GGTGGCGCTG 
CTGCTCCTGC TCCTGGTGGC CGCCAGCCGG CGCGCAGCAG GAGCGTCCGT GGTCACTGAA 
CTGCGCTGCC AGTGCTTGCA GACACTGCAG GGAATTCACC TCAAGAACAT CCAAAGTGTG 
AATGTAAGGT CCCCCGGACC CCACTGCGCC CAAACCGAAG TCATAGCCAC ACTCAAGAAT 
GGGAAGAAAG CTTGTCTCAA CCCCGCATCC CCCATGGTTC AGAAAATCAT CGAAAAGATA 
CTGAACAAGG GGAGCACCAA CTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Molecular cloning and biophysical characterization of CXCL3 chemokine.
International journal of biological macromolecules107(Pt A)575-584(2018 Feb)
Gulati K,Gangele K,Agarwal N,Jamsandekar M,Kumar D,Poluri KM

Suppression of Medulloblastoma Lesions by Forced Migration of Preneoplastic Precursor Cells with Intracerebellar Administration of the Chemokine Cxcl3.
Frontiers in pharmacology7484(2016)
Ceccarelli M,Micheli L,Tirone F