Cops5 cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Cops5
Entrez Gene ID	26754
Full Name	COP9 signalosome subunit 5
Synonyms	AI303502,CSN5,Jab1,Mov34,Sgn5
General protein information	Preferred Names COP9 signalosome subunit 5 Names COP9 signalosome complex subunit 5 COP9 (constitutive photomorphogenic) homolog, subunit 5 COP9 complex S5 Jun activation domain-binding protein 1 Jun coactivator Kip1 C-terminus-interacting protein 2
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 1 Map Location: 1 A2\|1 2.29 cM

mRNA and Protein(s)

mRNA	Protein	Name
NM_013715.2	NP_038743.1	COP9 signalosome complex subunit 5 isoform 1
NM_001277101.1	NP_001264030.1	COP9 signalosome complex subunit 5 isoform 2

Pathways from BioSystems

Homologies

Homo sapiens (human)	COPS5	NP_006828.2
Bos taurus (cattle)	COPS5	NP_001179068.1
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP002880	XP_312032.5
Mus musculus (house mouse)	Cops5	NP_038743.1
Arabidopsis thaliana (thale cress)	CSN5B	NP_177279.1
Oryza sativa (rice)	Os04g0654700	NP_001054112.1
Xenopus tropicalis (tropical clawed frog)	cops5	NP_989109.1
Pan troglodytes (chimpanzee)	COPS5	XP_001162723.1
Canis lupus familiaris (dog)	COPS5	XP_005638087.1
Gallus gallus (chicken)	COPS5	NP_001034400.1
Drosophila melanogaster (fruit fly)	CSN5	NP_477442.1
Caenorhabditis elegans (roundworm)	csn-5	NP_500841.1
Magnaporthe oryzae (rice blast fungus)	MGG_05274	XP_003712833.1
Neurospora crassa	NCU00467	XP_956786.1
	COPS5	XP_001097856.1
Rattus norvegicus (Norway rat)	Cops5	NP_001020866.1
Danio rerio (zebrafish)	cops5	NP_957019.1
Arabidopsis thaliana (thale cress)	CSN5A	NP_173705.1

Gene Ontology
Bibliography

Related articles in PubMed

Inhibition of atherogenesis by the COP9 signalosome subunit 5 in vivo.
Asare Y, Ommer M, Azombo FA, Alampour-Rajabi S, Sternkopf M, Sanati M, Gijbels MJ, Schmitz C, Sinitski D, Tilstam PV, Lue H, Gessner A, Lange D, Schmid JA, Weber C, Dichgans M, Jankowski J, Pardi R, de Winther MP, Noels H, Bernhagen J
Proceedings of the National Academy of Sciences of the United States of America114(13)E2766-E2775(2017 Mar)

The oxoglutarate receptor 1 (OXGR1) modulates pressure overload-induced cardiac hypertrophy in mice.
Omede A, Zi M, Prehar S, Maqsood A, Stafford N, Mamas M, Cartwright E, Oceandy D
Biochemical and biophysical research communications479(4)708-714(2016 Oct)

Decreased expression levels of Ifi genes is associated to the increased resistance to spontaneous arthritis disease in mice deficiency of IL-1RA.
Liu X, Jiao Y, Cao Y, Deng N, Ma Y, Hasty KA, Kang A, Chen H, Stuart JM, Gu W
BMC immunology17(1)25(2016 08)

COPS5 protein overexpression increases amyloid plaque burden, decreases spinophilin-immunoreactive puncta, and exacerbates learning and memory deficits in the mouse brain.
Wang R, Wang H, Carrera I, Xu S, Lakshmana MK
The Journal of biological chemistry290(14)9299-309(2015 Apr)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

COPS5 overexpression reduced spinophilin in both the cortex (19%, p < 0.05) and the hippocampus (20%, p < 0.05), leading to significant deficits in learning and memory skills
Title: COPS5 protein overexpression increases amyloid plaque burden, decreases spinophilin-immunoreactive puncta, and exacerbates learning and memory deficits in the mouse brain.

Jab1 is an essential regulator of early embryonic limb development.
Title: Loss of jab1 in osteochondral progenitor cells severely impairs embryonic limb development in mice.

Lack of COPS5 in regenerating livers causes substantial replicative stress which triggers a cyclin-dependent kinase inhibitor(CDKN)2A genetic program leading to cell cycle arrest, polyploidy, and apoptosis.
Title: The COP9 signalosome is a repressor of replicative stress responses and polyploidization in the regenerating liver.

Jab1 may transduce laminin211 signals to regulate Schwann cell number and differentiation during axonal sorting.
Title: Jab1 regulates Schwann cell proliferation and axonal sorting through p27.

Data indicate that in Cul4b-deficient embryonic fibroblasts showed Jab1 accumulation.
Title: X-linked intellectual disability gene CUL4B targets Jab1/CSN5 for degradation and regulates bone morphogenetic protein signaling.

The following Cops5 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Cops5 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OMu16373	NM_001277101.1 Latest version!	Mus musculus COP9 signalosome subunit 5 (Cops5), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$139.30 $199.00
OMu16414	NM_013715.2 Latest version!	Mus musculus COP9 signalosome subunit 5 (Cops5), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$188.30 $269.00

ORF Online Only Promotion

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Cops5 ( NM_001277101.1 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_001264030.1 Mus musculus COP9 signalosome subunit 5 (Cops5), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OMu16373
Clone ID Related Accession (Same CDS sequence)	NM_001277101.1
Accession Version	NM_001277101.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 954bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-28
Organism	Mus musculus(house mouse)
Product	COP9 signalosome complex subunit 5 isoform 2
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AC102570.8, BC046753.1, AK005728.1 and BY393956.1. Transcript Variant: This variant (2) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at an alternate start codon, compared to variant 1. The encoded isoform (2) is shorter and has a distinct N-terminus, compared to isoform 1. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## RNAseq introns :: single sample supports all introns SAMN00849381, SAMN01164134 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGTCGCTGC GCCGCCGCCG CGCCCCAGCG CGCGAATGGT CTGGACCAAC GTCACCTCCG 
GTCTCAAGTG TCATGGCTGC CTTGAGAGTC TATCACCACT ACTTTAAATA CTGCAAAATC 
TCAGCATTGG CTCTACTGAA AATGGTGATG CATGCCAGGT CAGGAGGCAA CTTGGAAGTG 
ATGGGTTTGA TGCTCGGGAA AGTCGACGGC GAGACCATGA TCATCATGGA CAGTTTCGCT 
TTGCCTGTAG AGGGCACAGA AACTCGAGTA AATGCTCAAG CTGCTGCGTA TGAGTATATG 
GCTGCATACA TAGAAAATGC CAAACAGGTT GGCCGCCTTG AGAATGCAAT CGGTTGGTAT 
CATAGCCACC CTGGTTATGG CTGCTGGCTC TCCGGGATTG ATGTTAGTAC ACAGATGCTG 
AACCAGCAGT TTCAAGAACC ATTTGTAGCA GTGGTGATTG ATCCAACCAG AACAATCTCT 
GCAGGAAAAG TGAATCTTGG CGCCTTTAGG ACATATCCAA AGGGCTACAA ACCTCCTGAT 
GAAGGACCTT CTGAGTACCA GACTATCCCA CTTAATAAAA TAGAAGATTT TGGCGTGCAC 
TGCAAACAAT ATTATGCCTT AGAAGTCTCA TATTTCAAAT CATCTTTGGA TCGTAAACTA 
CTTGAGCTTT TGTGGAATAA ATACTGGGTG AATACCCTGA GTTCCTCTAG CTTGCTTACT 
AATGCAGACT ACACCACAGG CCAGGTGTTT GATTTGTCTG AGAAGTTAGA GCAGTCGGAA 
GCCCAACTGG GACGTGGCAG TTTCATGTTG GGCTTAGAAA CACATGACCG CAAGTCGGAA 
GACAAACTTG CCAAAGCTAC TAGAGACAGC TGTAAAACCA CCATAGAAGC CATCCATGGA 
CTGATGTCTC AGGTTATTAA GGATAAACTG TTTAATCAGA TTAACGTTGC TTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001264030.1
CDS	150..1103
Translation	MSLRRRRAPAREWSGPTSPPVSSVMAALRVYHHYFKYCKISALALLKMVMHARSGGNLEVMGLMLGKVDGETMIIMDSFALPVEGTETRVNAQAAAYEYMAAYIENAKQVGRLENAIGWYHSHPGYGCWLSGIDVSTQMLNQQFQEPFVAVVIDPTRTISAGKVNLGAFRTYPKGYKPPDEGPSEYQTIPLNKIEDFGVHCKQYYALEVSYFKSSLDRKLLELLWNKYWVNTLSSSSLLTNADYTTGQVFDLSEKLEQSEAQLGRGSFMLGLETHDRKSEDKLAKATRDSCKTTIEAIHGLMSQVIKDKLFNQINVA

Target ORF information:

RefSeq Version	NM_001277101.1
Organism	Mus musculus(house mouse)
Definition	Mus musculus COP9 signalosome subunit 5 (Cops5), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001277101.1

ORF Insert Sequence:

ATGTCGCTGC GCCGCCGCCG CGCCCCAGCG CGCGAATGGT CTGGACCAAC GTCACCTCCG 
GTCTCAAGTG TCATGGCTGC CTTGAGAGTC TATCACCACT ACTTTAAATA CTGCAAAATC 
TCAGCATTGG CTCTACTGAA AATGGTGATG CATGCCAGGT CAGGAGGCAA CTTGGAAGTG 
ATGGGTTTGA TGCTCGGGAA AGTCGACGGC GAGACCATGA TCATCATGGA CAGTTTCGCT 
TTGCCTGTAG AGGGCACAGA AACTCGAGTA AATGCTCAAG CTGCTGCGTA TGAGTATATG 
GCTGCATACA TAGAAAATGC CAAACAGGTT GGCCGCCTTG AGAATGCAAT CGGTTGGTAT 
CATAGCCACC CTGGTTATGG CTGCTGGCTC TCCGGGATTG ATGTTAGTAC ACAGATGCTG 
AACCAGCAGT TTCAAGAACC ATTTGTAGCA GTGGTGATTG ATCCAACCAG AACAATCTCT 
GCAGGAAAAG TGAATCTTGG CGCCTTTAGG ACATATCCAA AGGGCTACAA ACCTCCTGAT 
GAAGGACCTT CTGAGTACCA GACTATCCCA CTTAATAAAA TAGAAGATTT TGGCGTGCAC 
TGCAAACAAT ATTATGCCTT AGAAGTCTCA TATTTCAAAT CATCTTTGGA TCGTAAACTA 
CTTGAGCTTT TGTGGAATAA ATACTGGGTG AATACCCTGA GTTCCTCTAG CTTGCTTACT 
AATGCAGACT ACACCACAGG CCAGGTGTTT GATTTGTCTG AGAAGTTAGA GCAGTCGGAA 
GCCCAACTGG GACGTGGCAG TTTCATGTTG GGCTTAGAAA CACATGACCG CAAGTCGGAA 
GACAAACTTG CCAAAGCTAC TAGAGACAGC TGTAAAACCA CCATAGAAGC CATCCATGGA 
CTGATGTCTC AGGTTATTAA GGATAAACTG TTTAATCAGA TTAACGTTGC TTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Cops5 ( NM_013715.2 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_038743.1 Mus musculus COP9 signalosome subunit 5 (Cops5), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OMu16414
Clone ID Related Accession (Same CDS sequence)	NM_013715.2
Accession Version	NM_013715.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1005bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-28
Organism	Mus musculus(house mouse)
Product	COP9 signalosome complex subunit 5 isoform 1
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AC102570.8, CX240457.1, AK012499.1, AK005728.1 and BY393956.1. On Mar 7, 2013 this sequence version replaced NM_013715.1. Transcript Variant: This variant (1) encodes the longer isoform (1). Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK005728.1, BC046753.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN01164134, SAMN01164135 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGCAGCTT CCGGGAGTGG TATGGCCCAG AAAACCTGGG AATTGGCCAA CAACATGCAG 
GAAGCGCAGA GTATCGATGA AATCTACAAA TATGACAAAA AACAACAACA AGAAATCCTG 
GCGGCGAAAC CCTGGACTAA GGATCACCAC TACTTTAAAT ACTGCAAAAT CTCAGCATTG 
GCTCTACTGA AAATGGTGAT GCATGCCAGG TCAGGAGGCA ACTTGGAAGT GATGGGTTTG 
ATGCTCGGGA AAGTCGACGG CGAGACCATG ATCATCATGG ACAGTTTCGC TTTGCCTGTA 
GAGGGCACAG AAACTCGAGT AAATGCTCAA GCTGCTGCGT ATGAGTATAT GGCTGCATAC 
ATAGAAAATG CCAAACAGGT TGGCCGCCTT GAGAATGCAA TCGGTTGGTA TCATAGCCAC 
CCTGGTTATG GCTGCTGGCT CTCCGGGATT GATGTTAGTA CACAGATGCT GAACCAGCAG 
TTTCAAGAAC CATTTGTAGC AGTGGTGATT GATCCAACCA GAACAATCTC TGCAGGAAAA 
GTGAATCTTG GCGCCTTTAG GACATATCCA AAGGGCTACA AACCTCCTGA TGAAGGACCT 
TCTGAGTACC AGACTATCCC ACTTAATAAA ATAGAAGATT TTGGCGTGCA CTGCAAACAA 
TATTATGCCT TAGAAGTCTC ATATTTCAAA TCATCTTTGG ATCGTAAACT ACTTGAGCTT 
TTGTGGAATA AATACTGGGT GAATACCCTG AGTTCCTCTA GCTTGCTTAC TAATGCAGAC 
TACACCACAG GCCAGGTGTT TGATTTGTCT GAGAAGTTAG AGCAGTCGGA AGCCCAACTG 
GGACGTGGCA GTTTCATGTT GGGCTTAGAA ACACATGACC GCAAGTCGGA AGACAAACTT 
GCCAAAGCTA CTAGAGACAG CTGTAAAACC ACCATAGAAG CCATCCATGG ACTGATGTCT 
CAGGTTATTA AGGATAAACT GTTTAATCAG ATTAACGTTG CTTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_038743.1
CDS	348..1352
Translation	MAASGSGMAQKTWELANNMQEAQSIDEIYKYDKKQQQEILAAKPWTKDHHYFKYCKISALALLKMVMHARSGGNLEVMGLMLGKVDGETMIIMDSFALPVEGTETRVNAQAAAYEYMAAYIENAKQVGRLENAIGWYHSHPGYGCWLSGIDVSTQMLNQQFQEPFVAVVIDPTRTISAGKVNLGAFRTYPKGYKPPDEGPSEYQTIPLNKIEDFGVHCKQYYALEVSYFKSSLDRKLLELLWNKYWVNTLSSSSLLTNADYTTGQVFDLSEKLEQSEAQLGRGSFMLGLETHDRKSEDKLAKATRDSCKTTIEAIHGLMSQVIKDKLFNQINVA

Target ORF information:

RefSeq Version	NM_013715.2
Organism	Mus musculus(house mouse)
Definition	Mus musculus COP9 signalosome subunit 5 (Cops5), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_013715.2

ORF Insert Sequence:

ATGGCAGCTT CCGGGAGTGG TATGGCCCAG AAAACCTGGG AATTGGCCAA CAACATGCAG 
GAAGCGCAGA GTATCGATGA AATCTACAAA TATGACAAAA AACAACAACA AGAAATCCTG 
GCGGCGAAAC CCTGGACTAA GGATCACCAC TACTTTAAAT ACTGCAAAAT CTCAGCATTG 
GCTCTACTGA AAATGGTGAT GCATGCCAGG TCAGGAGGCA ACTTGGAAGT GATGGGTTTG 
ATGCTCGGGA AAGTCGACGG CGAGACCATG ATCATCATGG ACAGTTTCGC TTTGCCTGTA 
GAGGGCACAG AAACTCGAGT AAATGCTCAA GCTGCTGCGT ATGAGTATAT GGCTGCATAC 
ATAGAAAATG CCAAACAGGT TGGCCGCCTT GAGAATGCAA TCGGTTGGTA TCATAGCCAC 
CCTGGTTATG GCTGCTGGCT CTCCGGGATT GATGTTAGTA CACAGATGCT GAACCAGCAG 
TTTCAAGAAC CATTTGTAGC AGTGGTGATT GATCCAACCA GAACAATCTC TGCAGGAAAA 
GTGAATCTTG GCGCCTTTAG GACATATCCA AAGGGCTACA AACCTCCTGA TGAAGGACCT 
TCTGAGTACC AGACTATCCC ACTTAATAAA ATAGAAGATT TTGGCGTGCA CTGCAAACAA 
TATTATGCCT TAGAAGTCTC ATATTTCAAA TCATCTTTGG ATCGTAAACT ACTTGAGCTT 
TTGTGGAATA AATACTGGGT GAATACCCTG AGTTCCTCTA GCTTGCTTAC TAATGCAGAC 
TACACCACAG GCCAGGTGTT TGATTTGTCT GAGAAGTTAG AGCAGTCGGA AGCCCAACTG 
GGACGTGGCA GTTTCATGTT GGGCTTAGAA ACACATGACC GCAAGTCGGA AGACAAACTT 
GCCAAAGCTA CTAGAGACAG CTGTAAAACC ACCATAGAAG CCATCCATGG ACTGATGTCT 
CAGGTTATTA AGGATAAACT GTTTAATCAG ATTAACGTTG CTTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Inhibition of atherogenesis by the COP9 signalosome subunit 5 in vivo.
Proceedings of the National Academy of Sciences of the United States of America114(13)E2766-E2775(2017 Mar)
Asare Y,Ommer M,Azombo FA,Alampour-Rajabi S,Sternkopf M,Sanati M,Gijbels MJ,Schmitz C,Sinitski D,Tilstam PV,Lue H,Gessner A,Lange D,Schmid JA,Weber C,Dichgans M,Jankowski J,Pardi R,de Winther MP,Noels H,Bernhagen J

The oxoglutarate receptor 1 (OXGR1) modulates pressure overload-induced cardiac hypertrophy in mice.
Biochemical and biophysical research communications479(4)708-714(2016 Oct)
Omede A,Zi M,Prehar S,Maqsood A,Stafford N,Mamas M,Cartwright E,Oceandy D

Decreased expression levels of Ifi genes is associated to the increased resistance to spontaneous arthritis disease in mice deficiency of IL-1RA.
BMC immunology17(1)25(2016 08)
Liu X,Jiao Y,Cao Y,Deng N,Ma Y,Hasty KA,Kang A,Chen H,Stuart JM,Gu W

COPS5 protein overexpression increases amyloid plaque burden, decreases spinophilin-immunoreactive puncta, and exacerbates learning and memory deficits in the mouse brain.
The Journal of biological chemistry290(14)9299-309(2015 Apr)
Wang R,Wang H,Carrera I,Xu S,Lakshmana MK