Adam6a cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Adam6a
Entrez Gene ID	238406
Full Name	a disintegrin and metallopeptidase domain 6A
Synonyms	Adam6,tMDCIV
General protein information	Preferred Names a disintegrin and metallopeptidase domain 6A Names a disintegrin and metalloprotease domain 6 a disintegrin and metallopeptidase domain 6 disintegrin and metalloproteinase domain 6
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 12 Map Location: 12\|12 F1

mRNA and Protein(s)

mRNA	Protein	Name
NM_174885.3	NP_777479.2	a disintegrin and metalloprotease domain 6

Pathways from BioSystems

Homologies

Mus musculus (house mouse)	Adam6a	NP_777479.2
Mus musculus (house mouse)	Adam6b	NP_001009545.1

Gene Ontology
Bibliography

Related articles in PubMed

Positive selection in the adhesion domain of Mus sperm Adam genes through gene duplications and function-driven gene complex formations.
Grayson P, Civetta A
BMC evolutionary biology13217(2013 Sep)

Lack of tyrosylprotein sulfotransferase-2 activity results in altered sperm-egg interactions and loss of ADAM3 and ADAM6 in epididymal sperm.
Marcello MR, Jia W, Leary JA, Moore KL, Evans JP
The Journal of biological chemistry286(15)13060-70(2011 Apr)

Comprehensive analysis of reproductive ADAMs: relationship of ADAM4 and ADAM6 with an ADAM complex required for fertilization in mice.
Han C, Choi E, Park I, Lee B, Jin S, Kim DH, Nishimura H, Cho C
Biology of reproduction80(5)1001-8(2009 May)

Characterization and comparative genomic analysis of intronless Adams with testicular gene expression.
Choi I, Oh J, Cho BN, Ahnn J, Jung YK, Han Kim D, Cho C
Genomics83(4)636-46(2004 Apr)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Lack of tyrosylprotein sulfotransferase-2 activity results in altered sperm-egg interactions and loss of ADAM3 and ADAM6 in epididymal sperm.
Title: Lack of tyrosylprotein sulfotransferase-2 activity results in altered sperm-egg interactions and loss of ADAM3 and ADAM6 in epididymal sperm.

The levels of ADAM4 and ADAM6 are dramatically reduced in Adam2 and Adam3 knockout sperm defective in various fertilization processes.
Title: Comprehensive analysis of reproductive ADAMs: relationship of ADAM4 and ADAM6 with an ADAM complex required for fertilization in mice.

The following Adam6a gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Adam6a cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OMu24739	NM_174885.3 Latest version!	Mus musculus a disintegrin and metallopeptidase domain 6A (Adam6a), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	12-14	$391.30 $559.00

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Adam6a ( NM_174885.3 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_777479.2 Mus musculus a disintegrin and metallopeptidase domain 6A (Adam6a), mRNA.

Price & Availability↑

CloneID	OMu24739
Clone ID Related Accession (Same CDS sequence)	NM_174885.3
Accession Version	NM_174885.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2265bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2018-05-25
Organism	Mus musculus(house mouse)
Product	a disintegrin and metalloprotease domain 6
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AC073553.5. On Dec 21, 2006 this sequence version replaced NM_174885.2. ##Evidence-Data-START## Transcript is intronless :: AY158689.1 [ECO:0000345] ##Evidence-Data-END##

ATGTTATCTC TGACCTGGGG CATGAGGCTA GTGGAAAGAC CTGTGGTCCC CAGGGTCCTC 
CTCTTGCTAT TTGCACTCTG GCTGCTCCTC CTGGTTCCAG TCTGGTGTTC TCAAGGCCAT 
CCCACTTGGC GTTACATCTC ATCGGAGGTG GTTATTCCTC GGAAGGAGAT CTACCATACC 
AAAGGACTTC AAGCACAAAG ACTGCTCTCG TATAGCTTGC GTTTTCGGGG CCAGAGACAT 
ATCATCCACC TGCGGAGAAA GACACTCATT TGGCCCAGAC ACTTGTTGCT GACAACTCAA 
GATGACCAAG GAGCCTTACA GATGGAGTAC CCCTTTTTTC CTGTAGATTG TTACTATATT 
GGCTACCTGG AGGGGATCCT GCAATCCATG GTCACTGTGG ATACTTGTTA TGGGGGCCTG 
TCAGGGGTCA TAAAGTTGGA TAACCTTACC TATGAAATCA AACCCCTCAA TGATTCACAG 
AGCTTTGAAC ACCTTGTTTC TCAGATAGTA TCTGAGTCTG ATGACACAGG GCCTATGAAT 
GCATGGAAGC ACTGGAGCCA TAATACAGGT TCTCCCTCCT CCAGATTGGA ATATGCAGAT 
GGAGCTCCCA GACTATCTAG TAAGAATTAC GCTACACATC CAGCTGCTAT AAAAGGCCAC 
TTTCAAGCAA CCCATTCTGT ATATAGTGCT TCTGGAGGTG ACAAACTTTC ATCTACTGTT 
GAGTATTTGT TTAAAGTCAT TAGTTTAATG GACACCTATC TGACCAATCT TCATATGCGG 
TACTATGTCT TTCTCATGAC TGTGTATACC GAGGCTGATC CATTTTCACA AGATTTTCGA 
GTTCCAGGAG GGCAGGCTCA TACTTTCTAT GAGAGAGTAT TTTATGCTCA TTTTAGGCCT 
GATGCAGGAG CTATAATTAA CAAGAATTCG CCAGGAGATG ATGCTGTTAA TCCAGCTGAG 
AGGAGTATAT GTTCTCCCTC AGCCCTAATT TGTCTTGGTC AACATGGTCG AAATCCTTTA 
TTTTTATCTA TTATAATAAC CAATCGTGTT GGAAGGAGTT TAGGCCTAAA ACATGATGAG 
GGGTACTGTA TCTGCCAGAG AAGGAACACC TGCATCATGT TCAAAAATCC TCAATTAACA 
GATGCTTTCA GCAATTGTTC CCTTGCAGAG ATAAGCAACA TACTTAATAC TCCTGATCTG 
ATGCCATGTC TTTTCTATGA CCGTCATGTT TATTATAATA CATCATTGAC TTATAAGTTT 
TGTGGAAACT TCAAAGTAGA TAACAATGAG CAGTGTGACT GTGGCTCCCA AAAGGCATGT 
TATTCAGATC CCTGCTGTGG AAATGATTGC AGGTTAACAC CTGGTAGCAT TTGTGATAAA 
GAATTATGCT GTGCAAATTG CACTTACAGT CCTTCTGGGA CACTCTGCAG ACCTATCCAG 
AACATATGTG ATCTTCCAGA GTACTGTAGT GGCTCTAAGT TCATTTGCCC AGATGACACT 
TATCTGCAAG ATGGGACACC ATGCTCAGAA GAGGGTTACT GCTATAAAGG TAACTGCACT 
GATCGCAACA TACAATGCAT GGAAATCTTT GGTGTAAGTG CTAAGAATGC TAATATTAAG 
TGCTATGACA TCAACAAACA ACGGTTTCGA TTTGGGCATT GTACTAGAGC AGAAGAAAGC 
CTCACATTCA ATGCTTGTGC TGATCAGGAC AAGCTGTGTG GAAGGTTGCA GTGTACCAAT 
GTCACCAATC TTCCATTTTT GCAAGAACAT GTTTCATTCC ATCAATCGGT TATCTCTGGG 
GTTACCTGCT TTGGGCTTGA TGAACATCGT GGGACAGAAA CAGCAGATGC TGGATTGGTG 
AGACATGGTA CCCCGTGTTC AAGGGGTAAG TTCTGTGATC GAGGAGCTTG CAATGGAAGT 
TTATCTCGTT TGGGTTATGA CTGCACCCCA GAAAAATGCA ATTTCAGAGG AGTGTGTAAC 
AATCGTCGGA ATTGCCATTG CCATTTTGGT TGGAGCCCTC CAAAGTGCAA AGAAGAGGGA 
CACAGTGGGA GCATAGACAG TGGGTCCCCT CCGGTTCAAA GGCGCATAAT AAAACAGAAC 
CTAGAGCCAG TAGTGTATTT AAGAATACTC TTTGGTCGTA TTTACTTCCT CTTTGTTGCA 
CTGCTCTTTG GCATTGCCAC TCGTGTAGGA GTTACTAAGA TATTTAGGTT TGAAGACTTG 
CAAGCTGCTT TACGTTCTTG GCAAGAACAA GCAAAGGACA AGTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_777479.2
CDS	102..2366
Translation	MLSLTWGMRLVERPVVPRVLLLLFALWLLLLVPVWCSQGHPTWRYISSEVVIPRKEIYHTKGLQAQRLLSYSLRFRGQRHIIHLRRKTLIWPRHLLLTTQDDQGALQMEYPFFPVDCYYIGYLEGILQSMVTVDTCYGGLSGVIKLDNLTYEIKPLNDSQSFEHLVSQIVSESDDTGPMNAWKHWSHNTGSPSSRLEYADGAPRLSSKNYATHPAAIKGHFQATHSVYSASGGDKLSSTVEYLFKVISLMDTYLTNLHMRYYVFLMTVYTEADPFSQDFRVPGGQAHTFYERVFYAHFRPDAGAIINKNSPGDDAVNPAERSICSPSALICLGQHGRNPLFLSIIITNRVGRSLGLKHDEGYCICQRRNTCIMFKNPQLTDAFSNCSLAEISNILNTPDLMPCLFYDRHVYYNTSLTYKFCGNFKVDNNEQCDCGSQKACYSDPCCGNDCRLTPGSICDKELCCANCTYSPSGTLCRPIQNICDLPEYCSGSKFICPDDTYLQDGTPCSEEGYCYKGNCTDRNIQCMEIFGVSAKNANIKCYDINKQRFRFGHCTRAEESLTFNACADQDKLCGRLQCTNVTNLPFLQEHVSFHQSVISGVTCFGLDEHRGTETADAGLVRHGTPCSRGKFCDRGACNGSLSRLGYDCTPEKCNFRGVCNNRRNCHCHFGWSPPKCKEEGHSGSIDSGSPPVQRRIIKQNLEPVVYLRILFGRIYFLFVALLFGIATRVGVTKIFRFEDLQAALRSWQEQAKDK

Target ORF information:

RefSeq Version	NM_174885.3
Organism	Mus musculus(house mouse)
Definition	Mus musculus a disintegrin and metallopeptidase domain 6A (Adam6a), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_174885.3

ORF Insert Sequence:

ATGTTATCTC TGACCTGGGG CATGAGGCTA GTGGAAAGAC CTGTGGTCCC CAGGGTCCTC 
CTCTTGCTAT TTGCACTCTG GCTGCTCCTC CTGGTTCCAG TCTGGTGTTC TCAAGGCCAT 
CCCACTTGGC GTTACATCTC ATCGGAGGTG GTTATTCCTC GGAAGGAGAT CTACCATACC 
AAAGGACTTC AAGCACAAAG ACTGCTCTCG TATAGCTTGC GTTTTCGGGG CCAGAGACAT 
ATCATCCACC TGCGGAGAAA GACACTCATT TGGCCCAGAC ACTTGTTGCT GACAACTCAA 
GATGACCAAG GAGCCTTACA GATGGAGTAC CCCTTTTTTC CTGTAGATTG TTACTATATT 
GGCTACCTGG AGGGGATCCT GCAATCCATG GTCACTGTGG ATACTTGTTA TGGGGGCCTG 
TCAGGGGTCA TAAAGTTGGA TAACCTTACC TATGAAATCA AACCCCTCAA TGATTCACAG 
AGCTTTGAAC ACCTTGTTTC TCAGATAGTA TCTGAGTCTG ATGACACAGG GCCTATGAAT 
GCATGGAAGC ACTGGAGCCA TAATACAGGT TCTCCCTCCT CCAGATTGGA ATATGCAGAT 
GGAGCTCCCA GACTATCTAG TAAGAATTAC GCTACACATC CAGCTGCTAT AAAAGGCCAC 
TTTCAAGCAA CCCATTCTGT ATATAGTGCT TCTGGAGGTG ACAAACTTTC ATCTACTGTT 
GAGTATTTGT TTAAAGTCAT TAGTTTAATG GACACCTATC TGACCAATCT TCATATGCGG 
TACTATGTCT TTCTCATGAC TGTGTATACC GAGGCTGATC CATTTTCACA AGATTTTCGA 
GTTCCAGGAG GGCAGGCTCA TACTTTCTAT GAGAGAGTAT TTTATGCTCA TTTTAGGCCT 
GATGCAGGAG CTATAATTAA CAAGAATTCG CCAGGAGATG ATGCTGTTAA TCCAGCTGAG 
AGGAGTATAT GTTCTCCCTC AGCCCTAATT TGTCTTGGTC AACATGGTCG AAATCCTTTA 
TTTTTATCTA TTATAATAAC CAATCGTGTT GGAAGGAGTT TAGGCCTAAA ACATGATGAG 
GGGTACTGTA TCTGCCAGAG AAGGAACACC TGCATCATGT TCAAAAATCC TCAATTAACA 
GATGCTTTCA GCAATTGTTC CCTTGCAGAG ATAAGCAACA TACTTAATAC TCCTGATCTG 
ATGCCATGTC TTTTCTATGA CCGTCATGTT TATTATAATA CATCATTGAC TTATAAGTTT 
TGTGGAAACT TCAAAGTAGA TAACAATGAG CAGTGTGACT GTGGCTCCCA AAAGGCATGT 
TATTCAGATC CCTGCTGTGG AAATGATTGC AGGTTAACAC CTGGTAGCAT TTGTGATAAA 
GAATTATGCT GTGCAAATTG CACTTACAGT CCTTCTGGGA CACTCTGCAG ACCTATCCAG 
AACATATGTG ATCTTCCAGA GTACTGTAGT GGCTCTAAGT TCATTTGCCC AGATGACACT 
TATCTGCAAG ATGGGACACC ATGCTCAGAA GAGGGTTACT GCTATAAAGG TAACTGCACT 
GATCGCAACA TACAATGCAT GGAAATCTTT GGTGTAAGTG CTAAGAATGC TAATATTAAG 
TGCTATGACA TCAACAAACA ACGGTTTCGA TTTGGGCATT GTACTAGAGC AGAAGAAAGC 
CTCACATTCA ATGCTTGTGC TGATCAGGAC AAGCTGTGTG GAAGGTTGCA GTGTACCAAT 
GTCACCAATC TTCCATTTTT GCAAGAACAT GTTTCATTCC ATCAATCGGT TATCTCTGGG 
GTTACCTGCT TTGGGCTTGA TGAACATCGT GGGACAGAAA CAGCAGATGC TGGATTGGTG 
AGACATGGTA CCCCGTGTTC AAGGGGTAAG TTCTGTGATC GAGGAGCTTG CAATGGAAGT 
TTATCTCGTT TGGGTTATGA CTGCACCCCA GAAAAATGCA ATTTCAGAGG AGTGTGTAAC 
AATCGTCGGA ATTGCCATTG CCATTTTGGT TGGAGCCCTC CAAAGTGCAA AGAAGAGGGA 
CACAGTGGGA GCATAGACAG TGGGTCCCCT CCGGTTCAAA GGCGCATAAT AAAACAGAAC 
CTAGAGCCAG TAGTGTATTT AAGAATACTC TTTGGTCGTA TTTACTTCCT CTTTGTTGCA 
CTGCTCTTTG GCATTGCCAC TCGTGTAGGA GTTACTAAGA TATTTAGGTT TGAAGACTTG 
CAAGCTGCTT TACGTTCTTG GCAAGAACAA GCAAAGGACA AGTAA