Gc cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Gc
Entrez Gene ID	14473
Full Name	group specific component
Synonyms	DBP,VDB
General protein information	Preferred Names group specific component Names vitamin D-binding protein gc-globulin
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 5 Map Location: 5 E1\|5 44.32 cM

mRNA and Protein(s)

mRNA	Protein	Name
NM_008096.2	NP_032122.1	vitamin D-binding protein precursor

Pathways from BioSystems

Homologies

Gallus gallus (chicken)	GC	NP_990213.1
Homo sapiens (human)	GC	NP_001191236.1
	GC	XP_001104833.2
Rattus norvegicus (Norway rat)	Gc	NP_036696.2
Danio rerio (zebrafish)	gc	NP_001002568.1
Xenopus tropicalis (tropical clawed frog)	gc	NP_001015745.1
Pan troglodytes (chimpanzee)	GC	XP_517242.3
Canis lupus familiaris (dog)	GC	XP_005628336.1
Bos taurus (cattle)	GC	NP_001030457.1
Mus musculus (house mouse)	Gc	NP_032122.1

Gene Ontology
Bibliography

Related articles in PubMed

High-throughput discovery of novel developmental phenotypes.
Dickinson ME, Flenniken AM, Ji X, Teboul L, Wong MD, White JK, Meehan TF, Weninger WJ, Westerberg H, Adissu H, Baker CN, Bower L, Brown JM, Caddle LB, Chiani F, Clary D, Cleak J, Daly MJ, Denegre JM, Doe B, Dolan ME, Edie SM, Fuchs H, Gailus-Durner V, Galli A, Gambadoro A, Gallegos J, Guo S, Horner NR, Hsu CW, Johnson SJ, Kalaga S, Keith LC, Lanoue L, Lawson TN, Lek M, Mark M, Marschall S, Mason J, McElwee ML, Newbigging S, Nutter LM, Peterson KA, Ramirez-Solis R, Rowland DJ, Ryder E, Samocha KE, Seavitt JR, Selloum M, Szoke-Kovacs Z, Tamura M, Trainor AG, Tudose I, Wakana S, Warren J, Wendling O, West DB, Wong L, Yoshiki A, , , , , , , , , MacArthur DG, Tocchini-Valentini GP, Gao X, Flicek P, Bradley A, Skarnes WC, Justice MJ, Parkinson HE, Moore M, Wells S, Braun RE, Svenson KL, de Angelis MH, Herault Y, Mohun T, Mallon AM, Henkelman RM, Brown SD, Adams DJ, Lloyd KC, McKerlie C, Beaudet AL, Bu?an M, Murray SA
Nature537(7621)508-514(2016 09)

Neutrophil recruitment to the lung in both C5a- and CXCL1-induced alveolitis is impaired in vitamin D-binding protein-deficient mice.
Trujillo G, Habiel DM, Ge L, Ramadass M, Cooke NE, Kew RR
Journal of immunology (Baltimore, Md. : 1950)191(2)848-56(2013 Jul)

Effects of estradiol on the endocytic transport of vitamin D carrier protein in hepatocytes.
Pirani T, Chen J, Vieira A
Biochimica et biophysica acta1830(6)3421-6(2013 Jun)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

results show DBP is a significant chemotactic cofactor in vivo and not specific for C5a, suggesting that this ubiquitous plasma protein may have a more significant role in neutrophil recruitment than previously recognized
Title: Neutrophil recruitment to the lung in both C5a- and CXCL1-induced alveolitis is impaired in vitamin D-binding protein-deficient mice.

Effects of estradiol on the endocytic transport of vitamin D carrier protein in hepatocytes.
Title: Effects of estradiol on the endocytic transport of vitamin D carrier protein in hepatocytes.

Data suggest that whereas DBP is important to total circulating 1,25(OH)(2)D(3) and sequesters extracellular levels of this hormone both in vivo and in vitro, the binding protein does not influence the hormone's biologically active pool.
Title: Vitamin D-binding protein influences total circulating levels of 1,25-dihydroxyvitamin D3 but does not directly modulate the bioactive levels of the hormone in vivo.

The following Gc gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Gc cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OMu01355	NM_008096.2 Latest version!	Mus musculus vitamin D binding protein (Gc), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$223.30 $319.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Gc ( NM_008096.2 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_032122.1 Mus musculus vitamin D binding protein (Gc), mRNA.

Price & Availability↑

CloneID	OMu01355
Clone ID Related Accession (Same CDS sequence)	NM_008096.2
Accession Version	NM_008096.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1431bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-09-16
Organism	Mus musculus(house mouse)
Product	vitamin D-binding protein precursor
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AI788221.1, M55413.1 and AI876501.1. On Mar 1, 2011 this sequence version replaced NM_008096.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC051395.1, AK010965.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849386, SAMN01164134 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGAAGAGGG TTCTGGTTCT CCTGCTGGCC TTAGCCTTTG GGCACGCTCT AGAGAGAGGC 
CGAGACTATG AGAAGGATAA AGTTTGCAAT GAACTCGCCA TGCTGGGGAA AGAGGACTTC 
AGATCTTTAT CACTAATCCT ATATAGCAGG AAGTTTTCCA GTAGCACATT TGAGCAGGTC 
AACCAGCTTG TGAAGGAAGT TGTCTCCTTG ACTGAGGAGT GCTGTGCTGA GGGAGCTGAC 
CCCACCTGCT ACGACACCAG GACCTCAGAG CTGTCTGTTA AGTCCTGTGA AAGTGATGCT 
CCCTTTCCGG TTCACCCTGG AACTCCTGAG TGTTGCACCA AGGAGGGGCT GGAGCGGAAA 
CTCTGCATGG CTGCCCTCAG TCACCAGCCG CAGGAATTTC CCACCTACGT GGAACCAACA 
AATGATGAGA TCTGTGAGGC CTTCAGGAGG GACCCAAAGG GATTTGCTGA CCAGTTTCTG 
TATGAGTATT CCAGCAATTA TGGACAAGCG CCTCTGCCAC TTTTAGTTGC TTACACCAAG 
AATTATCTCT CTATGGTTGG ATCCTGCTGT ACTTCTGCAA ACCCAACTGT ATGCTTTGTG 
AAGGAGAGAC TCCAGATGAA GCATTTGTCA CTTCTCACCA CCATGTCAAA CAGAGTCTGC 
TCACAATATG CTGCATATGG AAAGGAAAAA TCAAGGCTGA GCCATCTCAT AAAACTAGCC 
CAAAAAGTGC CAACTGCTAA CCTGGAGAAC GTTCTGCCAC TAGCTGAAGA CTTTACTGAA 
ATCCTGTCCA GATGTTGTGA GTCTACCTCA GAGGATTGCA TGGCCAGTGA GCTGCCTGAG 
CACACAATAA AAATCTGTCA AAACTTATCC AAAAAGAATT CTAAGTTTGA AGAGTGCTGT 
CAAGAAAACA CACCCATGAA CATTTTTATG TGCACCTACT TCATGCCAGC TGCTGAACCA 
CTTCAATTGC CAGCTATCAA GTTGCCAACT GGCAAAGACC TCTGTGGTCA GAGTACCACA 
CAAGCCATGG ACCAGTATAC ATTTGAACTA AGCAGAAGGA CTCAAGTTCC AGAAGTGTTC 
CTCAGCAAAG TTCTGGAGCC AACCCTGAAA ACCCTTAGGG AGTGCTGTGA CACTCAGGAT 
TCTGTTGCCT GTTTCAGCAC TCAGAGTCCC CTGCTGAAGA GGCAACTAAC TTCTTTCATC 
GAAAAAGGTC AAGAAATGTG TGCAGATTAT TCTGAGAACA CATTTACTGA GTACAAGAAA 
AAATTGGCAG AACGGCTAAG GACAAAAACA CCCAACACCT CTCCGGCAGA GCTGAAAGAC 
ATGGTGGAGA AACACTCGGA CTTTGCCTCT AAGTGCTGCT CTATAAACTC ACCTCCTCTC 
TACTGCAGCT CACAGATTGA TGCAGAAATG ATAGACACCC TGCAGTCCTG A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_032122.1
CDS	181..1611
Translation	MKRVLVLLLALAFGHALERGRDYEKDKVCNELAMLGKEDFRSLSLILYSRKFSSSTFEQVNQLVKEVVSLTEECCAEGADPTCYDTRTSELSVKSCESDAPFPVHPGTPECCTKEGLERKLCMAALSHQPQEFPTYVEPTNDEICEAFRRDPKGFADQFLYEYSSNYGQAPLPLLVAYTKNYLSMVGSCCTSANPTVCFVKERLQMKHLSLLTTMSNRVCSQYAAYGKEKSRLSHLIKLAQKVPTANLENVLPLAEDFTEILSRCCESTSEDCMASELPEHTIKICQNLSKKNSKFEECCQENTPMNIFMCTYFMPAAEPLQLPAIKLPTGKDLCGQSTTQAMDQYTFELSRRTQVPEVFLSKVLEPTLKTLRECCDTQDSVACFSTQSPLLKRQLTSFIEKGQEMCADYSENTFTEYKKKLAERLRTKTPNTSPAELKDMVEKHSDFASKCCSINSPPLYCSSQIDAEMIDTLQS

Target ORF information:

RefSeq Version	NM_008096.2
Organism	Mus musculus(house mouse)
Definition	Mus musculus vitamin D binding protein (Gc), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_008096.2

ORF Insert Sequence:

ATGAAGAGGG TTCTGGTTCT CCTGCTGGCC TTAGCCTTTG GGCACGCTCT AGAGAGAGGC 
CGAGACTATG AGAAGGATAA AGTTTGCAAT GAACTCGCCA TGCTGGGGAA AGAGGACTTC 
AGATCTTTAT CACTAATCCT ATATAGCAGG AAGTTTTCCA GTAGCACATT TGAGCAGGTC 
AACCAGCTTG TGAAGGAAGT TGTCTCCTTG ACTGAGGAGT GCTGTGCTGA GGGAGCTGAC 
CCCACCTGCT ACGACACCAG GACCTCAGAG CTGTCTGTTA AGTCCTGTGA AAGTGATGCT 
CCCTTTCCGG TTCACCCTGG AACTCCTGAG TGTTGCACCA AGGAGGGGCT GGAGCGGAAA 
CTCTGCATGG CTGCCCTCAG TCACCAGCCG CAGGAATTTC CCACCTACGT GGAACCAACA 
AATGATGAGA TCTGTGAGGC CTTCAGGAGG GACCCAAAGG GATTTGCTGA CCAGTTTCTG 
TATGAGTATT CCAGCAATTA TGGACAAGCG CCTCTGCCAC TTTTAGTTGC TTACACCAAG 
AATTATCTCT CTATGGTTGG ATCCTGCTGT ACTTCTGCAA ACCCAACTGT ATGCTTTGTG 
AAGGAGAGAC TCCAGATGAA GCATTTGTCA CTTCTCACCA CCATGTCAAA CAGAGTCTGC 
TCACAATATG CTGCATATGG AAAGGAAAAA TCAAGGCTGA GCCATCTCAT AAAACTAGCC 
CAAAAAGTGC CAACTGCTAA CCTGGAGAAC GTTCTGCCAC TAGCTGAAGA CTTTACTGAA 
ATCCTGTCCA GATGTTGTGA GTCTACCTCA GAGGATTGCA TGGCCAGTGA GCTGCCTGAG 
CACACAATAA AAATCTGTCA AAACTTATCC AAAAAGAATT CTAAGTTTGA AGAGTGCTGT 
CAAGAAAACA CACCCATGAA CATTTTTATG TGCACCTACT TCATGCCAGC TGCTGAACCA 
CTTCAATTGC CAGCTATCAA GTTGCCAACT GGCAAAGACC TCTGTGGTCA GAGTACCACA 
CAAGCCATGG ACCAGTATAC ATTTGAACTA AGCAGAAGGA CTCAAGTTCC AGAAGTGTTC 
CTCAGCAAAG TTCTGGAGCC AACCCTGAAA ACCCTTAGGG AGTGCTGTGA CACTCAGGAT 
TCTGTTGCCT GTTTCAGCAC TCAGAGTCCC CTGCTGAAGA GGCAACTAAC TTCTTTCATC 
GAAAAAGGTC AAGAAATGTG TGCAGATTAT TCTGAGAACA CATTTACTGA GTACAAGAAA 
AAATTGGCAG AACGGCTAAG GACAAAAACA CCCAACACCT CTCCGGCAGA GCTGAAAGAC 
ATGGTGGAGA AACACTCGGA CTTTGCCTCT AAGTGCTGCT CTATAAACTC ACCTCCTCTC 
TACTGCAGCT CACAGATTGA TGCAGAAATG ATAGACACCC TGCAGTCCTG A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

High-throughput discovery of novel developmental phenotypes.
Nature537(7621)508-514(2016 09)
Dickinson ME,Flenniken AM,Ji X,Teboul L,Wong MD,White JK,Meehan TF,Weninger WJ,Westerberg H,Adissu H,Baker CN,Bower L,Brown JM,Caddle LB,Chiani F,Clary D,Cleak J,Daly MJ,Denegre JM,Doe B,Dolan ME,Edie SM,Fuchs H,Gailus-Durner V,Galli A,Gambadoro A,Gallegos J,Guo S,Horner NR,Hsu CW,Johnson SJ,Kalaga S,Keith LC,Lanoue L,Lawson TN,Lek M,Mark M,Marschall S,Mason J,McElwee ML,Newbigging S,Nutter LM,Peterson KA,Ramirez-Solis R,Rowland DJ,Ryder E,Samocha KE,Seavitt JR,Selloum M,Szoke-Kovacs Z,Tamura M,Trainor AG,Tudose I,Wakana S,Warren J,Wendling O,West DB,Wong L,Yoshiki A,,,,,,,,,MacArthur DG,Tocchini-Valentini GP,Gao X,Flicek P,Bradley A,Skarnes WC,Justice MJ,Parkinson HE,Moore M,Wells S,Braun RE,Svenson KL,de Angelis MH,Herault Y,Mohun T,Mallon AM,Henkelman RM,Brown SD,Adams DJ,Lloyd KC,McKerlie C,Beaudet AL,Bu?an M,Murray SA

Neutrophil recruitment to the lung in both C5a- and CXCL1-induced alveolitis is impaired in vitamin D-binding protein-deficient mice.
Journal of immunology (Baltimore, Md. : 1950)191(2)848-56(2013 Jul)
Trujillo G,Habiel DM,Ge L,Ramadass M,Cooke NE,Kew RR

Effects of estradiol on the endocytic transport of vitamin D carrier protein in hepatocytes.
Biochimica et biophysica acta1830(6)3421-6(2013 Jun)
Pirani T,Chen J,Vieira A