Agrp cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Agrp
Entrez Gene ID	11604
Full Name	agouti related neuropeptide
Synonyms	Agrt,Art
General protein information	Preferred Names agouti related neuropeptide Names agouti-related protein orexigenic neuropeptide
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 8 Map Location: 8\|8 D3
Summary	This gene encodes a protein that regulates feeding behavior and plays a key role in the control of body weight. The encoded protein acts as an antagonist of melanocortin receptor signaling. Alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, Nov 2012].

mRNA and Protein(s)

mRNA	Protein	Name
NM_007427.3	NP_031453.1	agouti-related protein precursor
NM_001271806.1	NP_001258735.1	agouti-related protein precursor

Pathways from BioSystems

Homologies

Canis lupus familiaris (dog)	AGRP	XP_853932.1
Pan troglodytes (chimpanzee)	AGRP	XP_001164015.1
	AGRP	XP_001091740.1
Bos taurus (cattle)	AGRP	NP_776408.1
Mus musculus (house mouse)	Agrp	NP_001258735.1
Homo sapiens (human)	AGRP	NP_001129.1
Rattus norvegicus (Norway rat)	Agrp	NP_387499.1
Gallus gallus (chicken)	AGRP	NP_001026628.1
Gallus gallus (chicken)	LOC100859622	XP_004951049.1

Gene Ontology
Bibliography

Related articles in PubMed

The role of the Agouti-Related Protein in energy balance regulation.
Ilnytska O, Argyropoulos G
Cellular and molecular life sciences : CMLS65(17)2721-31(2008 Sep)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

It was concluded that a small population of neuroendocrine cells in the adrenal medulla, and the arcuate nucleus of the hypothalamus, express AgRP and neuropeptide Y and are functionally involved in the systemic response to fasting.
Title: AgRP-Expressing Adrenal Chromaffin Cells Are Involved in the Sympathetic Response to Fasting.

These findings indicate that the relevance of AgRP to POMC neuron GABA connectivity depends on the state of AgRP neuron activity and suggest that different types of transmitter release should be considered when circuit mapping.
Title: The Relevance of AgRP Neuron-Derived GABA Inputs to POMC Neurons Differs for Spontaneous and Evoked Release.

P2Y6 signaling in AgRP neurons is involved in the onset of obesity-associated hyperphagia.
Title: Inhibition of P2Y6 Signaling in AgRP Neurons Reduces Food Intake and Improves Systemic Insulin Sensitivity in Obesity.

These results identify SK3 as a key intrinsic mediator that coordinates nutritional status with AgRP/NPY neural activities and animals' feeding behavior and energy metabolism.
Title: A Small Potassium Current in AgRP/NPY Neurons Regulates Feeding Behavior and Energy Metabolism.

CRFR1, in a subset of AgRP neurons, plays a regulatory role that enables appropriate sympathetic nervous system activation and consequently protects the organism from hypothermia and hypoglycemia.
Title: CRFR1 in AgRP Neurons Modulates Sympathetic Nervous System Activity to Adapt to Cold Stress and Fasting.

The following Agrp gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Agrp cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OMu20263	NM_007427.3 Latest version!	Mus musculus agouti related neuropeptide (Agrp), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$69.30 $99.00
OMu20263	NM_001271806.1 Latest version!	Mus musculus agouti related neuropeptide (Agrp), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$69.30 $99.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Agrp ( NM_007427.3 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_031453.1 Mus musculus agouti related neuropeptide (Agrp), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OMu20263
Clone ID Related Accession (Same CDS sequence)	NM_007427.3 , NM_001271806.1
Accession Version	NM_007427.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 396bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-09
Organism	Mus musculus(house mouse)
Product	agouti-related protein precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from CO044337.1, BC079902.1 and AK138796.1. On Nov 22, 2012 this sequence version replaced NM_007427.2. Transcript Variant: This variant (1) represents the shorter transcript. Both variants 1 and 2 encode the same protein. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: CO044337.1, BC079902.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMN00849374, SAMN00849376 [ECO:0000350] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGCTGACTG CAATGTTGCT GAGTTGTGTT CTGCTGTTGG CACTGCCTCC CACACTGGGG 
GTCCAGATGG GCGTGGCTCC ACTGAAGGGC ATCAGAAGGC CTGACCAGGC TCTGTTCCCA 
GAGTTCCCAG GTCTAAGTCT GAATGGCCTC AAGAAGACAA CTGCAGACCG AGCAGAAGAA 
GTTCTGCTGC AGAAGGCAGA AGCTTTGGCG GAGGTGCTAG ATCCACAGAA CCGCGAGTCT 
CGTTCTCCGC GTCGCTGTGT AAGGCTGCAC GAGTCCTGCT TGGGACAGCA GGTACCTTGC 
TGCGACCCGT GCGCTACGTG CTACTGCCGC TTCTTCAATG CCTTTTGCTA CTGCCGCAAG 
CTGGGTACGG CCACGAACCT CTGTAGTCGC ACCTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_031453.1
CDS	211..606
Translation	MLTAMLLSCVLLLALPPTLGVQMGVAPLKGIRRPDQALFPEFPGLSLNGLKKTTADRAEEVLLQKAEALAEVLDPQNRESRSPRRCVRLHESCLGQQVPCCDPCATCYCRFFNAFCYCRKLGTATNLCSRT

Target ORF information:

RefSeq Version	NM_007427.3
Organism	Mus musculus(house mouse)
Definition	Mus musculus agouti related neuropeptide (Agrp), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_007427.3

ORF Insert Sequence:

ATGCTGACTG CAATGTTGCT GAGTTGTGTT CTGCTGTTGG CACTGCCTCC CACACTGGGG 
GTCCAGATGG GCGTGGCTCC ACTGAAGGGC ATCAGAAGGC CTGACCAGGC TCTGTTCCCA 
GAGTTCCCAG GTCTAAGTCT GAATGGCCTC AAGAAGACAA CTGCAGACCG AGCAGAAGAA 
GTTCTGCTGC AGAAGGCAGA AGCTTTGGCG GAGGTGCTAG ATCCACAGAA CCGCGAGTCT 
CGTTCTCCGC GTCGCTGTGT AAGGCTGCAC GAGTCCTGCT TGGGACAGCA GGTACCTTGC 
TGCGACCCGT GCGCTACGTG CTACTGCCGC TTCTTCAATG CCTTTTGCTA CTGCCGCAAG 
CTGGGTACGG CCACGAACCT CTGTAGTCGC ACCTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Agrp ( NM_001271806.1 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_001258735.1 Mus musculus agouti related neuropeptide (Agrp), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OMu20263
Clone ID Related Accession (Same CDS sequence)	NM_007427.3 , NM_001271806.1
Accession Version	NM_001271806.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 396bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-09
Organism	Mus musculus(house mouse)
Product	agouti-related protein precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AC151573.2, BC079902.1 and AK138796.1. Transcript Variant: This variant (2) contains an alternate 5' exon, compared to variant 1. Both variants 1 and 2 encode the same protein. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: CF900927.1, CF900283.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849374, SAMN00849380 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGCTGACTG CAATGTTGCT GAGTTGTGTT CTGCTGTTGG CACTGCCTCC CACACTGGGG 
GTCCAGATGG GCGTGGCTCC ACTGAAGGGC ATCAGAAGGC CTGACCAGGC TCTGTTCCCA 
GAGTTCCCAG GTCTAAGTCT GAATGGCCTC AAGAAGACAA CTGCAGACCG AGCAGAAGAA 
GTTCTGCTGC AGAAGGCAGA AGCTTTGGCG GAGGTGCTAG ATCCACAGAA CCGCGAGTCT 
CGTTCTCCGC GTCGCTGTGT AAGGCTGCAC GAGTCCTGCT TGGGACAGCA GGTACCTTGC 
TGCGACCCGT GCGCTACGTG CTACTGCCGC TTCTTCAATG CCTTTTGCTA CTGCCGCAAG 
CTGGGTACGG CCACGAACCT CTGTAGTCGC ACCTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001258735.1
CDS	321..716
Translation	MLTAMLLSCVLLLALPPTLGVQMGVAPLKGIRRPDQALFPEFPGLSLNGLKKTTADRAEEVLLQKAEALAEVLDPQNRESRSPRRCVRLHESCLGQQVPCCDPCATCYCRFFNAFCYCRKLGTATNLCSRT

Target ORF information:

RefSeq Version	NM_001271806.1
Organism	Mus musculus(house mouse)
Definition	Mus musculus agouti related neuropeptide (Agrp), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001271806.1

ORF Insert Sequence:

ATGCTGACTG CAATGTTGCT GAGTTGTGTT CTGCTGTTGG CACTGCCTCC CACACTGGGG 
GTCCAGATGG GCGTGGCTCC ACTGAAGGGC ATCAGAAGGC CTGACCAGGC TCTGTTCCCA 
GAGTTCCCAG GTCTAAGTCT GAATGGCCTC AAGAAGACAA CTGCAGACCG AGCAGAAGAA 
GTTCTGCTGC AGAAGGCAGA AGCTTTGGCG GAGGTGCTAG ATCCACAGAA CCGCGAGTCT 
CGTTCTCCGC GTCGCTGTGT AAGGCTGCAC GAGTCCTGCT TGGGACAGCA GGTACCTTGC 
TGCGACCCGT GCGCTACGTG CTACTGCCGC TTCTTCAATG CCTTTTGCTA CTGCCGCAAG 
CTGGGTACGG CCACGAACCT CTGTAGTCGC ACCTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

The role of the Agouti-Related Protein in energy balance regulation.
Cellular and molecular life sciences : CMLS65(17)2721-31(2008 Sep)
Ilnytska O,Argyropoulos G

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Agrp cDNA ORF clone, Mus musculus(house mouse)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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Services & Products

見積依頼

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電話

FAX

オンラインフォーム