Fgf16 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Fgf16
Entrez Gene ID	60464
Full Name	fibroblast growth factor 16
General protein information	Preferred Names fibroblast growth factor 16 Names fibroblast growth factor 16 FGF-16
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: X Map Location: Xq22
Summary	fibroblast growth factor; may play a role in the development of brown adipose tissue [RGD, Feb 2006].

mRNA and Protein(s)

mRNA	Protein	Name
NM_021867.3	NP_068639.1	fibroblast growth factor 16

Pathways from BioSystems

Homologies

Bos taurus (cattle)	FGF16	NP_001179706.1
	FGF16	XP_001098950.1
Canis lupus familiaris (dog)	FGF16	XP_549094.2
Mus musculus (house mouse)	Fgf16	NP_085117.2
Danio rerio (zebrafish)	fgf16	NP_001035497.1
Xenopus tropicalis (tropical clawed frog)	fgf16	XP_002931859.1
Homo sapiens (human)	FGF16	NP_003859.1
Pan troglodytes (chimpanzee)	FGF16	XP_529049.2
Rattus norvegicus (Norway rat)	Fgf16	NP_068639.1
Gallus gallus (chicken)	FGF16	NP_001038115.1

Gene Ontology
Bibliography

Related articles in PubMed

FGF-16 is released from neonatal cardiac myocytes and alters growth-related signaling: a possible role in postnatal development.
Lu SY, Sontag DP, Detillieux KA, Cattini PA
American journal of physiology. Cell physiology294(5)C1242-9(2008 May)

Fibroblast growth factor 16 and 18 are expressed in human cardiovascular tissues and induce on endothelial cells migration but not proliferation.
Antoine M, Wirz W, Tag CG, Gressner AM, Wycislo M, M?ller R, Kiefer P
Biochemical and biophysical research communications346(1)224-33(2006 Jul)

Secretion of FGF-16 requires an uncleaved bipartite signal sequence.
Miyakawa K, Imamura T
The Journal of biological chemistry278(37)35718-24(2003 Sep)

Fibroblast growth factor-16 is a growth factor for embryonic brown adipocytes.
Konishi M, Mikami T, Yamasaki M, Miyake A, Itoh N
The Journal of biological chemistry275(16)12119-22(2000 Apr)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Expression and release of FGF-16 in the neonatal myocardium interfere with cardiac myocyte proliferative potential by altering the local signaling environment via modulation of PKC activation and cell cycle-related gene expression.
Title: FGF-16 is released from neonatal cardiac myocytes and alters growth-related signaling: a possible role in postnatal development.

FGF-16 employs a unique bipartite signal sequence that is not cleaved, although it shares the same secretory machinery used by secreted proteins with cleavable signal sequences.
Title: Secretion of FGF-16 requires an uncleaved bipartite signal sequence.

The following Fgf16 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Fgf16 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa05326	NM_021867.3 Latest version!	Rattus norvegicus fibroblast growth factor 16 (Fgf16), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$188.30 $269.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Fgf16 ( NM_021867.3 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_068639.1 Rattus norvegicus fibroblast growth factor 16 (Fgf16), mRNA.

Price & Availability↑

CloneID	ORa05326
Clone ID Related Accession (Same CDS sequence)	NM_021867.3
Accession Version	NM_021867.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 624bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-24
Organism	Rattus norvegicus(Norway rat)
Product	fibroblast growth factor 16
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from AB002561.1. On Jun 10, 2007 this sequence version replaced NM_021867.2. ##Evidence-Data-START## Transcript exon combination :: AB002561.1, CK600063.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2689596, SAMEA2689600 [ECO:0000348] ##Evidence-Data-END##

ATGGCGGAGG TCGGGGGCGT CTTTGCCTCC TTGGACTGGG ACCTGCAAGG CTTCTCCTCC 
TCTCTGGGGA ACGTGCCCTT AGCTGACTCC CCGGGTTTCC TGAACGAGCG CCTGGGCCAG 
ATCGAGGGGA AGCTGCAGCG CGGCTCGCCC ACAGACTTCG CCCACCTGAA GGGGATCCTG 
CGGCGCCGCC AGCTCTACTG CCGCACGGGC TTCCACCTTG AAATCTTCCC CAATGGCACG 
GTGCATGGCA CCCGCCACGA CCACAGCCGC TTCGGAATTC TGGAATTTAT CAGCTTGGCT 
GTGGGGCTGA TCAGCATCCG GGGAGTAGAC TCTGGCCTAT ACCTAGGAAT GAATGAGCGA 
GGAGAGCTGT TTGGATCGAA GAAACTCACA CGAGAATGTG TTTTCCGGGA ACAGTTTGAA 
GAAAACTGGT ACAACACCTA TGCATCCACC TTGTACAAAC ACTCGGACTC GGAGAGACAG 
TATTATGTGG CCCTGAATAA AGACGGCTCA CCCCGGGAGG GATACAGGAC TAAACGACAC 
CAGAAATTCA CTCACTTTTT ACCCAGGCCA GTAGATCCTT CTAAGTTGCC CTCCATGTCC 
AGAGACCTCT TCCGCTATAG GTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_068639.1
CDS	1..624
Translation	MAEVGGVFASLDWDLQGFSSSLGNVPLADSPGFLNERLGQIEGKLQRGSPTDFAHLKGILRRRQLYCRTGFHLEIFPNGTVHGTRHDHSRFGILEFISLAVGLISIRGVDSGLYLGMNERGELFGSKKLTRECVFREQFEENWYNTYASTLYKHSDSERQYYVALNKDGSPREGYRTKRHQKFTHFLPRPVDPSKLPSMSRDLFRYR

Target ORF information:

RefSeq Version	NM_021867.3
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus fibroblast growth factor 16 (Fgf16), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_021867.3

ORF Insert Sequence:

ATGGCGGAGG TCGGGGGCGT CTTTGCCTCC TTGGACTGGG ACCTGCAAGG CTTCTCCTCC 
TCTCTGGGGA ACGTGCCCTT AGCTGACTCC CCGGGTTTCC TGAACGAGCG CCTGGGCCAG 
ATCGAGGGGA AGCTGCAGCG CGGCTCGCCC ACAGACTTCG CCCACCTGAA GGGGATCCTG 
CGGCGCCGCC AGCTCTACTG CCGCACGGGC TTCCACCTTG AAATCTTCCC CAATGGCACG 
GTGCATGGCA CCCGCCACGA CCACAGCCGC TTCGGAATTC TGGAATTTAT CAGCTTGGCT 
GTGGGGCTGA TCAGCATCCG GGGAGTAGAC TCTGGCCTAT ACCTAGGAAT GAATGAGCGA 
GGAGAGCTGT TTGGATCGAA GAAACTCACA CGAGAATGTG TTTTCCGGGA ACAGTTTGAA 
GAAAACTGGT ACAACACCTA TGCATCCACC TTGTACAAAC ACTCGGACTC GGAGAGACAG 
TATTATGTGG CCCTGAATAA AGACGGCTCA CCCCGGGAGG GATACAGGAC TAAACGACAC 
CAGAAATTCA CTCACTTTTT ACCCAGGCCA GTAGATCCTT CTAAGTTGCC CTCCATGTCC 
AGAGACCTCT TCCGCTATAG GTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

FGF-16 is released from neonatal cardiac myocytes and alters growth-related signaling: a possible role in postnatal development.
American journal of physiology. Cell physiology294(5)C1242-9(2008 May)
Lu SY,Sontag DP,Detillieux KA,Cattini PA

Fibroblast growth factor 16 and 18 are expressed in human cardiovascular tissues and induce on endothelial cells migration but not proliferation.
Biochemical and biophysical research communications346(1)224-33(2006 Jul)
Antoine M,Wirz W,Tag CG,Gressner AM,Wycislo M,M?ller R,Kiefer P

Secretion of FGF-16 requires an uncleaved bipartite signal sequence.
The Journal of biological chemistry278(37)35718-24(2003 Sep)
Miyakawa K,Imamura T

Fibroblast growth factor-16 is a growth factor for embryonic brown adipocytes.
The Journal of biological chemistry275(16)12119-22(2000 Apr)
Konishi M,Mikami T,Yamasaki M,Miyake A,Itoh N