Leprot cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Leprot
Entrez Gene ID	56766
Full Name	leptin receptor overlapping transcript
Synonyms	Ob-Rgrp,Obrgrp
General protein information	Preferred Names leptin receptor overlapping transcript Names leptin receptor gene-related protein OB-R gene-related protein OB-receptor gene related protein (OB-RGRP) endospanin-1
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 5 Map Location: 5q33
Summary	transcribed from the same promoter as the leptin receptor [RGD, Feb 2006].

mRNA and Protein(s)

mRNA	Protein	Name
NM_020099.2	NP_064484.1	leptin receptor gene-related protein

Pathways from BioSystems

Homologies

Danio rerio (zebrafish)	leprot	NP_001017787.1
Xenopus tropicalis (tropical clawed frog)	leprot	NP_001017102.1
Bos taurus (cattle)	LEPROT	NP_001029913.1
Mus musculus (house mouse)	Leprot	NP_778201.1
Homo sapiens (human)	LEPROT	NP_059996.1
Gallus gallus (chicken)	LEPROT	NP_001007959.1
Canis lupus familiaris (dog)	LOC609115	XP_852098.1
Rattus norvegicus (Norway rat)	Leprot	NP_064484.1

Gene Ontology
Bibliography

Related articles in PubMed

High-content genome-wide RNAi screens identify regulators of parkin upstream of mitophagy.
Hasson SA, Kane LA, Yamano K, Huang CH, Sliter DA, Buehler E, Wang C, Heman-Ackah SM, Hessa T, Guha R, Martin SE, Youle RJ
Nature504(7479)291-5(2013 Dec)

LEPROT and LEPROTL1 cooperatively decrease hepatic growth hormone action in mice.
Touvier T, Conte-Auriol F, Briand O, Cudejko C, Paumelle R, Caron S, Baug? E, Rouill? Y, Salles JP, Staels B, Bailleul B
The Journal of clinical investigation119(12)3830-8(2009 Dec)

Silencing of OB-RGRP in mouse hypothalamic arcuate nucleus increases leptin receptor signaling and prevents diet-induced obesity.
Couturier C, Sarkis C, S?ron K, Belouzard S, Chen P, Lenain A, Corset L, Dam J, Vauthier V, Dubart A, Mallet J, Froguel P, Rouill? Y, Jockers R
Proceedings of the National Academy of Sciences of the United States of America104(49)19476-81(2007 Dec)

Leptin receptor 5'untranslated regions in the rat: relative abundance, genomic organization and relation to putative response elements.
Lindell K, Bennett PA, Itoh Y, Robinson IC, Carlsson LM, Carlsson B
Molecular and cellular endocrinology172(1-2)37-45(2001 Feb)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The following Leprot gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Leprot cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa04676	NM_020099.2 Latest version!	Rattus norvegicus leptin receptor overlapping transcript (Leprot), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$69.30 $99.00

ORF Online Only Promotion

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Leprot ( NM_020099.2 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_064484.1 Rattus norvegicus leptin receptor overlapping transcript (Leprot), mRNA.

Price & Availability↑

CloneID	ORa04676
Clone ID Related Accession (Same CDS sequence)	NM_020099.2
Accession Version	NM_020099.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 396bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-24
Organism	Rattus norvegicus(Norway rat)
Product	leptin receptor gene-related protein
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC062003.1. On Jan 1, 2004 this sequence version replaced NM_020099.1. ##Evidence-Data-START## Transcript exon combination :: BC062003.1, DY318247.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMD00052296, SAMD00052297 [ECO:0000348] ##Evidence-Data-END##

ATGGCGGGCG TTAAAGCTCT TGTGGCACTC TCCTTCAGTG GGGCAATTGG GCTGACCTTT 
CTTATGCTGG GATGTGCCTT GGAGGACTAT GGCGTTTACT GGCCCCTGTT CGTCTTGATT 
TTCTACGTCA TCTCCCCCAT CCCCTACTTC ATTGCCAAAA GGGTCACCTA TGACTCGGAC 
GCGACTAGCA GTGCCTGTCG GGAACTGGCA TATTTCTTCA CCACTGGGAT TGTTGTTTCT 
GCCTTTGGAT TTCCTGTTAT TCTTGCTCGC GTGGCTGTGA TCAAGTGGGG AGCCTGTGGT 
CTTGTGCTGG CTGGCAATGC TGTTATTTTC CTCACGATCC AAGGCTTCTT CCTCGTCTTT 
GGGAGAGGAG ATGATTTCAG TTGGGAACAG TGGTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_064484.1
CDS	20..415
Translation	MAGVKALVALSFSGAIGLTFLMLGCALEDYGVYWPLFVLIFYVISPIPYFIAKRVTYDSDATSSACRELAYFFTTGIVVSAFGFPVILARVAVIKWGACGLVLAGNAVIFLTIQGFFLVFGRGDDFSWEQW

Target ORF information:

RefSeq Version	NM_020099.2
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus leptin receptor overlapping transcript (Leprot), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_020099.2

ORF Insert Sequence:

ATGGCGGGCG TTAAAGCTCT TGTGGCACTC TCCTTCAGTG GGGCAATTGG GCTGACCTTT 
CTTATGCTGG GATGTGCCTT GGAGGACTAT GGCGTTTACT GGCCCCTGTT CGTCTTGATT 
TTCTACGTCA TCTCCCCCAT CCCCTACTTC ATTGCCAAAA GGGTCACCTA TGACTCGGAC 
GCGACTAGCA GTGCCTGTCG GGAACTGGCA TATTTCTTCA CCACTGGGAT TGTTGTTTCT 
GCCTTTGGAT TTCCTGTTAT TCTTGCTCGC GTGGCTGTGA TCAAGTGGGG AGCCTGTGGT 
CTTGTGCTGG CTGGCAATGC TGTTATTTTC CTCACGATCC AAGGCTTCTT CCTCGTCTTT 
GGGAGAGGAG ATGATTTCAG TTGGGAACAG TGGTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

High-content genome-wide RNAi screens identify regulators of parkin upstream of mitophagy.
Nature504(7479)291-5(2013 Dec)
Hasson SA,Kane LA,Yamano K,Huang CH,Sliter DA,Buehler E,Wang C,Heman-Ackah SM,Hessa T,Guha R,Martin SE,Youle RJ

LEPROT and LEPROTL1 cooperatively decrease hepatic growth hormone action in mice.
The Journal of clinical investigation119(12)3830-8(2009 Dec)
Touvier T,Conte-Auriol F,Briand O,Cudejko C,Paumelle R,Caron S,Baug? E,Rouill? Y,Salles JP,Staels B,Bailleul B

Silencing of OB-RGRP in mouse hypothalamic arcuate nucleus increases leptin receptor signaling and prevents diet-induced obesity.
Proceedings of the National Academy of Sciences of the United States of America104(49)19476-81(2007 Dec)
Couturier C,Sarkis C,S?ron K,Belouzard S,Chen P,Lenain A,Corset L,Dam J,Vauthier V,Dubart A,Mallet J,Froguel P,Rouill? Y,Jockers R

Leptin receptor 5'untranslated regions in the rat: relative abundance, genomic organization and relation to putative response elements.
Molecular and cellular endocrinology172(1-2)37-45(2001 Feb)
Lindell K,Bennett PA,Itoh Y,Robinson IC,Carlsson LM,Carlsson B