Cpn1 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Cpn1
Entrez Gene ID	365466
Full Name	carboxypeptidase N subunit 1
Synonyms	Cpn
General protein information	Preferred Names carboxypeptidase N subunit 1 Names carboxypeptidase N catalytic chain carboxypeptidase N catalytic chain-like carboxypeptidase N small subunit carboxypeptidase N, polypeptide 1, 50kD
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 1 Map Location: 1q54
Summary	cleaves carboxy-terminal lysine residues from biologically active peptides [RGD, Feb 2006].

mRNA and Protein(s)

mRNA	Protein	Name
NM_053526.2	NP_445978.1	carboxypeptidase N catalytic chain precursor

Pathways from BioSystems

Homologies

Homo sapiens (human)	CPN1	NP_001299.1
Bos taurus (cattle)	CPN1	NP_001069548.1
Rattus norvegicus (Norway rat)	Cpn1	NP_445978.1
Danio rerio (zebrafish)	cpn1	NP_997935.1
Canis lupus familiaris (dog)	CPN1	XP_534989.3
Mus musculus (house mouse)	Cpn1	NP_109628.1
Gallus gallus (chicken)	CPN1	NP_001264183.1
Xenopus tropicalis (tropical clawed frog)	cpn1	NP_001017266.1

Gene Ontology
Bibliography

Related articles in PubMed

The kallikrein-kinin system: current and future pharmacological targets.
Moreau ME, Garbacki N, Molinaro G, Brown NJ, Marceau F, Adam A
Journal of pharmacological sciences99(1)6-38(2005 Sep)

Pathways of bradykinin degradation in blood and plasma of normotensive and hypertensive rats.
Dendorfer A, Wolfrum S, Wagemann M, Qadri F, Dominiak P
American journal of physiology. Heart and circulatory physiology280(5)H2182-8(2001 May)

Pro-carboxypeptidase R is an acute phase protein in the mouse, whereas carboxypeptidase N is not.
Sato T, Miwa T, Akatsu H, Matsukawa N, Obata K, Okada N, Campbell W, Okada H
Journal of immunology (Baltimore, Md. : 1950)165(2)1053-8(2000 Jul)

Molecular cloning and partial characterization of rat procarboxypeptidase R and carboxypeptidase N.
Kato T, Akatsu H, Sato T, Matsuo S, Yamamoto T, Campbell W, Hotta N, Okada N, Okada H
Microbiology and immunology44(8)719-28(2000)

Dexamethasone induced alterations in the levels of proteases involved in blood pressure homeostasis and blood coagulation in rats.
Rajashree S, Puvanakrishnan R
Molecular and cellular biochemistry197(1-2)203-8(1999 Jul)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The following Cpn1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Cpn1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa09804	NM_053526.2 Latest version!	Rattus norvegicus carboxypeptidase N subunit 1 (Cpn1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$272.30 $389.00

ORF Online Only Promotion

Next-day Shipping ORF Clones ( in default vector with tag)
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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Cpn1 ( NM_053526.2 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_445978.1 Rattus norvegicus carboxypeptidase N subunit 1 (Cpn1), mRNA.

Price & Availability↑

CloneID	ORa09804
Clone ID Related Accession (Same CDS sequence)	NM_053526.2
Accession Version	NM_053526.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1374bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-25
Organism	Rattus norvegicus(Norway rat)
Product	carboxypeptidase N catalytic chain precursor
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC088124.1. On Jun 10, 2007 this sequence version replaced NM_053526.1. ##Evidence-Data-START## Transcript exon combination :: BC088124.1, AB042599.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN01906353, SAMN01906355 [ECO:0000348] ##Evidence-Data-END##

ATGCCAGACC TGCCCTCAGC CTTCCTGCCC CTCCTCCTCC TCTCCAAGTT TGTTACCCCG 
GTGACCTTTC GTCACCACCG CTACGACGAC CTCGTGCGGA CGCTGTACAA GGTGCACAAC 
CAATGCCCGG ACATCACGCG GCTCTACAAC ATCGGGCGCA GCGTGAAGGG GAGGTACCTC 
TACGTGCTGG AGTTTAGCGA CTATCCTGGG ACCCATGAAC CCTTGGAACC GGAAGTCAAG 
TACGTGGGGA ACATGCACGG GAACGAGGTG CTGGGCCGCG AACTGCTGCT GCAGCTGTCG 
GAATTCCTCT GCGAGGAGTT CCGGAACCGG AACCAGCGCA TCCTGCGCCT CATCCAGGAC 
ACCCGCATTC ACATCCTTCC ATCCATGAAC CCTGACGGCT ACGAGGTGGC TGCTGCCCAG 
GGCCCAAACA CGTCTGGGTA TCTGGTTGGT AGGAACAATG CAAATGGGGT GGACCTGAAC 
CGAAACTTCC CGGATCTCAA CACCTATTTC TACTACAATT CGAAGTATGG CGGCCCCAAC 
CACCACCTGC CCCTCCCTGA CAACTGGAAA AGTCAGGTGG AACCAGAGAC CCGGGCAGTG 
ATCCAGTGGA TTCGATCCTT AAACTTCGTT CTCTCAGCCA ATATGCACGG CGGGGCTGTG 
GTGGCCAATT ACCCATATGA CAAGTCACTG GAACACAGGT TCCGAAGTCC CCATCGCACC 
TCCAATTCCC CCACACCGGA TGACGAGCTC TTCCAGACGC TGGCCAAGGT CTACTCCTAC 
GCACATGGAT GGATGCACCA AGGTTGGAAC TGTGGGGACT ACTTTCCAGA CGGCATCACC 
AATGGGGCAT CCTGGTATTC TCTAAGCAAG GGAATGCAAG ACTTCAATTA TCTCCATACC 
AACTGCTTTG AGATCACCCT AGAGCTGAGT TGCAACAAGT TTCCCCGGCA AGAAGAGCTG 
CAAAGGGAGT GGCTGGGTAA CCGGGAAGCC TTAATCCAGT TCTTGGAACA GGTTCACCAG 
GGCATCAAGG GAATGGTGCT TGACGAGAAC TATAACAACC TCACAGGGGC TGTCATTTCC 
GTCACCGGCA TCAACCACGA TGTCACTTCA GGTGAACACG GGGATTATTT CCGGCTGCTG 
CTTCCAGGTA CTTACTCAGT CACTGCCAAG GCATCAGGGT ATGAGCCCAA AACAGTGACT 
GTGACCGTGG GGCCTGCGGG ACCAACACTG GTTGACTTCC AGCTCAAGCG AAGCACGACT 
CAGGTGCACC CTGTGCAGAA AGCTCCTGGC CGAGGACAGG GAAGCAGGGC AAAGCAGCCC 
CGGACATCCA GAAAGAAAGA CCAGGCAGCA AAGCGGCACA GGGGCCCTGC ATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_445978.1
CDS	197..1570
Translation	MPDLPSAFLPLLLLSKFVTPVTFRHHRYDDLVRTLYKVHNQCPDITRLYNIGRSVKGRYLYVLEFSDYPGTHEPLEPEVKYVGNMHGNEVLGRELLLQLSEFLCEEFRNRNQRILRLIQDTRIHILPSMNPDGYEVAAAQGPNTSGYLVGRNNANGVDLNRNFPDLNTYFYYNSKYGGPNHHLPLPDNWKSQVEPETRAVIQWIRSLNFVLSANMHGGAVVANYPYDKSLEHRFRSPHRTSNSPTPDDELFQTLAKVYSYAHGWMHQGWNCGDYFPDGITNGASWYSLSKGMQDFNYLHTNCFEITLELSCNKFPRQEELQREWLGNREALIQFLEQVHQGIKGMVLDENYNNLTGAVISVTGINHDVTSGEHGDYFRLLLPGTYSVTAKASGYEPKTVTVTVGPAGPTLVDFQLKRSTTQVHPVQKAPGRGQGSRAKQPRTSRKKDQAAKRHRGPA

Target ORF information:

RefSeq Version	NM_053526.2
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus carboxypeptidase N subunit 1 (Cpn1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_053526.2

ORF Insert Sequence:

ATGCCAGACC TGCCCTCAGC CTTCCTGCCC CTCCTCCTCC TCTCCAAGTT TGTTACCCCG 
GTGACCTTTC GTCACCACCG CTACGACGAC CTCGTGCGGA CGCTGTACAA GGTGCACAAC 
CAATGCCCGG ACATCACGCG GCTCTACAAC ATCGGGCGCA GCGTGAAGGG GAGGTACCTC 
TACGTGCTGG AGTTTAGCGA CTATCCTGGG ACCCATGAAC CCTTGGAACC GGAAGTCAAG 
TACGTGGGGA ACATGCACGG GAACGAGGTG CTGGGCCGCG AACTGCTGCT GCAGCTGTCG 
GAATTCCTCT GCGAGGAGTT CCGGAACCGG AACCAGCGCA TCCTGCGCCT CATCCAGGAC 
ACCCGCATTC ACATCCTTCC ATCCATGAAC CCTGACGGCT ACGAGGTGGC TGCTGCCCAG 
GGCCCAAACA CGTCTGGGTA TCTGGTTGGT AGGAACAATG CAAATGGGGT GGACCTGAAC 
CGAAACTTCC CGGATCTCAA CACCTATTTC TACTACAATT CGAAGTATGG CGGCCCCAAC 
CACCACCTGC CCCTCCCTGA CAACTGGAAA AGTCAGGTGG AACCAGAGAC CCGGGCAGTG 
ATCCAGTGGA TTCGATCCTT AAACTTCGTT CTCTCAGCCA ATATGCACGG CGGGGCTGTG 
GTGGCCAATT ACCCATATGA CAAGTCACTG GAACACAGGT TCCGAAGTCC CCATCGCACC 
TCCAATTCCC CCACACCGGA TGACGAGCTC TTCCAGACGC TGGCCAAGGT CTACTCCTAC 
GCACATGGAT GGATGCACCA AGGTTGGAAC TGTGGGGACT ACTTTCCAGA CGGCATCACC 
AATGGGGCAT CCTGGTATTC TCTAAGCAAG GGAATGCAAG ACTTCAATTA TCTCCATACC 
AACTGCTTTG AGATCACCCT AGAGCTGAGT TGCAACAAGT TTCCCCGGCA AGAAGAGCTG 
CAAAGGGAGT GGCTGGGTAA CCGGGAAGCC TTAATCCAGT TCTTGGAACA GGTTCACCAG 
GGCATCAAGG GAATGGTGCT TGACGAGAAC TATAACAACC TCACAGGGGC TGTCATTTCC 
GTCACCGGCA TCAACCACGA TGTCACTTCA GGTGAACACG GGGATTATTT CCGGCTGCTG 
CTTCCAGGTA CTTACTCAGT CACTGCCAAG GCATCAGGGT ATGAGCCCAA AACAGTGACT 
GTGACCGTGG GGCCTGCGGG ACCAACACTG GTTGACTTCC AGCTCAAGCG AAGCACGACT 
CAGGTGCACC CTGTGCAGAA AGCTCCTGGC CGAGGACAGG GAAGCAGGGC AAAGCAGCCC 
CGGACATCCA GAAAGAAAGA CCAGGCAGCA AAGCGGCACA GGGGCCCTGC ATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

The kallikrein-kinin system: current and future pharmacological targets.
Journal of pharmacological sciences99(1)6-38(2005 Sep)
Moreau ME,Garbacki N,Molinaro G,Brown NJ,Marceau F,Adam A

Pathways of bradykinin degradation in blood and plasma of normotensive and hypertensive rats.
American journal of physiology. Heart and circulatory physiology280(5)H2182-8(2001 May)
Dendorfer A,Wolfrum S,Wagemann M,Qadri F,Dominiak P

Pro-carboxypeptidase R is an acute phase protein in the mouse, whereas carboxypeptidase N is not.
Journal of immunology (Baltimore, Md. : 1950)165(2)1053-8(2000 Jul)
Sato T,Miwa T,Akatsu H,Matsukawa N,Obata K,Okada N,Campbell W,Okada H

Molecular cloning and partial characterization of rat procarboxypeptidase R and carboxypeptidase N.
Microbiology and immunology44(8)719-28(2000)
Kato T,Akatsu H,Sato T,Matsuo S,Yamamoto T,Campbell W,Hotta N,Okada N,Okada H

Dexamethasone induced alterations in the levels of proteases involved in blood pressure homeostasis and blood coagulation in rats.
Molecular and cellular biochemistry197(1-2)203-8(1999 Jul)
Rajashree S,Puvanakrishnan R