Fcar cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Fcar
Entrez Gene ID	365183
Full Name	Fc fragment of IgA receptor
Synonyms	CD89
General protein information	Preferred Names Fc fragment of IgA receptor Names immunoglobulin alpha Fc receptor Fc fragment of IgA, receptor for IgA Fc receptor
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 1 Map Location: 1q12

mRNA and Protein(s)

mRNA	Protein	Name
NM_201992.1	NP_973721.1	immunoglobulin alpha Fc receptor precursor

Pathways from BioSystems

Homologies

	FCAR	NP_001035039.1
Pan troglodytes (chimpanzee)	FCAR	NP_001036089.1
Bos taurus (cattle)	FCAR	NP_001012703.1
Homo sapiens (human)	FCAR	NP_001991.1
Rattus norvegicus (Norway rat)	Fcar	NP_973721.1

Gene Ontology
Bibliography

Related articles in PubMed

Human IgA Fc receptor Fc?RI (CD89) triggers different forms of neutrophil death depending on the inflammatory microenvironment.
Wehrli M, Cortinas-Elizondo F, Hlushchuk R, Daudel F, Villiger PM, Miescher S, Zuercher AW, Djonov V, Simon HU, von Gunten S
Journal of immunology (Baltimore, Md. : 1950)193(11)5649-59(2014 Dec)

Transglutaminase is essential for IgA nephropathy development acting through IgA receptors.
Berthelot L, Papista C, Maciel TT, Biarnes-Pelicot M, Tissandie E, Wang PH, Tamouza H, Jamin A, Bex-Coudrat J, Gestin A, Boumediene A, Arcos-Fajardo M, England P, Pillebout E, Walker F, Daugas E, Vrtosvnik F, Flamant M, Benhamou M, Cogn? M, Moura IC, Monteiro RC
The Journal of experimental medicine209(4)793-806(2012 Apr)

IgA and IgG antineutrophil cytoplasmic antibody engagement of Fc receptor genetic variants influences granulomatosis with polyangiitis.
Kelley JM, Monach PA, Ji C, Zhou Y, Wu J, Tanaka S, Mahr AD, Johnson S, McAlear C, Cuthbertson D, Carette S, Davis JC Jr, Dellaripa PF, Hoffman GS, Khalidi N, Langford CA, Seo P, St Clair EW, Specks U, Stone JH, Spiera RF, Ytterberg SR, Merkel PA, Edberg JC, Kimberly RP
Proceedings of the National Academy of Sciences of the United States of America108(51)20736-41(2011 Dec)

Negative regulation of inflammatory responses by immunoglobulin A receptor (Fc?RI) inhibits the development of Toll-like receptor-9 signalling-accelerated glomerulonephritis.
Watanabe T, Kanamaru Y, Liu C, Suzuki Y, Tada N, Okumura K, Horikoshi S, Tomino Y
Clinical and experimental immunology166(2)235-50(2011 Nov)

Inhibitory ITAM signaling by Fc alpha RI-FcR gamma chain controls multiple activating responses and prevents renal inflammation.
Kanamaru Y, Pfirsch S, Aloulou M, Vrtovsnik F, Essig M, Loirat C, Desch?nes G, Gu?rin-Marchand C, Blank U, Monteiro RC
Journal of immunology (Baltimore, Md. : 1950)180(4)2669-78(2008 Feb)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The rat Fcar gene has an exon-intron structure essentially identical to that of the human counterpart and is encoded in the leukocyte receptor complex on Chromosome 1.
Title: Identification of the rat IgA Fc receptor encoded in the leukocyte receptor complex.

The following Fcar gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Fcar cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa05488	NM_201992.1 Latest version!	Rattus norvegicus Fc fragment of IgA receptor (Fcar), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$139.30 $199.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Fcar ( NM_201992.1 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_973721.1 Rattus norvegicus Fc fragment of IgA receptor (Fcar), mRNA.

Price & Availability↑

CloneID	ORa05488
Clone ID Related Accession (Same CDS sequence)	NM_201992.1
Accession Version	NM_201992.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 843bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-09-30
Organism	Rattus norvegicus(Norway rat)
Product	immunoglobulin alpha Fc receptor precursor
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from AB109766.1. ##Evidence-Data-START## Transcript exon combination :: AB109766.1, AB109767.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2689594 [ECO:0000348] ##Evidence-Data-END##

ATGGCCCCTC AGGACAACAC CTTCCTATGT CTTGTGATCT GCCTGGGTCA GACAATTTGG 
GCACAAGAAG ATTTTCCCAT TCCCATCATA TCCACTGCAA CAAATCCTAT GGTTTCCTGG 
AATGAGTCTG TGAGGATCCT GTGCAGGGGA ACACCGGAAG CCTTCCTGTA TCAGTTGTCC 
CTGATGAAAA ACTCCACACA AACAGTTATA GAGAAGAAAC TAGGATTTCA AAAAGAGGCT 
GAATTCATTA TCAACCACAT GAATTCAACA CTGGCAGGAT GTTATCAGTG TCAGTATAGG 
AAGAAGAACC ACTGGTCAGA GCAGAGTAAA CCCCTGAAGC TAGTGGTGAC AGGCTTGTAT 
GACAAACCTG TCCTCTCCAC AGATCAAAGC CTTGTGTTGT TACCAGGAGA GAACGTTTCC 
TTCAAGTGTA GTTCAGCCCA CAACCTGTTC AACAGATTTT CACTGGCCAA AGAGGGAGAA 
GCTTCCTTGC CATTGCACCA ACATAAGGAG TCTCAAGGCA ACTTCCACCT GGGTCCTGTG 
AACGCTGACT TCATTGGAAA ATACAGATGC TACGGCTGGC ACAACAACAG CCCCTATGTG 
TGGTCAGCCC CCAGTGATGC CCTGGAGCTC ATTGTCTCAG TTACATCTCT AGACTCCGAG 
AAGCATGATT ACGTGATGGA GAATTCAATC CGGATAGGTA TGGCTGGGCT GGTCCTTGTC 
ATACTCTTGG TGATAGTATC TGAAGATTGG TACAGCCACA GGATCTCACA CAAGGAATGC 
TGTCAGGAAC GGGCTGCAAA GAGATGGAGC AAACAGGGTG TCAGACCTAG TGACTGTAGA 
TAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_973721.1
CDS	35..877
Translation	MAPQDNTFLCLVICLGQTIWAQEDFPIPIISTATNPMVSWNESVRILCRGTPEAFLYQLSLMKNSTQTVIEKKLGFQKEAEFIINHMNSTLAGCYQCQYRKKNHWSEQSKPLKLVVTGLYDKPVLSTDQSLVLLPGENVSFKCSSAHNLFNRFSLAKEGEASLPLHQHKESQGNFHLGPVNADFIGKYRCYGWHNNSPYVWSAPSDALELIVSVTSLDSEKHDYVMENSIRIGMAGLVLVILLVIVSEDWYSHRISHKECCQERAAKRWSKQGVRPSDCR

Target ORF information:

RefSeq Version	NM_201992.1
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus Fc fragment of IgA receptor (Fcar), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_201992.1

ORF Insert Sequence:

ATGGCCCCTC AGGACAACAC CTTCCTATGT CTTGTGATCT GCCTGGGTCA GACAATTTGG 
GCACAAGAAG ATTTTCCCAT TCCCATCATA TCCACTGCAA CAAATCCTAT GGTTTCCTGG 
AATGAGTCTG TGAGGATCCT GTGCAGGGGA ACACCGGAAG CCTTCCTGTA TCAGTTGTCC 
CTGATGAAAA ACTCCACACA AACAGTTATA GAGAAGAAAC TAGGATTTCA AAAAGAGGCT 
GAATTCATTA TCAACCACAT GAATTCAACA CTGGCAGGAT GTTATCAGTG TCAGTATAGG 
AAGAAGAACC ACTGGTCAGA GCAGAGTAAA CCCCTGAAGC TAGTGGTGAC AGGCTTGTAT 
GACAAACCTG TCCTCTCCAC AGATCAAAGC CTTGTGTTGT TACCAGGAGA GAACGTTTCC 
TTCAAGTGTA GTTCAGCCCA CAACCTGTTC AACAGATTTT CACTGGCCAA AGAGGGAGAA 
GCTTCCTTGC CATTGCACCA ACATAAGGAG TCTCAAGGCA ACTTCCACCT GGGTCCTGTG 
AACGCTGACT TCATTGGAAA ATACAGATGC TACGGCTGGC ACAACAACAG CCCCTATGTG 
TGGTCAGCCC CCAGTGATGC CCTGGAGCTC ATTGTCTCAG TTACATCTCT AGACTCCGAG 
AAGCATGATT ACGTGATGGA GAATTCAATC CGGATAGGTA TGGCTGGGCT GGTCCTTGTC 
ATACTCTTGG TGATAGTATC TGAAGATTGG TACAGCCACA GGATCTCACA CAAGGAATGC 
TGTCAGGAAC GGGCTGCAAA GAGATGGAGC AAACAGGGTG TCAGACCTAG TGACTGTAGA 
TAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Human IgA Fc receptor Fc?RI (CD89) triggers different forms of neutrophil death depending on the inflammatory microenvironment.
Journal of immunology (Baltimore, Md. : 1950)193(11)5649-59(2014 Dec)
Wehrli M,Cortinas-Elizondo F,Hlushchuk R,Daudel F,Villiger PM,Miescher S,Zuercher AW,Djonov V,Simon HU,von Gunten S

Transglutaminase is essential for IgA nephropathy development acting through IgA receptors.
The Journal of experimental medicine209(4)793-806(2012 Apr)
Berthelot L,Papista C,Maciel TT,Biarnes-Pelicot M,Tissandie E,Wang PH,Tamouza H,Jamin A,Bex-Coudrat J,Gestin A,Boumediene A,Arcos-Fajardo M,England P,Pillebout E,Walker F,Daugas E,Vrtosvnik F,Flamant M,Benhamou M,Cogn? M,Moura IC,Monteiro RC

IgA and IgG antineutrophil cytoplasmic antibody engagement of Fc receptor genetic variants influences granulomatosis with polyangiitis.
Proceedings of the National Academy of Sciences of the United States of America108(51)20736-41(2011 Dec)
Kelley JM,Monach PA,Ji C,Zhou Y,Wu J,Tanaka S,Mahr AD,Johnson S,McAlear C,Cuthbertson D,Carette S,Davis JC Jr,Dellaripa PF,Hoffman GS,Khalidi N,Langford CA,Seo P,St Clair EW,Specks U,Stone JH,Spiera RF,Ytterberg SR,Merkel PA,Edberg JC,Kimberly RP

Negative regulation of inflammatory responses by immunoglobulin A receptor (Fc?RI) inhibits the development of Toll-like receptor-9 signalling-accelerated glomerulonephritis.
Clinical and experimental immunology166(2)235-50(2011 Nov)
Watanabe T,Kanamaru Y,Liu C,Suzuki Y,Tada N,Okumura K,Horikoshi S,Tomino Y

Inhibitory ITAM signaling by Fc alpha RI-FcR gamma chain controls multiple activating responses and prevents renal inflammation.
Journal of immunology (Baltimore, Md. : 1950)180(4)2669-78(2008 Feb)
Kanamaru Y,Pfirsch S,Aloulou M,Vrtovsnik F,Essig M,Loirat C,Desch?nes G,Gu?rin-Marchand C,Blank U,Monteiro RC