Panx2 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Panx2
Entrez Gene ID	362979
Full Name	pannexin 2
General protein information	Preferred Names pannexin 2 Names pannexin-2
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 7 Map Location: 7q34
Summary	structural component of gap junctions; forms heteromeric intercellular channels with pannexin 1; may facilitate electrical communication in the brain [RGD, Feb 2006].

mRNA and Protein(s)

mRNA	Protein	Name
NM_199409.2	NP_955441.2	pannexin-2

Pathways from BioSystems

Homologies

Homo sapiens (human)	PANX2	NP_443071.2
Xenopus tropicalis (tropical clawed frog)	LOC100486454	XP_002932244.1
	LOC720613	XP_001116218.2
Mus musculus (house mouse)	Panx2	NP_001002005.2
Pan troglodytes (chimpanzee)	PANX2	XP_001140508.1
Gallus gallus (chicken)	PANX2	XP_424545.3
Canis lupus familiaris (dog)	PANX2	XP_538316.4
Bos taurus (cattle)	PANX2	NP_001095695.1
Danio rerio (zebrafish)	panx2	NP_001243570.1
Rattus norvegicus (Norway rat)	Panx2	NP_955441.2

Gene Ontology
Bibliography

Related articles in PubMed

Pannexin-2-deficiency sensitizes pancreatic ?-cells to cytokine-induced apoptosis in?vitro and impairs glucose tolerance in?vivo.
Berchtold LA, Miani M, Diep TA, Madsen AN, Cigliola V, Colli M, Krivokapic JM, Pociot F, Eizirik DL, Meda P, Holst B, Billestrup N, St?rling J
Molecular and cellular endocrinology448108-121(2017 Jun)

Pannexin protein expression in the rat middle cerebral artery.
Burns AR, Phillips SC, Sokoya EM
Journal of vascular research49(2)101-10(2012)

Pannexins in ischemia-induced neurodegeneration.
Bargiotas P, Krenz A, Hormuzdi SG, Ridder DA, Herb A, Barakat W, Penuela S, von Engelhardt J, Monyer H, Schwaninger M
Proceedings of the National Academy of Sciences of the United States of America108(51)20772-7(2011 Dec)

Expression and roles of pannexins in ATP release in the pituitary gland.
Li S, Bjelobaba I, Yan Z, Kucka M, Tomic M, Stojilkovic SS
Endocrinology152(6)2342-52(2011 Jun)

Pannexin1 and Pannexin2 channels show quaternary similarities to connexons and different oligomerization numbers from each other.
Ambrosi C, Gassmann O, Pranskevich JN, Boassa D, Smock A, Wang J, Dahl G, Steinem C, Sosinsky GE
The Journal of biological chemistry285(32)24420-31(2010 Aug)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Panx2 is an important regulator of the insulin secretory capacity and apoptosis in pancreatic beta-cells.
Title: Pannexin-2-deficiency sensitizes pancreatic ?-cells to cytokine-induced apoptosis in?vitro and impairs glucose tolerance in?vivo.

pannexin 2 is expressed in both endothelium and smooth muscle of middle cerebral arteries.
Title: Pannexin protein expression in the rat middle cerebral artery.

Overexpression of pannexins 1 and 2 in pituitary cells enhanced the release of ATP.
Title: Expression and roles of pannexins in ATP release in the pituitary gland.

Pannexin1 and Pannexin2 channels show quaternary similarities to connexons and different oligomerization numbers from each other
Title: Pannexin1 and Pannexin2 channels show quaternary similarities to connexons and different oligomerization numbers from each other.

Results show that pannexins 1, 2, and 3 are abundantly expressed in the mouse and rat cochlea and demonstrate distinct cellular distributions.
Title: Identification and characterization of pannexin expression in the mammalian cochlea.

The following Panx2 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Panx2 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa05357	NM_199409.2 Latest version!	Rattus norvegicus pannexin 2 (Panx2), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	12-14	$398.30 $569.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Panx2 ( NM_199409.2 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_955441.2 Rattus norvegicus pannexin 2 (Panx2), mRNA.

Price & Availability↑

CloneID	ORa05357
Clone ID Related Accession (Same CDS sequence)	NM_199409.2
Accession Version	NM_199409.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2025bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-02-19
Organism	Rattus norvegicus(Norway rat)
Product	pannexin-2
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AJ557016.1, BC112319.1 and BQ204587.1. On Dec 21, 2007 this sequence version replaced NM_199409.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## RNAseq introns :: single sample supports all introns SAMD00052296, SAMD00052297 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGCACCACC TCCTGGAGCA GTCGGCGGAC ATGGCGACCG CGCTGCTGGC GGGCGAGAAG 
CTGAGGGAGC TGATCCTGCC TGGCTCGCAG GACGACAAGG CGGGTGCGCT GGCCGCGCTG 
CTGCTGCAGC TCAAGCTGGA ACTGCCGTTC GACCGCGTGG TCACCATCGG CACCGTGCTG 
GTACCCATCC TGCTGGTCAC CCTGGTCTTC ACCAAGAACT TCGCAGAGGA ACCAATTTAC 
TGTTATACTC CGCACAACTT CACCCGTGAC CAGGCGCTGT ACGCCCGTGG CTACTGCTGG 
ACAGAGCTGC GGGATGCCCT GCCCGGCGTG GATGCCAGCC TGTGGCCATC GCTGTTTGAG 
CACAAGTTCC TGCCCTACGC ACTGCTGGCC TTTGCCGCCA TCATGTATGT GCCCGCACTG 
GGCTGGGAGT TCCTGGCCTC CACGCGCCTC ACCTCCGAGC TCAACTTCCT GCTTCAGGAG 
ATCGACAACT GCTACCACCG AGCCGCCGAA GGTCGCGCCC CCAAGATTGA GAAGCAGATC 
CAGTCCAAGG GGCCAGGCAT CACGGAGCGC GAGAAGCGGG AAATCATTGA GAACGCTGAG 
AAGGAGAAGA GCCCTGAGCA GAATTTGTTT GAGAAGTACC TGGAGCGCCG GGGCCGCAGC 
AACTTCTTGG CCAAGCTGTA CTTGGCGCGG CACGTACTGA TCCTGCTACT CAGTGTGGTG 
CCCATCTCTT ACCTATGCAC ATACTACGCC ACCCAGAAGC AGAACGAGTT CACCTGCGCC 
CTGGGCGCCT CGCCTGACGG GCCGGTGGGT AGCGCCGGGC CCACGGTGCG CGTCAGCTGT 
AAGCTGCCCT CCGTGCAGCT GCAGCGGATC ATTGCGGGTG TGGACATCGT ATTGCTCTGC 
TTCATGAACC TCATCATCCT GGTCAACCTC ATCCACCTCT TCATCTTCCG CAAGAGCAAC 
TTCATTTTTG ACAAGCTGCA CAAGGTGGGT ATCAAGACGC GCCGGCAGTG GCGCCGCTCG 
CAGTTCTGCG ACATCAACAT CCTGGCCATG TTCTGTAACG AGAACCGTGA CCACATCAAG 
TCGCTTAACC GGCTGGACTT CATCACCAAC GAGAGCGACC TCATGTACGA CAACGTGGTG 
CGGCAGCTTC TGGCTGCCTT GGCTCAGTCT AACCACGACA CCACGCCCAC GGTTCGGGAC 
TCAGGCATCC AGACCGTGGA CCCCAGCATC AACCCCGCAG AGCCTGAGGG CTCTGCTGAG 
CCACCCGTGG TCAAGCGGCC CCGTAAGAAA ATGAAGTGGA TCCCCACCAG CAACCCGCTG 
CCACAGCCCT TCAAGGAGCA GCTGGCCATT ATGCGCGTAG AAAACAGCAA GACTGAGAAG 
CCCAAACCTG TGCGCAGGAA GACAGCCACG GATACACTTA TTGCCCCGCT GCTGGACGCT 
GGTGCCCGGG CTGCCCACCA CTACAAGGGG AGTGGAGGTG ATACAGGGCC CTCCTCTGCC 
CCGCCTGCTG CCTCTGAGAA AAAGCATACC CGGCACTTCT CCTTGGATGT GCATCCCTAT 
ATCCTAGGCA GCAAGAAGGC CAAGACTGAA GCAGTACCCC CTGCCCTACC AGCCTCCCGG 
AGCCAGGAAG GTGGCTTCCT GTCCCAGACA GAGGAATGTG GGCTGGGCTT GGCTGCAGCA 
CCCACCAAAG ATGCTCCGCT CCCTGAGAAG GAAATCCCAT ACCCCACAGA GTCTGCCCTG 
CCGTCTGGGG GCCCATTCCA TGTGTGCTCA CCCCCCACGG CCTCTGCTGC TGCTTCCCTG 
TCACCGAGCA GCCTGGGCAA GGCTGACCCC CTCACCATCC TGAGCCGAAA CGCCACTCAC 
CCCCTGCTCC ACATCAGCAC GTTGTACGAG GCCCGGGAAG AGGAGGAAGG AGGTCCCTGT 
GCACCCTCAG ACATGGGCGA CCTCCTCAGC ATACCCCCAC CCCAGCAGAT CCTCATCGCC 
ACCTTCGAGG AGCCGAGAAC AGTTGTGAGT ACTGTGGAGT TTTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_955441.2
CDS	324..2348
Translation	MHHLLEQSADMATALLAGEKLRELILPGSQDDKAGALAALLLQLKLELPFDRVVTIGTVLVPILLVTLVFTKNFAEEPIYCYTPHNFTRDQALYARGYCWTELRDALPGVDASLWPSLFEHKFLPYALLAFAAIMYVPALGWEFLASTRLTSELNFLLQEIDNCYHRAAEGRAPKIEKQIQSKGPGITEREKREIIENAEKEKSPEQNLFEKYLERRGRSNFLAKLYLARHVLILLLSVVPISYLCTYYATQKQNEFTCALGASPDGPVGSAGPTVRVSCKLPSVQLQRIIAGVDIVLLCFMNLIILVNLIHLFIFRKSNFIFDKLHKVGIKTRRQWRRSQFCDINILAMFCNENRDHIKSLNRLDFITNESDLMYDNVVRQLLAALAQSNHDTTPTVRDSGIQTVDPSINPAEPEGSAEPPVVKRPRKKMKWIPTSNPLPQPFKEQLAIMRVENSKTEKPKPVRRKTATDTLIAPLLDAGARAAHHYKGSGGDTGPSSAPPAASEKKHTRHFSLDVHPYILGSKKAKTEAVPPALPASRSQEGGFLSQTEECGLGLAAAPTKDAPLPEKEIPYPTESALPSGGPFHVCSPPTASAAASLSPSSLGKADPLTILSRNATHPLLHISTLYEAREEEEGGPCAPSDMGDLLSIPPPQQILIATFEEPRTVVSTVEF

Target ORF information:

RefSeq Version	NM_199409.2
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus pannexin 2 (Panx2), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_199409.2

ORF Insert Sequence:

ATGCACCACC TCCTGGAGCA GTCGGCGGAC ATGGCGACCG CGCTGCTGGC GGGCGAGAAG 
CTGAGGGAGC TGATCCTGCC TGGCTCGCAG GACGACAAGG CGGGTGCGCT GGCCGCGCTG 
CTGCTGCAGC TCAAGCTGGA ACTGCCGTTC GACCGCGTGG TCACCATCGG CACCGTGCTG 
GTACCCATCC TGCTGGTCAC CCTGGTCTTC ACCAAGAACT TCGCAGAGGA ACCAATTTAC 
TGTTATACTC CGCACAACTT CACCCGTGAC CAGGCGCTGT ACGCCCGTGG CTACTGCTGG 
ACAGAGCTGC GGGATGCCCT GCCCGGCGTG GATGCCAGCC TGTGGCCATC GCTGTTTGAG 
CACAAGTTCC TGCCCTACGC ACTGCTGGCC TTTGCCGCCA TCATGTATGT GCCCGCACTG 
GGCTGGGAGT TCCTGGCCTC CACGCGCCTC ACCTCCGAGC TCAACTTCCT GCTTCAGGAG 
ATCGACAACT GCTACCACCG AGCCGCCGAA GGTCGCGCCC CCAAGATTGA GAAGCAGATC 
CAGTCCAAGG GGCCAGGCAT CACGGAGCGC GAGAAGCGGG AAATCATTGA GAACGCTGAG 
AAGGAGAAGA GCCCTGAGCA GAATTTGTTT GAGAAGTACC TGGAGCGCCG GGGCCGCAGC 
AACTTCTTGG CCAAGCTGTA CTTGGCGCGG CACGTACTGA TCCTGCTACT CAGTGTGGTG 
CCCATCTCTT ACCTATGCAC ATACTACGCC ACCCAGAAGC AGAACGAGTT CACCTGCGCC 
CTGGGCGCCT CGCCTGACGG GCCGGTGGGT AGCGCCGGGC CCACGGTGCG CGTCAGCTGT 
AAGCTGCCCT CCGTGCAGCT GCAGCGGATC ATTGCGGGTG TGGACATCGT ATTGCTCTGC 
TTCATGAACC TCATCATCCT GGTCAACCTC ATCCACCTCT TCATCTTCCG CAAGAGCAAC 
TTCATTTTTG ACAAGCTGCA CAAGGTGGGT ATCAAGACGC GCCGGCAGTG GCGCCGCTCG 
CAGTTCTGCG ACATCAACAT CCTGGCCATG TTCTGTAACG AGAACCGTGA CCACATCAAG 
TCGCTTAACC GGCTGGACTT CATCACCAAC GAGAGCGACC TCATGTACGA CAACGTGGTG 
CGGCAGCTTC TGGCTGCCTT GGCTCAGTCT AACCACGACA CCACGCCCAC GGTTCGGGAC 
TCAGGCATCC AGACCGTGGA CCCCAGCATC AACCCCGCAG AGCCTGAGGG CTCTGCTGAG 
CCACCCGTGG TCAAGCGGCC CCGTAAGAAA ATGAAGTGGA TCCCCACCAG CAACCCGCTG 
CCACAGCCCT TCAAGGAGCA GCTGGCCATT ATGCGCGTAG AAAACAGCAA GACTGAGAAG 
CCCAAACCTG TGCGCAGGAA GACAGCCACG GATACACTTA TTGCCCCGCT GCTGGACGCT 
GGTGCCCGGG CTGCCCACCA CTACAAGGGG AGTGGAGGTG ATACAGGGCC CTCCTCTGCC 
CCGCCTGCTG CCTCTGAGAA AAAGCATACC CGGCACTTCT CCTTGGATGT GCATCCCTAT 
ATCCTAGGCA GCAAGAAGGC CAAGACTGAA GCAGTACCCC CTGCCCTACC AGCCTCCCGG 
AGCCAGGAAG GTGGCTTCCT GTCCCAGACA GAGGAATGTG GGCTGGGCTT GGCTGCAGCA 
CCCACCAAAG ATGCTCCGCT CCCTGAGAAG GAAATCCCAT ACCCCACAGA GTCTGCCCTG 
CCGTCTGGGG GCCCATTCCA TGTGTGCTCA CCCCCCACGG CCTCTGCTGC TGCTTCCCTG 
TCACCGAGCA GCCTGGGCAA GGCTGACCCC CTCACCATCC TGAGCCGAAA CGCCACTCAC 
CCCCTGCTCC ACATCAGCAC GTTGTACGAG GCCCGGGAAG AGGAGGAAGG AGGTCCCTGT 
GCACCCTCAG ACATGGGCGA CCTCCTCAGC ATACCCCCAC CCCAGCAGAT CCTCATCGCC 
ACCTTCGAGG AGCCGAGAAC AGTTGTGAGT ACTGTGGAGT TTTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Pannexin-2-deficiency sensitizes pancreatic ?-cells to cytokine-induced apoptosis in?vitro and impairs glucose tolerance in?vivo.
Molecular and cellular endocrinology448108-121(2017 Jun)
Berchtold LA,Miani M,Diep TA,Madsen AN,Cigliola V,Colli M,Krivokapic JM,Pociot F,Eizirik DL,Meda P,Holst B,Billestrup N,St?rling J

Pannexin protein expression in the rat middle cerebral artery.
Journal of vascular research49(2)101-10(2012)
Burns AR,Phillips SC,Sokoya EM

Pannexins in ischemia-induced neurodegeneration.
Proceedings of the National Academy of Sciences of the United States of America108(51)20772-7(2011 Dec)
Bargiotas P,Krenz A,Hormuzdi SG,Ridder DA,Herb A,Barakat W,Penuela S,von Engelhardt J,Monyer H,Schwaninger M

Expression and roles of pannexins in ATP release in the pituitary gland.
Endocrinology152(6)2342-52(2011 Jun)
Li S,Bjelobaba I,Yan Z,Kucka M,Tomic M,Stojilkovic SS

Pannexin1 and Pannexin2 channels show quaternary similarities to connexons and different oligomerization numbers from each other.
The Journal of biological chemistry285(32)24420-31(2010 Aug)
Ambrosi C,Gassmann O,Pranskevich JN,Boassa D,Smock A,Wang J,Dahl G,Steinem C,Sosinsky GE

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Panx2 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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