Erlin1 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Erlin1
Entrez Gene ID	293939
Full Name	ER lipid raft associated 1
Synonyms	RGD1307058,Spfh1
General protein information	Preferred Names ER lipid raft associated 1 Names erlin-1 SPFH domain family, member 1
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 1 Map Location: 1q54

mRNA and Protein(s)

mRNA	Protein	Name
XM_006231441.3	XP_006231503.1	erlin-1 isoform X1
NM_001106353.1	NP_001099823.1	erlin-1

Pathways from BioSystems

Homologies

Homo sapiens (human)	ERLIN1	NP_001094096.1
Canis lupus familiaris (dog)	ERLIN1	XP_005637667.1
	ERLIN1	XP_001107293.1
Mus musculus (house mouse)	Erlin1	NP_663477.3
Rattus norvegicus (Norway rat)	Erlin1	NP_001099823.1
Gallus gallus (chicken)	ERLIN1	NP_001026394.1
Danio rerio (zebrafish)	erlin1	NP_001014325.1
Pan troglodytes (chimpanzee)	ERLIN1	XP_001167929.2
Bos taurus (cattle)	ERLIN1	NP_001157504.1
Xenopus tropicalis (tropical clawed frog)	erlin1	NP_001016892.1

Gene Ontology
Bibliography

Related articles in PubMed

Erlins restrict SREBP activation in the ER and regulate cellular cholesterol homeostasis.
Huber MD, Vesely PW, Datta K, Gerace L
The Journal of cell biology203(3)427-36(2013 Nov)

An endoplasmic reticulum (ER) membrane complex composed of SPFH1 and SPFH2 mediates the ER-associated degradation of inositol 1,4,5-trisphosphate receptors.
Pearce MM, Wormer DB, Wilkens S, Wojcikiewicz RJ
The Journal of biological chemistry284(16)10433-45(2009 Apr)

Blood pressure is regulated by an alpha1D-adrenergic receptor/dystrophin signalosome.
Lyssand JS, DeFino MC, Tang XB, Hertz AL, Feller DB, Wacker JL, Adams ME, Hague C
The Journal of biological chemistry283(27)18792-800(2008 Jul)

Erlin-1 and erlin-2 are novel members of the prohibitin family of proteins that define lipid-raft-like domains of the ER.
Browman DT, Resek ME, Zajchowski LD, Robbins SM
Journal of cell science119(Pt 15)3149-60(2006 Aug)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Results suggest that this novel SPFH1/2 complex is a recognition factor that targets IP(3)Rs and perhaps other substrates for ERAD.
Title: An endoplasmic reticulum (ER) membrane complex composed of SPFH1 and SPFH2 mediates the ER-associated degradation of inositol 1,4,5-trisphosphate receptors.

The following Erlin1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Erlin1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa01074	NM_001106353.1 Latest version!	Rattus norvegicus ER lipid raft associated 1 (Erlin1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$223.30 $319.00
ORa01074	XM_006231441.3 Latest version!	Rattus norvegicus ER lipid raft associated 1 (Erlin1), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$223.30 $319.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Erlin1 ( NM_001106353.1 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_001099823.1 Rattus norvegicus ER lipid raft associated 1 (Erlin1), mRNA.

Price & Availability↑

CloneID	ORa01074
Clone ID Related Accession (Same CDS sequence)	XM_006231441.3 , NM_001106353.1
Accession Version	NM_001106353.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1047bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2018-05-27
Organism	Rattus norvegicus(Norway rat)
Product	erlin-1
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from CH473986.1. On or before Oct 4, 2007 this sequence version replaced XM_219858.4, XM_001056706.1. ##Evidence-Data-START## Transcript exon combination :: BC161938.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMD00052296, SAMD00052297 [ECO:0000350] ##Evidence-Data-END##

ATGAATATGA CTCAAGCCCG GCTTCTGGTG GCTGCAGTGG TGGGGTTGGT GGCGATCCTC 
CTTTACGCCT CCATCCACAA GATCGAGGAA GGACACCTGG CCGTGTACTA CAGGGGAGGA 
GCTTTACTAA CTAGCCCCAG TGGACCAGGC TATCATATCA TGTTACCTTT CATTACAACA 
TTCAGATCTG TGCAGACAAC ACTGCAAACG GATGAAGTTA AAAATGTGCC TTGTGGAACA 
AGTGGTGGAG TCATGATCTA TATTGACCGA ATAGAAGTGG TTAATATGTT GGCTCCTTAT 
GCAGTATTTG ACATTGTGAG GAACTATACT GCAGACTATG ACAAGACTTT AATCTTCAAT 
AAAATCCACC ATGAGCTGAA CCAGTTTTGC AGCGCCCACA CACTTCAAGA AGTTTATATA 
GAATTGTTTG ATCAAATAGA TGAAAACCTG AAGCAGGCCC TGCAAAAAGA CTTAAACACC 
ATGGCCCCAG GTCTCACTAT CCAGGCTGTG CGTGTTACAA AACCCAAAAT CCCAGAAGCC 
ATAAGAAGAA ATTTTGAGTT AATGGAGGCA GAGAAGACAA AACTTCTTAT AGCTGCACAG 
AAACAAAAGG TTGTGGAGAA AGAAGCTGAG ACAGAGAGGA AGAGAGCTGT TATAGAAGCA 
GAGAAGATTG CACAAGTGGC AAAAATTCGA TTTCAACAGA AAGTGATGGA GAAAGAAACT 
GAAAAACGCA TTTCTGAGAT TGAAGATGCT GCGTTCCTGG CCCGAGAGAA GGCGAAGGCA 
GATGCCGAGT ATTATGCTGC GCACAAATAT GCCACCTCAA ACAAGCACAA ATTGACCCCA 
GAATATCTGG AACTCAAGAA GTACCAGGCC ATTGCTTCTA ACAGTAAGAT CTACTTTGGC 
AGCAACATCC CTAACATGTT CGTGGACTCC TCTTGTGCTT TGAAGTACTC TGATGTTAGG 
ACTGAAAGAG AAGGCTCCCT TTCCCCTGAG GAGACTCATG AACCCTCTGG AGAGAGCCCC 
ATCCAAAACA AGGAGAACGC AGGTTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001099823.1
CDS	101..1147
Translation	MNMTQARLLVAAVVGLVAILLYASIHKIEEGHLAVYYRGGALLTSPSGPGYHIMLPFITTFRSVQTTLQTDEVKNVPCGTSGGVMIYIDRIEVVNMLAPYAVFDIVRNYTADYDKTLIFNKIHHELNQFCSAHTLQEVYIELFDQIDENLKQALQKDLNTMAPGLTIQAVRVTKPKIPEAIRRNFELMEAEKTKLLIAAQKQKVVEKEAETERKRAVIEAEKIAQVAKIRFQQKVMEKETEKRISEIEDAAFLAREKAKADAEYYAAHKYATSNKHKLTPEYLELKKYQAIASNSKIYFGSNIPNMFVDSSCALKYSDVRTEREGSLSPEETHEPSGESPIQNKENAG

Target ORF information:

RefSeq Version	NM_001106353.1
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus ER lipid raft associated 1 (Erlin1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001106353.1

ORF Insert Sequence:

ATGAATATGA CTCAAGCCCG GCTTCTGGTG GCTGCAGTGG TGGGGTTGGT GGCGATCCTC 
CTTTACGCCT CCATCCACAA GATCGAGGAA GGACACCTGG CCGTGTACTA CAGGGGAGGA 
GCTTTACTAA CTAGCCCCAG TGGACCAGGC TATCATATCA TGTTACCTTT CATTACAACA 
TTCAGATCTG TGCAGACAAC ACTGCAAACG GATGAAGTTA AAAATGTGCC TTGTGGAACA 
AGTGGTGGAG TCATGATCTA TATTGACCGA ATAGAAGTGG TTAATATGTT GGCTCCTTAT 
GCAGTATTTG ACATTGTGAG GAACTATACT GCAGACTATG ACAAGACTTT AATCTTCAAT 
AAAATCCACC ATGAGCTGAA CCAGTTTTGC AGCGCCCACA CACTTCAAGA AGTTTATATA 
GAATTGTTTG ATCAAATAGA TGAAAACCTG AAGCAGGCCC TGCAAAAAGA CTTAAACACC 
ATGGCCCCAG GTCTCACTAT CCAGGCTGTG CGTGTTACAA AACCCAAAAT CCCAGAAGCC 
ATAAGAAGAA ATTTTGAGTT AATGGAGGCA GAGAAGACAA AACTTCTTAT AGCTGCACAG 
AAACAAAAGG TTGTGGAGAA AGAAGCTGAG ACAGAGAGGA AGAGAGCTGT TATAGAAGCA 
GAGAAGATTG CACAAGTGGC AAAAATTCGA TTTCAACAGA AAGTGATGGA GAAAGAAACT 
GAAAAACGCA TTTCTGAGAT TGAAGATGCT GCGTTCCTGG CCCGAGAGAA GGCGAAGGCA 
GATGCCGAGT ATTATGCTGC GCACAAATAT GCCACCTCAA ACAAGCACAA ATTGACCCCA 
GAATATCTGG AACTCAAGAA GTACCAGGCC ATTGCTTCTA ACAGTAAGAT CTACTTTGGC 
AGCAACATCC CTAACATGTT CGTGGACTCC TCTTGTGCTT TGAAGTACTC TGATGTTAGG 
ACTGAAAGAG AAGGCTCCCT TTCCCCTGAG GAGACTCATG AACCCTCTGG AGAGAGCCCC 
ATCCAAAACA AGGAGAACGC AGGTTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Erlin1 ( XM_006231441.3 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> XP_006231503.1 Rattus norvegicus ER lipid raft associated 1 (Erlin1), transcript variant X1, mRNA.

Price & Availability↑

CloneID	ORa01074
Clone ID Related Accession (Same CDS sequence)	XM_006231441.3 , NM_001106353.1
Accession Version	XM_006231441.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1047bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2016-07-25
Organism	Rattus norvegicus(Norway rat)
Product	erlin-1 isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_005100.4) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Jul 26, 2016 this sequence version replaced XM_006231441.2. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Rattus norvegicus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGAATATGA CTCAAGCCCG GCTTCTGGTG GCTGCAGTGG TGGGGTTGGT GGCGATCCTC 
CTTTACGCCT CCATCCACAA GATCGAGGAA GGACACCTGG CCGTGTACTA CAGGGGAGGA 
GCTTTACTAA CTAGCCCCAG TGGACCAGGC TATCATATCA TGTTACCTTT CATTACAACA 
TTCAGATCTG TGCAGACAAC ACTGCAAACG GATGAAGTTA AAAATGTGCC TTGTGGAACA 
AGTGGTGGAG TCATGATCTA TATTGACCGA ATAGAAGTGG TTAATATGTT GGCTCCTTAT 
GCAGTATTTG ACATTGTGAG GAACTATACT GCAGACTATG ACAAGACTTT AATCTTCAAT 
AAAATCCACC ATGAGCTGAA CCAGTTTTGC AGCGCCCACA CACTTCAAGA AGTTTATATA 
GAATTGTTTG ATCAAATAGA TGAAAACCTG AAGCAGGCCC TGCAAAAAGA CTTAAACACC 
ATGGCCCCAG GTCTCACTAT CCAGGCTGTG CGTGTTACAA AACCCAAAAT CCCAGAAGCC 
ATAAGAAGAA ATTTTGAGTT AATGGAGGCA GAGAAGACAA AACTTCTTAT AGCTGCACAG 
AAACAAAAGG TTGTGGAGAA AGAAGCTGAG ACAGAGAGGA AGAGAGCTGT TATAGAAGCA 
GAGAAGATTG CACAAGTGGC AAAAATTCGA TTTCAACAGA AAGTGATGGA GAAAGAAACT 
GAAAAACGCA TTTCTGAGAT TGAAGATGCT GCGTTCCTGG CCCGAGAGAA GGCGAAGGCA 
GATGCCGAGT ATTATGCTGC GCACAAATAT GCCACCTCAA ACAAGCACAA ATTGACCCCA 
GAATATCTGG AACTCAAGAA GTACCAGGCC ATTGCTTCTA ACAGTAAGAT CTACTTTGGC 
AGCAACATCC CTAACATGTT CGTGGACTCC TCTTGTGCTT TGAAGTACTC TGATGTTAGG 
ACTGAAAGAG AAGGCTCCCT TTCCCCTGAG GAGACTCATG AACCCTCTGG AGAGAGCCCC 
ATCCAAAACA AGGAGAACGC AGGTTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_006231503.1
CDS	123..1169
Translation	MNMTQARLLVAAVVGLVAILLYASIHKIEEGHLAVYYRGGALLTSPSGPGYHIMLPFITTFRSVQTTLQTDEVKNVPCGTSGGVMIYIDRIEVVNMLAPYAVFDIVRNYTADYDKTLIFNKIHHELNQFCSAHTLQEVYIELFDQIDENLKQALQKDLNTMAPGLTIQAVRVTKPKIPEAIRRNFELMEAEKTKLLIAAQKQKVVEKEAETERKRAVIEAEKIAQVAKIRFQQKVMEKETEKRISEIEDAAFLAREKAKADAEYYAAHKYATSNKHKLTPEYLELKKYQAIASNSKIYFGSNIPNMFVDSSCALKYSDVRTEREGSLSPEETHEPSGESPIQNKENAG

Target ORF information:

RefSeq Version	XM_006231441.3
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus ER lipid raft associated 1 (Erlin1), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_006231441.3

ORF Insert Sequence:

ATGAATATGA CTCAAGCCCG GCTTCTGGTG GCTGCAGTGG TGGGGTTGGT GGCGATCCTC 
CTTTACGCCT CCATCCACAA GATCGAGGAA GGACACCTGG CCGTGTACTA CAGGGGAGGA 
GCTTTACTAA CTAGCCCCAG TGGACCAGGC TATCATATCA TGTTACCTTT CATTACAACA 
TTCAGATCTG TGCAGACAAC ACTGCAAACG GATGAAGTTA AAAATGTGCC TTGTGGAACA 
AGTGGTGGAG TCATGATCTA TATTGACCGA ATAGAAGTGG TTAATATGTT GGCTCCTTAT 
GCAGTATTTG ACATTGTGAG GAACTATACT GCAGACTATG ACAAGACTTT AATCTTCAAT 
AAAATCCACC ATGAGCTGAA CCAGTTTTGC AGCGCCCACA CACTTCAAGA AGTTTATATA 
GAATTGTTTG ATCAAATAGA TGAAAACCTG AAGCAGGCCC TGCAAAAAGA CTTAAACACC 
ATGGCCCCAG GTCTCACTAT CCAGGCTGTG CGTGTTACAA AACCCAAAAT CCCAGAAGCC 
ATAAGAAGAA ATTTTGAGTT AATGGAGGCA GAGAAGACAA AACTTCTTAT AGCTGCACAG 
AAACAAAAGG TTGTGGAGAA AGAAGCTGAG ACAGAGAGGA AGAGAGCTGT TATAGAAGCA 
GAGAAGATTG CACAAGTGGC AAAAATTCGA TTTCAACAGA AAGTGATGGA GAAAGAAACT 
GAAAAACGCA TTTCTGAGAT TGAAGATGCT GCGTTCCTGG CCCGAGAGAA GGCGAAGGCA 
GATGCCGAGT ATTATGCTGC GCACAAATAT GCCACCTCAA ACAAGCACAA ATTGACCCCA 
GAATATCTGG AACTCAAGAA GTACCAGGCC ATTGCTTCTA ACAGTAAGAT CTACTTTGGC 
AGCAACATCC CTAACATGTT CGTGGACTCC TCTTGTGCTT TGAAGTACTC TGATGTTAGG 
ACTGAAAGAG AAGGCTCCCT TTCCCCTGAG GAGACTCATG AACCCTCTGG AGAGAGCCCC 
ATCCAAAACA AGGAGAACGC AGGTTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Erlins restrict SREBP activation in the ER and regulate cellular cholesterol homeostasis.
The Journal of cell biology203(3)427-36(2013 Nov)
Huber MD,Vesely PW,Datta K,Gerace L

An endoplasmic reticulum (ER) membrane complex composed of SPFH1 and SPFH2 mediates the ER-associated degradation of inositol 1,4,5-trisphosphate receptors.
The Journal of biological chemistry284(16)10433-45(2009 Apr)
Pearce MM,Wormer DB,Wilkens S,Wojcikiewicz RJ

Blood pressure is regulated by an alpha1D-adrenergic receptor/dystrophin signalosome.
The Journal of biological chemistry283(27)18792-800(2008 Jul)
Lyssand JS,DeFino MC,Tang XB,Hertz AL,Feller DB,Wacker JL,Adams ME,Hague C

Erlin-1 and erlin-2 are novel members of the prohibitin family of proteins that define lipid-raft-like domains of the ER.
Journal of cell science119(Pt 15)3149-60(2006 Aug)
Browman DT,Resek ME,Zajchowski LD,Robbins SM