Csn2 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Csn2
Entrez Gene ID	29173
Full Name	casein beta
Synonyms	Csnb
General protein information	Preferred Names casein beta Names beta-casein
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 14 Map Location: 14p21
Summary	expression is induced by pseudophosphorylated prolactin in mammary gland [RGD, Feb 2006].

mRNA and Protein(s)

mRNA	Protein	Name
XM_017599144.1	XP_017454633.1	beta-casein isoform X1
NM_017120.3	NP_058816.2	beta-casein precursor

Pathways from BioSystems

Homologies

Rattus norvegicus (Norway rat)	Csn2	NP_058816.2
	CSN2	XP_001095936.2
Canis lupus familiaris (dog)	CSN2	NP_001003086.1
Mus musculus (house mouse)	Csn2	NP_034102.1
Bos taurus (cattle)	CSN2	NP_851351.1
Homo sapiens (human)	CSN2	NP_001882.1
Pan troglodytes (chimpanzee)	CSN2	XP_001143844.2

Gene Ontology
Bibliography

Related articles in PubMed

4-Vinylcyclohexene diepoxide (VCD) inhibits mammary epithelial differentiation and induces fibroadenoma formation in female Sprague Dawley rats.
Wright LE, Frye JB, Lukefahr AL, Marion SL, Hoyer PB, Besselsen DG, Funk JL
Reproductive toxicology (Elmsford, N.Y.)32(1)26-32(2011 Jul)

Uteroplacental insufficiency alters the mammary gland response to lactogenic hormones in vitro.
O'Dowd R, Wlodek ME, Nicholas KR
Reproduction, fertility, and development20(4)460-5(2008)

kappa-casein-deficient mice fail to lactate.
Shekar PC, Goel S, Rani SD, Sarathi DP, Alex JL, Singh S, Kumar S
Proceedings of the National Academy of Sciences of the United States of America103(21)8000-5(2006 May)

Human colostrum: identification of minor proteins in the aqueous phase by proteomics.
Palmer DJ, Kelly VC, Smit AM, Kuy S, Knight CG, Cooper GJ
Proteomics6(7)2208-16(2006 Apr)

Expression of the whey acidic protein (Wap) is necessary for adequate nourishment of the offspring but not functional differentiation of mammary epithelial cells.
Triplett AA, Sakamoto K, Matulka LA, Shen L, Smith GH, Wagner KU
Genesis (New York, N.Y. : 2000)43(1)1-11(2005 Sep)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

4-Vinylcyclohexene diepoxide administration to 1-month rats acutely decreased mammary alveolar bud number and expression of beta-casein.
Title: 4-Vinylcyclohexene diepoxide (VCD) inhibits mammary epithelial differentiation and induces fibroadenoma formation in female Sprague Dawley rats.

Mammary tissue from late pregnant Restricted rats had elevated alpha-lactalbumin, but not beta-casein mRNA.
Title: Uteroplacental insufficiency alters the mammary gland response to lactogenic hormones in vitro.

The following Csn2 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Csn2 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa40014	NM_017120.3 Latest version!	Rattus norvegicus casein beta (Csn2), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$188.30 $269.00
ORa58268	XM_017599144.1 Latest version!	Rattus norvegicus casein beta (Csn2), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	9-11	$139.30 $199.00

ORF Online Only Promotion

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Csn2 ( NM_017120.3 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_058816.2 Rattus norvegicus casein beta (Csn2), mRNA.

Price & Availability↑

CloneID	ORa40014
Clone ID Related Accession (Same CDS sequence)	NM_017120.3
Accession Version	NM_017120.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 696bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-09-20
Organism	Rattus norvegicus(Norway rat)
Product	beta-casein precursor
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from J00711.1, AC097835.8 and AA964718.1. On or before Sep 16, 2014 this sequence version replaced NM_001301723.1, NM_017120.2. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. ##Evidence-Data-START## Transcript exon combination :: J00711.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2689602, SAMN02642835 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGAAGGTCT TCATCCTTGC CTGCCTTGTG GCACTTGCTC TTGCAAGGGA GAAGGATGCA 
TTCACTGTGT CCTCTGAGAC TGGTAGTATT TCCAGTGAGG AATCCGTTGA ACATATCAAT 
GAGAAACTTC AGAAGGTGAA ACTCATGGGA CAGGTGCAGT CCGAGGATGT GCTCCAGAAT 
AAATTTCACT CCGGCATTCA GTCAGAACCC CAGGCCATTC CATATGCCCA GACCATCTCT 
TGCAGTCCCA TTCCACAAAA CATCCAGCCT ATTGCTCAAC CCCCTGTGGT GCCAACTGTT 
GGGCCTATCA TTTCTCCTGA ACTGGAATCC TTCCTTAAAG CTAAAGCCAC TGTCCTTCCC 
AAGCACAAAC AGATGCCCTT CCTTAACTCT GAAACCGTGC TCCGCCTCTT TAACTCTCAA 
ATCCCCAGTC TTGATCTTGC TAATCTGCAC CTTCCTCAGT CTCCAGCCCA GCTCCAGGCA 
CAAATTGTGC AGGCTTTTCC TCAGACTCCC GCGGTGGTTT CTTCTCAGCC CCAGCTGTCT 
CTTCCTCAGT CCAAAAGTCA GTACCTTGTG CAGCAACTAG CACCCCTCTT CCAACAAGGT 
ATGCCTGTTC AAGACCTTCT GCAGTACCTA GATCTTCTGC TTAACCCCAC CCTCCAGTTC 
CTTGCCACTC AACAACTTCA TTCCACTTCT GTCTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_058816.2
CDS	53..748
Translation	MKVFILACLVALALAREKDAFTVSSETGSISSEESVEHINEKLQKVKLMGQVQSEDVLQNKFHSGIQSEPQAIPYAQTISCSPIPQNIQPIAQPPVVPTVGPIISPELESFLKAKATVLPKHKQMPFLNSETVLRLFNSQIPSLDLANLHLPQSPAQLQAQIVQAFPQTPAVVSSQPQLSLPQSKSQYLVQQLAPLFQQGMPVQDLLQYLDLLLNPTLQFLATQQLHSTSV

Target ORF information:

RefSeq Version	NM_017120.3
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus casein beta (Csn2), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_017120.3

ORF Insert Sequence:

ATGAAGGTCT TCATCCTTGC CTGCCTTGTG GCACTTGCTC TTGCAAGGGA GAAGGATGCA 
TTCACTGTGT CCTCTGAGAC TGGTAGTATT TCCAGTGAGG AATCCGTTGA ACATATCAAT 
GAGAAACTTC AGAAGGTGAA ACTCATGGGA CAGGTGCAGT CCGAGGATGT GCTCCAGAAT 
AAATTTCACT CCGGCATTCA GTCAGAACCC CAGGCCATTC CATATGCCCA GACCATCTCT 
TGCAGTCCCA TTCCACAAAA CATCCAGCCT ATTGCTCAAC CCCCTGTGGT GCCAACTGTT 
GGGCCTATCA TTTCTCCTGA ACTGGAATCC TTCCTTAAAG CTAAAGCCAC TGTCCTTCCC 
AAGCACAAAC AGATGCCCTT CCTTAACTCT GAAACCGTGC TCCGCCTCTT TAACTCTCAA 
ATCCCCAGTC TTGATCTTGC TAATCTGCAC CTTCCTCAGT CTCCAGCCCA GCTCCAGGCA 
CAAATTGTGC AGGCTTTTCC TCAGACTCCC GCGGTGGTTT CTTCTCAGCC CCAGCTGTCT 
CTTCCTCAGT CCAAAAGTCA GTACCTTGTG CAGCAACTAG CACCCCTCTT CCAACAAGGT 
ATGCCTGTTC AAGACCTTCT GCAGTACCTA GATCTTCTGC TTAACCCCAC CCTCCAGTTC 
CTTGCCACTC AACAACTTCA TTCCACTTCT GTCTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Csn2 ( XM_017599144.1 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> XP_017454633.1 Rattus norvegicus casein beta (Csn2), transcript variant X1, mRNA.

Price & Availability↑

CloneID	ORa58268
Clone ID Related Accession (Same CDS sequence)	XM_017599144.1
Accession Version	XM_017599144.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 747bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2016-07-25
Organism	Rattus norvegicus(Norway rat)
Product	beta-casein isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_005113.4) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Rattus norvegicus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGAAGGTCT TCATCCTTGC CTGCCTTGTG GCACTTGCTC TTGCAAGGGA GAAGGATGCA 
TTCACTGTGT CCTCTGAGAC TGGTAGTATT TCCAGTGAGG AATGGAATTT AAAGATCTTA 
TGTAGAGAAA GAACCACGGT TGAAGAGGGA GAATCCGTTG AACATATCAA TGAGAAACTT 
CAGAAGGTGA AACTCATGGG ACAGGTGCAG TCCGAGGATG TGCTCCAGAA TAAATTTCAC 
TCCGGCATTC AGTCAGAACC CCAGGCCATT CCATATGCCC AGACCATCTC TTGCAGTCCC 
ATTCCACAAA ACATCCAGCC TATTGCTCAA CCCCCTGTGG TGCCAACTGT TGGGCCTATC 
ATTTCTCCTG AACTGGAATC CTTCCTTAAA GCTAAAGCCA CTGTCCTTCC CAAGCACAAA 
CAGATGCCCT TCCTTAACTC TGAAACCGTG CTCCGCCTCT TTAACTCTCA AATCCCCAGT 
CTTGATCTTG CTAATCTGCA CCTTCCTCAG TCTCCAGCCC AGCTCCAGGC ACAAATTGTG 
CAGGCTTTTC CTCAGACTCC CGCGGTGGTT TCTTCTCAGC CCCAGCTGTC TCTTCCTCAG 
TCCAAAAGTC AGTACCTTGT GCAGCAACTA GCACCCCTCT TCCAACAAGG TATGCCTGTT 
CAAGACCTTC TGCAGTACCT AGATCTTCTG CTTAACCCCA CCCTCCAGTT CCTTGCCACT 
CAACAACTTC ATTCCACTTC TGTCTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_017454633.1
CDS	38..784
Translation	MKVFILACLVALALAREKDAFTVSSETGSISSEEWNLKILCRERTTVEEGESVEHINEKLQKVKLMGQVQSEDVLQNKFHSGIQSEPQAIPYAQTISCSPIPQNIQPIAQPPVVPTVGPIISPELESFLKAKATVLPKHKQMPFLNSETVLRLFNSQIPSLDLANLHLPQSPAQLQAQIVQAFPQTPAVVSSQPQLSLPQSKSQYLVQQLAPLFQQGMPVQDLLQYLDLLLNPTLQFLATQQLHSTSV

Target ORF information:

RefSeq Version	XM_017599144.1
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus casein beta (Csn2), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_017599144.1

ORF Insert Sequence:

ATGAAGGTCT TCATCCTTGC CTGCCTTGTG GCACTTGCTC TTGCAAGGGA GAAGGATGCA 
TTCACTGTGT CCTCTGAGAC TGGTAGTATT TCCAGTGAGG AATGGAATTT AAAGATCTTA 
TGTAGAGAAA GAACCACGGT TGAAGAGGGA GAATCCGTTG AACATATCAA TGAGAAACTT 
CAGAAGGTGA AACTCATGGG ACAGGTGCAG TCCGAGGATG TGCTCCAGAA TAAATTTCAC 
TCCGGCATTC AGTCAGAACC CCAGGCCATT CCATATGCCC AGACCATCTC TTGCAGTCCC 
ATTCCACAAA ACATCCAGCC TATTGCTCAA CCCCCTGTGG TGCCAACTGT TGGGCCTATC 
ATTTCTCCTG AACTGGAATC CTTCCTTAAA GCTAAAGCCA CTGTCCTTCC CAAGCACAAA 
CAGATGCCCT TCCTTAACTC TGAAACCGTG CTCCGCCTCT TTAACTCTCA AATCCCCAGT 
CTTGATCTTG CTAATCTGCA CCTTCCTCAG TCTCCAGCCC AGCTCCAGGC ACAAATTGTG 
CAGGCTTTTC CTCAGACTCC CGCGGTGGTT TCTTCTCAGC CCCAGCTGTC TCTTCCTCAG 
TCCAAAAGTC AGTACCTTGT GCAGCAACTA GCACCCCTCT TCCAACAAGG TATGCCTGTT 
CAAGACCTTC TGCAGTACCT AGATCTTCTG CTTAACCCCA CCCTCCAGTT CCTTGCCACT 
CAACAACTTC ATTCCACTTC TGTCTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

4-Vinylcyclohexene diepoxide (VCD) inhibits mammary epithelial differentiation and induces fibroadenoma formation in female Sprague Dawley rats.
Reproductive toxicology (Elmsford, N.Y.)32(1)26-32(2011 Jul)
Wright LE,Frye JB,Lukefahr AL,Marion SL,Hoyer PB,Besselsen DG,Funk JL

Uteroplacental insufficiency alters the mammary gland response to lactogenic hormones in vitro.
Reproduction, fertility, and development20(4)460-5(2008)
O'Dowd R,Wlodek ME,Nicholas KR

kappa-casein-deficient mice fail to lactate.
Proceedings of the National Academy of Sciences of the United States of America103(21)8000-5(2006 May)
Shekar PC,Goel S,Rani SD,Sarathi DP,Alex JL,Singh S,Kumar S

Human colostrum: identification of minor proteins in the aqueous phase by proteomics.
Proteomics6(7)2208-16(2006 Apr)
Palmer DJ,Kelly VC,Smit AM,Kuy S,Knight CG,Cooper GJ

Expression of the whey acidic protein (Wap) is necessary for adequate nourishment of the offspring but not functional differentiation of mammary epithelial cells.
Genesis (New York, N.Y. : 2000)43(1)1-11(2005 Sep)
Triplett AA,Sakamoto K,Matulka LA,Shen L,Smith GH,Wagner KU