Kpna1 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Kpna1
Entrez Gene ID	288064
Full Name	karyopherin subunit alpha 1
General protein information	Preferred Names karyopherin subunit alpha 1 Names importin subunit alpha-5 importin alpha-5 importin subunit alpha-1 karyopherin alpha 1 karyopherin/importin alpha-1
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 11 Map Location: 11q22
Summary	a member of the importin/karyopherin family of nuclear transport proteins; upregulated in the striatum of rat brain after dopamine denervation [RGD, Feb 2006].

mRNA and Protein(s)

mRNA	Protein	Name
NM_198726.2	NP_942021.2	importin subunit alpha-5
XM_017597922.1	XP_017453411.1	importin subunit alpha-5 isoform X2
XM_008768714.2	XP_008766936.1	importin subunit alpha-5 isoform X1

Pathways from BioSystems

Homologies

	KPNA1	XP_001112537.1
Canis lupus familiaris (dog)	KPNA1	XP_005639616.1
Bos taurus (cattle)	KPNA1	NP_001075202.1
Pan troglodytes (chimpanzee)	KPNA1	XP_001167086.1
Gallus gallus (chicken)	KPNA1	NP_001025945.1
Homo sapiens (human)	KPNA1	NP_002255.3
Rattus norvegicus (Norway rat)	Kpna1	NP_942021.2
Danio rerio (zebrafish)	kpna1	XP_701359.5
Xenopus tropicalis (tropical clawed frog)	kpna1	NP_989192.1
Mus musculus (house mouse)	Kpna1	NP_032491.2
Arabidopsis thaliana (thale cress)	IMPA-4	NP_172398.1

Gene Ontology
Bibliography

Related articles in PubMed

Caldendrin-Jacob: a protein liaison that couples NMDA receptor signalling to the nucleus.
Dieterich DC, Karpova A, Mikhaylova M, Zdobnova I, K?nig I, Landwehr M, Kreutz M, Smalla KH, Richter K, Landgraf P, Reissner C, Boeckers TM, Zuschratter W, Spilker C, Seidenbecher CI, Garner CC, Gundelfinger ED, Kreutz MR
PLoS biology6(2)e34(2008 Feb)

Transcriptomic and phylogenetic analysis of Kpna genes: a family of nuclear import factors modulated in xenobiotic-mediated liver growth.
Plant KE, Everett DM, Gordon Gibson G, Lyon J, Plant NJ
Pharmacogenetics and genomics16(9)647-58(2006 Sep)

Type 1 parathyroid hormone receptor (PTH1R) nuclear trafficking: association of PTH1R with importin alpha1 and beta.
Pickard BW, Hodsman AB, Fraher LJ, Watson PH
Endocrinology147(7)3326-32(2006 Jul)

Synapse to nucleus signaling during long-term synaptic plasticity; a role for the classical active nuclear import pathway.
Thompson KR, Otis KO, Chen DY, Zhao Y, O'Dell TJ, Martin KC
Neuron44(6)997-1009(2004 Dec)

Molecular cloning and characterization of rat karyopherin alpha 1 gene: structure and expression.
Wang B, Li Z, Xu L, Goggi J, Yu Y, Zhou J
Gene331149-57(2004 Apr)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

PTH1R forms a complex with the transport regulatory proteins, importin alpha(1) and importin beta, and nuclear PTH1R is associated with the nucleoplasm
Title: Type 1 parathyroid hormone receptor (PTH1R) nuclear trafficking: association of PTH1R with importin alpha1 and beta.

Results suggest involvement of KPNA1 in the striatal responses to denervation following 6-hydroxydopamine (6-OHDA)-induced lesion.
Title: Molecular cloning and characterization of rat karyopherin alpha 1 gene: structure and expression.

The following Kpna1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Kpna1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
ORa04793	NM_198726.2 Latest version!	Rattus norvegicus karyopherin subunit alpha 1 (Kpna1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$307.30 $439.00
ORa04793	XM_017597922.1 Latest version!	Rattus norvegicus karyopherin subunit alpha 1 (Kpna1), transcript variant X2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$307.30 $439.00
ORa44662	XM_008768714.2 Latest version!	Rattus norvegicus karyopherin subunit alpha 1 (Kpna1), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$223.30 $319.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Kpna1 ( NM_198726.2 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_942021.2 Rattus norvegicus karyopherin subunit alpha 1 (Kpna1), mRNA.

Price & Availability↑

CloneID	ORa04793
Clone ID Related Accession (Same CDS sequence)	NM_198726.2 , XM_017597922.1
Accession Version	NM_198726.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1617bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-26
Organism	Rattus norvegicus(Norway rat)
Product	importin subunit alpha-5
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from AY779025.1. On Jun 10, 2007 this sequence version replaced NM_198726.1. ##Evidence-Data-START## Transcript exon combination :: AY779025.1, AY351984.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMD00052296 [ECO:0000348] ##Evidence-Data-END##

ATGTCCACGC CAGGAAAAGA GAACTTTCGC CTGAAAAGTT ACAAGAACAA ATCTCTGAAT 
CCTGATGAGA TGCGCAGGAG GAGGGAGGAA GAAGGACTGC AGTTACGGAA GCAGAAAAGG 
GAAGAACAGT TATTCAAGAG AAGAAATGTT GCTACAGCAG AAGAAGAAAC AGAAGAAGAA 
GTTATGTCTG ATGGTGGCTT TCATGAGGCC CAGATAAATA ACATGGAGAT GGCACCAGGG 
GGAGTCATTA CCTCTGACAT GACTGAGATG ATATTCTCCA ATAGCCCAGA ACAGCAGCTT 
TCTGCAACAC AGAAATTTAG GAAACTACTT TCAAAAGAAC CTAATCCTCC TATTGATGAA 
GTCATCAACA CACCAGGAGT AGTGGCCAGG TTTGTGGAGT TCCTCAAACG AAAAGAAAAT 
TGTACACTGC AGTTTGAATC AGCTTGGGTC CTGACAAATA TTGCTTCAGG AAACTCTCTT 
CAGACCCGGA TTGTGATTCA GGCAGGAGCT GTTCCTATCT TCATCGAGTT GCTTAGCTCA 
GAGTTTGAAG ATGTCCAGGA GCAGGCAGTC TGGGCTCTTG GCAACATTGC TGGAGATAGC 
ACCATGTGCA GGGACTACGT CTTAGACTGC AATATCCTTC CCCCTCTGCT GCAGTTATTT 
TCAAAGCAAA ACCGCTTGAC CATGACCCGG AATGCAGTGT GGGCTTTATC TAATCTATGT 
AGAGGGAAGA GTCCACCTCC AGAATTTGCT AAGGTTTCTC CCTGTCTGAA TGTCCTTTCT 
TGGTTGCTGT TTGTCAGTGA CACTGATGTA CTGGCTGATG CTTGCTGGGC TCTCTCATAC 
CTGTCAGATG GACCCAATGA TAAAATCCAA GCAGTCATCG ATGCAGGAGT ATGCAGGAGA 
CTTGTGGAGC TTCTGATGCA CAATGATTAT AAAGTGGTTT CTCCTGCTTT GCGGGCTGTG 
GGAAACATTG TTACAGGGGA TGACATTCAG ACACAGGTAA TTTTGAATTG CTCAGCTCTT 
CAGAGTTTAT TGCATCTGCT GAGTAGCCCA AAGGAATCTA TCAAAAAAGA AGCATGTTGG 
ACAATCTCTA ATATTACAGC TGGAAATAGG GCACAGATCC AGACTGTGAT AGACGCTAAC 
ATGTTCCCAG CTCTCATCAG TATATTGCAA ACAGCAGAGT TCCGGACGAG AAAGGAAGCT 
GCTTGGGCCA TCACAAATGC AACTTCTGGA GGATCAGCTG AGCAGATCAA GTACCTAGTA 
GAACTGGGTT GTATCAAGCC ACTCTGTGAT CTCCTCACTG TCATGGATGC AAAAATTGTA 
CAGGTTGCCC TAAATGGCTT AGAAAACATC CTGAGGCTTG GGGAACAAGA AGCCAAAAGA 
AATGGCTCAG GAATTAACCC TTACTGTGCT TTGATTGAGG AAGCATATGG TCTGGATAAA 
ATTGAGTTTT TACAGAGTCA TGAAAACCAG GAGATCTATC AGAAGGCTTT TGATCTTATT 
GAGCATTACT TTGGGACGGA GGACGAGGAC AGCAGCATCG CACCCCAGGT TGACCTTAGC 
CAGCAGCAGT ACATCTTCCA GCAGTGTGAG GCTCCCATGG AAGGTTTCCA GCTCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_942021.2
CDS	2..1618
Translation	MSTPGKENFRLKSYKNKSLNPDEMRRRREEEGLQLRKQKREEQLFKRRNVATAEEETEEEVMSDGGFHEAQINNMEMAPGGVITSDMTEMIFSNSPEQQLSATQKFRKLLSKEPNPPIDEVINTPGVVARFVEFLKRKENCTLQFESAWVLTNIASGNSLQTRIVIQAGAVPIFIELLSSEFEDVQEQAVWALGNIAGDSTMCRDYVLDCNILPPLLQLFSKQNRLTMTRNAVWALSNLCRGKSPPPEFAKVSPCLNVLSWLLFVSDTDVLADACWALSYLSDGPNDKIQAVIDAGVCRRLVELLMHNDYKVVSPALRAVGNIVTGDDIQTQVILNCSALQSLLHLLSSPKESIKKEACWTISNITAGNRAQIQTVIDANMFPALISILQTAEFRTRKEAAWAITNATSGGSAEQIKYLVELGCIKPLCDLLTVMDAKIVQVALNGLENILRLGEQEAKRNGSGINPYCALIEEAYGLDKIEFLQSHENQEIYQKAFDLIEHYFGTEDEDSSIAPQVDLSQQQYIFQQCEAPMEGFQL

Target ORF information:

RefSeq Version	NM_198726.2
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus karyopherin subunit alpha 1 (Kpna1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_198726.2

ORF Insert Sequence:

ATGTCCACGC CAGGAAAAGA GAACTTTCGC CTGAAAAGTT ACAAGAACAA ATCTCTGAAT 
CCTGATGAGA TGCGCAGGAG GAGGGAGGAA GAAGGACTGC AGTTACGGAA GCAGAAAAGG 
GAAGAACAGT TATTCAAGAG AAGAAATGTT GCTACAGCAG AAGAAGAAAC AGAAGAAGAA 
GTTATGTCTG ATGGTGGCTT TCATGAGGCC CAGATAAATA ACATGGAGAT GGCACCAGGG 
GGAGTCATTA CCTCTGACAT GACTGAGATG ATATTCTCCA ATAGCCCAGA ACAGCAGCTT 
TCTGCAACAC AGAAATTTAG GAAACTACTT TCAAAAGAAC CTAATCCTCC TATTGATGAA 
GTCATCAACA CACCAGGAGT AGTGGCCAGG TTTGTGGAGT TCCTCAAACG AAAAGAAAAT 
TGTACACTGC AGTTTGAATC AGCTTGGGTC CTGACAAATA TTGCTTCAGG AAACTCTCTT 
CAGACCCGGA TTGTGATTCA GGCAGGAGCT GTTCCTATCT TCATCGAGTT GCTTAGCTCA 
GAGTTTGAAG ATGTCCAGGA GCAGGCAGTC TGGGCTCTTG GCAACATTGC TGGAGATAGC 
ACCATGTGCA GGGACTACGT CTTAGACTGC AATATCCTTC CCCCTCTGCT GCAGTTATTT 
TCAAAGCAAA ACCGCTTGAC CATGACCCGG AATGCAGTGT GGGCTTTATC TAATCTATGT 
AGAGGGAAGA GTCCACCTCC AGAATTTGCT AAGGTTTCTC CCTGTCTGAA TGTCCTTTCT 
TGGTTGCTGT TTGTCAGTGA CACTGATGTA CTGGCTGATG CTTGCTGGGC TCTCTCATAC 
CTGTCAGATG GACCCAATGA TAAAATCCAA GCAGTCATCG ATGCAGGAGT ATGCAGGAGA 
CTTGTGGAGC TTCTGATGCA CAATGATTAT AAAGTGGTTT CTCCTGCTTT GCGGGCTGTG 
GGAAACATTG TTACAGGGGA TGACATTCAG ACACAGGTAA TTTTGAATTG CTCAGCTCTT 
CAGAGTTTAT TGCATCTGCT GAGTAGCCCA AAGGAATCTA TCAAAAAAGA AGCATGTTGG 
ACAATCTCTA ATATTACAGC TGGAAATAGG GCACAGATCC AGACTGTGAT AGACGCTAAC 
ATGTTCCCAG CTCTCATCAG TATATTGCAA ACAGCAGAGT TCCGGACGAG AAAGGAAGCT 
GCTTGGGCCA TCACAAATGC AACTTCTGGA GGATCAGCTG AGCAGATCAA GTACCTAGTA 
GAACTGGGTT GTATCAAGCC ACTCTGTGAT CTCCTCACTG TCATGGATGC AAAAATTGTA 
CAGGTTGCCC TAAATGGCTT AGAAAACATC CTGAGGCTTG GGGAACAAGA AGCCAAAAGA 
AATGGCTCAG GAATTAACCC TTACTGTGCT TTGATTGAGG AAGCATATGG TCTGGATAAA 
ATTGAGTTTT TACAGAGTCA TGAAAACCAG GAGATCTATC AGAAGGCTTT TGATCTTATT 
GAGCATTACT TTGGGACGGA GGACGAGGAC AGCAGCATCG CACCCCAGGT TGACCTTAGC 
CAGCAGCAGT ACATCTTCCA GCAGTGTGAG GCTCCCATGG AAGGTTTCCA GCTCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Kpna1 ( XM_017597922.1 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> XP_017453411.1 Rattus norvegicus karyopherin subunit alpha 1 (Kpna1), transcript variant X2, mRNA.

Price & Availability↑

CloneID	ORa04793
Clone ID Related Accession (Same CDS sequence)	NM_198726.2 , XM_017597922.1
Accession Version	XM_017597922.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1617bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2016-07-25
Organism	Rattus norvegicus(Norway rat)
Product	importin subunit alpha-5 isoform X2
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_005110.4) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Rattus norvegicus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGTCCACGC CAGGAAAAGA GAACTTTCGC CTGAAAAGTT ACAAGAACAA ATCTCTGAAT 
CCTGATGAGA TGCGCAGGAG GAGGGAGGAA GAAGGACTGC AGTTACGGAA GCAGAAAAGG 
GAAGAACAGT TATTCAAGAG AAGAAATGTT GCTACAGCAG AAGAAGAAAC AGAAGAAGAA 
GTTATGTCTG ATGGTGGCTT TCATGAGGCC CAGATAAATA ACATGGAGAT GGCACCAGGG 
GGAGTCATTA CCTCTGACAT GACTGAGATG ATATTCTCCA ATAGCCCAGA ACAGCAGCTT 
TCTGCAACAC AGAAATTTAG GAAACTACTT TCAAAAGAAC CTAATCCTCC TATTGATGAA 
GTCATCAACA CACCAGGAGT AGTGGCCAGG TTTGTGGAGT TCCTCAAACG AAAAGAAAAT 
TGTACACTGC AGTTTGAATC AGCTTGGGTC CTGACAAATA TTGCTTCAGG AAACTCTCTT 
CAGACCCGGA TTGTGATTCA GGCAGGAGCT GTTCCTATCT TCATCGAGTT GCTTAGCTCA 
GAGTTTGAAG ATGTCCAGGA GCAGGCAGTC TGGGCTCTTG GCAACATTGC TGGAGATAGC 
ACCATGTGCA GGGACTACGT CTTAGACTGC AATATCCTTC CCCCTCTGCT GCAGTTATTT 
TCAAAGCAAA ACCGCTTGAC CATGACCCGG AATGCAGTGT GGGCTTTATC TAATCTATGT 
AGAGGGAAGA GTCCACCTCC AGAATTTGCT AAGGTTTCTC CCTGTCTGAA TGTCCTTTCT 
TGGTTGCTGT TTGTCAGTGA CACTGATGTA CTGGCTGATG CTTGCTGGGC TCTCTCATAC 
CTGTCAGATG GACCCAATGA TAAAATCCAA GCAGTCATCG ATGCAGGAGT ATGCAGGAGA 
CTTGTGGAGC TTCTGATGCA CAATGATTAT AAAGTGGTTT CTCCTGCTTT GCGGGCTGTG 
GGAAACATTG TTACAGGGGA TGACATTCAG ACACAGGTAA TTTTGAATTG CTCAGCTCTT 
CAGAGTTTAT TGCATCTGCT GAGTAGCCCA AAGGAATCTA TCAAAAAAGA AGCATGTTGG 
ACAATCTCTA ATATTACAGC TGGAAATAGG GCACAGATCC AGACTGTGAT AGACGCTAAC 
ATGTTCCCAG CTCTCATCAG TATATTGCAA ACAGCAGAGT TCCGGACGAG AAAGGAAGCT 
GCTTGGGCCA TCACAAATGC AACTTCTGGA GGATCAGCTG AGCAGATCAA GTACCTAGTA 
GAACTGGGTT GTATCAAGCC ACTCTGTGAT CTCCTCACTG TCATGGATGC AAAAATTGTA 
CAGGTTGCCC TAAATGGCTT AGAAAACATC CTGAGGCTTG GGGAACAAGA AGCCAAAAGA 
AATGGCTCAG GAATTAACCC TTACTGTGCT TTGATTGAGG AAGCATATGG TCTGGATAAA 
ATTGAGTTTT TACAGAGTCA TGAAAACCAG GAGATCTATC AGAAGGCTTT TGATCTTATT 
GAGCATTACT TTGGGACGGA GGACGAGGAC AGCAGCATCG CACCCCAGGT TGACCTTAGC 
CAGCAGCAGT ACATCTTCCA GCAGTGTGAG GCTCCCATGG AAGGTTTCCA GCTCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_017453411.1
CDS	27..1643
Translation	MSTPGKENFRLKSYKNKSLNPDEMRRRREEEGLQLRKQKREEQLFKRRNVATAEEETEEEVMSDGGFHEAQINNMEMAPGGVITSDMTEMIFSNSPEQQLSATQKFRKLLSKEPNPPIDEVINTPGVVARFVEFLKRKENCTLQFESAWVLTNIASGNSLQTRIVIQAGAVPIFIELLSSEFEDVQEQAVWALGNIAGDSTMCRDYVLDCNILPPLLQLFSKQNRLTMTRNAVWALSNLCRGKSPPPEFAKVSPCLNVLSWLLFVSDTDVLADACWALSYLSDGPNDKIQAVIDAGVCRRLVELLMHNDYKVVSPALRAVGNIVTGDDIQTQVILNCSALQSLLHLLSSPKESIKKEACWTISNITAGNRAQIQTVIDANMFPALISILQTAEFRTRKEAAWAITNATSGGSAEQIKYLVELGCIKPLCDLLTVMDAKIVQVALNGLENILRLGEQEAKRNGSGINPYCALIEEAYGLDKIEFLQSHENQEIYQKAFDLIEHYFGTEDEDSSIAPQVDLSQQQYIFQQCEAPMEGFQL

Target ORF information:

RefSeq Version	XM_017597922.1
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus karyopherin subunit alpha 1 (Kpna1), transcript variant X2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_017597922.1

ORF Insert Sequence:

ATGTCCACGC CAGGAAAAGA GAACTTTCGC CTGAAAAGTT ACAAGAACAA ATCTCTGAAT 
CCTGATGAGA TGCGCAGGAG GAGGGAGGAA GAAGGACTGC AGTTACGGAA GCAGAAAAGG 
GAAGAACAGT TATTCAAGAG AAGAAATGTT GCTACAGCAG AAGAAGAAAC AGAAGAAGAA 
GTTATGTCTG ATGGTGGCTT TCATGAGGCC CAGATAAATA ACATGGAGAT GGCACCAGGG 
GGAGTCATTA CCTCTGACAT GACTGAGATG ATATTCTCCA ATAGCCCAGA ACAGCAGCTT 
TCTGCAACAC AGAAATTTAG GAAACTACTT TCAAAAGAAC CTAATCCTCC TATTGATGAA 
GTCATCAACA CACCAGGAGT AGTGGCCAGG TTTGTGGAGT TCCTCAAACG AAAAGAAAAT 
TGTACACTGC AGTTTGAATC AGCTTGGGTC CTGACAAATA TTGCTTCAGG AAACTCTCTT 
CAGACCCGGA TTGTGATTCA GGCAGGAGCT GTTCCTATCT TCATCGAGTT GCTTAGCTCA 
GAGTTTGAAG ATGTCCAGGA GCAGGCAGTC TGGGCTCTTG GCAACATTGC TGGAGATAGC 
ACCATGTGCA GGGACTACGT CTTAGACTGC AATATCCTTC CCCCTCTGCT GCAGTTATTT 
TCAAAGCAAA ACCGCTTGAC CATGACCCGG AATGCAGTGT GGGCTTTATC TAATCTATGT 
AGAGGGAAGA GTCCACCTCC AGAATTTGCT AAGGTTTCTC CCTGTCTGAA TGTCCTTTCT 
TGGTTGCTGT TTGTCAGTGA CACTGATGTA CTGGCTGATG CTTGCTGGGC TCTCTCATAC 
CTGTCAGATG GACCCAATGA TAAAATCCAA GCAGTCATCG ATGCAGGAGT ATGCAGGAGA 
CTTGTGGAGC TTCTGATGCA CAATGATTAT AAAGTGGTTT CTCCTGCTTT GCGGGCTGTG 
GGAAACATTG TTACAGGGGA TGACATTCAG ACACAGGTAA TTTTGAATTG CTCAGCTCTT 
CAGAGTTTAT TGCATCTGCT GAGTAGCCCA AAGGAATCTA TCAAAAAAGA AGCATGTTGG 
ACAATCTCTA ATATTACAGC TGGAAATAGG GCACAGATCC AGACTGTGAT AGACGCTAAC 
ATGTTCCCAG CTCTCATCAG TATATTGCAA ACAGCAGAGT TCCGGACGAG AAAGGAAGCT 
GCTTGGGCCA TCACAAATGC AACTTCTGGA GGATCAGCTG AGCAGATCAA GTACCTAGTA 
GAACTGGGTT GTATCAAGCC ACTCTGTGAT CTCCTCACTG TCATGGATGC AAAAATTGTA 
CAGGTTGCCC TAAATGGCTT AGAAAACATC CTGAGGCTTG GGGAACAAGA AGCCAAAAGA 
AATGGCTCAG GAATTAACCC TTACTGTGCT TTGATTGAGG AAGCATATGG TCTGGATAAA 
ATTGAGTTTT TACAGAGTCA TGAAAACCAG GAGATCTATC AGAAGGCTTT TGATCTTATT 
GAGCATTACT TTGGGACGGA GGACGAGGAC AGCAGCATCG CACCCCAGGT TGACCTTAGC 
CAGCAGCAGT ACATCTTCCA GCAGTGTGAG GCTCCCATGG AAGGTTTCCA GCTCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Kpna1 ( XM_008768714.2 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> XP_008766936.1 Rattus norvegicus karyopherin subunit alpha 1 (Kpna1), transcript variant X1, mRNA.

Price & Availability↑

CloneID	ORa44662
Clone ID Related Accession (Same CDS sequence)	XM_008768714.2
Accession Version	XM_008768714.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1446bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2016-07-25
Organism	Rattus norvegicus(Norway rat)
Product	importin subunit alpha-5 isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_005110.4) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On Jul 26, 2016 this sequence version replaced XM_008768714.1. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Rattus norvegicus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGTTGTCTT TCTTTCCTGA ACTAAGGTTA ATGTTGTGTT GTATTTGCTC TTTGTCTATG 
GTCCAGGGGG GAGTCATTAC CTCTGACATG ACTGAGATGA TATTCTCCAA TAGCCCAGAA 
CAGCAGCTTT CTGCAACACA GAAATTTAGG AAACTACTTT CAAAAGAACC TAATCCTCCT 
ATTGATGAAG TCATCAACAC ACCAGGAGTA GTGGCCAGGT TTGTGGAGTT CCTCAAACGA 
AAAGAAAATT GTACACTGCA GTTTGAATCA GCTTGGGTCC TGACAAATAT TGCTTCAGGA 
AACTCTCTTC AGACCCGGAT TGTGATTCAG GCAGGAGCTG TTCCTATCTT CATCGAGTTG 
CTTAGCTCAG AGTTTGAAGA TGTCCAGGAG CAGGCAGTCT GGGCTCTTGG CAACATTGCT 
GGAGATAGCA CCATGTGCAG GGACTACGTC TTAGACTGCA ATATCCTTCC CCCTCTGCTG 
CAGTTATTTT CAAAGCAAAA CCGCTTGACC ATGACCCGGA ATGCAGTGTG GGCTTTATCT 
AATCTATGTA GAGGGAAGAG TCCACCTCCA GAATTTGCTA AGGTTTCTCC CTGTCTGAAT 
GTCCTTTCTT GGTTGCTGTT TGTCAGTGAC ACTGATGTAC TGGCTGATGC TTGCTGGGCT 
CTCTCATACC TGTCAGATGG ACCCAATGAT AAAATCCAAG CAGTCATCGA TGCAGGAGTA 
TGCAGGAGAC TTGTGGAGCT TCTGATGCAC AATGATTATA AAGTGGTTTC TCCTGCTTTG 
CGGGCTGTGG GAAACATTGT TACAGGGGAT GACATTCAGA CACAGGTAAT TTTGAATTGC 
TCAGCTCTTC AGAGTTTATT GCATCTGCTG AGTAGCCCAA AGGAATCTAT CAAAAAAGAA 
GCATGTTGGA CAATCTCTAA TATTACAGCT GGAAATAGGG CACAGATCCA GACTGTGATA 
GACGCTAACA TGTTCCCAGC TCTCATCAGT ATATTGCAAA CAGCAGAGTT CCGGACGAGA 
AAGGAAGCTG CTTGGGCCAT CACAAATGCA ACTTCTGGAG GATCAGCTGA GCAGATCAAG 
TACCTAGTAG AACTGGGTTG TATCAAGCCA CTCTGTGATC TCCTCACTGT CATGGATGCA 
AAAATTGTAC AGGTTGCCCT AAATGGCTTA GAAAACATCC TGAGGCTTGG GGAACAAGAA 
GCCAAAAGAA ATGGCTCAGG AATTAACCCT TACTGTGCTT TGATTGAGGA AGCATATGGT 
CTGGATAAAA TTGAGTTTTT ACAGAGTCAT GAAAACCAGG AGATCTATCA GAAGGCTTTT 
GATCTTATTG AGCATTACTT TGGGACGGAG GACGAGGACA GCAGCATCGC ACCCCAGGTT 
GACCTTAGCC AGCAGCAGTA CATCTTCCAG CAGTGTGAGG CTCCCATGGA AGGTTTCCAG 
CTCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_008766936.1
CDS	172..1617
Translation	MLSFFPELRLMLCCICSLSMVQGGVITSDMTEMIFSNSPEQQLSATQKFRKLLSKEPNPPIDEVINTPGVVARFVEFLKRKENCTLQFESAWVLTNIASGNSLQTRIVIQAGAVPIFIELLSSEFEDVQEQAVWALGNIAGDSTMCRDYVLDCNILPPLLQLFSKQNRLTMTRNAVWALSNLCRGKSPPPEFAKVSPCLNVLSWLLFVSDTDVLADACWALSYLSDGPNDKIQAVIDAGVCRRLVELLMHNDYKVVSPALRAVGNIVTGDDIQTQVILNCSALQSLLHLLSSPKESIKKEACWTISNITAGNRAQIQTVIDANMFPALISILQTAEFRTRKEAAWAITNATSGGSAEQIKYLVELGCIKPLCDLLTVMDAKIVQVALNGLENILRLGEQEAKRNGSGINPYCALIEEAYGLDKIEFLQSHENQEIYQKAFDLIEHYFGTEDEDSSIAPQVDLSQQQYIFQQCEAPMEGFQL

Target ORF information:

RefSeq Version	XM_008768714.2
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus karyopherin subunit alpha 1 (Kpna1), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_008768714.2

ORF Insert Sequence:

ATGTTGTCTT TCTTTCCTGA ACTAAGGTTA ATGTTGTGTT GTATTTGCTC TTTGTCTATG 
GTCCAGGGGG GAGTCATTAC CTCTGACATG ACTGAGATGA TATTCTCCAA TAGCCCAGAA 
CAGCAGCTTT CTGCAACACA GAAATTTAGG AAACTACTTT CAAAAGAACC TAATCCTCCT 
ATTGATGAAG TCATCAACAC ACCAGGAGTA GTGGCCAGGT TTGTGGAGTT CCTCAAACGA 
AAAGAAAATT GTACACTGCA GTTTGAATCA GCTTGGGTCC TGACAAATAT TGCTTCAGGA 
AACTCTCTTC AGACCCGGAT TGTGATTCAG GCAGGAGCTG TTCCTATCTT CATCGAGTTG 
CTTAGCTCAG AGTTTGAAGA TGTCCAGGAG CAGGCAGTCT GGGCTCTTGG CAACATTGCT 
GGAGATAGCA CCATGTGCAG GGACTACGTC TTAGACTGCA ATATCCTTCC CCCTCTGCTG 
CAGTTATTTT CAAAGCAAAA CCGCTTGACC ATGACCCGGA ATGCAGTGTG GGCTTTATCT 
AATCTATGTA GAGGGAAGAG TCCACCTCCA GAATTTGCTA AGGTTTCTCC CTGTCTGAAT 
GTCCTTTCTT GGTTGCTGTT TGTCAGTGAC ACTGATGTAC TGGCTGATGC TTGCTGGGCT 
CTCTCATACC TGTCAGATGG ACCCAATGAT AAAATCCAAG CAGTCATCGA TGCAGGAGTA 
TGCAGGAGAC TTGTGGAGCT TCTGATGCAC AATGATTATA AAGTGGTTTC TCCTGCTTTG 
CGGGCTGTGG GAAACATTGT TACAGGGGAT GACATTCAGA CACAGGTAAT TTTGAATTGC 
TCAGCTCTTC AGAGTTTATT GCATCTGCTG AGTAGCCCAA AGGAATCTAT CAAAAAAGAA 
GCATGTTGGA CAATCTCTAA TATTACAGCT GGAAATAGGG CACAGATCCA GACTGTGATA 
GACGCTAACA TGTTCCCAGC TCTCATCAGT ATATTGCAAA CAGCAGAGTT CCGGACGAGA 
AAGGAAGCTG CTTGGGCCAT CACAAATGCA ACTTCTGGAG GATCAGCTGA GCAGATCAAG 
TACCTAGTAG AACTGGGTTG TATCAAGCCA CTCTGTGATC TCCTCACTGT CATGGATGCA 
AAAATTGTAC AGGTTGCCCT AAATGGCTTA GAAAACATCC TGAGGCTTGG GGAACAAGAA 
GCCAAAAGAA ATGGCTCAGG AATTAACCCT TACTGTGCTT TGATTGAGGA AGCATATGGT 
CTGGATAAAA TTGAGTTTTT ACAGAGTCAT GAAAACCAGG AGATCTATCA GAAGGCTTTT 
GATCTTATTG AGCATTACTT TGGGACGGAG GACGAGGACA GCAGCATCGC ACCCCAGGTT 
GACCTTAGCC AGCAGCAGTA CATCTTCCAG CAGTGTGAGG CTCCCATGGA AGGTTTCCAG 
CTCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Caldendrin-Jacob: a protein liaison that couples NMDA receptor signalling to the nucleus.
PLoS biology6(2)e34(2008 Feb)
Dieterich DC,Karpova A,Mikhaylova M,Zdobnova I,K?nig I,Landwehr M,Kreutz M,Smalla KH,Richter K,Landgraf P,Reissner C,Boeckers TM,Zuschratter W,Spilker C,Seidenbecher CI,Garner CC,Gundelfinger ED,Kreutz MR

Transcriptomic and phylogenetic analysis of Kpna genes: a family of nuclear import factors modulated in xenobiotic-mediated liver growth.
Pharmacogenetics and genomics16(9)647-58(2006 Sep)
Plant KE,Everett DM,Gordon Gibson G,Lyon J,Plant NJ

Type 1 parathyroid hormone receptor (PTH1R) nuclear trafficking: association of PTH1R with importin alpha1 and beta.
Endocrinology147(7)3326-32(2006 Jul)
Pickard BW,Hodsman AB,Fraher LJ,Watson PH

Synapse to nucleus signaling during long-term synaptic plasticity; a role for the classical active nuclear import pathway.
Neuron44(6)997-1009(2004 Dec)
Thompson KR,Otis KO,Chen DY,Zhao Y,O'Dell TJ,Martin KC

Molecular cloning and characterization of rat karyopherin alpha 1 gene: structure and expression.
Gene331149-57(2004 Apr)
Wang B,Li Z,Xu L,Goggi J,Yu Y,Zhou J