Ugt2b1 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Ugt2b1
Entrez Gene ID	286954
Full Name	UDP glucuronosyltransferase 2 family, polypeptide B1
Synonyms	2B1,Udpgtr2,Ugt2b17
General protein information	Preferred Names UDP glucuronosyltransferase 2 family, polypeptide B1 Names UDP-glucuronosyltransferase 2B1 UDP glucuronosyltransferase 2 family, polypeptide B17 UDP-glucuronosyltransferase 2B4 UDPGT 2B1 UDPGTr-2 liver UDP-glucuronosyltransferase, phenobarbital-inducible form
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 14 Map Location: 14p21
Summary	catalyzes the transfer of glucuronate from UDP-glucuronate to beta-D-glucuronoside; may play a role in drug metabolism [RGD, Feb 2006].

mRNA and Protein(s)

mRNA	Protein	Name
NM_173295.1	NP_775417.1	UDP-glucuronosyltransferase 2B1 precursor

Pathways from BioSystems

Homologies

Canis lupus familiaris (dog)	UGT2B4	XP_537895.3
Canis lupus familiaris (dog)	LOC100686607	XP_003435459.1
Bos taurus (cattle)	LOC100138004	XP_002688365.1
Homo sapiens (human)	UGT2B17	NP_001068.1
Canis lupus familiaris (dog)	LOC608760	XP_850502.2
Bos taurus (cattle)	LOC100296421	XP_002688375.1
Mus musculus (house mouse)	Ugt2b1	NP_690024.1
Bos taurus (cattle)	UGT2B17	XP_002688371.2
Canis lupus familiaris (dog)	LOC100856068	XP_003639508.1
Bos taurus (cattle)	UGT2B4	XP_002688367.1
Bos taurus (cattle)	UGT2B10	NP_001039819.1
Bos taurus (cattle)	LOC100140261	XP_002688369.2
Bos taurus (cattle)	LOC100138908	XP_002688373.1
Pan troglodytes (chimpanzee)	UGT2B17	XP_001163237.1
Canis lupus familiaris (dog)	UGT2B31	NP_001003381.1
Bos taurus (cattle)	UGT2B15	XP_002688378.1
Rattus norvegicus (Norway rat)	Ugt2b1	NP_775417.1
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP007028	XP_308744.4

Gene Ontology
Bibliography

Related articles in PubMed

Simultaneous evaluation of six human glucuronidation activities in liver microsomes using liquid chromatography-tandem mass spectrometry.
Gagez AL, Rouguieg-Malki K, Sauvage FL, Marquet P, Picard N
Analytical biochemistry427(1)52-9(2012 Aug)

Role of UDP-glucuronosyltransferase isoforms in 13-cis retinoic acid metabolism in humans.
Rowbotham SE, Illingworth NA, Daly AK, Veal GJ, Boddy AV
Drug metabolism and disposition: the biological fate of chemicals38(7)1211-7(2010 Jul)

Effect of the acute phase response induced by endotoxin administration on the expression and activity of UGT isoforms in rats.
Alkharfy KM, Poloyac SM, Congiu M, Desmond PV, Frye RF
Drug metabolism letters2(4)248-55(2008 Dec)

Protein-protein interactions between rat hepatic cytochromes P450 (P450s) and UDP-glucuronosyltransferases (UGTs): evidence for the functionally active UGT in P450-UGT complex.
Ishii Y, Iwanaga M, Nishimura Y, Takeda S, Ikushiro S, Nagata K, Yamazoe Y, Mackenzie PI, Yamada H
Drug metabolism and pharmacokinetics22(5)367-76(2007 Oct)

UDP-glucuronosyltransferase isoforms catalyzing glucuronidation of hydroxy-polychlorinated biphenyls in rat.
Daidoji T, Gozu K, Iwano H, Inoue H, Yokota H
Drug metabolism and disposition: the biological fate of chemicals33(10)1466-76(2005 Oct)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The following Ugt2b1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Ugt2b1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa03612	NM_173295.1 Latest version!	Rattus norvegicus UDP glucuronosyltransferase 2 family, polypeptide B1 (Ugt2b1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$307.30 $439.00

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Ugt2b1 ( NM_173295.1 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_775417.1 Rattus norvegicus UDP glucuronosyltransferase 2 family, polypeptide B1 (Ugt2b1), mRNA.

Price & Availability↑

CloneID	ORa03612
Clone ID Related Accession (Same CDS sequence)	NM_173295.1
Accession Version	NM_173295.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1590bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-10-19
Organism	Rattus norvegicus(Norway rat)
Product	UDP-glucuronosyltransferase 2B1 precursor
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from M13506.1. ##Evidence-Data-START## Transcript exon combination :: M13506.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2689598, SAMN01906348 [ECO:0000348] ##Evidence-Data-END##

ATGTCTATGA AACAGACTTC AGTGTTTCTG TTGATACAGC TCATATGCTA CTTTAGACCT 
GGAGCCTGTG GAAAAGTGCT AGTGTGGCCC ACAGAATACA GCCACTGGAT TAATATAAAG 
ATAATTCTGA ATGAACTTGC CCAGAGAGGT CATGAAGTCA CGGTTCTTGT ATCTTCGGCT 
TCCATTCTCA TTGAGCCTAC CAAGGAATCT TCTATTAATT TTGAGATTTA CTCTGTACCT 
TTGAGTAAAA GTGATCTTGA ATATAGTTTT GCAAAATGGA TAGATGAATG GACACGTGAT 
TTTGAAACAC TCTCGATTTG GACATATTAT TCAAAAATGC AAAAAGTCTT CAATGAATAT 
TCTGATGTCG TTGAAAATTT ATGCAAAGCA CTCATTTGGA ACAAGAGTCT TATGAAAAAA 
CTCCAAGGAT CTCAATTTGA TGTCATTCTC GCAGATGCTG TGGGTCCCTG TGGTGAGCTG 
CTAGCAGAAC TGCTTAAGAC ACCTTTAGTG TACAGTCTCC GCTTCTGTCC TGGATACAGA 
TGTGAAAAGT TCAGTGGGGG ACTTCCACTG CCTCCTTCCT ATGTGCCTGT TGTTCTTTCA 
GAATTAAGTG ACCGCATGAC ATTTGTGGAA AGAGTGAAGA ATATGTTGCA GATGCTGTAT 
TTTGACTTTT GGTTTCAACC ATTTAAAGAG AAGTCCTGGA GTCAGTTTTA CAGTGATGTT 
CTAGGTAGAC CCACAACATT AACTGAGATG ATGGGGAAGG CAGATATATG GCTCATTCGA 
ACCTTCTGGG ACTTGGAATT TCCACACCCA TTCTTACCTA ATTTTGACTT TGTTGGAGGA 
CTACATTGCA AACCAGCCAA ACCACTGCCT AGGGAAATGG AAGAATTTGT TCAGAGCTCT 
GGAGAACATG GTGTAGTGGT GTTTTCTCTG GGATCAATGG TTAAAAACCT GACTGAAGAA 
AAAGCCAATG TAGTTGCTTC TGCTCTTGCC CAAATTCCAC AGAAGGTTGT ATGGAGATTT 
GATGGTAAGA AACCAGATAC CTTAGGATCT AACACTCGGC TGTACAAGTG GATCCCCCAG 
AATGACCTTC TTGGTCATCC AAAAACCAAA GCTTTTGTAG CTCATGGTGG AACAAATGGC 
ATCTATGAGG CAATCTACCA TGGCATTCCT ATTGTTGGTA TTCCCTTGTT TGCAGATCAA 
CCGGATAACA TTAATCACAT GGTAGCCAAA GGAGCTGCTG TTAGAGTTGA CTTCAGCATA 
CTGTCAACTA CAGGCCTTCT CACTGCCTTG AAGATTGTCA TGAATGACCC TTCCTATAAG 
GAGAATGCCA TGAGATTATC CAGAATCCAC CATGATCAGC CAGTGAAGCC CCTGGACCGA 
GCCGTCTTCT GGATCGAGTA TGTCATGCGT CACAAAGGAG CCAAGCACCT CCGCTCAACT 
CTGCATGACC TTAGCTGGTT CCAGTACCAC TCTCTGGATG TCATTGGGTT CCTATTGCTC 
TGTGTGGTAG GTGTGGTATT CATCATCACA AAATTCTGCC TCTTTTGTTG CCGTAAGACT 
GCTAACATGG GAAAGAAGAA GAAAGAGTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_775417.1
CDS	26..1615
Translation	MSMKQTSVFLLIQLICYFRPGACGKVLVWPTEYSHWINIKIILNELAQRGHEVTVLVSSASILIEPTKESSINFEIYSVPLSKSDLEYSFAKWIDEWTRDFETLSIWTYYSKMQKVFNEYSDVVENLCKALIWNKSLMKKLQGSQFDVILADAVGPCGELLAELLKTPLVYSLRFCPGYRCEKFSGGLPLPPSYVPVVLSELSDRMTFVERVKNMLQMLYFDFWFQPFKEKSWSQFYSDVLGRPTTLTEMMGKADIWLIRTFWDLEFPHPFLPNFDFVGGLHCKPAKPLPREMEEFVQSSGEHGVVVFSLGSMVKNLTEEKANVVASALAQIPQKVVWRFDGKKPDTLGSNTRLYKWIPQNDLLGHPKTKAFVAHGGTNGIYEAIYHGIPIVGIPLFADQPDNINHMVAKGAAVRVDFSILSTTGLLTALKIVMNDPSYKENAMRLSRIHHDQPVKPLDRAVFWIEYVMRHKGAKHLRSTLHDLSWFQYHSLDVIGFLLLCVVGVVFIITKFCLFCCRKTANMGKKKKE

Target ORF information:

RefSeq Version	NM_173295.1
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus UDP glucuronosyltransferase 2 family, polypeptide B1 (Ugt2b1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_173295.1

ORF Insert Sequence:

ATGTCTATGA AACAGACTTC AGTGTTTCTG TTGATACAGC TCATATGCTA CTTTAGACCT 
GGAGCCTGTG GAAAAGTGCT AGTGTGGCCC ACAGAATACA GCCACTGGAT TAATATAAAG 
ATAATTCTGA ATGAACTTGC CCAGAGAGGT CATGAAGTCA CGGTTCTTGT ATCTTCGGCT 
TCCATTCTCA TTGAGCCTAC CAAGGAATCT TCTATTAATT TTGAGATTTA CTCTGTACCT 
TTGAGTAAAA GTGATCTTGA ATATAGTTTT GCAAAATGGA TAGATGAATG GACACGTGAT 
TTTGAAACAC TCTCGATTTG GACATATTAT TCAAAAATGC AAAAAGTCTT CAATGAATAT 
TCTGATGTCG TTGAAAATTT ATGCAAAGCA CTCATTTGGA ACAAGAGTCT TATGAAAAAA 
CTCCAAGGAT CTCAATTTGA TGTCATTCTC GCAGATGCTG TGGGTCCCTG TGGTGAGCTG 
CTAGCAGAAC TGCTTAAGAC ACCTTTAGTG TACAGTCTCC GCTTCTGTCC TGGATACAGA 
TGTGAAAAGT TCAGTGGGGG ACTTCCACTG CCTCCTTCCT ATGTGCCTGT TGTTCTTTCA 
GAATTAAGTG ACCGCATGAC ATTTGTGGAA AGAGTGAAGA ATATGTTGCA GATGCTGTAT 
TTTGACTTTT GGTTTCAACC ATTTAAAGAG AAGTCCTGGA GTCAGTTTTA CAGTGATGTT 
CTAGGTAGAC CCACAACATT AACTGAGATG ATGGGGAAGG CAGATATATG GCTCATTCGA 
ACCTTCTGGG ACTTGGAATT TCCACACCCA TTCTTACCTA ATTTTGACTT TGTTGGAGGA 
CTACATTGCA AACCAGCCAA ACCACTGCCT AGGGAAATGG AAGAATTTGT TCAGAGCTCT 
GGAGAACATG GTGTAGTGGT GTTTTCTCTG GGATCAATGG TTAAAAACCT GACTGAAGAA 
AAAGCCAATG TAGTTGCTTC TGCTCTTGCC CAAATTCCAC AGAAGGTTGT ATGGAGATTT 
GATGGTAAGA AACCAGATAC CTTAGGATCT AACACTCGGC TGTACAAGTG GATCCCCCAG 
AATGACCTTC TTGGTCATCC AAAAACCAAA GCTTTTGTAG CTCATGGTGG AACAAATGGC 
ATCTATGAGG CAATCTACCA TGGCATTCCT ATTGTTGGTA TTCCCTTGTT TGCAGATCAA 
CCGGATAACA TTAATCACAT GGTAGCCAAA GGAGCTGCTG TTAGAGTTGA CTTCAGCATA 
CTGTCAACTA CAGGCCTTCT CACTGCCTTG AAGATTGTCA TGAATGACCC TTCCTATAAG 
GAGAATGCCA TGAGATTATC CAGAATCCAC CATGATCAGC CAGTGAAGCC CCTGGACCGA 
GCCGTCTTCT GGATCGAGTA TGTCATGCGT CACAAAGGAG CCAAGCACCT CCGCTCAACT 
CTGCATGACC TTAGCTGGTT CCAGTACCAC TCTCTGGATG TCATTGGGTT CCTATTGCTC 
TGTGTGGTAG GTGTGGTATT CATCATCACA AAATTCTGCC TCTTTTGTTG CCGTAAGACT 
GCTAACATGG GAAAGAAGAA GAAAGAGTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Simultaneous evaluation of six human glucuronidation activities in liver microsomes using liquid chromatography-tandem mass spectrometry.
Analytical biochemistry427(1)52-9(2012 Aug)
Gagez AL,Rouguieg-Malki K,Sauvage FL,Marquet P,Picard N

Role of UDP-glucuronosyltransferase isoforms in 13-cis retinoic acid metabolism in humans.
Drug metabolism and disposition: the biological fate of chemicals38(7)1211-7(2010 Jul)
Rowbotham SE,Illingworth NA,Daly AK,Veal GJ,Boddy AV

Effect of the acute phase response induced by endotoxin administration on the expression and activity of UGT isoforms in rats.
Drug metabolism letters2(4)248-55(2008 Dec)
Alkharfy KM,Poloyac SM,Congiu M,Desmond PV,Frye RF

Protein-protein interactions between rat hepatic cytochromes P450 (P450s) and UDP-glucuronosyltransferases (UGTs): evidence for the functionally active UGT in P450-UGT complex.
Drug metabolism and pharmacokinetics22(5)367-76(2007 Oct)
Ishii Y,Iwanaga M,Nishimura Y,Takeda S,Ikushiro S,Nagata K,Yamazoe Y,Mackenzie PI,Yamada H

UDP-glucuronosyltransferase isoforms catalyzing glucuronidation of hydroxy-polychlorinated biphenyls in rat.
Drug metabolism and disposition: the biological fate of chemicals33(10)1466-76(2005 Oct)
Daidoji T,Gozu K,Iwano H,Inoue H,Yokota H