Slc13a5 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Slc13a5
Entrez Gene ID	266998
Full Name	solute carrier family 13 member 5
Synonyms	Nact
General protein information	Preferred Names solute carrier family 13 member 5 Names solute carrier family 13 member 5 Na(+)/citrate cotransporter sodium-coupled citrate transporter sodium-dependent citrate transporter solute carrier family 13 (sodium-dependent citrate transporter), member 5
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 10 Map Location: 10q24
Summary	Na+ -coupled citrate transporter that mediates uphill cellular uptake of citrate coupled to an electrochemical Na+ gradient [RGD, Feb 2006].

mRNA and Protein(s)

mRNA	Protein	Name
NM_170668.1	NP_733768.1	solute carrier family 13 member 5
XM_006246602.3	XP_006246664.1	solute carrier family 13 member 5 isoform X1

Pathways from BioSystems

Homologies

Canis lupus familiaris (dog)	SLC13A5	XP_848573.1
Bos taurus (cattle)	SLC13A5	NP_001178375.1
Xenopus tropicalis (tropical clawed frog)	slc13a5	XP_002933559.1
Pan troglodytes (chimpanzee)	SLC13A5	XP_511987.3
Homo sapiens (human)	SLC13A5	NP_808218.1
Mus musculus (house mouse)	Slc13a5	NP_001004148.1
Danio rerio (zebrafish)	slc13a5a	NP_001136038.1
Rattus norvegicus (Norway rat)	Slc13a5	NP_733768.1
Gallus gallus (chicken)	SLC13A5	XP_004946862.1

Gene Ontology
Bibliography

Related articles in PubMed

Prevention of diet-induced hepatic steatosis and hepatic insulin resistance by second generation antisense oligonucleotides targeted to the longevity gene mIndy (Slc13a5).
Pesta DH, Perry RJ, Guebre-Egziabher F, Zhang D, Jurczak M, Fischer-Rosinsky A, Daniels MA, Willmes DM, Bhanot S, Bornstein SR, Knauf F, Samuel VT, Shulman GI, Birkenfeld AL
Aging7(12)1086-93(2015 Dec)

Recessive mutations in SLC13A5 result in a loss of citrate transport and cause neonatal epilepsy, developmental delay and teeth hypoplasia.
Hardies K, de Kovel CG, Weckhuysen S, Asselbergh B, Geuens T, Deconinck T, Azmi A, May P, Brilstra E, Becker F, Barisic N, Craiu D, Braun KP, Lal D, Thiele H, Schubert J, Weber Y, van 't Slot R, N?rnberg P, Balling R, Timmerman V, Lerche H, Maudsley S, Helbig I, Suls A, Koeleman BP, De Jonghe P,
Brain : a journal of neurology138(Pt 11)3238-50(2015 Nov)

Arylhydrocarbon receptor-dependent mIndy (Slc13a5) induction as possible contributor to benzo[a]pyrene-induced lipid accumulation in hepatocytes.
Neusch?fer-Rube F, Schraplau A, Schewe B, Lieske S, Kr?tzfeldt JM, Ringel S, Henkel J, Birkenfeld AL, P?schel GP
Toxicology3371-9(2015 Nov)

The mammalian INDY homolog is induced by CREB in a rat model of type 2 diabetes.
Neusch?fer-Rube F, Lieske S, Kuna M, Henkel J, Perry RJ, Erion DM, Pesta D, Willmes DM, Brachs S, von Loeffelholz C, Tolkachov A, Schupp M, Pathe-Neusch?fer-Rube A, Pfeiffer AF, Shulman GI, P?schel GP, Birkenfeld AL
Diabetes63(3)1048-57(2014 Mar)

Expression and functional features of NaCT, a sodium-coupled citrate transporter, in human and rat livers and cell lines.
Gopal E, Miyauchi S, Martin PM, Ananth S, Srinivas SR, Smith SB, Prasad PD, Ganapathy V
American journal of physiology. Gastrointestinal and liver physiology292(1)G402-8(2007 Jan)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

These data suggest that inducible liver-selective reduction of mIndy in rats is able to ameliorate hepatic steatosis and insulin resistance, conditions occurring with high calorie diets and during aging.
Title: Prevention of diet-induced hepatic steatosis and hepatic insulin resistance by second generation antisense oligonucleotides targeted to the longevity gene mIndy (Slc13a5).

This study thus identified the Slc13a5 as an AhR target gene
Title: Arylhydrocarbon receptor-dependent mIndy (Slc13a5) induction as possible contributor to benzo[a]pyrene-induced lipid accumulation in hepatocytes.

suggest that mIndy is a CREB-dependent glucagon target gene that is induced in fasting and in type 2 diabetes
Title: The mammalian INDY homolog is induced by CREB in a rat model of type 2 diabetes.

Expression and function of NaCT in a cell line and in primary hepatocytes from rat liver.
Title: Expression and functional features of NaCT, a sodium-coupled citrate transporter, in human and rat livers and cell lines.

NaCT is expressed in liver, testis and brain in rat and shows preference for citrate over dicarboxylates; it may play a role in cellular utilization of citrate in blood for the synthesis of fatty acids and cholesterol and for the generation of energy
Title: Structure, function, and expression pattern of a novel sodium-coupled citrate transporter (NaCT) cloned from mammalian brain.

The following Slc13a5 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Slc13a5 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa13098	NM_170668.1 Latest version!	Rattus norvegicus solute carrier family 13 member 5 (Slc13a5), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$307.30 $439.00
ORa33238	XM_006246602.3 Latest version!	Rattus norvegicus solute carrier family 13 member 5 (Slc13a5), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$307.30 $439.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Slc13a5 ( NM_170668.1 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_733768.1 Rattus norvegicus solute carrier family 13 member 5 (Slc13a5), mRNA.

Price & Availability↑

CloneID	ORa13098
Clone ID Related Accession (Same CDS sequence)	NM_170668.1
Accession Version	NM_170668.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1719bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-02-15
Organism	Rattus norvegicus(Norway rat)
Product	solute carrier family 13 member 5
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from AF522186.1. ##Evidence-Data-START## Transcript exon combination :: AF522186.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMD00052296, SAMD00052297 [ECO:0000348] ##Evidence-Data-END##

ATGGCTTCGG CGAAGACTTA TGTGACCAAG TTCAAGTCCT TCGTGATTTT GTTCTTCGCC 
CCGATCCTGC TGCTTCCACT CATCATTCTG GTACCTGACA AGTTTGCCAG GTGTGCCTAT 
GTTATAATCC TCATGGCCAT CTACTGGTGC ACAGATGTCA TCCCAGTGGC TATCACTTCC 
CTCCTGCCTG TCTTACTCTT CCCACTTTTG AAGGTTCTGG ACTCCAAGCA GGTATGTGTC 
CAATACATGA CGGACACCAA CATGCTGTTC CTGGGCAGTC TCATTGTGGC CACGGCTGTG 
GAACGTTGGG AACTTCATAA GAGGATTGCT CTGAGAATGC TACTCTTTGT GGGGACCAAG 
CCTTCACGGC TGATGCTGGG CTTCATGTTC GTCACAGCCT TCCTGTCCAT GTGGATCAGC 
AATACTGCCA CCACGGCCAT GATGATACCC ATTGTGGAGG CCATGCTGGA GCAAATGGTA 
GCCACAAATG TAGCGGTGGA TGCCAGCCAG AGGACAATGG AACTGTTGGA CAAGAACAAG 
GCCAGCGAAT TGCCAGGAAG CCAGGTGGTA TTTGAAGACC CCAGTGTGCA GAAGCAGGAG 
GATGAAGAAA CAAAGAATAT GTACAAGGCT ATGAACCTAT GTGTGTGCTA CGCAGCCAGC 
ATCGGGGGTA CAGCCACCTT GACCGGGACG GGACCCAACG TGGTGCTCCT GGGCCAGATG 
CAGGAATTGT TTCCTGACAG TAAAGACGTC ATGAACTTTG CATCTTGGTT TGCATTTGCC 
CTCCCAAACA TGCTTTTGAT GCTGGTGATG GCCTGGCTGT GGCTCCTGTG TTTTTACATG 
AGACCCAATT TAAAAAAAAC TTGCATCTGC TGTGGGAGGA AGAAGAAGGA CACGGAGAAG 
ATTGCCTCCA AGGTGCTGTA TGAGGAGTAC AGGAAGCTGG GGCCCTTGAG CTACGCTGAA 
TGCAACGTGC TCTTTTGCTT CGGCCTGCTC ATCATCCTGT GGTTCTCCCG AGACCCCGGC 
TTCATGCCTG GCTGGCTGTC CATCGCCTGG ATCGAGGGAA ATACCAAGCA TGTCACGGAC 
GCCACAGTGG CCATCTTTGT GGCCATTTTG CTTTTCATCG TACCCTCACA AAAGCCCAAG 
TTCAATTTCA GCCGCCAGAC TGAGGAAGAA AGGAAAACTC CCTTCTACCC CCCGCCACTG 
CTGAATTGGA AAGTCACCCA AGAGAAAGTG CCCTGGGGCA TTGTGCTGCT CCTGGGGGGA 
GGATTTGCTA TGGCCAAAGG ATGTGAGACT TCAGGGCTCT CTGAGTGGAT GGCGAGACAG 
ATGGAGCCCT TGAGCTCAGT GAGACCTGCT ATTATTACCT TGATCTTGTC CTGTATTGTT 
GCAATGACCA CAGAGTGCAC GAGTAACGTG GCCACTACTA CCCTGTTCCT GCCTATCTTT 
GCCTCCATGG CTCGTTCCAT CGGCATCCAT CCACTGTATG TCATGATTCC CTGCACCTTG 
AGTGCGTCAC TTGCCTTCAT GTTGCCTGTG GCCACCCCAC CTAACGCCAT CGTGTTTGCC 
TACGGACACC TCAAAGTTAT TGACATGGTA AAAACAGGAT TGGTAATGAA CATCCTTGGA 
ATTGCATCTG TGTTTCTGTC AGTCAACACC TGGGGACGGG CTGTGTTTAA CTTGGATAAA 
TTCCCTGACT GGGCAAATTT GACACATATT AACACTTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_733768.1
CDS	24..1742
Translation	MASAKTYVTKFKSFVILFFAPILLLPLIILVPDKFARCAYVIILMAIYWCTDVIPVAITSLLPVLLFPLLKVLDSKQVCVQYMTDTNMLFLGSLIVATAVERWELHKRIALRMLLFVGTKPSRLMLGFMFVTAFLSMWISNTATTAMMIPIVEAMLEQMVATNVAVDASQRTMELLDKNKASELPGSQVVFEDPSVQKQEDEETKNMYKAMNLCVCYAASIGGTATLTGTGPNVVLLGQMQELFPDSKDVMNFASWFAFALPNMLLMLVMAWLWLLCFYMRPNLKKTCICCGRKKKDTEKIASKVLYEEYRKLGPLSYAECNVLFCFGLLIILWFSRDPGFMPGWLSIAWIEGNTKHVTDATVAIFVAILLFIVPSQKPKFNFSRQTEEERKTPFYPPPLLNWKVTQEKVPWGIVLLLGGGFAMAKGCETSGLSEWMARQMEPLSSVRPAIITLILSCIVAMTTECTSNVATTTLFLPIFASMARSIGIHPLYVMIPCTLSASLAFMLPVATPPNAIVFAYGHLKVIDMVKTGLVMNILGIASVFLSVNTWGRAVFNLDKFPDWANLTHINT

Target ORF information:

RefSeq Version	NM_170668.1
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus solute carrier family 13 member 5 (Slc13a5), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_170668.1

ORF Insert Sequence:

ATGGCTTCGG CGAAGACTTA TGTGACCAAG TTCAAGTCCT TCGTGATTTT GTTCTTCGCC 
CCGATCCTGC TGCTTCCACT CATCATTCTG GTACCTGACA AGTTTGCCAG GTGTGCCTAT 
GTTATAATCC TCATGGCCAT CTACTGGTGC ACAGATGTCA TCCCAGTGGC TATCACTTCC 
CTCCTGCCTG TCTTACTCTT CCCACTTTTG AAGGTTCTGG ACTCCAAGCA GGTATGTGTC 
CAATACATGA CGGACACCAA CATGCTGTTC CTGGGCAGTC TCATTGTGGC CACGGCTGTG 
GAACGTTGGG AACTTCATAA GAGGATTGCT CTGAGAATGC TACTCTTTGT GGGGACCAAG 
CCTTCACGGC TGATGCTGGG CTTCATGTTC GTCACAGCCT TCCTGTCCAT GTGGATCAGC 
AATACTGCCA CCACGGCCAT GATGATACCC ATTGTGGAGG CCATGCTGGA GCAAATGGTA 
GCCACAAATG TAGCGGTGGA TGCCAGCCAG AGGACAATGG AACTGTTGGA CAAGAACAAG 
GCCAGCGAAT TGCCAGGAAG CCAGGTGGTA TTTGAAGACC CCAGTGTGCA GAAGCAGGAG 
GATGAAGAAA CAAAGAATAT GTACAAGGCT ATGAACCTAT GTGTGTGCTA CGCAGCCAGC 
ATCGGGGGTA CAGCCACCTT GACCGGGACG GGACCCAACG TGGTGCTCCT GGGCCAGATG 
CAGGAATTGT TTCCTGACAG TAAAGACGTC ATGAACTTTG CATCTTGGTT TGCATTTGCC 
CTCCCAAACA TGCTTTTGAT GCTGGTGATG GCCTGGCTGT GGCTCCTGTG TTTTTACATG 
AGACCCAATT TAAAAAAAAC TTGCATCTGC TGTGGGAGGA AGAAGAAGGA CACGGAGAAG 
ATTGCCTCCA AGGTGCTGTA TGAGGAGTAC AGGAAGCTGG GGCCCTTGAG CTACGCTGAA 
TGCAACGTGC TCTTTTGCTT CGGCCTGCTC ATCATCCTGT GGTTCTCCCG AGACCCCGGC 
TTCATGCCTG GCTGGCTGTC CATCGCCTGG ATCGAGGGAA ATACCAAGCA TGTCACGGAC 
GCCACAGTGG CCATCTTTGT GGCCATTTTG CTTTTCATCG TACCCTCACA AAAGCCCAAG 
TTCAATTTCA GCCGCCAGAC TGAGGAAGAA AGGAAAACTC CCTTCTACCC CCCGCCACTG 
CTGAATTGGA AAGTCACCCA AGAGAAAGTG CCCTGGGGCA TTGTGCTGCT CCTGGGGGGA 
GGATTTGCTA TGGCCAAAGG ATGTGAGACT TCAGGGCTCT CTGAGTGGAT GGCGAGACAG 
ATGGAGCCCT TGAGCTCAGT GAGACCTGCT ATTATTACCT TGATCTTGTC CTGTATTGTT 
GCAATGACCA CAGAGTGCAC GAGTAACGTG GCCACTACTA CCCTGTTCCT GCCTATCTTT 
GCCTCCATGG CTCGTTCCAT CGGCATCCAT CCACTGTATG TCATGATTCC CTGCACCTTG 
AGTGCGTCAC TTGCCTTCAT GTTGCCTGTG GCCACCCCAC CTAACGCCAT CGTGTTTGCC 
TACGGACACC TCAAAGTTAT TGACATGGTA AAAACAGGAT TGGTAATGAA CATCCTTGGA 
ATTGCATCTG TGTTTCTGTC AGTCAACACC TGGGGACGGG CTGTGTTTAA CTTGGATAAA 
TTCCCTGACT GGGCAAATTT GACACATATT AACACTTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Slc13a5 ( XM_006246602.3 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> XP_006246664.1 Rattus norvegicus solute carrier family 13 member 5 (Slc13a5), transcript variant X1, mRNA.

Price & Availability↑

CloneID	ORa33238
Clone ID Related Accession (Same CDS sequence)	XM_006246602.3
Accession Version	XM_006246602.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1833bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2016-07-25
Organism	Rattus norvegicus(Norway rat)
Product	solute carrier family 13 member 5 isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_005109.4) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Jul 26, 2016 this sequence version replaced XM_006246602.2. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Rattus norvegicus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGAGAAGGC GAGCGCTTTG GGGAGAGAAG CCTGAGAAAC CTACAGGCTG GTGGAGTTTT 
TCATCTGGGA CACTCCGGAG CCCAGGAGAG AGCAGTCTGT CTCCCTTTCA CGCGATGGCT 
TCGGCGAAGA CTTATGTGAC CAAGTTCAAG TCCTTCGTGA TTTTGTTCTT CGCCCCGATC 
CTGCTGCTTC CACTCATCAT TCTGGTACCT GACAAGTTTG CCAGGTGTGC CTATGTTATA 
ATCCTCATGG CCATCTACTG GTGCACAGAT GTCATCCCAG TGGCTATCAC CTCCCTCCTG 
CCTGTCTTAC TCTTCCCACT TTTGAAGGTT CTGGACTCCA AGCAGGTATG TGTCCAATAC 
ATGACGGACA CCAACATGCT GTTCCTGGGC AGTCTCATTG TGGCCACGGC TGTGGAACGT 
TGGGAACTTC ATAAGAGGAT TGCTCTGAGA ATGCTACTCT TTGTGGGGAC CAAGCCTTCA 
CGGCTGATGC TGGGCTTCAT GTTCGTCACA GCCTTCCTGT CCATGTGGAT CAGCAATACT 
GCCACCACGG CCATGATGAT ACCCATTGTG GAGGCCATGC TGGAGCAAAT GGTAGCCACA 
AATGTAGCGG TGGATGCCAG CCAGAGGACA ATGGAACTGT TGGACAAGAA CAAGGCCAGC 
GAATTGCCAG GAAGCCAGGT GGTATTTGAA GACCCCAGTG TGCAGAAGCA GGAGGATGAA 
GAAACAAAGA ATATGTACAA GGCTATGAAC CTATGTGTGT GCTACGCAGC CAGCATCGGG 
GGTACAGCCA CCTTGACCGG GACGGGACCC AACGTGGTGC TCCTGGGCCA GATGCAGGAA 
TTGTTTCCTG ACAGTAAAGA CGTCATGAAC TTTGCATCTT GGTTTGCATT TGCCCTCCCA 
AACATGCTTT TGATGCTGGT GATGGCCTGG CTGTGGCTCC TGTGTTTTTA CATGAGACCC 
AATTTAAAAA AAACTTGCAT CTGCTGTGGG AGGAAGAAGA AGGACACGGA GAAGATTGCC 
TCCAAGGTGC TGTATGAGGA GTACAGGAAG CTGGGGCCCT TGAGCTATGC TGAATGCAAC 
GTGCTCTTTT GCTTCGGCCT GCTCATCATC CTGTGGTTCT CCCGAGACCC CGGCTTCATG 
CCTGGCTGGC TGTCCATCGC CTGGATCGAG GGAAATACCA AGCATGTCAC GGACGCCACA 
GTGGCCATCT TTGTGGCCAT TTTGCTTTTC ATCGTACCCT CACAAAAGCC CAAGTTCAAT 
TTCAGCCGCC AGACTGAGGA AGAAAGGAAA ACTCCCTTCT ACCCCCCGCC ACTGCTGAAT 
TGGAAAGTCA CCCAAGAGAA AGTGCCCTGG GGCATTGTGC TGCTCCTGGG GGGAGGATTT 
GCTATGGCCA AAGGATGTGA GACTTCAGGG CTCTCTGAGT GGATGGCGAG ACAGATGGAG 
CCCTTGAGCT CAGTGAGACC TGCTATTATT ACCTTGATCT TGTCCTGTAT TGTTGCAATG 
ACCACAGAGT GCACGAGTAA CGTGGCCACT ACTACCCTGT TCCTGCCTAT CTTTGCCTCC 
ATGGCTCGTT CCATCGGCAT CCATCCACTG TATGTCATGA TTCCCTGCAC CTTGAGTGCG 
TCACTTGCCT TCATGTTGCC TGTGGCCACC CCACCTAACG CCATCGTGTT TGCCTACGGA 
CACCTCAAAG TTATTGACAT GGTAAAAACA GGATTGGTAA TGAACATCCT TGGAATTGCA 
TCTGTGTTTC TGTCAGTCAA CACCTGGGGA CGGGCTGTGT TTAACTTGGA TAAATTCCCT 
GACTGGGCAA ATTTGACACA TATTAACACT TAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_006246664.1
CDS	1210..3042
Translation	MRRRALWGEKPEKPTGWWSFSSGTLRSPGESSLSPFHAMASAKTYVTKFKSFVILFFAPILLLPLIILVPDKFARCAYVIILMAIYWCTDVIPVAITSLLPVLLFPLLKVLDSKQVCVQYMTDTNMLFLGSLIVATAVERWELHKRIALRMLLFVGTKPSRLMLGFMFVTAFLSMWISNTATTAMMIPIVEAMLEQMVATNVAVDASQRTMELLDKNKASELPGSQVVFEDPSVQKQEDEETKNMYKAMNLCVCYAASIGGTATLTGTGPNVVLLGQMQELFPDSKDVMNFASWFAFALPNMLLMLVMAWLWLLCFYMRPNLKKTCICCGRKKKDTEKIASKVLYEEYRKLGPLSYAECNVLFCFGLLIILWFSRDPGFMPGWLSIAWIEGNTKHVTDATVAIFVAILLFIVPSQKPKFNFSRQTEEERKTPFYPPPLLNWKVTQEKVPWGIVLLLGGGFAMAKGCETSGLSEWMARQMEPLSSVRPAIITLILSCIVAMTTECTSNVATTTLFLPIFASMARSIGIHPLYVMIPCTLSASLAFMLPVATPPNAIVFAYGHLKVIDMVKTGLVMNILGIASVFLSVNTWGRAVFNLDKFPDWANLTHINT

Target ORF information:

RefSeq Version	XM_006246602.3
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus solute carrier family 13 member 5 (Slc13a5), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_006246602.3

ORF Insert Sequence:

ATGAGAAGGC GAGCGCTTTG GGGAGAGAAG CCTGAGAAAC CTACAGGCTG GTGGAGTTTT 
TCATCTGGGA CACTCCGGAG CCCAGGAGAG AGCAGTCTGT CTCCCTTTCA CGCGATGGCT 
TCGGCGAAGA CTTATGTGAC CAAGTTCAAG TCCTTCGTGA TTTTGTTCTT CGCCCCGATC 
CTGCTGCTTC CACTCATCAT TCTGGTACCT GACAAGTTTG CCAGGTGTGC CTATGTTATA 
ATCCTCATGG CCATCTACTG GTGCACAGAT GTCATCCCAG TGGCTATCAC CTCCCTCCTG 
CCTGTCTTAC TCTTCCCACT TTTGAAGGTT CTGGACTCCA AGCAGGTATG TGTCCAATAC 
ATGACGGACA CCAACATGCT GTTCCTGGGC AGTCTCATTG TGGCCACGGC TGTGGAACGT 
TGGGAACTTC ATAAGAGGAT TGCTCTGAGA ATGCTACTCT TTGTGGGGAC CAAGCCTTCA 
CGGCTGATGC TGGGCTTCAT GTTCGTCACA GCCTTCCTGT CCATGTGGAT CAGCAATACT 
GCCACCACGG CCATGATGAT ACCCATTGTG GAGGCCATGC TGGAGCAAAT GGTAGCCACA 
AATGTAGCGG TGGATGCCAG CCAGAGGACA ATGGAACTGT TGGACAAGAA CAAGGCCAGC 
GAATTGCCAG GAAGCCAGGT GGTATTTGAA GACCCCAGTG TGCAGAAGCA GGAGGATGAA 
GAAACAAAGA ATATGTACAA GGCTATGAAC CTATGTGTGT GCTACGCAGC CAGCATCGGG 
GGTACAGCCA CCTTGACCGG GACGGGACCC AACGTGGTGC TCCTGGGCCA GATGCAGGAA 
TTGTTTCCTG ACAGTAAAGA CGTCATGAAC TTTGCATCTT GGTTTGCATT TGCCCTCCCA 
AACATGCTTT TGATGCTGGT GATGGCCTGG CTGTGGCTCC TGTGTTTTTA CATGAGACCC 
AATTTAAAAA AAACTTGCAT CTGCTGTGGG AGGAAGAAGA AGGACACGGA GAAGATTGCC 
TCCAAGGTGC TGTATGAGGA GTACAGGAAG CTGGGGCCCT TGAGCTATGC TGAATGCAAC 
GTGCTCTTTT GCTTCGGCCT GCTCATCATC CTGTGGTTCT CCCGAGACCC CGGCTTCATG 
CCTGGCTGGC TGTCCATCGC CTGGATCGAG GGAAATACCA AGCATGTCAC GGACGCCACA 
GTGGCCATCT TTGTGGCCAT TTTGCTTTTC ATCGTACCCT CACAAAAGCC CAAGTTCAAT 
TTCAGCCGCC AGACTGAGGA AGAAAGGAAA ACTCCCTTCT ACCCCCCGCC ACTGCTGAAT 
TGGAAAGTCA CCCAAGAGAA AGTGCCCTGG GGCATTGTGC TGCTCCTGGG GGGAGGATTT 
GCTATGGCCA AAGGATGTGA GACTTCAGGG CTCTCTGAGT GGATGGCGAG ACAGATGGAG 
CCCTTGAGCT CAGTGAGACC TGCTATTATT ACCTTGATCT TGTCCTGTAT TGTTGCAATG 
ACCACAGAGT GCACGAGTAA CGTGGCCACT ACTACCCTGT TCCTGCCTAT CTTTGCCTCC 
ATGGCTCGTT CCATCGGCAT CCATCCACTG TATGTCATGA TTCCCTGCAC CTTGAGTGCG 
TCACTTGCCT TCATGTTGCC TGTGGCCACC CCACCTAACG CCATCGTGTT TGCCTACGGA 
CACCTCAAAG TTATTGACAT GGTAAAAACA GGATTGGTAA TGAACATCCT TGGAATTGCA 
TCTGTGTTTC TGTCAGTCAA CACCTGGGGA CGGGCTGTGT TTAACTTGGA TAAATTCCCT 
GACTGGGCAA ATTTGACACA TATTAACACT TAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Prevention of diet-induced hepatic steatosis and hepatic insulin resistance by second generation antisense oligonucleotides targeted to the longevity gene mIndy (Slc13a5).
Aging7(12)1086-93(2015 Dec)
Pesta DH,Perry RJ,Guebre-Egziabher F,Zhang D,Jurczak M,Fischer-Rosinsky A,Daniels MA,Willmes DM,Bhanot S,Bornstein SR,Knauf F,Samuel VT,Shulman GI,Birkenfeld AL

Recessive mutations in SLC13A5 result in a loss of citrate transport and cause neonatal epilepsy, developmental delay and teeth hypoplasia.
Brain : a journal of neurology138(Pt 11)3238-50(2015 Nov)
Hardies K,de Kovel CG,Weckhuysen S,Asselbergh B,Geuens T,Deconinck T,Azmi A,May P,Brilstra E,Becker F,Barisic N,Craiu D,Braun KP,Lal D,Thiele H,Schubert J,Weber Y,van 't Slot R,N?rnberg P,Balling R,Timmerman V,Lerche H,Maudsley S,Helbig I,Suls A,Koeleman BP,De Jonghe P,

Arylhydrocarbon receptor-dependent mIndy (Slc13a5) induction as possible contributor to benzo[a]pyrene-induced lipid accumulation in hepatocytes.
Toxicology3371-9(2015 Nov)
Neusch?fer-Rube F,Schraplau A,Schewe B,Lieske S,Kr?tzfeldt JM,Ringel S,Henkel J,Birkenfeld AL,P?schel GP

The mammalian INDY homolog is induced by CREB in a rat model of type 2 diabetes.
Diabetes63(3)1048-57(2014 Mar)
Neusch?fer-Rube F,Lieske S,Kuna M,Henkel J,Perry RJ,Erion DM,Pesta D,Willmes DM,Brachs S,von Loeffelholz C,Tolkachov A,Schupp M,Pathe-Neusch?fer-Rube A,Pfeiffer AF,Shulman GI,P?schel GP,Birkenfeld AL

Expression and functional features of NaCT, a sodium-coupled citrate transporter, in human and rat livers and cell lines.
American journal of physiology. Gastrointestinal and liver physiology292(1)G402-8(2007 Jan)
Gopal E,Miyauchi S,Martin PM,Ananth S,Srinivas SR,Smith SB,Prasad PD,Ganapathy V

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Slc13a5 cDNA ORF clone, Rattus norvegicus(Norway rat)

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