Ttr cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Ttr
Entrez Gene ID	24856
Full Name	transthyretin
Synonyms	Lr1,TT,Tbpa
General protein information	Preferred Names transthyretin Names transthyretin prealbumin, amyloidosis type I
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 18 Map Location: 18p12
Summary	binds thyroxine (T4) and 3,5,3' triiodothyronine (T3); plays a role in thyroid hormone transport in serum [RGD, Feb 2006].

mRNA and Protein(s)

mRNA	Protein	Name
XM_006254457.1	XP_006254519.1	transthyretin isoform X1
NM_012681.2	NP_036813.2	transthyretin precursor

Pathways from BioSystems

Homologies

Canis lupus familiaris (dog)	TTR	XP_537290.1
Bos taurus (cattle)	TTR	NP_776392.1
Danio rerio (zebrafish)	ttr	NP_001005598.2
Homo sapiens (human)	TTR	NP_000362.1
Pan troglodytes (chimpanzee)	TTR	NP_001009137.1
	TTR	XP_001099005.1
Gallus gallus (chicken)	TTR	NP_990666.1
Xenopus tropicalis (tropical clawed frog)	ttr	NP_001096539.1
Mus musculus (house mouse)	Ttr	NP_038725.1
Rattus norvegicus (Norway rat)	Ttr	NP_036813.2

Gene Ontology
Bibliography

Related articles in PubMed

Novel mutations in transthyretin gene associated with hepatocellular carcinoma.
P Katare D, Malik S, J Mani R, Ranjpour M, Jain SK
Molecular carcinogenesis57(1)70-77(2018 Jan)

Effect of simulated air dive and decompression sickness on the plasma proteome of rats.
Lautridou J, Pichereau V, Artigaud S, Buzzacott P, Wang Q, Bernay B, Driad S, Mazur A, Lambrechts K, Th?ron M, Guerrero F
Proteomics. Clinical applications10(5)614-20(2016 05)

The role of salt bridges, charge density, and subunit flexibility in determining disassembly routes of protein complexes.
Hall Z, Hern?ndez H, Marsh JA, Teichmann SA, Robinson CV
Structure (London, England : 1993)21(8)1325-37(2013 Aug)

Structural evidence for native state stabilization of a conformationally labile amyloidogenic transthyretin variant by fibrillogenesis inhibitors.
Zanotti G, Cendron L, Folli C, Florio P, Imbimbo BP, Berni R
FEBS letters587(15)2325-31(2013 Aug)

Stress and glucocorticoids increase transthyretin expression in rat choroid plexus via mineralocorticoid and glucocorticoid receptors.
Martinho A, Gon?alves I, Costa M, Santos CR
Journal of molecular neuroscience : MN48(1)1-13(2012 Sep)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Data suggest that the mutated transthyretin (TTR) seems to have potential as biomarker for early detection of hepatocellular carcinoma (HCC).
Title: Novel mutations in transthyretin gene associated with hepatocellular carcinoma.

Serum transthyretin level dramatically decreased in animals displaying decompression sickness symptoms.
Title: Effect of simulated air dive and decompression sickness on the plasma proteome of rats.

We conclude that stress upregulates TTR expression in choroid plexus.
Title: Stress and glucocorticoids increase transthyretin expression in rat choroid plexus via mineralocorticoid and glucocorticoid receptors.

Decreased trophoblast expression of retinol transport proteins suggest that nitrofen may interfere with the fetal retinol transport resulting in reduced pulmonary RBP and TTR levels and causing pulmonary hypoplasia in CDH.
Title: Nitrofen interferes with trophoblastic expression of retinol-binding protein and transthyretin during lung morphogenesis in the nitrofen-induced congenital diaphragmatic hernia model.

Data demonstrate that, in vitro and in vivo, transthyretin is up-regulated by progesterone, and suggest that this response is mediated through a progesterone receptor-mediated mechanism.
Title: Progesterone enhances transthyretin expression in the rat choroid plexus in vitro and in vivo via progesterone receptor.

The following Ttr gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Ttr cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa00602	NM_012681.2 Latest version!	Rattus norvegicus transthyretin (Ttr), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$69.30 $99.00
ORa00602	XM_006254457.1 Latest version!	Rattus norvegicus transthyretin (Ttr), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$69.30 $99.00

ORF Online Only Promotion

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Ttr ( NM_012681.2 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_036813.2 Rattus norvegicus transthyretin (Ttr), mRNA.

Price & Availability↑

CloneID	ORa00602
Clone ID Related Accession (Same CDS sequence)	XM_006254457.1 , NM_012681.2
Accession Version	NM_012681.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 444bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-09-20
Organism	Rattus norvegicus(Norway rat)
Product	transthyretin precursor
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AABR07031489.1 and BC086946.1. On May 14, 2011 this sequence version replaced NM_012681.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: FQ209724.1, AF479660.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMD00052296, SAMD00052297 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGCTTCCC TTCGCCTGTT CCTCCTCTGC CTCGCTGGAC TGATATTTGC GTCTGAAGCT 
GGCCCTGGGG GTGCTGGAGA ATCCAAGTGT CCTCTGATGG TCAAAGTCCT GGATGCTGTC 
CGAGGCAGCC CTGCTGTCGA TGTGGCCGTG AAAGTGTTCA AAAAGACTGC AGACGGAAGC 
TGGGAGCCGT TTGCCTCTGG GAAGACCGCC GAGTCTGGAG AGCTGCACGG GCTCACCACA 
GATGAGAAGT TCACGGAAGG GGTGTACAGG GTAGAACTGG ACACCAAATC GTACTGGAAG 
GCTCTTGGCA TTTCCCCATT CCATGAATAC GCAGAGGTGG TTTTCACAGC CAATGACTCT 
GGTCATCGCC ACTACACCAT CGCAGCCCTG CTCAGCCCGT ACTCCTACAG CACCACTGCT 
GTCGTCAGTA ACCCCCAGAA CTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_036813.2
CDS	112..555
Translation	MASLRLFLLCLAGLIFASEAGPGGAGESKCPLMVKVLDAVRGSPAVDVAVKVFKKTADGSWEPFASGKTAESGELHGLTTDEKFTEGVYRVELDTKSYWKALGISPFHEYAEVVFTANDSGHRHYTIAALLSPYSYSTTAVVSNPQN

Target ORF information:

RefSeq Version	NM_012681.2
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus transthyretin (Ttr), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_012681.2

ORF Insert Sequence:

ATGGCTTCCC TTCGCCTGTT CCTCCTCTGC CTCGCTGGAC TGATATTTGC GTCTGAAGCT 
GGCCCTGGGG GTGCTGGAGA ATCCAAGTGT CCTCTGATGG TCAAAGTCCT GGATGCTGTC 
CGAGGCAGCC CTGCTGTCGA TGTGGCCGTG AAAGTGTTCA AAAAGACTGC AGACGGAAGC 
TGGGAGCCGT TTGCCTCTGG GAAGACCGCC GAGTCTGGAG AGCTGCACGG GCTCACCACA 
GATGAGAAGT TCACGGAAGG GGTGTACAGG GTAGAACTGG ACACCAAATC GTACTGGAAG 
GCTCTTGGCA TTTCCCCATT CCATGAATAC GCAGAGGTGG TTTTCACAGC CAATGACTCT 
GGTCATCGCC ACTACACCAT CGCAGCCCTG CTCAGCCCGT ACTCCTACAG CACCACTGCT 
GTCGTCAGTA ACCCCCAGAA CTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Ttr ( XM_006254457.1 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> XP_006254519.1 Rattus norvegicus transthyretin (Ttr), transcript variant X1, mRNA.

Price & Availability↑

CloneID	ORa00602
Clone ID Related Accession (Same CDS sequence)	XM_006254457.1 , NM_012681.2
Accession Version	XM_006254457.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 444bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2016-07-25
Organism	Rattus norvegicus(Norway rat)
Product	transthyretin isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_005117.4) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Rattus norvegicus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGGCTTCCC TTCGCCTGTT CCTCCTCTGC CTCGCTGGAC TGATATTTGC GTCTGAAGCT 
GGCCCTGGGG GTGCTGGAGA ATCCAAGTGT CCTCTGATGG TCAAAGTCCT GGATGCTGTC 
CGAGGCAGCC CTGCTGTCGA TGTGGCCGTG AAAGTGTTCA AAAAGACTGC AGACGGAAGC 
TGGGAGCCGT TTGCCTCTGG GAAGACCGCC GAGTCTGGAG AGCTGCACGG GCTCACCACA 
GATGAGAAGT TCACGGAAGG GGTGTACAGG GTAGAACTGG ACACCAAATC GTACTGGAAG 
GCTCTTGGCA TTTCCCCATT CCATGAATAC GCAGAGGTGG TTTTCACAGC CAATGACTCT 
GGTCATCGCC ACTACACCAT CGCAGCCCTG CTCAGCCCGT ACTCCTACAG CACCACTGCT 
GTCGTCAGTA ACCCCCAGAA CTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_006254519.1
CDS	169..612
Translation	MASLRLFLLCLAGLIFASEAGPGGAGESKCPLMVKVLDAVRGSPAVDVAVKVFKKTADGSWEPFASGKTAESGELHGLTTDEKFTEGVYRVELDTKSYWKALGISPFHEYAEVVFTANDSGHRHYTIAALLSPYSYSTTAVVSNPQN

Target ORF information:

RefSeq Version	XM_006254457.1
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus transthyretin (Ttr), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_006254457.1

ORF Insert Sequence:

ATGGCTTCCC TTCGCCTGTT CCTCCTCTGC CTCGCTGGAC TGATATTTGC GTCTGAAGCT 
GGCCCTGGGG GTGCTGGAGA ATCCAAGTGT CCTCTGATGG TCAAAGTCCT GGATGCTGTC 
CGAGGCAGCC CTGCTGTCGA TGTGGCCGTG AAAGTGTTCA AAAAGACTGC AGACGGAAGC 
TGGGAGCCGT TTGCCTCTGG GAAGACCGCC GAGTCTGGAG AGCTGCACGG GCTCACCACA 
GATGAGAAGT TCACGGAAGG GGTGTACAGG GTAGAACTGG ACACCAAATC GTACTGGAAG 
GCTCTTGGCA TTTCCCCATT CCATGAATAC GCAGAGGTGG TTTTCACAGC CAATGACTCT 
GGTCATCGCC ACTACACCAT CGCAGCCCTG CTCAGCCCGT ACTCCTACAG CACCACTGCT 
GTCGTCAGTA ACCCCCAGAA CTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Novel mutations in transthyretin gene associated with hepatocellular carcinoma.
Molecular carcinogenesis57(1)70-77(2018 Jan)
P Katare D,Malik S,J Mani R,Ranjpour M,Jain SK

Effect of simulated air dive and decompression sickness on the plasma proteome of rats.
Proteomics. Clinical applications10(5)614-20(2016 05)
Lautridou J,Pichereau V,Artigaud S,Buzzacott P,Wang Q,Bernay B,Driad S,Mazur A,Lambrechts K,Th?ron M,Guerrero F

The role of salt bridges, charge density, and subunit flexibility in determining disassembly routes of protein complexes.
Structure (London, England : 1993)21(8)1325-37(2013 Aug)
Hall Z,Hern?ndez H,Marsh JA,Teichmann SA,Robinson CV

Structural evidence for native state stabilization of a conformationally labile amyloidogenic transthyretin variant by fibrillogenesis inhibitors.
FEBS letters587(15)2325-31(2013 Aug)
Zanotti G,Cendron L,Folli C,Florio P,Imbimbo BP,Berni R

Stress and glucocorticoids increase transthyretin expression in rat choroid plexus via mineralocorticoid and glucocorticoid receptors.
Journal of molecular neuroscience : MN48(1)1-13(2012 Sep)
Martinho A,Gon?alves I,Costa M,Santos CR