Ccl17 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Ccl17
Entrez Gene ID	117518
Full Name	C-C motif chemokine ligand 17
Synonyms	Scya17,Tarc
General protein information	Preferred Names C-C motif chemokine ligand 17 Names C-C motif chemokine 17 chemokine (C-C motif) ligand 17 small inducible cytokine subfamily A (Cys-Cys), member 17
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 19 Map Location: 19p13
Summary	a thymus and activation-regulated chemokine [RGD, Feb 2006].

mRNA and Protein(s)

mRNA	Protein	Name
NM_057151.1	NP_476492.1	C-C motif chemokine 17 precursor

Pathways from BioSystems

Homologies

Rattus norvegicus (Norway rat)	Ccl17	NP_476492.1
Pan troglodytes (chimpanzee)	CCL17	XP_523377.2
Bos taurus (cattle)	CCL17	XP_002694838.1
Mus musculus (house mouse)	Ccl17	NP_035462.2
Homo sapiens (human)	CCL17	NP_002978.1
Canis lupus familiaris (dog)	CCL17	NP_001003051.1
	CCL17	NP_001028024.1

Gene Ontology
Bibliography

Related articles in PubMed

RNAi screen reveals potentially novel roles of cytokines in myoblast differentiation.
Ge Y, Waldemer RJ, Nalluri R, Nuzzi PD, Chen J
PloS one8(7)e68068(2013)

Chemokine receptor 4 plays a key role in T cell recruitment into the airways of asthmatic patients.
Vijayanand P, Durkin K, Hartmann G, Morjaria J, Seumois G, Staples KJ, Hall D, Bessant C, Bartholomew M, Howarth PH, Friedmann PS, Djukanovic R
Journal of immunology (Baltimore, Md. : 1950)184(8)4568-74(2010 Apr)

ANG II receptor blockade enhances anti-inflammatory macrophages in anti-glomerular basement membrane glomerulonephritis.
Aki K, Shimizu A, Masuda Y, Kuwahara N, Arai T, Ishikawa A, Fujita E, Mii A, Natori Y, Fukunaga Y, Fukuda Y
American journal of physiology. Renal physiology298(4)F870-82(2010 Apr)

GGTI-2133, an inhibitor of geranylgeranyltransferase, inhibits infiltration of inflammatory cells into airways in mouse experimental asthma.
Chiba Y, Sato S, Misawa M
International journal of immunopathology and pharmacology22(4)929-35(2009 Oct-Dec)

Macrophage derived chemokine (CCL22), thymus and activation-regulated chemokine (CCL17), and CCR4 in idiopathic pulmonary fibrosis.
Yogo Y, Fujishima S, Inoue T, Saito F, Shiomi T, Yamaguchi K, Ishizaka A
Respiratory research1080(2009 Aug)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Our data indicate that instead of Th2 cells, airway epithelial cells expressing CCR4 might be the principal targets for MDC and TARC released from alveolar macrophages during cigarette smoke-induced airway inflammation.
Title: Elevated expression of TARC (CCL17) and MDC (CCL22) in models of cigarette smoke-induced pulmonary inflammation.

The following Ccl17 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Ccl17 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa11492	NM_057151.1 Latest version!	Rattus norvegicus C-C motif chemokine ligand 17 (Ccl17), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$69.30 $99.00

ORF Online Only Promotion

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Ccl17 ( NM_057151.1 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_476492.1 Rattus norvegicus C-C motif chemokine ligand 17 (Ccl17), mRNA.

Price & Availability↑

CloneID	ORa11492
Clone ID Related Accession (Same CDS sequence)	NM_057151.1
Accession Version	NM_057151.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 282bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-10-09
Organism	Rattus norvegicus(Norway rat)
Product	C-C motif chemokine 17 precursor
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from AF312687.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AF312687.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMD00052296, SAMEA2689599 [ECO:0000348] ##Evidence-Data-END##

ATGATGTCAC TTCAGATGCT GCTCCTGGCT GCCCTGCTTC TGGGGACTTC TCTGCAGCAT 
GCCAGCGCTG CTCGAGCCAC CAATGTAGGC CGAGAGTGCT GCCTGGACTA CTTCAAGGGG 
GCCATTCCCA TCAGGAAGCT GGTGACGTGG TTCAGGACCT CAGTGGAGTG TCCCAAGGAT 
GCCATCGTGT TTGAGACTGT CCAGGGAAGG CTTATCTGCA CAGACCCCAA AGACAAGCAT 
GTGAAGAAGG CCATCAGACA CCTGAAAAAC CAAAGGCTGT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_476492.1
CDS	1..282
Translation	MMSLQMLLLAALLLGTSLQHASAARATNVGRECCLDYFKGAIPIRKLVTWFRTSVECPKDAIVFETVQGRLICTDPKDKHVKKAIRHLKNQRL

Target ORF information:

RefSeq Version	NM_057151.1
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus C-C motif chemokine ligand 17 (Ccl17), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_057151.1

ORF Insert Sequence:

ATGATGTCAC TTCAGATGCT GCTCCTGGCT GCCCTGCTTC TGGGGACTTC TCTGCAGCAT 
GCCAGCGCTG CTCGAGCCAC CAATGTAGGC CGAGAGTGCT GCCTGGACTA CTTCAAGGGG 
GCCATTCCCA TCAGGAAGCT GGTGACGTGG TTCAGGACCT CAGTGGAGTG TCCCAAGGAT 
GCCATCGTGT TTGAGACTGT CCAGGGAAGG CTTATCTGCA CAGACCCCAA AGACAAGCAT 
GTGAAGAAGG CCATCAGACA CCTGAAAAAC CAAAGGCTGT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

RNAi screen reveals potentially novel roles of cytokines in myoblast differentiation.
PloS one8(7)e68068(2013)
Ge Y,Waldemer RJ,Nalluri R,Nuzzi PD,Chen J

Chemokine receptor 4 plays a key role in T cell recruitment into the airways of asthmatic patients.
Journal of immunology (Baltimore, Md. : 1950)184(8)4568-74(2010 Apr)
Vijayanand P,Durkin K,Hartmann G,Morjaria J,Seumois G,Staples KJ,Hall D,Bessant C,Bartholomew M,Howarth PH,Friedmann PS,Djukanovic R

ANG II receptor blockade enhances anti-inflammatory macrophages in anti-glomerular basement membrane glomerulonephritis.
American journal of physiology. Renal physiology298(4)F870-82(2010 Apr)
Aki K,Shimizu A,Masuda Y,Kuwahara N,Arai T,Ishikawa A,Fujita E,Mii A,Natori Y,Fukunaga Y,Fukuda Y

GGTI-2133, an inhibitor of geranylgeranyltransferase, inhibits infiltration of inflammatory cells into airways in mouse experimental asthma.
International journal of immunopathology and pharmacology22(4)929-35(2009 Oct-Dec)
Chiba Y,Sato S,Misawa M

Macrophage derived chemokine (CCL22), thymus and activation-regulated chemokine (CCL17), and CCR4 in idiopathic pulmonary fibrosis.
Respiratory research1080(2009 Aug)
Yogo Y,Fujishima S,Inoue T,Saito F,Shiomi T,Yamaguchi K,Ishizaka A