Samsn1 cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Samsn1
Entrez Gene ID	67742
Full Name	SAM domain, SH3 domain and nuclear localization signals, 1
Synonyms	4930571B16Rik,930571B16Rik,Hacs1,SLy2
General protein information	Preferred Names SAM domain, SH3 domain and nuclear localization signals, 1 Names SAM domain-containing protein SAMSN-1 SAM domain, SH3 domain and nuclear localisation signals, 1 SAM domain, SH3 domain and nuclear localization signals protein 1 SH3 protein expressed in lymphocytes 2 SH3-lymphocyte protein 2
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 16 Map Location: 16\|16 C3.1

mRNA and Protein(s)

mRNA	Protein	Name
NM_023380.2	NP_075869.2	SAM domain-containing protein SAMSN-1

Pathways from BioSystems

Homologies

Bos taurus (cattle)	SAMSN1	NP_001030481.1
Pan troglodytes (chimpanzee)	SAMSN1	XP_001154786.1
Rattus norvegicus (Norway rat)	Samsn1	NP_570834.1
Danio rerio (zebrafish)	samsn1b	NP_001006039.1
Canis lupus familiaris (dog)	SAMSN1	XP_005638818.1
Homo sapiens (human)	SAMSN1	NP_001243299.1
	SAMSN1	XP_001082777.1
Mus musculus (house mouse)	Samsn1	NP_075869.2
Gallus gallus (chicken)	SAMSN1	NP_001006256.1
Xenopus tropicalis (tropical clawed frog)	samsn1	XP_002939381.2

Gene Ontology
Bibliography

Related articles in PubMed

Whole Genome Sequence of Multiple Myeloma-Prone C57BL/KaLwRij Mouse Strain Suggests the Origin of Disease Involves Multiple Cell Types.
Amend SR, Wilson WC, Chu L, Lu L, Liu P, Serie D, Su X, Xu Y, Wang D, Gramolini A, Wen XY, O'Neal J, Hurchla M, Vachon CM, Colditz G, Vij R, Weilbaecher KN, Tomasson MH
PloS one10(5)e0127828(2015)

SLy2 controls the antibody response to pneumococcal vaccine through an IL-5R?-dependent mechanism in B-1 cells.
Schmitt F, Sch?ll D, Bucher K, Schindler TI, Hector A, Biedermann T, Zemlin M, Hartl D, Beer-Hammer S
European journal of immunology45(1)60-70(2015 Jan)

SAMSN1 is a tumor suppressor gene in multiple myeloma.
Noll JE, Hewett DR, Williams SA, Vandyke K, Kok C, To LB, Zannettino AC
Neoplasia (New York, N.Y.)16(7)572-85(2014 Jul)

Immunoinhibitory adapter protein Src homology domain 3 lymphocyte protein 2 (SLy2) regulates actin dynamics and B cell spreading.
von Holleben M, Gohla A, Janssen KP, Iritani BM, Beer-Hammer S
The Journal of biological chemistry286(15)13489-501(2011 Apr)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

SLy2 controls the antibody response to pneumococcal vaccine through an IL-5Ralpha-dependent mechanism in B-1 cells.
Title: SLy2 controls the antibody response to pneumococcal vaccine through an IL-5R?-dependent mechanism in B-1 cells.

This is the first study to identify deletion of a key gene in the C57BL/KaLwRij mice that also displays reduced gene expression in patients with MM and is therefore likely to play an integral role in MM disease development.
Title: SAMSN1 is a tumor suppressor gene in multiple myeloma.

the immunoinhibitory roles of SLy2 in vivo and suggest that the physiological up-regulation of SLy2 observed upon B cell activation functions to counteract excessive B cell spreading.
Title: Immunoinhibitory adapter protein Src homology domain 3 lymphocyte protein 2 (SLy2) regulates actin dynamics and B cell spreading.

This study suggests that Hacs1 is an immunoinhibitory adaptor that might be a useful target for immune suppression therapy.
Title: Enhanced adaptive immunity in mice lacking the immunoinhibitory adaptor Hacs1.

The following Samsn1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Samsn1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OMu02074	NM_023380.2 Latest version!	Mus musculus SAM domain, SH3 domain and nuclear localization signals, 1 (Samsn1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$188.30 $269.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Samsn1 ( NM_023380.2 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_075869.2 Mus musculus SAM domain, SH3 domain and nuclear localization signals, 1 (Samsn1), mRNA.

Price & Availability↑

CloneID	OMu02074
Clone ID Related Accession (Same CDS sequence)	NM_023380.2
Accession Version	NM_023380.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1119bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-15
Organism	Mus musculus(house mouse)
Product	SAM domain-containing protein SAMSN-1
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from DQ333189.1. On Jan 24, 2006 this sequence version replaced NM_023380.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: DQ333189.1, BC064778.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN01164135, SAMN01164138 [ECO:0000348] ##Evidence-Data-END##

ATGCTAAAGA GGAAGCCATC CAATGCCTCA GACAAGGAGA AACACCAAAA ACCGAAGCGC 
AGCAGCAGTT TTGGGAATTT TGACCGTTTT CGGAATAATT CCGTATCAAA ATCTGATGAC 
TCAATTGAGG TCCATGACAG GGAACTGACA AATGGAAGTG AAGAACAAAG CAAGACTTCA 
AGCAGTGGAG GAAGTCTAGG TAAAAAAGTG AGGGCTATTT CATGGACAAT GAAGAAAAAA 
GTAGGAAAAA AATACATCAA AGCTCTTTCT GAGGAAAAAG AGGAAGAAAG TGGAGAGGAA 
GCCCTCCCAT ATCGGAACAG TGATCCCATG ATTGGAACAC ATACAGAGAA GATCTCACTC 
AAAGCCAGCG ACTCTATGGA CAGTCTTTAC AGTGGGCAGA GTTCATCAAG TGGAATAACA 
AGCTGTTCAG ATGGAACAAG TAATCGGGAC AGCTTCCGAC TGGATGATGA CAGCCCCTAC 
TCAGGGCCAT TCTGTGGCCG GGCCAAAGTG CACACAGACT TCACGCCAAG TCCCTATGAC 
ACCGACTCCC TTAAAATCAA GAAAGGAGAC ATCATAGACA TTATCTGCAA AACACCAATG 
GGAATGTGGA CAGGGATGCT GAACAATAAA GTGGGAAACT TCAAATTTAT TTATGTGGAT 
GTTATCTTAG AAGAGGAAGC AGCTCCTAAG AAGATAAAGG TCCCCAGAAG CAGGAGAAGA 
GAGAACCACC AGACTATCCA GGAGTTCTTA GAGAGGATTC ACCTTCAGGA ATACACTTCA 
ACACTTCTGC TTAATGGCTA TGAGACCCTG GATGACTTGA AGGATATCAA AGAAAGTCAT 
CTCATTGAAT TAAACATTGC AGATCCAGAA GACAGGGCGA GGCTGCTGTC TGCTGCCGAG 
AGTCTCCTGG ATGAAGAAAC CACTGTAGAA CATGAAAAGG AATCCGTGCC TCTATCCTCA 
AACCCAGACA TCTTGAGTGC ATCACAGCTA GAGGACTGCC CGAGGGACTC TGGCTGTTAT 
ATCTCATCGG AAAACTCAGA TAATGGCAAG GAAGATCTGG AGTCAGAAAA TCTGTCTGAC 
ATGGTGCAGA AGATTGCCAT CACAGAATCC AGTGACTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_075869.2
CDS	81..1199
Translation	MLKRKPSNASDKEKHQKPKRSSSFGNFDRFRNNSVSKSDDSIEVHDRELTNGSEEQSKTSSSGGSLGKKVRAISWTMKKKVGKKYIKALSEEKEEESGEEALPYRNSDPMIGTHTEKISLKASDSMDSLYSGQSSSSGITSCSDGTSNRDSFRLDDDSPYSGPFCGRAKVHTDFTPSPYDTDSLKIKKGDIIDIICKTPMGMWTGMLNNKVGNFKFIYVDVILEEEAAPKKIKVPRSRRRENHQTIQEFLERIHLQEYTSTLLLNGYETLDDLKDIKESHLIELNIADPEDRARLLSAAESLLDEETTVEHEKESVPLSSNPDILSASQLEDCPRDSGCYISSENSDNGKEDLESENLSDMVQKIAITESSD

Target ORF information:

RefSeq Version	NM_023380.2
Organism	Mus musculus(house mouse)
Definition	Mus musculus SAM domain, SH3 domain and nuclear localization signals, 1 (Samsn1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_023380.2

ORF Insert Sequence:

ATGCTAAAGA GGAAGCCATC CAATGCCTCA GACAAGGAGA AACACCAAAA ACCGAAGCGC 
AGCAGCAGTT TTGGGAATTT TGACCGTTTT CGGAATAATT CCGTATCAAA ATCTGATGAC 
TCAATTGAGG TCCATGACAG GGAACTGACA AATGGAAGTG AAGAACAAAG CAAGACTTCA 
AGCAGTGGAG GAAGTCTAGG TAAAAAAGTG AGGGCTATTT CATGGACAAT GAAGAAAAAA 
GTAGGAAAAA AATACATCAA AGCTCTTTCT GAGGAAAAAG AGGAAGAAAG TGGAGAGGAA 
GCCCTCCCAT ATCGGAACAG TGATCCCATG ATTGGAACAC ATACAGAGAA GATCTCACTC 
AAAGCCAGCG ACTCTATGGA CAGTCTTTAC AGTGGGCAGA GTTCATCAAG TGGAATAACA 
AGCTGTTCAG ATGGAACAAG TAATCGGGAC AGCTTCCGAC TGGATGATGA CAGCCCCTAC 
TCAGGGCCAT TCTGTGGCCG GGCCAAAGTG CACACAGACT TCACGCCAAG TCCCTATGAC 
ACCGACTCCC TTAAAATCAA GAAAGGAGAC ATCATAGACA TTATCTGCAA AACACCAATG 
GGAATGTGGA CAGGGATGCT GAACAATAAA GTGGGAAACT TCAAATTTAT TTATGTGGAT 
GTTATCTTAG AAGAGGAAGC AGCTCCTAAG AAGATAAAGG TCCCCAGAAG CAGGAGAAGA 
GAGAACCACC AGACTATCCA GGAGTTCTTA GAGAGGATTC ACCTTCAGGA ATACACTTCA 
ACACTTCTGC TTAATGGCTA TGAGACCCTG GATGACTTGA AGGATATCAA AGAAAGTCAT 
CTCATTGAAT TAAACATTGC AGATCCAGAA GACAGGGCGA GGCTGCTGTC TGCTGCCGAG 
AGTCTCCTGG ATGAAGAAAC CACTGTAGAA CATGAAAAGG AATCCGTGCC TCTATCCTCA 
AACCCAGACA TCTTGAGTGC ATCACAGCTA GAGGACTGCC CGAGGGACTC TGGCTGTTAT 
ATCTCATCGG AAAACTCAGA TAATGGCAAG GAAGATCTGG AGTCAGAAAA TCTGTCTGAC 
ATGGTGCAGA AGATTGCCAT CACAGAATCC AGTGACTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Whole Genome Sequence of Multiple Myeloma-Prone C57BL/KaLwRij Mouse Strain Suggests the Origin of Disease Involves Multiple Cell Types.
PloS one10(5)e0127828(2015)
Amend SR,Wilson WC,Chu L,Lu L,Liu P,Serie D,Su X,Xu Y,Wang D,Gramolini A,Wen XY,O'Neal J,Hurchla M,Vachon CM,Colditz G,Vij R,Weilbaecher KN,Tomasson MH

SLy2 controls the antibody response to pneumococcal vaccine through an IL-5R?-dependent mechanism in B-1 cells.
European journal of immunology45(1)60-70(2015 Jan)
Schmitt F,Sch?ll D,Bucher K,Schindler TI,Hector A,Biedermann T,Zemlin M,Hartl D,Beer-Hammer S

SAMSN1 is a tumor suppressor gene in multiple myeloma.
Neoplasia (New York, N.Y.)16(7)572-85(2014 Jul)
Noll JE,Hewett DR,Williams SA,Vandyke K,Kok C,To LB,Zannettino AC

Immunoinhibitory adapter protein Src homology domain 3 lymphocyte protein 2 (SLy2) regulates actin dynamics and B cell spreading.
The Journal of biological chemistry286(15)13489-501(2011 Apr)
von Holleben M,Gohla A,Janssen KP,Iritani BM,Beer-Hammer S