Tril cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Tril
Entrez Gene ID	66873
Full Name	TLR4 interactor with leucine-rich repeats
Synonyms	1200009O22Rik,AI316813,mKIAA0644
General protein information	Preferred Names TLR4 interactor with leucine-rich repeats Names TLR4 interactor with leucine rich repeats
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 6 Map Location: 6\|6 B3

mRNA and Protein(s)

mRNA	Protein	Name
NM_025817.4	NP_080093.1	TLR4 interactor with leucine rich repeats precursor

Pathways from BioSystems

Homologies

Pan troglodytes (chimpanzee)	TRIL	XP_527706.3
Canis lupus familiaris (dog)	TRIL	XP_005628727.1
Bos taurus (cattle)	TRIL	XP_005205601.1
Gallus gallus (chicken)	TRIL	XP_425996.3
Homo sapiens (human)	TRIL	NP_055632.2
Mus musculus (house mouse)	Tril	NP_080093.1
Xenopus tropicalis (tropical clawed frog)	tril	XP_002933436.1
	TRIL	XP_001088293.1
Rattus norvegicus (Norway rat)	Tril	NP_001029182.1

Gene Ontology
Bibliography

Related articles in PubMed

TRIL is involved in cytokine production in the brain following Escherichia coli infection.
Wochal P, Rathinam VA, Dunne A, Carlson T, Kuang W, Seidl KJ, Hall JP, Lin LL, Collins M, Schattgen SA, MacKay CR, Fagundes CT, Carpenter S, Fitzgerald KA, O'Neill LA
Journal of immunology (Baltimore, Md. : 1950)193(4)1911-9(2014 Aug)

Global gene expression analysis of murine limb development.
Taher L, Collette NM, Murugesh D, Maxwell E, Ovcharenko I, Loots GG
PloS one6(12)e28358(2011)

TRIL, a functional component of the TLR4 signaling complex, highly expressed in brain.
Carpenter S, Carlson T, Dellacasagrande J, Garcia A, Gibbons S, Hertzog P, Lyons A, Lin LL, Lynch M, Monie T, Murphy C, Seidl KJ, Wells C, Dunne A, O'Neill LA
Journal of immunology (Baltimore, Md. : 1950)183(6)3989-95(2009 Sep)

PlexinA1 signaling directs the segregation of proprioceptive sensory axons in the developing spinal cord.
Yoshida Y, Han B, Mendelsohn M, Jessell TM
Neuron52(5)775-88(2006 Dec)

Conserved expression domains for genes upstream and within the HoxA and HoxD clusters suggests a long-range enhancer existed before cluster duplication.
Lehoczky JA, Williams ME, Innis JW
Evolution & development6(6)423-30(2004 Nov-Dec)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

these data uncover TRIL as a mediator of innate immune responses within the brain, where it enhances neuronal cytokine responses to infection.
Title: TRIL is involved in cytokine production in the brain following Escherichia coli infection.

TRIL is a novel component of the TLR4 complex which may have particular relevance for the functional role of TLR4 in the brain
Title: TRIL, a functional component of the TLR4 signaling complex, highly expressed in brain.

The following Tril gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Tril cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OMu58552	NM_025817.4 Latest version!	Mus musculus TLR4 interactor with leucine-rich repeats (Tril), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$391.30 $559.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Tril ( NM_025817.4 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_080093.1 Mus musculus TLR4 interactor with leucine-rich repeats (Tril), mRNA.

Price & Availability↑

CloneID	OMu58552
Clone ID Related Accession (Same CDS sequence)	NM_025817.4
Accession Version	NM_025817.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2430bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-07-05
Organism	Mus musculus(house mouse)
Product	TLR4 interactor with leucine rich repeats precursor
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from BY291576.1, BC059224.1 and AC079130.4. On Dec 23, 2009 this sequence version replaced NM_025817.3. COMPLETENESS: complete on the 3' end.

ATGGAGGGTG TGGGTGCCGT GCGCTTCTGG CTCGTGGTGT GCGGCTGCCT GGCGTTCCCG 
CCGCGGGCCG AGTCCGTGTG CCCGGAGCGC TGCGACTGCC AGCACCCCCA ACATCTCCTA 
TGCACCAACA GGGGACTTCG CGCTGTACCC AAGACCAGCT CGCTGCCTAG TCCCCAGGAC 
GTGCTCACCT ACAGCCTAGG CGGCAACTTC ATCACCAACA TCACCGCCTT CGACTTCCAC 
CGTCTGGGGC AGCTCAGACG GCTGGATCTG CAGTACAACC AGATCCGTTC TCTCCACCCC 
AAGACCTTCG AGAAGCTCTC ACGACTAGAG GAGCTGTACC TGGGGAACAA CCTCTTGCAG 
GCGCTCGTTC CTGGCACGTT GGCTCCGCTG CGCAAGTTGC GCATCCTTTA CGCCAACGGC 
AACGAGATTG GACGCCTGAG TCGCGGGTCC TTCGAGGGCC TGGAGAGTTT GGTCAAGCTA 
CGGCTGGACG GGAACGTGCT GGGAGCGCTG CCGGACGCGG TCTTCGCTCC CCTGGGCAAC 
CTGCTCTACC TACACCTGGA ATCTAACCGG ATCCGTTTTT TGGGCAAGAA CGCCTTCAGC 
CAGCTGGGTA AGCTTCGATT CCTCAATCTC TCGGCCAACG AGCTGCAACC CTCTCTGCGC 
CACGCGGCCA CCTTTGTCCC TCTGCGCTCC CTCTCTACTC TCATCCTCTC AGCCAACAGC 
CTACAGCACC TCGGCCCCCG CGTCTTCCAG CACCTGCCAC GCCTAGGCCT GCTCTCCCTC 
AGTGGAAACC AGCTCACGCA CCTCGCCCCA GAGGCCTTTT GGGGACTGGA GGCCCTACGT 
GAGCTGCGCC TGGAAGGTAA CCGGCTGAAC CAGCTCCCCC TGACACTGCT GGAGCCTCTG 
CACAGCTTGG AGGCACTAGA CCTGAGTGGC AATGAGCTTT CTGCTCTGCA CCCTGCCACC 
TTTGGCCACC AGGGCCGGCT CCGTGAGCTC AGCCTGCGCG ACAACGCGCT CAGCGCCCTT 
TCTGGGGACA TCTTTGCCGC CAGTCCGGCT CTCTACCGGC TGGATCTAGA CGGCAATGGT 
TGGACCTGCG ACTGCCGGTT GCGGGGTCTG AAACGCTGGA TGGGCAACTG GCATTCTCAG 
GGTCGCCTCC TTACGGTCTT CGTGCAGTGT CGCCACCCCC CGGCCCTGCG GGGCAAGTAC 
CTGGATTACC TGGATGACCA ACTGCTGCAG AATGGGTCTT GCGTGGATCC CTCACCTTCC 
CCTACAGCAG GCAGTAGGCA GTGGCCGCTA CCCACATCGT CAGAAGAGGG GATGACGCCC 
CCTGCAGGCC TCTCGCAGGA GCTACCACTG CAGCCGCAGC CGCAGCCCCA GCAGCGGGGA 
AGACTTCTAC CAGGAGTGGC CTGGGGTGGG GCTGCCAAGG AACTGGTGGG CAACCGCAGC 
GCATTAAGGT TGAGCCGGCG GGGACCAGGT CCCCATCAGG GCCCCTCTGC TGCGGCTCCG 
GGCTCTGCCC CACAGTCCTT GGACCTGCAC GAGAAGCCGG GGAGAGGACG TCACACCCGA 
GCCAATCTCT CCCAGACGGA GCCCACCCCG ACGTCTGAGC CCGCCTCTGG GACACCATCT 
GCCAGAGACA GCTGGCAGCG CGCAGCAAAG CAGCGCCTAG CGTCCGAGCA GCAAGAGAGC 
GCAGTCCAGT CCGTTAGTGG GGTTGGTTTG CCACCTCTGG TGTCTGACCC CTGTGACTTC 
AACAAATTCA TTCTGTGCAA CCTGACAGTA GAGGCGGTGA GCGCCAACAG CGCCTCGGTG 
CGCTGGGCGG TTCGCGAACA CCGCAGTCCC CGGCCGCAGG GCGGCGCACG CTTCCGCCTG 
CTTTTCGACC GCTTTGGCCA GCAGCCCAAG TTCCAGCGCT TCGTCTACCT GCCGGAGCGC 
AGCGACTCGG CCACGCTGCA CGAGCTGCGC GGAGACACCC CCTACCTAGT ATGCGTGGAG 
GGTGTGCTCG GGGGTCGCGT TTGCCCCGTG GCCCCCCGAG ACCACTGCGC AGGGTTAGTA 
ACCCTGCCAG AGGCAGGAGG TCGAGGTGGC GTCGACTACC AGCTCCTGAC CTTGGTCTTG 
CTGGCTGTCA ACGCGCTTCT GGTGCTCCTG GCACTGGCAG CCTGGGGATC GCGATGGCTG 
CGGAGGAAGC TGCGTGCCAG GCGGAAGGGA GGGGCCCCGG TCCACGTTCG CCACATGTAC 
TCCACCCGAC GGCCACTGCG CTCCATGGGC ACTGGTGTGT CCGCGGACTT CTCAGGCTTC 
CAGTCGCACC GTCCCCGCAC CACCGTGTGC GCGCTCAGCG AGGCCGACCT CATTGAGTTC 
CCCTGCGACC GCTTCATGGA CAGCACCGGC GGTGGTACCA GTGGCAGCTT GAGGCGGGAG 
GATCACCTCT TGCAAAGATT CGCTGACTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_080093.1
CDS	591..3020
Translation	MEGVGAVRFWLVVCGCLAFPPRAESVCPERCDCQHPQHLLCTNRGLRAVPKTSSLPSPQDVLTYSLGGNFITNITAFDFHRLGQLRRLDLQYNQIRSLHPKTFEKLSRLEELYLGNNLLQALVPGTLAPLRKLRILYANGNEIGRLSRGSFEGLESLVKLRLDGNVLGALPDAVFAPLGNLLYLHLESNRIRFLGKNAFSQLGKLRFLNLSANELQPSLRHAATFVPLRSLSTLILSANSLQHLGPRVFQHLPRLGLLSLSGNQLTHLAPEAFWGLEALRELRLEGNRLNQLPLTLLEPLHSLEALDLSGNELSALHPATFGHQGRLRELSLRDNALSALSGDIFAASPALYRLDLDGNGWTCDCRLRGLKRWMGNWHSQGRLLTVFVQCRHPPALRGKYLDYLDDQLLQNGSCVDPSPSPTAGSRQWPLPTSSEEGMTPPAGLSQELPLQPQPQPQQRGRLLPGVAWGGAAKELVGNRSALRLSRRGPGPHQGPSAAAPGSAPQSLDLHEKPGRGRHTRANLSQTEPTPTSEPASGTPSARDSWQRAAKQRLASEQQESAVQSVSGVGLPPLVSDPCDFNKFILCNLTVEAVSANSASVRWAVREHRSPRPQGGARFRLLFDRFGQQPKFQRFVYLPERSDSATLHELRGDTPYLVCVEGVLGGRVCPVAPRDHCAGLVTLPEAGGRGGVDYQLLTLVLLAVNALLVLLALAAWGSRWLRRKLRARRKGGAPVHVRHMYSTRRPLRSMGTGVSADFSGFQSHRPRTTVCALSEADLIEFPCDRFMDSTGGGTSGSLRREDHLLQRFAD

Target ORF information:

RefSeq Version	NM_025817.4
Organism	Mus musculus(house mouse)
Definition	Mus musculus TLR4 interactor with leucine-rich repeats (Tril), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_025817.4

ORF Insert Sequence:

ATGGAGGGTG TGGGTGCCGT GCGCTTCTGG CTCGTGGTGT GCGGCTGCCT GGCGTTCCCG 
CCGCGGGCCG AGTCCGTGTG CCCGGAGCGC TGCGACTGCC AGCACCCCCA ACATCTCCTA 
TGCACCAACA GGGGACTTCG CGCTGTACCC AAGACCAGCT CGCTGCCTAG TCCCCAGGAC 
GTGCTCACCT ACAGCCTAGG CGGCAACTTC ATCACCAACA TCACCGCCTT CGACTTCCAC 
CGTCTGGGGC AGCTCAGACG GCTGGATCTG CAGTACAACC AGATCCGTTC TCTCCACCCC 
AAGACCTTCG AGAAGCTCTC ACGACTAGAG GAGCTGTACC TGGGGAACAA CCTCTTGCAG 
GCGCTCGTTC CTGGCACGTT GGCTCCGCTG CGCAAGTTGC GCATCCTTTA CGCCAACGGC 
AACGAGATTG GACGCCTGAG TCGCGGGTCC TTCGAGGGCC TGGAGAGTTT GGTCAAGCTA 
CGGCTGGACG GGAACGTGCT GGGAGCGCTG CCGGACGCGG TCTTCGCTCC CCTGGGCAAC 
CTGCTCTACC TACACCTGGA ATCTAACCGG ATCCGTTTTT TGGGCAAGAA CGCCTTCAGC 
CAGCTGGGTA AGCTTCGATT CCTCAATCTC TCGGCCAACG AGCTGCAACC CTCTCTGCGC 
CACGCGGCCA CCTTTGTCCC TCTGCGCTCC CTCTCTACTC TCATCCTCTC AGCCAACAGC 
CTACAGCACC TCGGCCCCCG CGTCTTCCAG CACCTGCCAC GCCTAGGCCT GCTCTCCCTC 
AGTGGAAACC AGCTCACGCA CCTCGCCCCA GAGGCCTTTT GGGGACTGGA GGCCCTACGT 
GAGCTGCGCC TGGAAGGTAA CCGGCTGAAC CAGCTCCCCC TGACACTGCT GGAGCCTCTG 
CACAGCTTGG AGGCACTAGA CCTGAGTGGC AATGAGCTTT CTGCTCTGCA CCCTGCCACC 
TTTGGCCACC AGGGCCGGCT CCGTGAGCTC AGCCTGCGCG ACAACGCGCT CAGCGCCCTT 
TCTGGGGACA TCTTTGCCGC CAGTCCGGCT CTCTACCGGC TGGATCTAGA CGGCAATGGT 
TGGACCTGCG ACTGCCGGTT GCGGGGTCTG AAACGCTGGA TGGGCAACTG GCATTCTCAG 
GGTCGCCTCC TTACGGTCTT CGTGCAGTGT CGCCACCCCC CGGCCCTGCG GGGCAAGTAC 
CTGGATTACC TGGATGACCA ACTGCTGCAG AATGGGTCTT GCGTGGATCC CTCACCTTCC 
CCTACAGCAG GCAGTAGGCA GTGGCCGCTA CCCACATCGT CAGAAGAGGG GATGACGCCC 
CCTGCAGGCC TCTCGCAGGA GCTACCACTG CAGCCGCAGC CGCAGCCCCA GCAGCGGGGA 
AGACTTCTAC CAGGAGTGGC CTGGGGTGGG GCTGCCAAGG AACTGGTGGG CAACCGCAGC 
GCATTAAGGT TGAGCCGGCG GGGACCAGGT CCCCATCAGG GCCCCTCTGC TGCGGCTCCG 
GGCTCTGCCC CACAGTCCTT GGACCTGCAC GAGAAGCCGG GGAGAGGACG TCACACCCGA 
GCCAATCTCT CCCAGACGGA GCCCACCCCG ACGTCTGAGC CCGCCTCTGG GACACCATCT 
GCCAGAGACA GCTGGCAGCG CGCAGCAAAG CAGCGCCTAG CGTCCGAGCA GCAAGAGAGC 
GCAGTCCAGT CCGTTAGTGG GGTTGGTTTG CCACCTCTGG TGTCTGACCC CTGTGACTTC 
AACAAATTCA TTCTGTGCAA CCTGACAGTA GAGGCGGTGA GCGCCAACAG CGCCTCGGTG 
CGCTGGGCGG TTCGCGAACA CCGCAGTCCC CGGCCGCAGG GCGGCGCACG CTTCCGCCTG 
CTTTTCGACC GCTTTGGCCA GCAGCCCAAG TTCCAGCGCT TCGTCTACCT GCCGGAGCGC 
AGCGACTCGG CCACGCTGCA CGAGCTGCGC GGAGACACCC CCTACCTAGT ATGCGTGGAG 
GGTGTGCTCG GGGGTCGCGT TTGCCCCGTG GCCCCCCGAG ACCACTGCGC AGGGTTAGTA 
ACCCTGCCAG AGGCAGGAGG TCGAGGTGGC GTCGACTACC AGCTCCTGAC CTTGGTCTTG 
CTGGCTGTCA ACGCGCTTCT GGTGCTCCTG GCACTGGCAG CCTGGGGATC GCGATGGCTG 
CGGAGGAAGC TGCGTGCCAG GCGGAAGGGA GGGGCCCCGG TCCACGTTCG CCACATGTAC 
TCCACCCGAC GGCCACTGCG CTCCATGGGC ACTGGTGTGT CCGCGGACTT CTCAGGCTTC 
CAGTCGCACC GTCCCCGCAC CACCGTGTGC GCGCTCAGCG AGGCCGACCT CATTGAGTTC 
CCCTGCGACC GCTTCATGGA CAGCACCGGC GGTGGTACCA GTGGCAGCTT GAGGCGGGAG 
GATCACCTCT TGCAAAGATT CGCTGACTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

TRIL is involved in cytokine production in the brain following Escherichia coli infection.
Journal of immunology (Baltimore, Md. : 1950)193(4)1911-9(2014 Aug)
Wochal P,Rathinam VA,Dunne A,Carlson T,Kuang W,Seidl KJ,Hall JP,Lin LL,Collins M,Schattgen SA,MacKay CR,Fagundes CT,Carpenter S,Fitzgerald KA,O'Neill LA

Global gene expression analysis of murine limb development.
PloS one6(12)e28358(2011)
Taher L,Collette NM,Murugesh D,Maxwell E,Ovcharenko I,Loots GG

TRIL, a functional component of the TLR4 signaling complex, highly expressed in brain.
Journal of immunology (Baltimore, Md. : 1950)183(6)3989-95(2009 Sep)
Carpenter S,Carlson T,Dellacasagrande J,Garcia A,Gibbons S,Hertzog P,Lyons A,Lin LL,Lynch M,Monie T,Murphy C,Seidl KJ,Wells C,Dunne A,O'Neill LA

PlexinA1 signaling directs the segregation of proprioceptive sensory axons in the developing spinal cord.
Neuron52(5)775-88(2006 Dec)
Yoshida Y,Han B,Mendelsohn M,Jessell TM

Conserved expression domains for genes upstream and within the HoxA and HoxD clusters suggests a long-range enhancer existed before cluster duplication.
Evolution & development6(6)423-30(2004 Nov-Dec)
Lehoczky JA,Williams ME,Innis JW