Nell1 cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Nell1
Entrez Gene ID	338352
Full Name	NEL-like 1
Synonyms	B230343H07Rik,l7R6
General protein information	Preferred Names NEL-like 1 Names protein kinase C-binding protein NELL1 NEL-like protein 1
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 7 Map Location: 7\|7 B4

mRNA and Protein(s)

mRNA	Protein	Name
NM_001037906.2	NP_001032995.1	protein kinase C-binding protein NELL1 precursor

Pathways from BioSystems

Homologies

Canis lupus familiaris (dog)	NELL1	XP_534090.3
Mus musculus (house mouse)	Nell1	NP_001032995.1
Xenopus tropicalis (tropical clawed frog)	nell1	XP_004914252.1
Rattus norvegicus (Norway rat)	Nell1	NP_112331.1
Gallus gallus (chicken)	NELL1	XP_001234167.2
Homo sapiens (human)	NELL1	NP_001275642.1
Pan troglodytes (chimpanzee)	NELL1	XP_001173867.3
	NELL1	XP_001092428.1
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP010335	XP_311609.4

Gene Ontology
Bibliography

Related articles in PubMed

Neural EGFL-Like 1 Is a Downstream Regulator of Runt-Related Transcription Factor 2 in Chondrogenic Differentiation and Maturation.
Li C, Jiang J, Zheng Z, Lee KS, Zhou Y, Chen E, Culiat CT, Qiao Y, Chen X, Ting K, Zhang X, Soo C
The American journal of pathology187(5)963-972(2017 May)

Operational redundancy in axon guidance through the multifunctional receptor Robo3 and its ligand NELL2.
Jaworski A, Tom I, Tong RK, Gildea HK, Koch AW, Gonzalez LC, Tessier-Lavigne M
Science (New York, N.Y.)350(6263)961-5(2015 Nov)

NELL-1 in the treatment of osteoporotic bone loss.
James AW, Shen J, Zhang X, Asatrian G, Goyal R, Kwak JH, Jiang L, Bengs B, Culiat CT, Turner AS, Seim Iii HB, Wu BM, Lyons K, Adams JS, Ting K, Soo C
Nature communications67362(2015 Jun)

Proliferation and osteogenic differentiation of mesenchymal stem cells induced by a short isoform of NELL-1.
Pang S, Shen J, Liu Y, Chen F, Zheng Z, James AW, Hsu CY, Zhang H, Lee KS, Wang C, Li C, Chen X, Jia H, Zhang X, Soo C, Ting K
Stem cells (Dayton, Ohio)33(3)904-15(2015 Mar)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Nell-1-haploinsufficient mice have normal skeletal development but undergo age-related osteoporosis, characterized by a reduction in osteoblast:osteoclast ratio and increased bone fragility.
Title: NELL-1 in the treatment of osteoporotic bone loss.

NELL-1570 has the potential to be used for cell-based or hormone-based therapy of bone regeneration.
Title: Proliferation and osteogenic differentiation of mesenchymal stem cells induced by a short isoform of NELL-1.

These results suggest that an oligomerization-induced conformational change in the C-terminal region of NELL1 is important for the efficient mediation of cell adhesion and spreading by NELL1.
Title: Oligomerization-induced conformational change in the C-terminal region of Nel-like molecule 1 (NELL1) protein is necessary for the efficient mediation of murine MC3T3-E1 cell adhesion and spreading.

Nell-1 might play a role in ameloblast and odontoblast differentiation, secretion and mineralization of the extracellular enamel matrix, molar crown morphogenesis, as well as root formation during the entire development period.
Title: Expression and localization of Nell-1 during murine molar development.

NELL-1 protein promotes cell adhesion in ST2 cells.
Title: NELL-1 promotes cell adhesion and differentiation via Integrin?1.

The following Nell1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Nell1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OMu00125	NM_001037906.2 Latest version!	Mus musculus NEL-like 1 (Nell1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	12-14	$475.30 $679.00

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Nell1 ( NM_001037906.2 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_001032995.1 Mus musculus NEL-like 1 (Nell1), mRNA.

Price & Availability↑

CloneID	OMu00125
Clone ID Related Accession (Same CDS sequence)	NM_001037906.2
Accession Version	NM_001037906.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2433bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-27
Organism	Mus musculus(house mouse)
Product	protein kinase C-binding protein NELL1 precursor
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from AC116694.9, AC163402.5, AC115080.13, AC161929.4, AC110036.8, AC116734.14, AC128699.4 and AC171557.7. On Nov 17, 2006 this sequence version replaced NM_001037906.1. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AY622226.1, SRR1660811.251556.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN01164131, SAMN01164132 [ECO:0000348] ##Evidence-Data-END##

ATGCCGATGG ATGTGATTTT AGTTTTGTGG TTCTGTGTGT GCACCGCCAG GACAGTGCTG 
GGCTTTGGGA TGGACCCTGA CCTTCAGATG GACATCATCA CTGAACTTGA CCTTGTGAAC 
ACCACCCTGG GCGTCACTCA GGTGGCTGGA CTACACAATG CCAGTAAGGC ATTTCTGTTT 
CAAGATGTAC AGAGAGAGAT CCACTCAGCC CCTCATGTGA GTGAGAAGCT GATCCAGCTA 
TTCCGGAATA AGAGTGAGTT TACCTTTTTG GCTACAGTGC AGCAGAAGCC GTCCACCTCA 
GGGGTGATAC TGTCGATCCG GGAGCTGGAA CACAGCTATT TTGAACTGGA GAGCAGTGGC 
CCAAGAGAAG AGATACGCTA TCATTACATC CATGGCGGCA AGCCCAGGAC TGAGGCCCTT 
CCCTACCGCA TGGCCGATGG ACAGTGGCAC AAGGTCGCGC TGTCTGTGAG CGCCTCTCAC 
CTCCTACTCC ATGTCGACTG CAATAGGATT TATGAGCGTG TGATAGATCC TCCGGAGACC 
AACCTTCCTC CAGGAAGCAA TCTATGGCTT GGGCAACGTA ATCAAAAGCA TGGCTTTTTC 
AAAGGAATCA TCCAAGATGG CAAGATCATC TTCATGCCGA ACGGCTTCAT CACACAGTGC 
CCCAACCTAA ATCGCACTTG CCCAACATGC AGTGATTTCC TGAGCCTGGT TCAAGGAATA 
ATGGATTTGC AAGAGCTTTT GGCCAAGATG ACTGCAAAAC TGAATTATGC AGAGACGAGA 
CTTGGTCAAC TGGAAAATTG CCACTGTGAG AAGACCTGCC AAGTGAGTGG GCTGCTCTAC 
AGGGACCAAG ACTCCTGGGT AGATGGTGAC AACTGCAGGA ACTGCACATG CAAAAGTGGT 
GCTGTGGAGT GCCGAAGGAT GTCCTGTCCC CCACTCAACT GTTCCCCAGA CTCACTTCCT 
GTGCATATTT CTGGCCAATG TTGTAAAGTT TGCAGACCAA AATGTATCTA TGGAGGAAAA 
GTTCTTGCTG AGGGCCAGCG GATTTTAACC AAGACCTGCC GGGAATGTCG AGGTGGAGTC 
TTGGTAAAAA TCACAGAAGC TTGCCCTCCT TTGAACTGCT CAGAGAAGGA TCATATTCTT 
CCGGAGAACC AGTGCTGCAG GGTCTGCCGA GGTCATAACT TCTGTGCAGA AGCACCTAAG 
TGTGGAGAAA ACTCGGAATG CAAAAATTGG AATACAAAAG CGACTTGTGA GTGCAAGAAT 
GGATACATCT CTGTCCAGGG CAACTCTGCA TACTGTGAAG ATATCGATGA GTGTGCAGCA 
AAGATGCACT ACTGTCATGC CAACACGGTG TGTGTCAACT TGCCGGGGTT ATATCGCTGT 
GACTGCATCC CAGGATACAT CCGTGTGGAT GACTTCTCTT GTACGGAGCA TGATGATTGT 
GGCAGCGGAC AACACAACTG TGACAAAAAT GCCATCTGTA CCAACACAGT CCAGGGACAC 
AGCTGTACCT GCCAGCCAGG CTACGTGGGA AATGGTACTG TCTGCAAAGC ATTCTGTGAA 
GAGGGTTGCA GATACGGAGG TACCTGTGTG GCCCCTAACA AATGTGTCTG TCCTTCTGGA 
TTCACAGGAA GCCACTGTGA GAAAGATATT GATGAATGTG CAGAGGGATT CGTTGAGTGC 
CACAACCACT CCCGCTGCGT TAACCTTCCA GGGTGGTACC ACTGTGAGTG CAGAAGCGGT 
TTCCATGACG ATGGGACCTA TTCACTGTCC GGGGAGTCCT GCATTGATAT TGATGAATGT 
GCCTTAAGAA CTCACACTTG TTGGAATGAC TCTGCCTGCA TCAACTTAGC AGGAGGATTT 
GACTGCCTGT GTCCCTCTGG GCCCTCCTGC TCTGGTGACT GTCCCCACGA AGGGGGGCTG 
AAGCATAATG GGCAGGTGTG GATTCTGAGA GAAGACAGGT GTTCAGTCTG TTCCTGTAAG 
GATGGGAAGA TATTCTGCCG GCGGACAGCT TGTGATTGCC AGAATCCAAA TGTTGACCTT 
TTCTGCTGCC CAGAGTGTGA CACCAGGGTC ACTAGCCAAT GTTTAGATCA AAGCGGACAG 
AAGCTCTATC GAAGTGGAGA CAACTGGACC CACAGCTGCC AGCAGTGCCG ATGTCTGGAA 
GGAGAGGCAG ACTGCTGGCC TCTAGCTTGC CCTAGTTTGA GCTGTGAATA CACAGCCATC 
TTTGAAGGAG AGTGTTGTCC CCGCTGTGTC AGTGACCCCT GCCTGGCTGA TAATATTGCC 
TATGACATCA GAAAAACTTG CCTGGACAGC TCTGGTATTT CGAGGCTGAG CGGCGCAGTG 
TGGACAATGG CTGGATCTCC CTGTACAACC TGTCAATGCA AGAATGGGAG AGTCTGCTGC 
TCTGTGGATC TGGTGTGTCT TGAGAATAAC TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001032995.1
CDS	40..2472
Translation	MPMDVILVLWFCVCTARTVLGFGMDPDLQMDIITELDLVNTTLGVTQVAGLHNASKAFLFQDVQREIHSAPHVSEKLIQLFRNKSEFTFLATVQQKPSTSGVILSIRELEHSYFELESSGPREEIRYHYIHGGKPRTEALPYRMADGQWHKVALSVSASHLLLHVDCNRIYERVIDPPETNLPPGSNLWLGQRNQKHGFFKGIIQDGKIIFMPNGFITQCPNLNRTCPTCSDFLSLVQGIMDLQELLAKMTAKLNYAETRLGQLENCHCEKTCQVSGLLYRDQDSWVDGDNCRNCTCKSGAVECRRMSCPPLNCSPDSLPVHISGQCCKVCRPKCIYGGKVLAEGQRILTKTCRECRGGVLVKITEACPPLNCSEKDHILPENQCCRVCRGHNFCAEAPKCGENSECKNWNTKATCECKNGYISVQGNSAYCEDIDECAAKMHYCHANTVCVNLPGLYRCDCIPGYIRVDDFSCTEHDDCGSGQHNCDKNAICTNTVQGHSCTCQPGYVGNGTVCKAFCEEGCRYGGTCVAPNKCVCPSGFTGSHCEKDIDECAEGFVECHNHSRCVNLPGWYHCECRSGFHDDGTYSLSGESCIDIDECALRTHTCWNDSACINLAGGFDCLCPSGPSCSGDCPHEGGLKHNGQVWILREDRCSVCSCKDGKIFCRRTACDCQNPNVDLFCCPECDTRVTSQCLDQSGQKLYRSGDNWTHSCQQCRCLEGEADCWPLACPSLSCEYTAIFEGECCPRCVSDPCLADNIAYDIRKTCLDSSGISRLSGAVWTMAGSPCTTCQCKNGRVCCSVDLVCLENN

Target ORF information:

RefSeq Version	NM_001037906.2
Organism	Mus musculus(house mouse)
Definition	Mus musculus NEL-like 1 (Nell1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001037906.2

ORF Insert Sequence:

ATGCCGATGG ATGTGATTTT AGTTTTGTGG TTCTGTGTGT GCACCGCCAG GACAGTGCTG 
GGCTTTGGGA TGGACCCTGA CCTTCAGATG GACATCATCA CTGAACTTGA CCTTGTGAAC 
ACCACCCTGG GCGTCACTCA GGTGGCTGGA CTACACAATG CCAGTAAGGC ATTTCTGTTT 
CAAGATGTAC AGAGAGAGAT CCACTCAGCC CCTCATGTGA GTGAGAAGCT GATCCAGCTA 
TTCCGGAATA AGAGTGAGTT TACCTTTTTG GCTACAGTGC AGCAGAAGCC GTCCACCTCA 
GGGGTGATAC TGTCGATCCG GGAGCTGGAA CACAGCTATT TTGAACTGGA GAGCAGTGGC 
CCAAGAGAAG AGATACGCTA TCATTACATC CATGGCGGCA AGCCCAGGAC TGAGGCCCTT 
CCCTACCGCA TGGCCGATGG ACAGTGGCAC AAGGTCGCGC TGTCTGTGAG CGCCTCTCAC 
CTCCTACTCC ATGTCGACTG CAATAGGATT TATGAGCGTG TGATAGATCC TCCGGAGACC 
AACCTTCCTC CAGGAAGCAA TCTATGGCTT GGGCAACGTA ATCAAAAGCA TGGCTTTTTC 
AAAGGAATCA TCCAAGATGG CAAGATCATC TTCATGCCGA ACGGCTTCAT CACACAGTGC 
CCCAACCTAA ATCGCACTTG CCCAACATGC AGTGATTTCC TGAGCCTGGT TCAAGGAATA 
ATGGATTTGC AAGAGCTTTT GGCCAAGATG ACTGCAAAAC TGAATTATGC AGAGACGAGA 
CTTGGTCAAC TGGAAAATTG CCACTGTGAG AAGACCTGCC AAGTGAGTGG GCTGCTCTAC 
AGGGACCAAG ACTCCTGGGT AGATGGTGAC AACTGCAGGA ACTGCACATG CAAAAGTGGT 
GCTGTGGAGT GCCGAAGGAT GTCCTGTCCC CCACTCAACT GTTCCCCAGA CTCACTTCCT 
GTGCATATTT CTGGCCAATG TTGTAAAGTT TGCAGACCAA AATGTATCTA TGGAGGAAAA 
GTTCTTGCTG AGGGCCAGCG GATTTTAACC AAGACCTGCC GGGAATGTCG AGGTGGAGTC 
TTGGTAAAAA TCACAGAAGC TTGCCCTCCT TTGAACTGCT CAGAGAAGGA TCATATTCTT 
CCGGAGAACC AGTGCTGCAG GGTCTGCCGA GGTCATAACT TCTGTGCAGA AGCACCTAAG 
TGTGGAGAAA ACTCGGAATG CAAAAATTGG AATACAAAAG CGACTTGTGA GTGCAAGAAT 
GGATACATCT CTGTCCAGGG CAACTCTGCA TACTGTGAAG ATATCGATGA GTGTGCAGCA 
AAGATGCACT ACTGTCATGC CAACACGGTG TGTGTCAACT TGCCGGGGTT ATATCGCTGT 
GACTGCATCC CAGGATACAT CCGTGTGGAT GACTTCTCTT GTACGGAGCA TGATGATTGT 
GGCAGCGGAC AACACAACTG TGACAAAAAT GCCATCTGTA CCAACACAGT CCAGGGACAC 
AGCTGTACCT GCCAGCCAGG CTACGTGGGA AATGGTACTG TCTGCAAAGC ATTCTGTGAA 
GAGGGTTGCA GATACGGAGG TACCTGTGTG GCCCCTAACA AATGTGTCTG TCCTTCTGGA 
TTCACAGGAA GCCACTGTGA GAAAGATATT GATGAATGTG CAGAGGGATT CGTTGAGTGC 
CACAACCACT CCCGCTGCGT TAACCTTCCA GGGTGGTACC ACTGTGAGTG CAGAAGCGGT 
TTCCATGACG ATGGGACCTA TTCACTGTCC GGGGAGTCCT GCATTGATAT TGATGAATGT 
GCCTTAAGAA CTCACACTTG TTGGAATGAC TCTGCCTGCA TCAACTTAGC AGGAGGATTT 
GACTGCCTGT GTCCCTCTGG GCCCTCCTGC TCTGGTGACT GTCCCCACGA AGGGGGGCTG 
AAGCATAATG GGCAGGTGTG GATTCTGAGA GAAGACAGGT GTTCAGTCTG TTCCTGTAAG 
GATGGGAAGA TATTCTGCCG GCGGACAGCT TGTGATTGCC AGAATCCAAA TGTTGACCTT 
TTCTGCTGCC CAGAGTGTGA CACCAGGGTC ACTAGCCAAT GTTTAGATCA AAGCGGACAG 
AAGCTCTATC GAAGTGGAGA CAACTGGACC CACAGCTGCC AGCAGTGCCG ATGTCTGGAA 
GGAGAGGCAG ACTGCTGGCC TCTAGCTTGC CCTAGTTTGA GCTGTGAATA CACAGCCATC 
TTTGAAGGAG AGTGTTGTCC CCGCTGTGTC AGTGACCCCT GCCTGGCTGA TAATATTGCC 
TATGACATCA GAAAAACTTG CCTGGACAGC TCTGGTATTT CGAGGCTGAG CGGCGCAGTG 
TGGACAATGG CTGGATCTCC CTGTACAACC TGTCAATGCA AGAATGGGAG AGTCTGCTGC 
TCTGTGGATC TGGTGTGTCT TGAGAATAAC TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Neural EGFL-Like 1 Is a Downstream Regulator of Runt-Related Transcription Factor 2 in Chondrogenic Differentiation and Maturation.
The American journal of pathology187(5)963-972(2017 May)
Li C,Jiang J,Zheng Z,Lee KS,Zhou Y,Chen E,Culiat CT,Qiao Y,Chen X,Ting K,Zhang X,Soo C

Operational redundancy in axon guidance through the multifunctional receptor Robo3 and its ligand NELL2.
Science (New York, N.Y.)350(6263)961-5(2015 Nov)
Jaworski A,Tom I,Tong RK,Gildea HK,Koch AW,Gonzalez LC,Tessier-Lavigne M

NELL-1 in the treatment of osteoporotic bone loss.
Nature communications67362(2015 Jun)
James AW,Shen J,Zhang X,Asatrian G,Goyal R,Kwak JH,Jiang L,Bengs B,Culiat CT,Turner AS,Seim Iii HB,Wu BM,Lyons K,Adams JS,Ting K,Soo C

Proliferation and osteogenic differentiation of mesenchymal stem cells induced by a short isoform of NELL-1.
Stem cells (Dayton, Ohio)33(3)904-15(2015 Mar)
Pang S,Shen J,Liu Y,Chen F,Zheng Z,James AW,Hsu CY,Zhang H,Lee KS,Wang C,Li C,Chen X,Jia H,Zhang X,Soo C,Ting K

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Nell1 cDNA ORF clone, Mus musculus(house mouse)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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