Coro1c cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Coro1c
Entrez Gene ID	23790
Full Name	coronin, actin binding protein 1C
Synonyms	AL022675,AW455561,AW548837
General protein information	Preferred Names coronin, actin binding protein 1C Names coronin-1C coronin 1c coronin-3
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 5 Map Location: 5\|5 F

mRNA and Protein(s)

mRNA	Protein	Name
NM_011779.3	NP_035909.2	coronin-1C

Pathways from BioSystems

Homologies

Danio rerio (zebrafish)	coro1cb	XP_005172017.1
Pan troglodytes (chimpanzee)	CORO1C	XP_003313960.1
Bos taurus (cattle)	CORO1C	NP_001075059.1
Gallus gallus (chicken)	CORO1C	NP_001264798.1
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP005891	XP_001688746.1
Eremothecium gossypii	AGOS_AER114W	NP_984974.1
Neurospora crassa	NCU00202	XP_956587.1
Xenopus tropicalis (tropical clawed frog)	coro1c	NP_989383.1
Danio rerio (zebrafish)	coro1ca	NP_958452.1
Caenorhabditis elegans (roundworm)	cor-1	NP_741270.1
Kluyveromyces lactis	KLLA0D02530g	XP_453181.1
Drosophila melanogaster (fruit fly)	coro	NP_001260743.1
Saccharomyces cerevisiae (baker's yeast)	CRN1	NP_013533.1
Schizosaccharomyces pombe (fission yeast)	crn1	NP_593175.1
Magnaporthe oryzae (rice blast fungus)	MGG_06389	XP_003717184.1
Homo sapiens (human)	CORO1C	NP_001098707.1
	CORO1C	XP_002798812.1
Canis lupus familiaris (dog)	CORO1C	XP_003433441.1
Mus musculus (house mouse)	Coro1c	NP_035909.2
Rattus norvegicus (Norway rat)	Coro1c	NP_001102797.1

Gene Ontology
Bibliography

Related articles in PubMed

WD40-repeat 47, a microtubule-associated protein, is essential for brain development and autophagy.
Kannan M, Bayam E, Wagner C, Rinaldi B, Kretz PF, Tilly P, Roos M, McGillewie L, B?r S, Minocha S, Chevalier C, Po C, , Chelly J, Mandel JL, Borgatti R, Piton A, Kinnear C, Loos B, Adams DJ, H?rault Y, Collins SC, Friant S, Godin JD, Yalcin B
Proceedings of the National Academy of Sciences of the United States of America114(44)E9308-E9317(2017 Oct)

Coronin 1C-free primary mouse fibroblasts exhibit robust rearrangements in the orientation of actin filaments, microtubules and intermediate filaments.
Behrens J, Solga R, Ziemann A, Rastetter RH, Berwanger C, Herrmann H, Noegel AA, Clemen CS
European journal of cell biology95(8)239-51(2016 Aug)

Coronin-1C Protein and Caveolin Protein Provide Constitutive and Inducible Mechanisms of Rac1 Protein Trafficking.
Williamson RC, Cowell CA, Reville T, Roper JA, Rendall TC, Bass MD
The Journal of biological chemistry290(25)15437-49(2015 Jun)

Coronin-1C and RCC2 guide mesenchymal migration by trafficking Rac1 and controlling GEF exposure.
Williamson RC, Cowell CA, Hammond CL, Bergen DJ, Roper JA, Feng Y, Rendall TC, Race PR, Bass MD
Journal of cell science127(Pt 19)4292-307(2014 Oct)

Coronin-1 is a neurotrophin endosomal effector that is required for developmental competition for survival.
Suo D, Park J, Harrington AW, Zweifel LS, Mihalas S, Deppmann CD
Nature neuroscience17(1)36-45(2014 Jan)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Coronin-1C Protein and Caveolin Protein Provide Constitutive and Inducible Mechanisms of Rac1 Protein
Title: Coronin-1C Protein and Caveolin Protein Provide Constitutive and Inducible Mechanisms of Rac1 Protein Trafficking.

Coronin 1C displays highly co-operative binding to actin filaments. We highlight a novel mode of coronin regulation, which has implications for how coronins orchestrate cytoskeletal dynamics.
Title: Coronin 1C harbours a second actin-binding site that confers co-operative binding to F-actin.

These results indicate that glucose recruits coronin 3 near the plasma membrane, and that it regulates the retrograde transport of the secretory membrane in pancreatic beta-cells.
Title: Glucose-induced translocation of coronin 3 regulates the retrograde transport of the secretory membrane in the pancreatic beta-cells.

Results indicate that interaction of GDP-Rab27a and coronin 3 is important in stimulus-endocytosis coupling, and that GTP- and GDP-Rab27a regulates insulin membrane recycling at the distinct stages.
Title: The GDP-dependent Rab27a effector coronin 3 controls endocytosis of secretory membrane in insulin-secreting cell lines.

Coronin 3 is abundantly expressed in the adult CNS. All murine brain areas express coronin 3 during embryogenesis and the first postnatal stages.
Title: Coronin 3 and its role in murine brain morphogenesis.

The following Coro1c gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Coro1c cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OMu08818	NM_011779.3 Latest version!	Mus musculus coronin, actin binding protein 1C (Coro1c), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$223.30 $319.00

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Coro1c ( NM_011779.3 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_035909.2 Mus musculus coronin, actin binding protein 1C (Coro1c), mRNA.

Price & Availability↑

CloneID	OMu08818
Clone ID Related Accession (Same CDS sequence)	NM_011779.3
Accession Version	NM_011779.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1425bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-25
Organism	Mus musculus(house mouse)
Product	coronin-1C
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from AK082986.1. On Apr 6, 2007 this sequence version replaced NM_011779.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK077552.1, AK082986.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMN00849374, SAMN00849375 [ECO:0000350] ##Evidence-Data-END##

ATGCGGCGAG TGGTGCGGCA GAGCAAGTTC CGCCACGTCT TTGGACAGGC GGTGAAGAAT 
GACCAGTGCT ATGACGACAT CCGTGTCTCC CGAGTCACCT GGGACAGTTC CTTTTGTGCC 
GTCAACCCCA GATTCGTGGC CATCATCATA GAAGCGAGTG GGGGAGGGGC CTTCCTGGTG 
CTCCCTCTGC ACAAGACGGG ACGAATTGAC AAATCCTACC CTACAGTGTG TGGCCACACA 
GGACCAGTGC TGGACATAGA CTGGTGTCCA CATAATGACC AGGTCATTGC CAGCGGCTCA 
GAGGACTGCA CTGTTATGGT TTGGCAGATC CCGGAAAATG GACTCACCCT TTCCCTGACC 
GAGCCTGTGG TGATTCTAGA AGGGCACTCA AAAAGAGTTG GCATCGTGGC CTGGCACCCG 
ACGGCCCGCA ATGTGCTTCT CAGTGCAGGC TGTGATAATG CCATTATCAT CTGGAACGTG 
GGGACAGGGG AAGCCCTCAT CAACTTGGAC GATATGCATT CAGACATGAT TTACAATGTG 
AGCTGGAGCC GTAACGGTAG TCTCATCTGC ACCGCATCCA AAGACAAGAA AGTGAGAGTC 
ATTGACCCCA GGAAACAGGA GATTGTGGCG GAGAAGGAGA AAGCACACGA AGGAGCCAGG 
CCTATGCGTG CCATCTTCCT GGCGGACGGC AACGTCTTCA CTACTGGCTT TAGCCGCATG 
AGCGAGCGGC AGTTGGCGCT CTGGAACCCA AAAAACATGC AGGAACCAAT TGCTCTCCAT 
GAAATGGACA CTAGCAATGG GGTGCTGCTC CCCTTCTACG ATCCGGACAC CAGCATCATC 
TACTTATGTG GGAAGGGTGA CAGCAGTATC CGCTATTTTG AGATCACGGA TGAATCCCCA 
TATGTCCACT ACCTCAACAC ATTCAGCAGC AAGGAGCCTC AGCGAGGGAT GGGCTACATG 
CCCAAGCGGG GCCTTGACGT CAACAAGTGT GAAATTGCCA GATTCTTCAA GCTTCATGAG 
AGAAAGTGCG AGCCCATTAT CATGACGGTC CCCAGGAAGT CTGACCTCTT CCAAGACGAC 
CTGTACCCTG ACACGGCAGG GCCGGAAGCC GCCCTTGAGG CCGAGGAGTG GTTTGAGGGG 
AAGAACGCGG ACCCCATCCT CATATCGTTG AAGCACGGGT ACATTCCAGG CAAGAACAGG 
GACCTCAAGG TGGTCAAGAA GAACATCCTG GACAGCAAGC CGGCTGCAAA CAAGAAGAGC 
GAGCTCAGCT GTGCCCCCAA GAAGCCCACA GACACGGCCA GTGTGCAAAA CGAAGCCAAG 
TTGGATGAGA TTCTGAAAGA GATCAAATCC ATAAAGGAAA CAATCTGCAG TCAAGACGAG 
CGCATTTCCA AGTTGGAGCA GCAGCTGGCG AAGATGGCTG CCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_035909.2
CDS	102..1526
Translation	MRRVVRQSKFRHVFGQAVKNDQCYDDIRVSRVTWDSSFCAVNPRFVAIIIEASGGGAFLVLPLHKTGRIDKSYPTVCGHTGPVLDIDWCPHNDQVIASGSEDCTVMVWQIPENGLTLSLTEPVVILEGHSKRVGIVAWHPTARNVLLSAGCDNAIIIWNVGTGEALINLDDMHSDMIYNVSWSRNGSLICTASKDKKVRVIDPRKQEIVAEKEKAHEGARPMRAIFLADGNVFTTGFSRMSERQLALWNPKNMQEPIALHEMDTSNGVLLPFYDPDTSIIYLCGKGDSSIRYFEITDESPYVHYLNTFSSKEPQRGMGYMPKRGLDVNKCEIARFFKLHERKCEPIIMTVPRKSDLFQDDLYPDTAGPEAALEAEEWFEGKNADPILISLKHGYIPGKNRDLKVVKKNILDSKPAANKKSELSCAPKKPTDTASVQNEAKLDEILKEIKSIKETICSQDERISKLEQQLAKMAA

Target ORF information:

RefSeq Version	NM_011779.3
Organism	Mus musculus(house mouse)
Definition	Mus musculus coronin, actin binding protein 1C (Coro1c), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_011779.3

ORF Insert Sequence:

ATGCGGCGAG TGGTGCGGCA GAGCAAGTTC CGCCACGTCT TTGGACAGGC GGTGAAGAAT 
GACCAGTGCT ATGACGACAT CCGTGTCTCC CGAGTCACCT GGGACAGTTC CTTTTGTGCC 
GTCAACCCCA GATTCGTGGC CATCATCATA GAAGCGAGTG GGGGAGGGGC CTTCCTGGTG 
CTCCCTCTGC ACAAGACGGG ACGAATTGAC AAATCCTACC CTACAGTGTG TGGCCACACA 
GGACCAGTGC TGGACATAGA CTGGTGTCCA CATAATGACC AGGTCATTGC CAGCGGCTCA 
GAGGACTGCA CTGTTATGGT TTGGCAGATC CCGGAAAATG GACTCACCCT TTCCCTGACC 
GAGCCTGTGG TGATTCTAGA AGGGCACTCA AAAAGAGTTG GCATCGTGGC CTGGCACCCG 
ACGGCCCGCA ATGTGCTTCT CAGTGCAGGC TGTGATAATG CCATTATCAT CTGGAACGTG 
GGGACAGGGG AAGCCCTCAT CAACTTGGAC GATATGCATT CAGACATGAT TTACAATGTG 
AGCTGGAGCC GTAACGGTAG TCTCATCTGC ACCGCATCCA AAGACAAGAA AGTGAGAGTC 
ATTGACCCCA GGAAACAGGA GATTGTGGCG GAGAAGGAGA AAGCACACGA AGGAGCCAGG 
CCTATGCGTG CCATCTTCCT GGCGGACGGC AACGTCTTCA CTACTGGCTT TAGCCGCATG 
AGCGAGCGGC AGTTGGCGCT CTGGAACCCA AAAAACATGC AGGAACCAAT TGCTCTCCAT 
GAAATGGACA CTAGCAATGG GGTGCTGCTC CCCTTCTACG ATCCGGACAC CAGCATCATC 
TACTTATGTG GGAAGGGTGA CAGCAGTATC CGCTATTTTG AGATCACGGA TGAATCCCCA 
TATGTCCACT ACCTCAACAC ATTCAGCAGC AAGGAGCCTC AGCGAGGGAT GGGCTACATG 
CCCAAGCGGG GCCTTGACGT CAACAAGTGT GAAATTGCCA GATTCTTCAA GCTTCATGAG 
AGAAAGTGCG AGCCCATTAT CATGACGGTC CCCAGGAAGT CTGACCTCTT CCAAGACGAC 
CTGTACCCTG ACACGGCAGG GCCGGAAGCC GCCCTTGAGG CCGAGGAGTG GTTTGAGGGG 
AAGAACGCGG ACCCCATCCT CATATCGTTG AAGCACGGGT ACATTCCAGG CAAGAACAGG 
GACCTCAAGG TGGTCAAGAA GAACATCCTG GACAGCAAGC CGGCTGCAAA CAAGAAGAGC 
GAGCTCAGCT GTGCCCCCAA GAAGCCCACA GACACGGCCA GTGTGCAAAA CGAAGCCAAG 
TTGGATGAGA TTCTGAAAGA GATCAAATCC ATAAAGGAAA CAATCTGCAG TCAAGACGAG 
CGCATTTCCA AGTTGGAGCA GCAGCTGGCG AAGATGGCTG CCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

WD40-repeat 47, a microtubule-associated protein, is essential for brain development and autophagy.
Proceedings of the National Academy of Sciences of the United States of America114(44)E9308-E9317(2017 Oct)
Kannan M,Bayam E,Wagner C,Rinaldi B,Kretz PF,Tilly P,Roos M,McGillewie L,B?r S,Minocha S,Chevalier C,Po C,,Chelly J,Mandel JL,Borgatti R,Piton A,Kinnear C,Loos B,Adams DJ,H?rault Y,Collins SC,Friant S,Godin JD,Yalcin B

Coronin 1C-free primary mouse fibroblasts exhibit robust rearrangements in the orientation of actin filaments, microtubules and intermediate filaments.
European journal of cell biology95(8)239-51(2016 Aug)
Behrens J,Solga R,Ziemann A,Rastetter RH,Berwanger C,Herrmann H,Noegel AA,Clemen CS

Coronin-1C Protein and Caveolin Protein Provide Constitutive and Inducible Mechanisms of Rac1 Protein Trafficking.
The Journal of biological chemistry290(25)15437-49(2015 Jun)
Williamson RC,Cowell CA,Reville T,Roper JA,Rendall TC,Bass MD

Coronin-1C and RCC2 guide mesenchymal migration by trafficking Rac1 and controlling GEF exposure.
Journal of cell science127(Pt 19)4292-307(2014 Oct)
Williamson RC,Cowell CA,Hammond CL,Bergen DJ,Roper JA,Feng Y,Rendall TC,Race PR,Bass MD

Coronin-1 is a neurotrophin endosomal effector that is required for developmental competition for survival.
Nature neuroscience17(1)36-45(2014 Jan)
Suo D,Park J,Harrington AW,Zweifel LS,Mihalas S,Deppmann CD