Rab40c cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Rab40c
Entrez Gene ID	224624
Full Name	Rab40C, member RAS oncogene family
Synonyms	RAR3
General protein information	Preferred Names Rab40C, member RAS oncogene family Names ras-related protein Rab-40C RAR (RAS like GTPASE) like SOCS box containing protein RAR3
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 17 Map Location: 17\|17 A3.3

mRNA and Protein(s)

mRNA	Protein	Name
NM_139154.2	NP_631893.1	ras-related protein Rab-40C

Pathways from BioSystems

Homologies

Rattus norvegicus (Norway rat)	Rab40c	NP_872616.1
Pan troglodytes (chimpanzee)	RAB40C	XP_003314936.1
Canis lupus familiaris (dog)	RAB40C	XP_005622162.1
Bos taurus (cattle)	RAB40C	NP_001075014.1
Mus musculus (house mouse)	Rab40c	NP_631893.1
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP000841	XP_316810.5
Gallus gallus (chicken)	RAB40C	NP_001166133.1
Drosophila melanogaster (fruit fly)	Rab40	NP_727611.1
Homo sapiens (human)	RAB40C	NP_066991.3
Xenopus tropicalis (tropical clawed frog)	rab40c	XP_004918048.1
Danio rerio (zebrafish)	rab40c	NP_001035438.1

Gene Ontology
Bibliography

Related articles in PubMed

High-throughput discovery of novel developmental phenotypes.
Dickinson ME, Flenniken AM, Ji X, Teboul L, Wong MD, White JK, Meehan TF, Weninger WJ, Westerberg H, Adissu H, Baker CN, Bower L, Brown JM, Caddle LB, Chiani F, Clary D, Cleak J, Daly MJ, Denegre JM, Doe B, Dolan ME, Edie SM, Fuchs H, Gailus-Durner V, Galli A, Gambadoro A, Gallegos J, Guo S, Horner NR, Hsu CW, Johnson SJ, Kalaga S, Keith LC, Lanoue L, Lawson TN, Lek M, Mark M, Marschall S, Mason J, McElwee ML, Newbigging S, Nutter LM, Peterson KA, Ramirez-Solis R, Rowland DJ, Ryder E, Samocha KE, Seavitt JR, Selloum M, Szoke-Kovacs Z, Tamura M, Trainor AG, Tudose I, Wakana S, Warren J, Wendling O, West DB, Wong L, Yoshiki A, , , , , , , , , MacArthur DG, Tocchini-Valentini GP, Gao X, Flicek P, Bradley A, Skarnes WC, Justice MJ, Parkinson HE, Moore M, Wells S, Braun RE, Svenson KL, de Angelis MH, Herault Y, Mohun T, Mallon AM, Henkelman RM, Brown SD, Adams DJ, Lloyd KC, McKerlie C, Beaudet AL, Bu?an M, Murray SA
Nature537(7621)508-514(2016 09)

Rab40C is a novel Varp-binding protein that promotes proteasomal degradation of Varp in melanocytes.
Yatsu A, Shimada H, Ohbayashi N, Fukuda M
Biology open4(3)267-75(2015 Feb)

The International Mouse Phenotyping Consortium Web Portal, a unified point of access for knockout mice and related phenotyping data.
Koscielny G, Yaikhom G, Iyer V, Meehan TF, Morgan H, Atienza-Herrero J, Blake A, Chen CK, Easty R, Di Fenza A, Fiegel T, Grifiths M, Horne A, Karp NA, Kurbatova N, Mason JC, Matthews P, Oakley DJ, Qazi A, Regnart J, Retha A, Santos LA, Sneddon DJ, Warren J, Westerberg H, Wilson RJ, Melvin DG, Smedley D, Brown SD, Flicek P, Skarnes WC, Mallon AM, Parkinson H
Nucleic acids research42(Database issue)D802-9(2014 Jan)

Small GTPase Rab40c associates with lipid droplets and modulates the biogenesis of lipid droplets.
Tan R, Wang W, Wang S, Wang Z, Sun L, He W, Fan R, Zhou Y, Xu X, Hong W, Wang T
PloS one8(4)e63213(2013)

Screening for target Rabs of TBC (Tre-2/Bub2/Cdc16) domain-containing proteins based on their Rab-binding activity.
Itoh T, Satoh M, Kanno E, Fukuda M
Genes to cells : devoted to molecular & cellular mechanisms11(9)1023-37(2006 Sep)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Stimulation for adipocyte differentiation increases the expression of Rab40c in 3T3-L1 cells.
Title: Small GTPase Rab40c associates with lipid droplets and modulates the biogenesis of lipid droplets.

The following Rab40c gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Rab40c cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OMu18480	NM_139154.2 Latest version!	Mus musculus Rab40C, member RAS oncogene family (Rab40c), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	Quote Price

ORF Online Only Promotion

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Rab40c ( NM_139154.2 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_631893.1 Mus musculus Rab40C, member RAS oncogene family (Rab40c), mRNA.

Price & Availability↑

CloneID	OMu18480
Clone ID Related Accession (Same CDS sequence)	NM_139154.2
Accession Version	NM_139154.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 846bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-10-18
Organism	Mus musculus(house mouse)
Product	ras-related protein Rab-40C
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AC159277.3. On Aug 21, 2009 this sequence version replaced NM_139154.1. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. ##Evidence-Data-START## Transcript exon combination :: BC027008.1, SRR1660815.60261.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849380, SAMN01164131 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGGCACCC AGGGCAGTCC AGTGAAGAGC TACGATTACC TGCTCAAGTT CCTGCTGGTG 
GGCGACAGCG ACGTGGGCAA AGGCGAGATC CTGGAGAGCC TTCAGGACGG CGCAGCTGAA 
TCCCCGTACG CCTACAGCAA CGGGATAGAC TATAAGACTA CCACCATCCT CCTGGATGGA 
CGGCGTGTCA AGCTGGAGCT ATGGGACACA TCGGGCCAGG GAAGGTTCTG TACCATCTTC 
AGGTCCTACT CAAGGGGTGC ACAGGGAATC CTTCTGGTGT ACGACATCAC CAACCGTTGG 
TCCTTTGATG GCATTGACCG GTGGATCAAG GAGATCGATG AGCATGCACC TGGTGTTCCC 
CGGATCCTGG TTGGGAACCG GCTGCACCTG GCCTTCAAGC GGCAAGTTCC AACGGAGCAG 
GCCAGAGCCT ATGCAGAGAA GAACTGCATG ACCTTCTTTG AAGTCAGCCC CCTGTGCAAC 
TTCAACGTCA TTGAGTCCTT CACTGAGCTC TCCCGTATCG TGCTCATGCG GCATGGCATG 
GAGAAGATCT GGAGACCCAA TCGAGTTTTC AGCCTGCAGG ACCTCTGCTG CCGTGCCATT 
GTCTCCTGTA CCCCTGTGCA CCTCATCGAC AAGCTCCCAC TACCTGTCAC CATCAAAAGC 
CACCTCAAGT CCTTTTCCAT GGCCAACGGC ATGAACGCTG TCATGATGCA CGGCCGCTCC 
TACTCCCTGG CAAGTGGGGC CGGGGGCAGT GGCAGCAAGG GCAACAGCCT TAAGAGGTCT 
AAGTCCATCC GGCCCCCTCA GAGCCCACCT CAGAACTGCT CTCGGAGCAA CTGCAAGATC 
TCCTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_631893.1
CDS	107..952
Translation	MGTQGSPVKSYDYLLKFLLVGDSDVGKGEILESLQDGAAESPYAYSNGIDYKTTTILLDGRRVKLELWDTSGQGRFCTIFRSYSRGAQGILLVYDITNRWSFDGIDRWIKEIDEHAPGVPRILVGNRLHLAFKRQVPTEQARAYAEKNCMTFFEVSPLCNFNVIESFTELSRIVLMRHGMEKIWRPNRVFSLQDLCCRAIVSCTPVHLIDKLPLPVTIKSHLKSFSMANGMNAVMMHGRSYSLASGAGGSGSKGNSLKRSKSIRPPQSPPQNCSRSNCKIS

Target ORF information:

RefSeq Version	NM_139154.2
Organism	Mus musculus(house mouse)
Definition	Mus musculus Rab40C, member RAS oncogene family (Rab40c), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_139154.2

ORF Insert Sequence:

ATGGGCACCC AGGGCAGTCC AGTGAAGAGC TACGATTACC TGCTCAAGTT CCTGCTGGTG 
GGCGACAGCG ACGTGGGCAA AGGCGAGATC CTGGAGAGCC TTCAGGACGG CGCAGCTGAA 
TCCCCGTACG CCTACAGCAA CGGGATAGAC TATAAGACTA CCACCATCCT CCTGGATGGA 
CGGCGTGTCA AGCTGGAGCT ATGGGACACA TCGGGCCAGG GAAGGTTCTG TACCATCTTC 
AGGTCCTACT CAAGGGGTGC ACAGGGAATC CTTCTGGTGT ACGACATCAC CAACCGTTGG 
TCCTTTGATG GCATTGACCG GTGGATCAAG GAGATCGATG AGCATGCACC TGGTGTTCCC 
CGGATCCTGG TTGGGAACCG GCTGCACCTG GCCTTCAAGC GGCAAGTTCC AACGGAGCAG 
GCCAGAGCCT ATGCAGAGAA GAACTGCATG ACCTTCTTTG AAGTCAGCCC CCTGTGCAAC 
TTCAACGTCA TTGAGTCCTT CACTGAGCTC TCCCGTATCG TGCTCATGCG GCATGGCATG 
GAGAAGATCT GGAGACCCAA TCGAGTTTTC AGCCTGCAGG ACCTCTGCTG CCGTGCCATT 
GTCTCCTGTA CCCCTGTGCA CCTCATCGAC AAGCTCCCAC TACCTGTCAC CATCAAAAGC 
CACCTCAAGT CCTTTTCCAT GGCCAACGGC ATGAACGCTG TCATGATGCA CGGCCGCTCC 
TACTCCCTGG CAAGTGGGGC CGGGGGCAGT GGCAGCAAGG GCAACAGCCT TAAGAGGTCT 
AAGTCCATCC GGCCCCCTCA GAGCCCACCT CAGAACTGCT CTCGGAGCAA CTGCAAGATC 
TCCTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

High-throughput discovery of novel developmental phenotypes.
Nature537(7621)508-514(2016 09)
Dickinson ME,Flenniken AM,Ji X,Teboul L,Wong MD,White JK,Meehan TF,Weninger WJ,Westerberg H,Adissu H,Baker CN,Bower L,Brown JM,Caddle LB,Chiani F,Clary D,Cleak J,Daly MJ,Denegre JM,Doe B,Dolan ME,Edie SM,Fuchs H,Gailus-Durner V,Galli A,Gambadoro A,Gallegos J,Guo S,Horner NR,Hsu CW,Johnson SJ,Kalaga S,Keith LC,Lanoue L,Lawson TN,Lek M,Mark M,Marschall S,Mason J,McElwee ML,Newbigging S,Nutter LM,Peterson KA,Ramirez-Solis R,Rowland DJ,Ryder E,Samocha KE,Seavitt JR,Selloum M,Szoke-Kovacs Z,Tamura M,Trainor AG,Tudose I,Wakana S,Warren J,Wendling O,West DB,Wong L,Yoshiki A,,,,,,,,,MacArthur DG,Tocchini-Valentini GP,Gao X,Flicek P,Bradley A,Skarnes WC,Justice MJ,Parkinson HE,Moore M,Wells S,Braun RE,Svenson KL,de Angelis MH,Herault Y,Mohun T,Mallon AM,Henkelman RM,Brown SD,Adams DJ,Lloyd KC,McKerlie C,Beaudet AL,Bu?an M,Murray SA

Rab40C is a novel Varp-binding protein that promotes proteasomal degradation of Varp in melanocytes.
Biology open4(3)267-75(2015 Feb)
Yatsu A,Shimada H,Ohbayashi N,Fukuda M

The International Mouse Phenotyping Consortium Web Portal, a unified point of access for knockout mice and related phenotyping data.
Nucleic acids research42(Database issue)D802-9(2014 Jan)
Koscielny G,Yaikhom G,Iyer V,Meehan TF,Morgan H,Atienza-Herrero J,Blake A,Chen CK,Easty R,Di Fenza A,Fiegel T,Grifiths M,Horne A,Karp NA,Kurbatova N,Mason JC,Matthews P,Oakley DJ,Qazi A,Regnart J,Retha A,Santos LA,Sneddon DJ,Warren J,Westerberg H,Wilson RJ,Melvin DG,Smedley D,Brown SD,Flicek P,Skarnes WC,Mallon AM,Parkinson H

Small GTPase Rab40c associates with lipid droplets and modulates the biogenesis of lipid droplets.
PloS one8(4)e63213(2013)
Tan R,Wang W,Wang S,Wang Z,Sun L,He W,Fan R,Zhou Y,Xu X,Hong W,Wang T

Screening for target Rabs of TBC (Tre-2/Bub2/Cdc16) domain-containing proteins based on their Rab-binding activity.
Genes to cells : devoted to molecular & cellular mechanisms11(9)1023-37(2006 Sep)
Itoh T,Satoh M,Kanno E,Fukuda M