Padi3 cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Padi3
Entrez Gene ID	18601
Full Name	peptidyl arginine deiminase, type III
Synonyms	AI507004,Pad3,Pdi3,mKIAA4171
General protein information	Preferred Names peptidyl arginine deiminase, type III Names protein-arginine deiminase type-3 PAD type III PROTEIN-ARGININE DEIMINASE TYPE III (PEPTIDYLARGININE DEIMINASE III) peptidylarginine deiminase III
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 4 Map Location: 4 D3\|4 72.5 cM

mRNA and Protein(s)

mRNA	Protein	Name
NM_011060.4	NP_035190.3	protein-arginine deiminase type-3

Pathways from BioSystems

Homologies

	PADI3	XP_001089024.1
Bos taurus (cattle)	PADI3	XP_003585850.2
Mus musculus (house mouse)	Padi3	NP_035190.3
Gallus gallus (chicken)	PADI3	NP_990374.1
Homo sapiens (human)	PADI3	NP_057317.2
Pan troglodytes (chimpanzee)	PADI3	XP_524563.1
Canis lupus familiaris (dog)	PADI3	XP_535391.2
Rattus norvegicus (Norway rat)	Padi3	NP_058926.1

Gene Ontology
Bibliography

Related articles in PubMed

Peptidylarginine deiminase 1-catalyzed histone citrullination is essential for early embryo development.
Zhang X, Liu X, Zhang M, Li T, Muth A, Thompson PR, Coonrod SA, Zhang X
Scientific reports638727(2016 Dec)

Mutations in Three Genes Encoding Proteins Involved in Hair Shaft Formation Cause Uncombable Hair Syndrome.
? Basmanav FB, Cau L, Tafazzoli A, M?chin MC, Wolf S, Romano MT, Valentin F, Wiegmann H, Huchenq A, Kandil R, Garcia Bartels N, Kilic A, George S, Ralser DJ, Bergner S, Ferguson DJP, Oprisoreanu AM, Wehner M, Thiele H, Altm?ller J, N?rnberg P, Swan D, Houniet D, B?chner A, Weibel L, Wagner N, Grimalt R, Bygum A, Serre G, Blume-Peytavi U, Sprecher E, Schoch S, Oji V, Hamm H, Farrant P, Simon M, Betz RC
American journal of human genetics99(6)1292-1304(2016 Dec)

Comparative analysis of the mouse and human peptidylarginine deiminase gene clusters reveals highly conserved non-coding segments and a new human gene, PADI6.
Chavanas S, M?chin MC, Takahara H, Kawada A, Nachat R, Serre G, Simon M
Gene33019-27(2004 Apr)

Human peptidylarginine deiminase type III: molecular cloning and nucleotide sequence of the cDNA, properties of the recombinant enzyme, and immunohistochemical localization in human skin.
Kanno T, Kawada A, Yamanouchi J, Yosida-Noro C, Yoshiki A, Shiraiwa M, Kusakabe M, Manabe M, Tezuka T, Takahara H
The Journal of investigative dermatology115(5)813-23(2000 Nov)

Molecular cloning of cDNAs of mouse peptidylarginine deiminase type I, type III and type IV, and the expression pattern of type I in mouse.
Rus'd AA, Ikejiri Y, Ono H, Yonekawa T, Shiraiwa M, Kawada A, Takahara H
European journal of biochemistry259(3)660-9(1999 Feb)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The two enzymes PADI3 and TGM3, responsible for posttranslational protein modifications, and their target structural protein TCHH are all involved in hair shaft formation.
Title: Mutations in Three Genes Encoding Proteins Involved in Hair Shaft Formation Cause Uncombable Hair Syndrome.

The following Padi3 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Padi3 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OMu07395	NM_011060.4 Latest version!	Mus musculus peptidyl arginine deiminase, type III (Padi3), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$307.30 $439.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Padi3 ( NM_011060.4 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_035190.3 Mus musculus peptidyl arginine deiminase, type III (Padi3), mRNA.

Price & Availability↑

CloneID	OMu07395
Clone ID Related Accession (Same CDS sequence)	NM_011060.4
Accession Version	NM_011060.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1995bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-09-20
Organism	Mus musculus(house mouse)
Product	protein-arginine deiminase type-3
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AB013849.1, AL807805.7 and AK220522.1. On Sep 6, 2007 this sequence version replaced NM_011060.3. ##Evidence-Data-START## Transcript exon combination :: AB013849.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849383, SAMN01164133 [ECO:0000348] ##Evidence-Data-END##

ATGTCTCTAC AGAGGATTGT GCGTGTGTCT CTGGAGCACC CCACCAGCGC TGTGTGTGTG 
GCAGGGGTTG AGACCATCGT GGACATTTAT GGGGCGGTTC CTGAGGGCAC AGACATGTTT 
GAGGTCTACG GGACACCGGG AGTGGACATC TATGTGTCTC CCAGCATGGA GAGGAGCCGA 
GAGCGAGCTG ACACCAGGCG GTGGTGCTTC AACAAGGGCC TGGAGATTAT TGTAATCATG 
AACTCCCCTA GCAATGACCT CAACGACAGC CATGTTCAGA TAGCCTACCA CTCCAGCCGA 
GAGCATTTGC CCCTGGCCTA TGCAGTACTC TACCTCACCT GTGTGGACAT CACCCTAGAC 
TGTGACATGA ACTGTGCGGA CCGGCAGGAC AGGAGCTTCG TGGATAAGAG GCAGTGGGTG 
TGGGGGCCTG ATGGGTACGG AGCCATCTTG CTGGTGAACT GTGATCGGGA CAATGTCGAC 
TCTAATGCCC AAGATAACTG TGACCAATAT GTGCGTTGCC TGCAAGATCT GGAAGACATG 
TCCGTCATGG TCCTACGGAC CCAGGGCCCC GAAGCCCTCT TTGAGGACCA CAGGCTTATC 
CTCCACACCT CCAGCTGTGA TGCAGAGCGG GCACGGGTCT TCCATGTCTG CGGCCCCGAG 
GATTCCTGTG AGTCCTATAA GTGTGTTCTG GGCCCAGACA GGATGTCCTA TGAGGTGCCC 
CGCCTGAAGG GCTATGAGGA GCGCTTCTTC GTGGAGGGCC TCTCCTTCCC GGATGCAGGC 
TTCCCAGGGC TCATTTCCTT CCATGTCACT CTGCTGGATG ATTCTAATGA GGACTTCTCC 
GAGACCCCCA TCTTCACCGA CACAGCAGTG TTCCGGGTGG CCCCCTGGAT CATGACACCC 
AGCACCCTGC CACCCCTAGA GGTGTACGTG TGCCGGGTGA GGAATAACAC CTGCTTTGTG 
GAAGCCGTGG AGGAGCTGGC TAGGAAGGCG GGCTGCAAAC TCACCATCTG TCCTCAGGCA 
GAGAACCGGA ACGACCGCTG GATCCAGGAT GAGATGGAGC TGGGGTATGT GCAGGCGCCA 
CACAAGACCT TGCCGGTGGT CTTCGATTCT CCGAGGAACG GAGAGCTGCA GGGCTTCCCT 
TACAAAAGGA TCCTGGGTCT AGATTTCGGC TATGTGACAC GGGAACCTAA AGACAGTTCT 
GTGAGTGGTC TGGACTCTTT TGGCAACCTG GAGGTCAGCC CACCCGTGGT GGCCAATGGG 
AAGGAGTATC CCTTGGGGAG AATCCTCATC GGGGGCAACC TGCCTGGGTC GAGAGGCCGC 
AGAGTGACCC AGGTGGTGCG AAACTTCCTC CATGCCCAGA AAGTGCAACC TCTGGTGGAG 
CTGTTTGTGG ACTGGCTGGC TGTGGGCCAC GTGGATGAGT TCCTGAGCTT CGTCCCTGCA 
CCCGACGGGA AGGGCTTCCG GCTCCTCCTG GCCAGCCCTG GCGCCTGCTT CAGGCTATTC 
CAGGAAAAGC AGAAGTGGGG CCATGGCCGG TCCCTGCTTT TCGAGGGTGT CATTGGCGAC 
AGGCGGGTCC AGACCGTCTC CATCAATCAG ATTCTTAACA ACCAGAGCCT TATCAACTTT 
AATAAGTTTG CACAGAGCTG TATCGACTGG AACCGCGAGG TACTGAAGCG GGAGCTGGGC 
CTGGCGGAGG GTGACATCAT CGACATCCCG CAGCTCTTCA AGACGGAGAA GAGGAAGGCA 
GTAGCGTTCT TCCCCGACTT GGTGAATATG CTGGTCCTGG GCAAGCACCT GGGCATCCCC 
AAGCCCTTCG GGCCCATCAT CAATGGTCGC TGCTGCCTGG AGGAGAAGGT GCGCTCCCTG 
CTGGAGCCGC TGGGTCTGCA CTGCACCTTC ATCGATGACT TCACGCCATA CCACATGCTG 
CACGGGGAGG TTCACTGTGG CACCAACGTG CGCCGGGAGC CCTTCGCCTT CAAGTGGTGG 
CACATGGTGC CCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_035190.3
CDS	42..2036
Translation	MSLQRIVRVSLEHPTSAVCVAGVETIVDIYGAVPEGTDMFEVYGTPGVDIYVSPSMERSRERADTRRWCFNKGLEIIVIMNSPSNDLNDSHVQIAYHSSREHLPLAYAVLYLTCVDITLDCDMNCADRQDRSFVDKRQWVWGPDGYGAILLVNCDRDNVDSNAQDNCDQYVRCLQDLEDMSVMVLRTQGPEALFEDHRLILHTSSCDAERARVFHVCGPEDSCESYKCVLGPDRMSYEVPRLKGYEERFFVEGLSFPDAGFPGLISFHVTLLDDSNEDFSETPIFTDTAVFRVAPWIMTPSTLPPLEVYVCRVRNNTCFVEAVEELARKAGCKLTICPQAENRNDRWIQDEMELGYVQAPHKTLPVVFDSPRNGELQGFPYKRILGLDFGYVTREPKDSSVSGLDSFGNLEVSPPVVANGKEYPLGRILIGGNLPGSRGRRVTQVVRNFLHAQKVQPLVELFVDWLAVGHVDEFLSFVPAPDGKGFRLLLASPGACFRLFQEKQKWGHGRSLLFEGVIGDRRVQTVSINQILNNQSLINFNKFAQSCIDWNREVLKRELGLAEGDIIDIPQLFKTEKRKAVAFFPDLVNMLVLGKHLGIPKPFGPIINGRCCLEEKVRSLLEPLGLHCTFIDDFTPYHMLHGEVHCGTNVRREPFAFKWWHMVP

Target ORF information:

RefSeq Version	NM_011060.4
Organism	Mus musculus(house mouse)
Definition	Mus musculus peptidyl arginine deiminase, type III (Padi3), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_011060.4

ORF Insert Sequence:

ATGTCTCTAC AGAGGATTGT GCGTGTGTCT CTGGAGCACC CCACCAGCGC TGTGTGTGTG 
GCAGGGGTTG AGACCATCGT GGACATTTAT GGGGCGGTTC CTGAGGGCAC AGACATGTTT 
GAGGTCTACG GGACACCGGG AGTGGACATC TATGTGTCTC CCAGCATGGA GAGGAGCCGA 
GAGCGAGCTG ACACCAGGCG GTGGTGCTTC AACAAGGGCC TGGAGATTAT TGTAATCATG 
AACTCCCCTA GCAATGACCT CAACGACAGC CATGTTCAGA TAGCCTACCA CTCCAGCCGA 
GAGCATTTGC CCCTGGCCTA TGCAGTACTC TACCTCACCT GTGTGGACAT CACCCTAGAC 
TGTGACATGA ACTGTGCGGA CCGGCAGGAC AGGAGCTTCG TGGATAAGAG GCAGTGGGTG 
TGGGGGCCTG ATGGGTACGG AGCCATCTTG CTGGTGAACT GTGATCGGGA CAATGTCGAC 
TCTAATGCCC AAGATAACTG TGACCAATAT GTGCGTTGCC TGCAAGATCT GGAAGACATG 
TCCGTCATGG TCCTACGGAC CCAGGGCCCC GAAGCCCTCT TTGAGGACCA CAGGCTTATC 
CTCCACACCT CCAGCTGTGA TGCAGAGCGG GCACGGGTCT TCCATGTCTG CGGCCCCGAG 
GATTCCTGTG AGTCCTATAA GTGTGTTCTG GGCCCAGACA GGATGTCCTA TGAGGTGCCC 
CGCCTGAAGG GCTATGAGGA GCGCTTCTTC GTGGAGGGCC TCTCCTTCCC GGATGCAGGC 
TTCCCAGGGC TCATTTCCTT CCATGTCACT CTGCTGGATG ATTCTAATGA GGACTTCTCC 
GAGACCCCCA TCTTCACCGA CACAGCAGTG TTCCGGGTGG CCCCCTGGAT CATGACACCC 
AGCACCCTGC CACCCCTAGA GGTGTACGTG TGCCGGGTGA GGAATAACAC CTGCTTTGTG 
GAAGCCGTGG AGGAGCTGGC TAGGAAGGCG GGCTGCAAAC TCACCATCTG TCCTCAGGCA 
GAGAACCGGA ACGACCGCTG GATCCAGGAT GAGATGGAGC TGGGGTATGT GCAGGCGCCA 
CACAAGACCT TGCCGGTGGT CTTCGATTCT CCGAGGAACG GAGAGCTGCA GGGCTTCCCT 
TACAAAAGGA TCCTGGGTCT AGATTTCGGC TATGTGACAC GGGAACCTAA AGACAGTTCT 
GTGAGTGGTC TGGACTCTTT TGGCAACCTG GAGGTCAGCC CACCCGTGGT GGCCAATGGG 
AAGGAGTATC CCTTGGGGAG AATCCTCATC GGGGGCAACC TGCCTGGGTC GAGAGGCCGC 
AGAGTGACCC AGGTGGTGCG AAACTTCCTC CATGCCCAGA AAGTGCAACC TCTGGTGGAG 
CTGTTTGTGG ACTGGCTGGC TGTGGGCCAC GTGGATGAGT TCCTGAGCTT CGTCCCTGCA 
CCCGACGGGA AGGGCTTCCG GCTCCTCCTG GCCAGCCCTG GCGCCTGCTT CAGGCTATTC 
CAGGAAAAGC AGAAGTGGGG CCATGGCCGG TCCCTGCTTT TCGAGGGTGT CATTGGCGAC 
AGGCGGGTCC AGACCGTCTC CATCAATCAG ATTCTTAACA ACCAGAGCCT TATCAACTTT 
AATAAGTTTG CACAGAGCTG TATCGACTGG AACCGCGAGG TACTGAAGCG GGAGCTGGGC 
CTGGCGGAGG GTGACATCAT CGACATCCCG CAGCTCTTCA AGACGGAGAA GAGGAAGGCA 
GTAGCGTTCT TCCCCGACTT GGTGAATATG CTGGTCCTGG GCAAGCACCT GGGCATCCCC 
AAGCCCTTCG GGCCCATCAT CAATGGTCGC TGCTGCCTGG AGGAGAAGGT GCGCTCCCTG 
CTGGAGCCGC TGGGTCTGCA CTGCACCTTC ATCGATGACT TCACGCCATA CCACATGCTG 
CACGGGGAGG TTCACTGTGG CACCAACGTG CGCCGGGAGC CCTTCGCCTT CAAGTGGTGG 
CACATGGTGC CCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Peptidylarginine deiminase 1-catalyzed histone citrullination is essential for early embryo development.
Scientific reports638727(2016 Dec)
Zhang X,Liu X,Zhang M,Li T,Muth A,Thompson PR,Coonrod SA,Zhang X

Mutations in Three Genes Encoding Proteins Involved in Hair Shaft Formation Cause Uncombable Hair Syndrome.
American journal of human genetics99(6)1292-1304(2016 Dec)
? Basmanav FB,Cau L,Tafazzoli A,M?chin MC,Wolf S,Romano MT,Valentin F,Wiegmann H,Huchenq A,Kandil R,Garcia Bartels N,Kilic A,George S,Ralser DJ,Bergner S,Ferguson DJP,Oprisoreanu AM,Wehner M,Thiele H,Altm?ller J,N?rnberg P,Swan D,Houniet D,B?chner A,Weibel L,Wagner N,Grimalt R,Bygum A,Serre G,Blume-Peytavi U,Sprecher E,Schoch S,Oji V,Hamm H,Farrant P,Simon M,Betz RC

Comparative analysis of the mouse and human peptidylarginine deiminase gene clusters reveals highly conserved non-coding segments and a new human gene, PADI6.
Gene33019-27(2004 Apr)
Chavanas S,M?chin MC,Takahara H,Kawada A,Nachat R,Serre G,Simon M

Human peptidylarginine deiminase type III: molecular cloning and nucleotide sequence of the cDNA, properties of the recombinant enzyme, and immunohistochemical localization in human skin.
The Journal of investigative dermatology115(5)813-23(2000 Nov)
Kanno T,Kawada A,Yamanouchi J,Yosida-Noro C,Yoshiki A,Shiraiwa M,Kusakabe M,Manabe M,Tezuka T,Takahara H

Molecular cloning of cDNAs of mouse peptidylarginine deiminase type I, type III and type IV, and the expression pattern of type I in mouse.
European journal of biochemistry259(3)660-9(1999 Feb)
Rus'd AA,Ikejiri Y,Ono H,Yonekawa T,Shiraiwa M,Kawada A,Takahara H