Mxd3 cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Mxd3
Entrez Gene ID	17121
Full Name	Max dimerization protein 3
Synonyms	4631412E13Rik,Mad3,bHLHc13
General protein information	Preferred Names Max dimerization protein 3 Names max dimerization protein 3 max dimerizer 3 max-associated protein 3
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 13 Map Location: 13 B1\|13 29.8 cM

mRNA and Protein(s)

mRNA	Protein	Name
NM_016662.4	NP_057871.2	max dimerization protein 3
NM_016662.5	NP_057871.2	max dimerization protein 3

Pathways from BioSystems

Homologies

Danio rerio (zebrafish)	mxd3	NP_957350.1
Pan troglodytes (chimpanzee)	MXD3	XP_003311040.1
Canis lupus familiaris (dog)	MXD3	XP_546209.2
Xenopus tropicalis (tropical clawed frog)	mxd3	NP_001017299.1
Homo sapiens (human)	MXD3	NP_112590.1
Mus musculus (house mouse)	Mxd3	NP_057871.2
Bos taurus (cattle)	MXD3	NP_001180188.1
Rattus norvegicus (Norway rat)	Mxd3	NP_665716.1

Gene Ontology
Bibliography

Related articles in PubMed

Downregulation of Max dimerization protein 3 is involved in decreased visceral adipose tissue by inhibiting adipocyte differentiation in zebrafish and mice.
Shimada Y, Kuroyanagi J, Zhang B, Ariyoshi M, Umemoto N, Nishimura Y, Tanaka T
International journal of obesity (2005)38(8)1053-60(2014 Aug)

A high-resolution spatiotemporal atlas of gene expression of the developing mouse brain.
Thompson CL, Ng L, Menon V, Martinez S, Lee CK, Glattfelder K, Sunkin SM, Henry A, Lau C, Dang C, Garcia-Lopez R, Martinez-Ferre A, Pombero A, Rubenstein JLR, Wakeman WB, Hohmann J, Dee N, Sodt AJ, Young R, Smith K, Nguyen TN, Kidney J, Kuan L, Jeromin A, Kaykas A, Miller J, Page D, Orta G, Bernard A, Riley Z, Smith S, Wohnoutka P, Hawrylycz MJ, Puelles L, Jones AR
Neuron83(2)309-323(2014 Jul)

Genes expressed in Atoh1 neuronal lineages arising from the r1/isthmus rhombic lip.
Machold R, Klein C, Fishell G
Gene expression patterns : GEP11(5-6)349-59(2011 Jun-Jul)

Mad3 negatively regulates B cell differentiation in the spleen by inducing Id2 expression.
Gore Y, Lantner F, Hart G, Shachar I
Molecular biology of the cell21(11)1864-71(2010 Jun)

Resolution of cell fate decisions revealed by single-cell gene expression analysis from zygote to blastocyst.
Guo G, Huss M, Tong GQ, Wang C, Li Sun L, Clarke ND, Robson P
Developmental cell18(4)675-85(2010 Apr)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Mxd3 regulates preadipocyte proliferation and early adipocyte differentiation via Cebpd downregulation in vitro and in vivo.
Title: Downregulation of Max dimerization protein 3 is involved in decreased visceral adipose tissue by inhibiting adipocyte differentiation in zebrafish and mice.

Results demonstrate that high expression levels of Mad3 in immature B cells induce Id2 expression, which inhibits transcription of genes essential for B cell differentiation.
Title: Mad3 negatively regulates B cell differentiation in the spleen by inducing Id2 expression.

Adenosine signaling mediates SUMO-1 modification of IkappaBalpha during hypoxia and reoxygenation.
Title: Adenosine signaling mediates SUMO-1 modification of IkappaBalpha during hypoxia and reoxygenation.

These studies support a novel role for Mad3 in cerebellar granule neuron precursors proliferation and possibly tumorigenesis.
Title: A novel role of the Mad family member Mad3 in cerebellar granule neuron precursor proliferation.

identification as a novel target for regulation by E2F1
Title: The transcriptional repressor gene Mad3 is a novel target for regulation by E2F1.

The following Mxd3 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Mxd3 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OMu10416	NM_016662.5 Latest version!	Mus musculus Max dimerization protein 3 (Mxd3), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$188.30 $269.00
View Old Accession Versions >>
OMu10416	NM_016662.4	Mus musculus Max dimerization protein 3 (Mxd3), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$188.30 $269.00
Hide Old Accession Versions >>

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Mxd3 ( NM_016662.4 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_057871.2 Mus musculus Max dimerization protein 3 (Mxd3), mRNA.

Price & Availability↑

CloneID	OMu10416
Clone ID Related Accession (Same CDS sequence)	NM_016662.4 , NM_016662.5
Accession Version	NM_016662.4	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 621bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2018-09-15
Organism	Mus musculus(house mouse)
Product	max dimerization protein 3
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from AK138742.1. On Apr 6, 2007 this sequence version replaced NM_016662.3. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK138742.1, BC051970.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMN00849374, SAMN00849375 [ECO:0000350] ##Evidence-Data-END##

ATGGAACCCG TGGCTAGCAA CATCCAGGTC CTGCTGCAGG CAGCGGAGTT CCTGGAGAGG 
CGCGAGAGAG AGGCAGAGCA CGGTTATGCG TCCCTGTGTC CACACCACAG CCCCGGGACC 
GTCTGCAGGA GGAGGAAGCC ACCCCTGCAA GCTCCTGGCG CGCTGAACAG TGGGCGGTCT 
GTGCACAACG AGCTGGAGAA GCGCAGGAGA GCCCAGCTGA AGCGGTGCTT AGAGCAACTG 
AGGCAGCAGA TGCCCCTGGG AGTTGACTGT ACCCGATACA CTACACTAAG CCTCCTGCGC 
CGGGCCAGGG TGCATATCCA GAAGCTGGAG GAGCAGGAGC AGCAAGCCCG GCGGCTCAAG 
GAAAAGCTTC GCAGCAAACA GCAGAGCCTG CAGCAGCAGC TGGAGCAGCT CCAGGGGCTG 
CCAGGAGCTA GGGAGCGAGA GCGGCTGAGG GCAGACAGCT TGGACTCTTC AGGCCTGTCC 
TCTGAGCGCT CAGACTCAGA CCAAGAGGAT CTGGAGGTGG ATGTGGAGAG CCTGGTGTTT 
GGGACTGAAA CAGAGCTCCT ACAGAGCTTC AGCGCTGGGC GGGAGCACAG CTACTCACAC 
AGCACCTGCG CCTGGCTATG A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_057871.2
CDS	64..684
Translation	MEPVASNIQVLLQAAEFLERREREAEHGYASLCPHHSPGTVCRRRKPPLQAPGALNSGRSVHNELEKRRRAQLKRCLEQLRQQMPLGVDCTRYTTLSLLRRARVHIQKLEEQEQQARRLKEKLRSKQQSLQQQLEQLQGLPGARERERLRADSLDSSGLSSERSDSDQEDLEVDVESLVFGTETELLQSFSAGREHSYSHSTCAWL

Target ORF information:

RefSeq Version	NM_016662.4
Organism	Mus musculus(house mouse)
Definition	Mus musculus Max dimerization protein 3 (Mxd3), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_016662.4

ORF Insert Sequence:

ATGGAACCCG TGGCTAGCAA CATCCAGGTC CTGCTGCAGG CAGCGGAGTT CCTGGAGAGG 
CGCGAGAGAG AGGCAGAGCA CGGTTATGCG TCCCTGTGTC CACACCACAG CCCCGGGACC 
GTCTGCAGGA GGAGGAAGCC ACCCCTGCAA GCTCCTGGCG CGCTGAACAG TGGGCGGTCT 
GTGCACAACG AGCTGGAGAA GCGCAGGAGA GCCCAGCTGA AGCGGTGCTT AGAGCAACTG 
AGGCAGCAGA TGCCCCTGGG AGTTGACTGT ACCCGATACA CTACACTAAG CCTCCTGCGC 
CGGGCCAGGG TGCATATCCA GAAGCTGGAG GAGCAGGAGC AGCAAGCCCG GCGGCTCAAG 
GAAAAGCTTC GCAGCAAACA GCAGAGCCTG CAGCAGCAGC TGGAGCAGCT CCAGGGGCTG 
CCAGGAGCTA GGGAGCGAGA GCGGCTGAGG GCAGACAGCT TGGACTCTTC AGGCCTGTCC 
TCTGAGCGCT CAGACTCAGA CCAAGAGGAT CTGGAGGTGG ATGTGGAGAG CCTGGTGTTT 
GGGACTGAAA CAGAGCTCCT ACAGAGCTTC AGCGCTGGGC GGGAGCACAG CTACTCACAC 
AGCACCTGCG CCTGGCTATG A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Mxd3 ( NM_016662.5 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_057871.2 Mus musculus Max dimerization protein 3 (Mxd3), mRNA.

Price & Availability↑

CloneID	OMu10416
Clone ID Related Accession (Same CDS sequence)	NM_016662.4 , NM_016662.5
Accession Version	NM_016662.5 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 621bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-09-26
Organism	Mus musculus(house mouse)
Product	max dimerization protein 3
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from BC051970.1 and AK138742.1. On Feb 5, 2019 this sequence version replaced NM_016662.4. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR7345562.1607320.1, AK138742.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMN00849374, SAMN00849375 [ECO:0000350] ##Evidence-Data-END##

ATGGAACCCG TGGCTAGCAA CATCCAGGTC CTGCTGCAGG CAGCGGAGTT CCTGGAGAGG 
CGCGAGAGAG AGGCAGAGCA CGGTTATGCG TCCCTGTGTC CACACCACAG CCCCGGGACC 
GTCTGCAGGA GGAGGAAGCC ACCCCTGCAA GCTCCTGGCG CGCTGAACAG TGGGCGGTCT 
GTGCACAACG AGCTGGAGAA GCGCAGGAGA GCCCAGCTGA AGCGGTGCTT AGAGCAACTG 
AGGCAGCAGA TGCCCCTGGG AGTTGACTGT ACCCGATACA CTACACTAAG CCTCCTGCGC 
CGGGCCAGGG TGCATATCCA GAAGCTGGAG GAGCAGGAGC AGCAAGCCCG GCGGCTCAAG 
GAAAAGCTTC GCAGCAAACA GCAGAGCCTG CAGCAGCAGC TGGAGCAGCT CCAGGGGCTG 
CCAGGAGCTA GGGAGCGAGA GCGGCTGAGG GCAGACAGCT TGGACTCTTC AGGCCTGTCC 
TCTGAGCGCT CAGACTCAGA CCAAGAGGAT CTGGAGGTGG ATGTGGAGAG CCTGGTGTTT 
GGGACTGAAA CAGAGCTCCT ACAGAGCTTC AGCGCTGGGC GGGAGCACAG CTACTCACAC 
AGCACCTGCG CCTGGCTATG A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_057871.2
CDS	65..685
Translation	MEPVASNIQVLLQAAEFLERREREAEHGYASLCPHHSPGTVCRRRKPPLQAPGALNSGRSVHNELEKRRRAQLKRCLEQLRQQMPLGVDCTRYTTLSLLRRARVHIQKLEEQEQQARRLKEKLRSKQQSLQQQLEQLQGLPGARERERLRADSLDSSGLSSERSDSDQEDLEVDVESLVFGTETELLQSFSAGREHSYSHSTCAWL

Target ORF information:

RefSeq Version	NM_016662.5
Organism	Mus musculus(house mouse)
Definition	Mus musculus Max dimerization protein 3 (Mxd3), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_016662.5

ORF Insert Sequence:

ATGGAACCCG TGGCTAGCAA CATCCAGGTC CTGCTGCAGG CAGCGGAGTT CCTGGAGAGG 
CGCGAGAGAG AGGCAGAGCA CGGTTATGCG TCCCTGTGTC CACACCACAG CCCCGGGACC 
GTCTGCAGGA GGAGGAAGCC ACCCCTGCAA GCTCCTGGCG CGCTGAACAG TGGGCGGTCT 
GTGCACAACG AGCTGGAGAA GCGCAGGAGA GCCCAGCTGA AGCGGTGCTT AGAGCAACTG 
AGGCAGCAGA TGCCCCTGGG AGTTGACTGT ACCCGATACA CTACACTAAG CCTCCTGCGC 
CGGGCCAGGG TGCATATCCA GAAGCTGGAG GAGCAGGAGC AGCAAGCCCG GCGGCTCAAG 
GAAAAGCTTC GCAGCAAACA GCAGAGCCTG CAGCAGCAGC TGGAGCAGCT CCAGGGGCTG 
CCAGGAGCTA GGGAGCGAGA GCGGCTGAGG GCAGACAGCT TGGACTCTTC AGGCCTGTCC 
TCTGAGCGCT CAGACTCAGA CCAAGAGGAT CTGGAGGTGG ATGTGGAGAG CCTGGTGTTT 
GGGACTGAAA CAGAGCTCCT ACAGAGCTTC AGCGCTGGGC GGGAGCACAG CTACTCACAC 
AGCACCTGCG CCTGGCTATG A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Downregulation of Max dimerization protein 3 is involved in decreased visceral adipose tissue by inhibiting adipocyte differentiation in zebrafish and mice.
International journal of obesity (2005)38(8)1053-60(2014 Aug)
Shimada Y,Kuroyanagi J,Zhang B,Ariyoshi M,Umemoto N,Nishimura Y,Tanaka T

A high-resolution spatiotemporal atlas of gene expression of the developing mouse brain.
Neuron83(2)309-323(2014 Jul)
Thompson CL,Ng L,Menon V,Martinez S,Lee CK,Glattfelder K,Sunkin SM,Henry A,Lau C,Dang C,Garcia-Lopez R,Martinez-Ferre A,Pombero A,Rubenstein JLR,Wakeman WB,Hohmann J,Dee N,Sodt AJ,Young R,Smith K,Nguyen TN,Kidney J,Kuan L,Jeromin A,Kaykas A,Miller J,Page D,Orta G,Bernard A,Riley Z,Smith S,Wohnoutka P,Hawrylycz MJ,Puelles L,Jones AR

Genes expressed in Atoh1 neuronal lineages arising from the r1/isthmus rhombic lip.
Gene expression patterns : GEP11(5-6)349-59(2011 Jun-Jul)
Machold R,Klein C,Fishell G

Mad3 negatively regulates B cell differentiation in the spleen by inducing Id2 expression.
Molecular biology of the cell21(11)1864-71(2010 Jun)
Gore Y,Lantner F,Hart G,Shachar I

Resolution of cell fate decisions revealed by single-cell gene expression analysis from zygote to blastocyst.
Developmental cell18(4)675-85(2010 Apr)
Guo G,Huss M,Tong GQ,Wang C,Li Sun L,Clarke ND,Robson P