Aplp1 cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Aplp1
Entrez Gene ID	11803
Full Name	amyloid beta (A4) precursor-like protein 1
General protein information	Preferred Names amyloid beta (A4) precursor-like protein 1 Names amyloid-like protein 1 APLP APLP-1
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 7 Map Location: 7 B1\|7 18.32 cM

mRNA and Protein(s)

mRNA	Protein	Name
XM_017321948.1	XP_017177437.1	amyloid-like protein 1 isoform X1
NM_007467.3	NP_031493.2	amyloid-like protein 1 precursor

Pathways from BioSystems

Homologies

Pan troglodytes (chimpanzee)	APLP1	XP_003316371.1
Xenopus tropicalis (tropical clawed frog)	aplp1	NP_001120906.1
Canis lupus familiaris (dog)	APLP1	XP_533688.4
Danio rerio (zebrafish)	aplp1	XP_001342921.4
Homo sapiens (human)	APLP1	NP_005157.1
Bos taurus (cattle)	APLP1	NP_001033184.1
Mus musculus (house mouse)	Aplp1	NP_031493.2
	APLP1	XP_001099423.1
Rattus norvegicus (Norway rat)	Aplp1	NP_001094272.1

Gene Ontology
Bibliography

Related articles in PubMed

APLP1 Is a Synaptic Cell Adhesion Molecule, Supporting Maintenance of Dendritic Spines and Basal Synaptic Transmission.
Schilling S, Mehr A, Ludewig S, Stephan J, Zimmermann M, August A, Strecker P, Korte M, Koo EH, M?ller UC, Kins S, Eggert S
The Journal of neuroscience : the official journal of the Society for Neuroscience37(21)5345-5365(2017 May)

Deletion of the amyloid precursor-like protein 1 (APLP1) enhances excitatory synaptic transmission, reduces network inhibition but does not impair synaptic plasticity in the mouse dentate gyrus.
Vnencak M, Paul MH, Hick M, Schwarzacher SW, Del Turco D, M?ller UC, Deller T, Jedlicka P
The Journal of comparative neurology523(11)1717-29(2015 Aug)

A high-resolution spatiotemporal atlas of gene expression of the developing mouse brain.
Thompson CL, Ng L, Menon V, Martinez S, Lee CK, Glattfelder K, Sunkin SM, Henry A, Lau C, Dang C, Garcia-Lopez R, Martinez-Ferre A, Pombero A, Rubenstein JLR, Wakeman WB, Hohmann J, Dee N, Sodt AJ, Young R, Smith K, Nguyen TN, Kidney J, Kuan L, Jeromin A, Kaykas A, Miller J, Page D, Orta G, Bernard A, Riley Z, Smith S, Wohnoutka P, Hawrylycz MJ, Puelles L, Jones AR
Neuron83(2)309-323(2014 Jul)

Differential role of APP and APLPs for neuromuscular synaptic morphology and function.
Klevanski M, Saar M, Baumk?tter F, Weyer SW, Kins S, M?ller UC
Molecular and cellular neurosciences61201-10(2014 Jul)

Amyloid precursor proteins are constituents of the presynaptic active zone.
La?ek M, Weingarten J, Einsfelder U, Brendel P, M?ller U, Volknandt W
Journal of neurochemistry127(1)48-56(2013 Oct)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

APLP1 exhibits synaptogenic activity, involving trans-synaptic dimerization. APLP1 knock-out mice show impaired basal transmission and a reduced mEPSC frequency.
Title: APLP1 Is a Synaptic Cell Adhesion Molecule, Supporting Maintenance of Dendritic Spines and Basal Synaptic Transmission.

Results suggest that APLP1 deficiency on its own does not lead to defects in synaptic plasticity, but affects synaptic transmission and network inhibition in the dentate gyrus
Title: Deletion of the amyloid precursor-like protein 1 (APLP1) enhances excitatory synaptic transmission, reduces network inhibition but does not impair synaptic plasticity in the mouse dentate gyrus.

[review] A role of APP and its two closely related homologues APLP1 and APLP2 has been determined in various aspects of nervous system development and function, in particular, for synapse formation and function.
Title: Functions of the APP gene family in the nervous system: insights from mouse models.

findings demonstrated that NB-2 interacts with APLP and that both NB-2 and APLP1 are localized at presynaptic sites, suggesting that NB-2 associates with APLP1 in a cis manner on the presynaptic membrane
Title: A cis-complex of NB-2/contactin-5 with amyloid precursor-like protein 1 is localized on the presynaptic membrane.

Crystal structure of the E2 domain of amyloid precursor protein-like protein 1 in complex with sucrose octasulfate.
Title: Crystal structure of the E2 domain of amyloid precursor protein-like protein 1 in complex with sucrose octasulfate.

The following Aplp1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Aplp1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OMu00225	NM_007467.3 Latest version!	Mus musculus amyloid beta (A4) precursor-like protein 1 (Aplp1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	TBD	$384.30 $549.00
OMu81905	XM_017321948.1 Latest version!	Mus musculus amyloid beta (A4) precursor-like protein 1 (Aplp1), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	TBD	$391.30 $559.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Aplp1 ( NM_007467.3 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_031493.2 Mus musculus amyloid beta (A4) precursor-like protein 1 (Aplp1), mRNA.

Price & Availability↑

CloneID	OMu00225
Clone ID Related Accession (Same CDS sequence)	NM_007467.3
Accession Version	NM_007467.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1965bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-08-01
Organism	Mus musculus(house mouse)
Product	amyloid-like protein 1 precursor
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AC149067.3, AK160871.1 and AI840595.1. On Mar 19, 2011 this sequence version replaced NM_007467.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC021877.1, SRR1660817.16167.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN01164131, SAMN01164132 [ECO:0000348] ##Evidence-Data-END##

ATGGGGCCCA CCAGCCCCGC CGCTCGCGGT CAGGGTCGCC GCTGGCGACC GCCGCCGCTG 
CCGCTGTTGC TGCCACTGTC ATTGCTGCTT CTGCGCGCGC AGCTCGCCGT CGGGAACCTG 
GCTGTTGGGA GCCCCAGCGC GGCCGAGGCT CCGGGGTCGG CTCAAGTGGC TGGACTATGT 
GGGCGTCTAA CCCTTCACCG GGACCTGCGC ACCGGCCGCT GGGAACCAGA CCCACAGCGA 
TCACGACGCT GTCTTCTGGA CCCGCAGCGC GTGCTGGAGT ACTGCAGACA GATGTACCCC 
GAGCTGCACA TAGCACGCGT GGAGCAGGCT GCACAGGCCA TCCCGATGGA GCGCTGGTGT 
GGGGGTACCC GGAGTGGCAG ATGCGCCCAC CCCCACCATG AGGTTGTGCC CTTCCATTGC 
CTGCCTGGCG AATTCGTGAG TGAAGCCCTG CTAGTGCCCG AAGGCTGTCG GTTCTTGCAC 
CAGGAGCGTA TGGACCAGTG TGAGAGTTCA ACCAGGAGGC ATCAGGAGGC TCAGGAGGCC 
TGCAGCTCTC AGGGCCTCAT CCTGCATGGC TCTGGCATGC TTTTGCCCTG TGGCTCTGAT 
CGGTTCCGAG GTGTGGAGTA TGTATGCTGT CCACCTCCTG CAACTCCCAA CCCATCTGGG 
ATGGCAGCTG GTGACCCCTC TACCCGGTCC TGGCCCCTGG GGGGCAGAGC AGAGGGAGGT 
GAGGATGAAG AGGAGGTGGA ATCTTTCCCT CAGCCAGTAG ACGATTACTT CGTAGAGCCC 
CCTCAGGCTG AAGAAGAAGA GGAAGAGGAG GAAGAAAGGG CCCCACCTCC CAGCTCCCAC 
ACCCCTGTCA TGGTTAGCAG AGTCACTCCC ACCCCAAGGC CTACTGATGG TGTGGATGTT 
TACTTTGGCA TGCCTGGGGA AATCGGCGAG CATGAGGGTT TCCTGAGGGC CAAGATGGAC 
CTGGAGGAGC GTAGGATGCG CCAGATTAAT GAGGTGATGC GTGAATGGGC CATGGCTGAC 
AGCCAATCTA AGAACCTGCC AAAGGCGGAC AGGCAGGCCC TGAATGAGCA CTTCCAGTCC 
ATTCTGCAGA CCCTGGAAGA ACAAGTGTCT GGTGAACGGC AACGCCTGGT GGAGACCCAC 
GCCACCAGAG TCATCGCTCT GATCAACGAC CAGCGCCGAG CAGCCCTGGA AGGTTTCCTG 
GCAGCCTTAC AGGGCGATCC GCCTCAGGCT GAGCGAGTTC TGATGGCCCT GAGGCGCTAC 
CTGCGCGCCG AGCAGAAAGA GCAGAGGCAC ACTCTGAGGC ACTACCAGCA CGTGGCCGCA 
GTGGATCCTG AGAAGGCCCA GCAGATGCGC TTTCAGGTCC AGACCCACCT TCAGGTGATC 
GAAGAGCGAA TGAATCAGAG CCTGGGGCTG CTCGACCAGA ACCCTCACCT GGCTCAGGAG 
CTGCGGCCAC AGATCCAGGA GCTTCTCCTT GCTGAACACT TGGGTCCCAG TGAACTGGAC 
GCCTCTGTGC CCGGGAGCAG CAGTGAGGAC AAAGGTAGCC TCCAGCCTCC CGAATCCAAG 
GACGATCCCC CAGTGACCCT TCCAAAAGGG TCCACAGATC AAGAGTCATC CTCCTCTGGG 
AGAGAGAAGC TAACTCCACT GGAGCAGTAT GAGCAAAAGG TGAATGCATC CGCCCCGAGG 
GGGTTTCCCT TCCACTCGTC AGATATCCAG CGGGATGAAC TGGCTCCTTC CGGGACTGGA 
GTGTCCCGAG AGGCCTTGTC AGGTCTGCTG ATCATGGGAG CTGGAGGAGG CTCCCTCATT 
GTCCTATCCT TGCTGCTTCT GCGCAAGAAG AAACCCTATG GGACTATCAG CCATGGAGTG 
GTGGAGGTGG ACCCCATGCT GACCCTGGAG GAGCAGCAGC TCCGGGAACT TCAGAGGCAT 
GGCTATGAGA ACCCCACCTA CCGCTTCCTG GAAGAACGAC CTTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_031493.2
CDS	115..2079
Translation	MGPTSPAARGQGRRWRPPPLPLLLPLSLLLLRAQLAVGNLAVGSPSAAEAPGSAQVAGLCGRLTLHRDLRTGRWEPDPQRSRRCLLDPQRVLEYCRQMYPELHIARVEQAAQAIPMERWCGGTRSGRCAHPHHEVVPFHCLPGEFVSEALLVPEGCRFLHQERMDQCESSTRRHQEAQEACSSQGLILHGSGMLLPCGSDRFRGVEYVCCPPPATPNPSGMAAGDPSTRSWPLGGRAEGGEDEEEVESFPQPVDDYFVEPPQAEEEEEEEEERAPPPSSHTPVMVSRVTPTPRPTDGVDVYFGMPGEIGEHEGFLRAKMDLEERRMRQINEVMREWAMADSQSKNLPKADRQALNEHFQSILQTLEEQVSGERQRLVETHATRVIALINDQRRAALEGFLAALQGDPPQAERVLMALRRYLRAEQKEQRHTLRHYQHVAAVDPEKAQQMRFQVQTHLQVIEERMNQSLGLLDQNPHLAQELRPQIQELLLAEHLGPSELDASVPGSSSEDKGSLQPPESKDDPPVTLPKGSTDQESSSSGREKLTPLEQYEQKVNASAPRGFPFHSSDIQRDELAPSGTGVSREALSGLLIMGAGGGSLIVLSLLLLRKKKPYGTISHGVVEVDPMLTLEEQQLRELQRHGYENPTYRFLEERP

Target ORF information:

RefSeq Version	NM_007467.3
Organism	Mus musculus(house mouse)
Definition	Mus musculus amyloid beta (A4) precursor-like protein 1 (Aplp1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_007467.3

ORF Insert Sequence:

ATGGGGCCCA CCAGCCCCGC CGCTCGCGGT CAGGGTCGCC GCTGGCGACC GCCGCCGCTG 
CCGCTGTTGC TGCCACTGTC ATTGCTGCTT CTGCGCGCGC AGCTCGCCGT CGGGAACCTG 
GCTGTTGGGA GCCCCAGCGC GGCCGAGGCT CCGGGGTCGG CTCAAGTGGC TGGACTATGT 
GGGCGTCTAA CCCTTCACCG GGACCTGCGC ACCGGCCGCT GGGAACCAGA CCCACAGCGA 
TCACGACGCT GTCTTCTGGA CCCGCAGCGC GTGCTGGAGT ACTGCAGACA GATGTACCCC 
GAGCTGCACA TAGCACGCGT GGAGCAGGCT GCACAGGCCA TCCCGATGGA GCGCTGGTGT 
GGGGGTACCC GGAGTGGCAG ATGCGCCCAC CCCCACCATG AGGTTGTGCC CTTCCATTGC 
CTGCCTGGCG AATTCGTGAG TGAAGCCCTG CTAGTGCCCG AAGGCTGTCG GTTCTTGCAC 
CAGGAGCGTA TGGACCAGTG TGAGAGTTCA ACCAGGAGGC ATCAGGAGGC TCAGGAGGCC 
TGCAGCTCTC AGGGCCTCAT CCTGCATGGC TCTGGCATGC TTTTGCCCTG TGGCTCTGAT 
CGGTTCCGAG GTGTGGAGTA TGTATGCTGT CCACCTCCTG CAACTCCCAA CCCATCTGGG 
ATGGCAGCTG GTGACCCCTC TACCCGGTCC TGGCCCCTGG GGGGCAGAGC AGAGGGAGGT 
GAGGATGAAG AGGAGGTGGA ATCTTTCCCT CAGCCAGTAG ACGATTACTT CGTAGAGCCC 
CCTCAGGCTG AAGAAGAAGA GGAAGAGGAG GAAGAAAGGG CCCCACCTCC CAGCTCCCAC 
ACCCCTGTCA TGGTTAGCAG AGTCACTCCC ACCCCAAGGC CTACTGATGG TGTGGATGTT 
TACTTTGGCA TGCCTGGGGA AATCGGCGAG CATGAGGGTT TCCTGAGGGC CAAGATGGAC 
CTGGAGGAGC GTAGGATGCG CCAGATTAAT GAGGTGATGC GTGAATGGGC CATGGCTGAC 
AGCCAATCTA AGAACCTGCC AAAGGCGGAC AGGCAGGCCC TGAATGAGCA CTTCCAGTCC 
ATTCTGCAGA CCCTGGAAGA ACAAGTGTCT GGTGAACGGC AACGCCTGGT GGAGACCCAC 
GCCACCAGAG TCATCGCTCT GATCAACGAC CAGCGCCGAG CAGCCCTGGA AGGTTTCCTG 
GCAGCCTTAC AGGGCGATCC GCCTCAGGCT GAGCGAGTTC TGATGGCCCT GAGGCGCTAC 
CTGCGCGCCG AGCAGAAAGA GCAGAGGCAC ACTCTGAGGC ACTACCAGCA CGTGGCCGCA 
GTGGATCCTG AGAAGGCCCA GCAGATGCGC TTTCAGGTCC AGACCCACCT TCAGGTGATC 
GAAGAGCGAA TGAATCAGAG CCTGGGGCTG CTCGACCAGA ACCCTCACCT GGCTCAGGAG 
CTGCGGCCAC AGATCCAGGA GCTTCTCCTT GCTGAACACT TGGGTCCCAG TGAACTGGAC 
GCCTCTGTGC CCGGGAGCAG CAGTGAGGAC AAAGGTAGCC TCCAGCCTCC CGAATCCAAG 
GACGATCCCC CAGTGACCCT TCCAAAAGGG TCCACAGATC AAGAGTCATC CTCCTCTGGG 
AGAGAGAAGC TAACTCCACT GGAGCAGTAT GAGCAAAAGG TGAATGCATC CGCCCCGAGG 
GGGTTTCCCT TCCACTCGTC AGATATCCAG CGGGATGAAC TGGCTCCTTC CGGGACTGGA 
GTGTCCCGAG AGGCCTTGTC AGGTCTGCTG ATCATGGGAG CTGGAGGAGG CTCCCTCATT 
GTCCTATCCT TGCTGCTTCT GCGCAAGAAG AAACCCTATG GGACTATCAG CCATGGAGTG 
GTGGAGGTGG ACCCCATGCT GACCCTGGAG GAGCAGCAGC TCCGGGAACT TCAGAGGCAT 
GGCTATGAGA ACCCCACCTA CCGCTTCCTG GAAGAACGAC CTTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Aplp1 ( XM_017321948.1 ) cDNA ORF clone, Mus musculus(house mouse) -> XP_017177437.1 Mus musculus amyloid beta (A4) precursor-like protein 1 (Aplp1), transcript variant X1, mRNA.

Price & Availability↑

CloneID	OMu81905
Clone ID Related Accession (Same CDS sequence)	XM_017321948.1
Accession Version	XM_017321948.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2091bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2016-06-21
Organism	Mus musculus(house mouse)
Product	amyloid-like protein 1 isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000073.6) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Mus musculus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGGGGCCCA CCAGCCCCGC CGCTCGCGGT CAGGGTCGCC GCTGGCGACC GCCGCCGCTG 
CCGCTGTTGC TGCCACTGTC ATTGCTGCTT CTGCGCGCGC AGCTCGCCGT CGGGAACCTG 
GCTGTTGGGA GCCCCAGCGC GGCCGAGGCT CCGGGGTCGG CTCAAGTGGC TGGACTATGT 
GGGCGTCTAA CCCTTCACCG GGACCTGCGC ACCGGCCGCT GGGAACCAGA CCCACAGCGA 
TCACGACGCT GTCTTCTGGA CCCGCAGCGC GTGCTGGAGT ACTGCAGACA GATGTACCCC 
GAGCTGCACA TAGCACGCGT GGAGCAGGCT GCACAGGCCA TCCCGATGGA GCGCTGGTGT 
GGGGGTACCC GGAGTGGCAG ATGCGCCCAC CCCCACCATG AGGTTGTGCC CTTCCATTGC 
CTGCCTGGCG AATTCGTGAG TGAAGCCCTG CTAGTGCCCG AAGGCTGTCG GTTCTTGCAC 
CAGGAGCGTA TGGACCAGTG TGAGAGTTCA ACCAGGAGGC ATCAGGAGGC TCAGGAGGCC 
TGCAGCTCTC AGGGCCTCAT CCTGCATGGC TCTGGCATGC TTTTGCCCTG TGGCTCTGAT 
CGGTTCCGAG GTGTGGAGTA TGTATGCTGT CCACCTCCTG CAACTCCCAA CCCATCTGGG 
ATGGCAGCTG GTGACCCCTC TACCCGGTCC TGGCCCCTGG GGGGCAGAGC AGAGGGAGGT 
GAGGATGAAG AGGAGGTGGA ATCTTTCCCT CAGCCAGTAG ACGATTACTT CGTAGAGCCC 
CCTCAGGCTG AAGAAGAAGA GGAAGAGGAG GAAGAAAGGG CCCCACCTCC CAGCTCCCAC 
ACCCCTGTCA TGGTTAGCAG AGTCACTCCC ACCCCAAGGC CTACTGATGG TGTGGATGTT 
TACTTTGGCA TGCCTGGGGA AATCGGCGAG CATGAGGGTT TCCTGAGGGC CAAGATGGAC 
CTGGAGGAGC GTAGGATGCG CCAGATTAAT GAGGTGATGC GTGAATGGGC CATGGCTGAC 
AGCCAATCTA AGAACCTGCC AAAGGCGGAC AGGCAGGCCC TGAATGAGCA CTTCCAGTCC 
ATTCTGCAGA CCCTGGAAGA ACAAGTGTCT GGTGAACGGC AACGCCTGGT GGAGACCCAC 
GCCACCAGAG TCATCGCTCT GATCAACGAC CAGCGCCGAG CAGCCCTGGA AGGTTTCCTG 
GCAGCCTTAC AGGGCGATCC GCCTCAGGCT GAGCGAGTTC TGATGGCCCT GAGGCGCTAC 
CTGCGCGCCG AGCAGAAAGA GCAGAGGCAC ACTCTGAGGC ACTACCAGCA CGTGGCCGCA 
GTGGATCCTG AGAAGGCCCA GCAGATGCGC TTTCAGGTCC AGACCCACCT TCAGGTGATC 
GAAGAGCGAA TGAATCAGAG CCTGGGGCTG CTCGACCAGA ACCCTCACCT GGCTCAGGAG 
CTGCGGCCAC AGATCCAGGA GCTTCTCCTT GCTGAACACT TGGGTCCCAG TGAACTGGAC 
GCCTCTGTGC CCGGGAGCAG CAGTGAGGAC AAAGGTAGCC TCCAGCCTCC CGAATCCAAG 
GACGATCCCC CAGTGACCCT TCCAAAAGGG TCCACAGATC AAGAGTCATC CTCCTCTGGG 
AGAGAGAAGC TAACTCCACT GGAGCAGTAT GAGCAAAAGG TGAATGCATC CGCCCCGAGG 
GGGTTTCCCT TCCACTCGTC AGATATCCAG CGGGATGAAC TGGTAAGAAG AGGCAGATCT 
GGGGGCGAGG TCAGAGGTTG GCATCCAGGC TGTAACCTCC AAAGCCGCAG TGCCCTGGAT 
CCTGGTGAGC CTCAAAGATA CTCTTGGTCC GGTCTCCTTT CTCCCCAGGC TCCTTCCGGG 
ACTGGAGTGT CCCGAGAGGC CTTGTCAGGT CTGCTGATCA TGGGAGCTGG AGGAGGCTCC 
CTCATTGTCC TATCCTTGCT GCTTCTGCGC AAGAAGAAAC CCTATGGGAC TATCAGCCAT 
GGAGTGGTGG AGGTGGACCC CATGCTGACC CTGGAGGAGC AGCAGCTCCG GGAACTTCAG 
AGGCATGGCT ATGAGAACCC CACCTACCGC TTCCTGGAAG AACGACCTTG A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_017177437.1
CDS	135..2225
Translation	MGPTSPAARGQGRRWRPPPLPLLLPLSLLLLRAQLAVGNLAVGSPSAAEAPGSAQVAGLCGRLTLHRDLRTGRWEPDPQRSRRCLLDPQRVLEYCRQMYPELHIARVEQAAQAIPMERWCGGTRSGRCAHPHHEVVPFHCLPGEFVSEALLVPEGCRFLHQERMDQCESSTRRHQEAQEACSSQGLILHGSGMLLPCGSDRFRGVEYVCCPPPATPNPSGMAAGDPSTRSWPLGGRAEGGEDEEEVESFPQPVDDYFVEPPQAEEEEEEEEERAPPPSSHTPVMVSRVTPTPRPTDGVDVYFGMPGEIGEHEGFLRAKMDLEERRMRQINEVMREWAMADSQSKNLPKADRQALNEHFQSILQTLEEQVSGERQRLVETHATRVIALINDQRRAALEGFLAALQGDPPQAERVLMALRRYLRAEQKEQRHTLRHYQHVAAVDPEKAQQMRFQVQTHLQVIEERMNQSLGLLDQNPHLAQELRPQIQELLLAEHLGPSELDASVPGSSSEDKGSLQPPESKDDPPVTLPKGSTDQESSSSGREKLTPLEQYEQKVNASAPRGFPFHSSDIQRDELVRRGRSGGEVRGWHPGCNLQSRSALDPGEPQRYSWSGLLSPQAPSGTGVSREALSGLLIMGAGGGSLIVLSLLLLRKKKPYGTISHGVVEVDPMLTLEEQQLRELQRHGYENPTYRFLEERP

Target ORF information:

RefSeq Version	XM_017321948.1
Organism	Mus musculus(house mouse)
Definition	Mus musculus amyloid beta (A4) precursor-like protein 1 (Aplp1), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_017321948.1

ORF Insert Sequence:

ATGGGGCCCA CCAGCCCCGC CGCTCGCGGT CAGGGTCGCC GCTGGCGACC GCCGCCGCTG 
CCGCTGTTGC TGCCACTGTC ATTGCTGCTT CTGCGCGCGC AGCTCGCCGT CGGGAACCTG 
GCTGTTGGGA GCCCCAGCGC GGCCGAGGCT CCGGGGTCGG CTCAAGTGGC TGGACTATGT 
GGGCGTCTAA CCCTTCACCG GGACCTGCGC ACCGGCCGCT GGGAACCAGA CCCACAGCGA 
TCACGACGCT GTCTTCTGGA CCCGCAGCGC GTGCTGGAGT ACTGCAGACA GATGTACCCC 
GAGCTGCACA TAGCACGCGT GGAGCAGGCT GCACAGGCCA TCCCGATGGA GCGCTGGTGT 
GGGGGTACCC GGAGTGGCAG ATGCGCCCAC CCCCACCATG AGGTTGTGCC CTTCCATTGC 
CTGCCTGGCG AATTCGTGAG TGAAGCCCTG CTAGTGCCCG AAGGCTGTCG GTTCTTGCAC 
CAGGAGCGTA TGGACCAGTG TGAGAGTTCA ACCAGGAGGC ATCAGGAGGC TCAGGAGGCC 
TGCAGCTCTC AGGGCCTCAT CCTGCATGGC TCTGGCATGC TTTTGCCCTG TGGCTCTGAT 
CGGTTCCGAG GTGTGGAGTA TGTATGCTGT CCACCTCCTG CAACTCCCAA CCCATCTGGG 
ATGGCAGCTG GTGACCCCTC TACCCGGTCC TGGCCCCTGG GGGGCAGAGC AGAGGGAGGT 
GAGGATGAAG AGGAGGTGGA ATCTTTCCCT CAGCCAGTAG ACGATTACTT CGTAGAGCCC 
CCTCAGGCTG AAGAAGAAGA GGAAGAGGAG GAAGAAAGGG CCCCACCTCC CAGCTCCCAC 
ACCCCTGTCA TGGTTAGCAG AGTCACTCCC ACCCCAAGGC CTACTGATGG TGTGGATGTT 
TACTTTGGCA TGCCTGGGGA AATCGGCGAG CATGAGGGTT TCCTGAGGGC CAAGATGGAC 
CTGGAGGAGC GTAGGATGCG CCAGATTAAT GAGGTGATGC GTGAATGGGC CATGGCTGAC 
AGCCAATCTA AGAACCTGCC AAAGGCGGAC AGGCAGGCCC TGAATGAGCA CTTCCAGTCC 
ATTCTGCAGA CCCTGGAAGA ACAAGTGTCT GGTGAACGGC AACGCCTGGT GGAGACCCAC 
GCCACCAGAG TCATCGCTCT GATCAACGAC CAGCGCCGAG CAGCCCTGGA AGGTTTCCTG 
GCAGCCTTAC AGGGCGATCC GCCTCAGGCT GAGCGAGTTC TGATGGCCCT GAGGCGCTAC 
CTGCGCGCCG AGCAGAAAGA GCAGAGGCAC ACTCTGAGGC ACTACCAGCA CGTGGCCGCA 
GTGGATCCTG AGAAGGCCCA GCAGATGCGC TTTCAGGTCC AGACCCACCT TCAGGTGATC 
GAAGAGCGAA TGAATCAGAG CCTGGGGCTG CTCGACCAGA ACCCTCACCT GGCTCAGGAG 
CTGCGGCCAC AGATCCAGGA GCTTCTCCTT GCTGAACACT TGGGTCCCAG TGAACTGGAC 
GCCTCTGTGC CCGGGAGCAG CAGTGAGGAC AAAGGTAGCC TCCAGCCTCC CGAATCCAAG 
GACGATCCCC CAGTGACCCT TCCAAAAGGG TCCACAGATC AAGAGTCATC CTCCTCTGGG 
AGAGAGAAGC TAACTCCACT GGAGCAGTAT GAGCAAAAGG TGAATGCATC CGCCCCGAGG 
GGGTTTCCCT TCCACTCGTC AGATATCCAG CGGGATGAAC TGGTAAGAAG AGGCAGATCT 
GGGGGCGAGG TCAGAGGTTG GCATCCAGGC TGTAACCTCC AAAGCCGCAG TGCCCTGGAT 
CCTGGTGAGC CTCAAAGATA CTCTTGGTCC GGTCTCCTTT CTCCCCAGGC TCCTTCCGGG 
ACTGGAGTGT CCCGAGAGGC CTTGTCAGGT CTGCTGATCA TGGGAGCTGG AGGAGGCTCC 
CTCATTGTCC TATCCTTGCT GCTTCTGCGC AAGAAGAAAC CCTATGGGAC TATCAGCCAT 
GGAGTGGTGG AGGTGGACCC CATGCTGACC CTGGAGGAGC AGCAGCTCCG GGAACTTCAG 
AGGCATGGCT ATGAGAACCC CACCTACCGC TTCCTGGAAG AACGACCTTG A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

APLP1 Is a Synaptic Cell Adhesion Molecule, Supporting Maintenance of Dendritic Spines and Basal Synaptic Transmission.
The Journal of neuroscience : the official journal of the Society for Neuroscience37(21)5345-5365(2017 May)
Schilling S,Mehr A,Ludewig S,Stephan J,Zimmermann M,August A,Strecker P,Korte M,Koo EH,M?ller UC,Kins S,Eggert S

Deletion of the amyloid precursor-like protein 1 (APLP1) enhances excitatory synaptic transmission, reduces network inhibition but does not impair synaptic plasticity in the mouse dentate gyrus.
The Journal of comparative neurology523(11)1717-29(2015 Aug)
Vnencak M,Paul MH,Hick M,Schwarzacher SW,Del Turco D,M?ller UC,Deller T,Jedlicka P

A high-resolution spatiotemporal atlas of gene expression of the developing mouse brain.
Neuron83(2)309-323(2014 Jul)
Thompson CL,Ng L,Menon V,Martinez S,Lee CK,Glattfelder K,Sunkin SM,Henry A,Lau C,Dang C,Garcia-Lopez R,Martinez-Ferre A,Pombero A,Rubenstein JLR,Wakeman WB,Hohmann J,Dee N,Sodt AJ,Young R,Smith K,Nguyen TN,Kidney J,Kuan L,Jeromin A,Kaykas A,Miller J,Page D,Orta G,Bernard A,Riley Z,Smith S,Wohnoutka P,Hawrylycz MJ,Puelles L,Jones AR

Differential role of APP and APLPs for neuromuscular synaptic morphology and function.
Molecular and cellular neurosciences61201-10(2014 Jul)
Klevanski M,Saar M,Baumk?tter F,Weyer SW,Kins S,M?ller UC

Amyloid precursor proteins are constituents of the presynaptic active zone.
Journal of neurochemistry127(1)48-56(2013 Oct)
La?ek M,Weingarten J,Einsfelder U,Brendel P,M?ller U,Volknandt W

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Aplp1 cDNA ORF clone, Mus musculus(house mouse)

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