| Gene Symbol | TLE6 |
| Entrez Gene ID | 79816 |
| Full Name | transducin like enhancer of split 6 |
| Synonyms | GRG6,PREMBL |
| General protein information |
|
| Gene Type | protein-coding |
| Organism | Homo sapiens(human) |
| Genome | |
| Summary | This gene encodes a member of the Groucho/ transducin-like Enhancer of split family of transcriptional co-repressors. The encoded protein is a component of the mammalian subcortical maternal complex, which is required for preimplantation development. In mouse, knock out of this gene results in cleavage-stage embryonic arrest resulting from defective cytoplasmic F-actin meshwork formation and asymmetric cell division. In human, an allelic variant in this gene is associated with preimplantation embryonic lethality. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2016]. |
| Disorder MIM: | |
| Disorder Html: | Preimplantation embryonic lethality, 616814 (3) |









































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