CCDC86 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	CCDC86
Entrez Gene ID	79080
Full Name	coiled-coil domain containing 86
General protein information	Preferred Names coiled-coil domain containing 86 Names coiled-coil domain-containing protein 86 cyclon cytokine-induced protein with coiled-coil domain
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 11 Map Location: 11q12.2
Disorder MIM:	611293

mRNA and Protein(s)

mRNA	Protein	Name
NM_024098.3	NP_077003.1	coiled-coil domain-containing protein 86
NM_024098.4	NP_077003.1	coiled-coil domain-containing protein 86

Pathways from BioSystems

Homologies

Rattus norvegicus (Norway rat)	Ccdc86	NP_001006975.1
Homo sapiens (human)	CCDC86	NP_077003.1
	CCDC86	XP_001085103.1
Pan troglodytes (chimpanzee)	CCDC86	NP_001233482.1
Mus musculus (house mouse)	Ccdc86	NP_076220.2
Bos taurus (cattle)	CCDC86	NP_001033663.1
Xenopus tropicalis (tropical clawed frog)	LOC101733466	XP_004917180.1

Gene Ontology
Bibliography

Related articles in PubMed

Association of granulomatosis with polyangiitis (Wegener's) with HLA-DPB1*04 and SEMA6A gene variants: evidence from genome-wide analysis.
Xie G, Roshandel D, Sherva R, Monach PA, Lu EY, Kung T, Carrington K, Zhang SS, Pulit SL, Ripke S, Carette S, Dellaripa PF, Edberg JC, Hoffman GS, Khalidi N, Langford CA, Mahr AD, St Clair EW, Seo P, Specks U, Spiera RF, Stone JH, Ytterberg SR, Raychaudhuri S, de Bakker PI, Farrer LA, Amos CI, Merkel PA, Siminovitch KA
Arthritis and rheumatism65(9)2457-68(2013 Sep)

Expression and differential response to haloperidol treatment of Cyclon/CCDC86 mRNA in schizophrenia patients.
Chervenkov T, Shishkov R, Tonchev AB
Neurochemistry international62(6)870-2(2013 May)

Insights into RNA biology from an atlas of mammalian mRNA-binding proteins.
Castello A, Fischer B, Eichelbaum K, Horos R, Beckmann BM, Strein C, Davey NE, Humphreys DT, Preiss T, Steinmetz LM, Krijgsveld J, Hentze MW
Cell149(6)1393-406(2012 Jun)

The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts.
Baltz AG, Munschauer M, Schwanh?usser B, Vasile A, Murakawa Y, Schueler M, Youngs N, Penfold-Brown D, Drew K, Milek M, Wyler E, Bonneau R, Selbach M, Dieterich C, Landthaler M
Molecular cell46(5)674-90(2012 Jun)

Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study.
Bailey SD, Xie C, Do R, Montpetit A, Diaz R, Mohan V, Keavney B, Yusuf S, Gerstein HC, Engert JC, Anand S,
Diabetes care33(10)2250-3(2010 Oct)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Cyclon/CCDC68 levels correlate with the clinical presentation of relapsed schizophrenia
Title: Expression and differential response to haloperidol treatment of Cyclon/CCDC86 mRNA in schizophrenia patients.

Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
Title: Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study.

Observational study of gene-disease association. (HuGE Navigator)
Title: Association of genetic variants with hemorrhagic stroke in Japanese individuals.

Observational study of gene-disease association. (HuGE Navigator)
Title: Assessment of a polymorphism of SDK1 with hypertension in Japanese Individuals.

Observational study of gene-disease association. (HuGE Navigator)
Title: Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.

The following CCDC86 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the CCDC86 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu13913	NM_024098.4 Latest version!	Homo sapiens coiled-coil domain containing 86 (CCDC86), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$159.50-$223.30 $319.00
View Old Accession Versions >>
OHu13913	NM_024098.3	Homo sapiens coiled-coil domain containing 86 (CCDC86), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$159.50-$223.30 $319.00
Hide Old Accession Versions >>

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

CCDC86 ( NM_024098.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_077003.1 Homo sapiens coiled-coil domain containing 86 (CCDC86), mRNA.

Price & Availability↑

CloneID	OHu13913
Clone ID Related Accession (Same CDS sequence)	NM_024098.3 , NM_024098.4
Accession Version	NM_024098.3	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1083bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-10-01
Organism	Homo sapiens(human)
Product	coiled-coil domain-containing protein 86
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from DA292314.1, AK025974.1, BE795888.1 and AI018490.1. On Jul 25, 2007 this sequence version replaced NM_024098.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1163658.312525.1, AK025974.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END##

ATGGATACAC CGTTAAGGCG CAGCCGACGG CTGGGAGGCC TAAGGCCCGA ATCCCCCGAG 
AGCCTCACCT CAGTTTCGCG GACGAGACGG GCCCTTGTGG AGTTCGAGTC GAACCCAGAA 
GAAACGAGGG AGCCCGGGTC TCCTCCGAGT GTGCAGCGGG CTGGCCTGGG GTCCCCCGAA 
AGGCCGCCGA AGACAAGCCC AGGATCACCC CGTCTGCAGC AGGGTGCAGG CTTGGAGTCA 
CCCCAAGGGC AGCCAGAGCC AGGCGCAGCG TCCCCCCAGC GTCAGCAAGA CCTACACCTG 
GAGTCGCCTC AAAGACAGCC AGAGTACAGT CCTGAATCCC CACGATGTCA GCCGAAGCCA 
AGTGAGGAGG CACCAAAGTG TTCTCAGGAC CAGGGAGTAC TGGCCTCGGA GTTGGCCCAG 
AATAAGGAGG AGCTGACCCC GGGGGCCCCC CAGCATCAGC TACCGCCGGT CCCAGGATCA 
CCAGAGCCTT ACCCCGGTCA GCAAGCTCCC GGTCCGGAGC CCTCTCAGCC ACTACTGGAG 
CTGACACCCA GGGCACCTGG CTCCCCCCGG GGTCAGCATG AGCCGAGCAA GCCACCTCCA 
GCTGGGGAGA CGGTGACAGG CGGCTTCGGG GCAAAGAAGC GAAAAGGTTC TTCATCCCAG 
GCCCCAGCGT CCAAGAAGTT GAATAAAGAG GAGCTTCCTG TAATCCCGAA GGGGAAGCCC 
AAATCGGGGC GAGTGTGGAA GGACCGCTCC AAGAAAAGAT TCTCCCAGAT GCTTCAGGAC 
AAGCCCCTGC GCACATCGTG GCAGCGGAAG ATGAAGGAAC GACAGGAGAG GAAGCTGGCC 
AAGGACTTTG CCCGTCACCT GGAGGAGGAG AAGGAGAGGC GCCGCCAGGA GAAGAAACAG 
CGCCGGGCTG AGAACCTGAA ACGCCGCCTG GAGAATGAGC GGAAGGCAGA GGTCGTCCAA 
GTGATCCGAA ACCCCGCCAA GCTCAAGCGG GCAAAGAAGA AGCAGCTGCG CTCCATTGAG 
AAGCGGGACA CCCTGGCCCT GCTGCAGAAG CAGCCGCCCC AGCAGCCGGC AGCCAAGATC 
TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_077003.1
CDS	170..1252
Translation	MDTPLRRSRRLGGLRPESPESLTSVSRTRRALVEFESNPEETREPGSPPSVQRAGLGSPERPPKTSPGSPRLQQGAGLESPQGQPEPGAASPQRQQDLHLESPQRQPEYSPESPRCQPKPSEEAPKCSQDQGVLASELAQNKEELTPGAPQHQLPPVPGSPEPYPGQQAPGPEPSQPLLELTPRAPGSPRGQHEPSKPPPAGETVTGGFGAKKRKGSSSQAPASKKLNKEELPVIPKGKPKSGRVWKDRSKKRFSQMLQDKPLRTSWQRKMKERQERKLAKDFARHLEEEKERRRQEKKQRRAENLKRRLENERKAEVVQVIRNPAKLKRAKKKQLRSIEKRDTLALLQKQPPQQPAAKI

Target ORF information:

RefSeq Version	NM_024098.3
Organism	Homo sapiens(human)
Definition	Homo sapiens coiled-coil domain containing 86 (CCDC86), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_024098.3

ORF Insert Sequence:

ATGGATACAC CGTTAAGGCG CAGCCGACGG CTGGGAGGCC TAAGGCCCGA ATCCCCCGAG 
AGCCTCACCT CAGTTTCGCG GACGAGACGG GCCCTTGTGG AGTTCGAGTC GAACCCAGAA 
GAAACGAGGG AGCCCGGGTC TCCTCCGAGT GTGCAGCGGG CTGGCCTGGG GTCCCCCGAA 
AGGCCGCCGA AGACAAGCCC AGGATCACCC CGTCTGCAGC AGGGTGCAGG CTTGGAGTCA 
CCCCAAGGGC AGCCAGAGCC AGGCGCAGCG TCCCCCCAGC GTCAGCAAGA CCTACACCTG 
GAGTCGCCTC AAAGACAGCC AGAGTACAGT CCTGAATCCC CACGATGTCA GCCGAAGCCA 
AGTGAGGAGG CACCAAAGTG TTCTCAGGAC CAGGGAGTAC TGGCCTCGGA GTTGGCCCAG 
AATAAGGAGG AGCTGACCCC GGGGGCCCCC CAGCATCAGC TACCGCCGGT CCCAGGATCA 
CCAGAGCCTT ACCCCGGTCA GCAAGCTCCC GGTCCGGAGC CCTCTCAGCC ACTACTGGAG 
CTGACACCCA GGGCACCTGG CTCCCCCCGG GGTCAGCATG AGCCGAGCAA GCCACCTCCA 
GCTGGGGAGA CGGTGACAGG CGGCTTCGGG GCAAAGAAGC GAAAAGGTTC TTCATCCCAG 
GCCCCAGCGT CCAAGAAGTT GAATAAAGAG GAGCTTCCTG TAATCCCGAA GGGGAAGCCC 
AAATCGGGGC GAGTGTGGAA GGACCGCTCC AAGAAAAGAT TCTCCCAGAT GCTTCAGGAC 
AAGCCCCTGC GCACATCGTG GCAGCGGAAG ATGAAGGAAC GACAGGAGAG GAAGCTGGCC 
AAGGACTTTG CCCGTCACCT GGAGGAGGAG AAGGAGAGGC GCCGCCAGGA GAAGAAACAG 
CGCCGGGCTG AGAACCTGAA ACGCCGCCTG GAGAATGAGC GGAAGGCAGA GGTCGTCCAA 
GTGATCCGAA ACCCCGCCAA GCTCAAGCGG GCAAAGAAGA AGCAGCTGCG CTCCATTGAG 
AAGCGGGACA CCCTGGCCCT GCTGCAGAAG CAGCCGCCCC AGCAGCCGGC AGCCAAGATC 
TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

CCDC86 ( NM_024098.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_077003.1 Homo sapiens coiled-coil domain containing 86 (CCDC86), mRNA.

Price & Availability↑

CloneID	OHu13913
Clone ID Related Accession (Same CDS sequence)	NM_024098.3 , NM_024098.4
Accession Version	NM_024098.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1083bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-29
Organism	Homo sapiens(human)
Product	coiled-coil domain-containing protein 86
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AP000777.4. On Nov 23, 2018 this sequence version replaced NM_024098.3. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC001378.1, AK025974.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000227520.10/ ENSP00000227520.5 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGGATACAC CGTTAAGGCG CAGCCGACGG CTGGGAGGCC TAAGGCCCGA ATCCCCCGAG 
AGCCTCACCT CAGTTTCGCG GACGAGACGG GCCCTTGTGG AGTTCGAGTC GAACCCAGAA 
GAAACGAGGG AGCCCGGGTC TCCTCCGAGT GTGCAGCGGG CTGGCCTGGG GTCCCCCGAA 
AGGCCGCCGA AGACAAGCCC AGGATCACCC CGTCTGCAGC AGGGTGCAGG CTTGGAGTCA 
CCCCAAGGGC AGCCAGAGCC AGGCGCAGCG TCCCCCCAGC GTCAGCAAGA CCTACACCTG 
GAGTCGCCTC AAAGACAGCC AGAGTACAGT CCTGAATCCC CACGATGTCA GCCGAAGCCA 
AGTGAGGAGG CACCAAAGTG TTCTCAGGAC CAGGGAGTAC TGGCCTCGGA GTTGGCCCAG 
AATAAGGAGG AGCTGACCCC GGGGGCCCCC CAGCATCAGC TACCGCCGGT CCCAGGATCA 
CCAGAGCCTT ACCCCGGTCA GCAAGCTCCC GGTCCGGAGC CCTCTCAGCC ACTACTGGAG 
CTGACACCCA GGGCACCTGG CTCCCCCCGG GGTCAGCATG AGCCGAGCAA GCCACCTCCA 
GCTGGGGAGA CGGTGACAGG CGGCTTCGGG GCAAAGAAGC GAAAAGGTTC TTCATCCCAG 
GCCCCAGCGT CCAAGAAGTT GAATAAAGAG GAGCTTCCTG TAATCCCGAA GGGGAAGCCC 
AAATCGGGGC GAGTGTGGAA GGACCGCTCC AAGAAAAGAT TCTCCCAGAT GCTTCAGGAC 
AAGCCCCTGC GCACATCGTG GCAGCGGAAG ATGAAGGAAC GACAGGAGAG GAAGCTGGCC 
AAGGACTTTG CCCGTCACCT GGAGGAGGAG AAGGAGAGGC GCCGCCAGGA GAAGAAACAG 
CGCCGGGCTG AGAACCTGAA ACGCCGCCTG GAGAATGAGC GGAAGGCAGA GGTCGTCCAA 
GTGATCCGAA ACCCCGCCAA GCTCAAGCGG GCAAAGAAGA AGCAGCTGCG CTCCATTGAG 
AAGCGGGACA CCCTGGCCCT GCTGCAGAAG CAGCCGCCCC AGCAGCCGGC AGCCAAGATC 
TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_077003.1
CDS	13..1095
Translation	MDTPLRRSRRLGGLRPESPESLTSVSRTRRALVEFESNPEETREPGSPPSVQRAGLGSPERPPKTSPGSPRLQQGAGLESPQGQPEPGAASPQRQQDLHLESPQRQPEYSPESPRCQPKPSEEAPKCSQDQGVLASELAQNKEELTPGAPQHQLPPVPGSPEPYPGQQAPGPEPSQPLLELTPRAPGSPRGQHEPSKPPPAGETVTGGFGAKKRKGSSSQAPASKKLNKEELPVIPKGKPKSGRVWKDRSKKRFSQMLQDKPLRTSWQRKMKERQERKLAKDFARHLEEEKERRRQEKKQRRAENLKRRLENERKAEVVQVIRNPAKLKRAKKKQLRSIEKRDTLALLQKQPPQQPAAKI

Target ORF information:

RefSeq Version	NM_024098.4
Organism	Homo sapiens(human)
Definition	Homo sapiens coiled-coil domain containing 86 (CCDC86), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_024098.4

ORF Insert Sequence:

ATGGATACAC CGTTAAGGCG CAGCCGACGG CTGGGAGGCC TAAGGCCCGA ATCCCCCGAG 
AGCCTCACCT CAGTTTCGCG GACGAGACGG GCCCTTGTGG AGTTCGAGTC GAACCCAGAA 
GAAACGAGGG AGCCCGGGTC TCCTCCGAGT GTGCAGCGGG CTGGCCTGGG GTCCCCCGAA 
AGGCCGCCGA AGACAAGCCC AGGATCACCC CGTCTGCAGC AGGGTGCAGG CTTGGAGTCA 
CCCCAAGGGC AGCCAGAGCC AGGCGCAGCG TCCCCCCAGC GTCAGCAAGA CCTACACCTG 
GAGTCGCCTC AAAGACAGCC AGAGTACAGT CCTGAATCCC CACGATGTCA GCCGAAGCCA 
AGTGAGGAGG CACCAAAGTG TTCTCAGGAC CAGGGAGTAC TGGCCTCGGA GTTGGCCCAG 
AATAAGGAGG AGCTGACCCC GGGGGCCCCC CAGCATCAGC TACCGCCGGT CCCAGGATCA 
CCAGAGCCTT ACCCCGGTCA GCAAGCTCCC GGTCCGGAGC CCTCTCAGCC ACTACTGGAG 
CTGACACCCA GGGCACCTGG CTCCCCCCGG GGTCAGCATG AGCCGAGCAA GCCACCTCCA 
GCTGGGGAGA CGGTGACAGG CGGCTTCGGG GCAAAGAAGC GAAAAGGTTC TTCATCCCAG 
GCCCCAGCGT CCAAGAAGTT GAATAAAGAG GAGCTTCCTG TAATCCCGAA GGGGAAGCCC 
AAATCGGGGC GAGTGTGGAA GGACCGCTCC AAGAAAAGAT TCTCCCAGAT GCTTCAGGAC 
AAGCCCCTGC GCACATCGTG GCAGCGGAAG ATGAAGGAAC GACAGGAGAG GAAGCTGGCC 
AAGGACTTTG CCCGTCACCT GGAGGAGGAG AAGGAGAGGC GCCGCCAGGA GAAGAAACAG 
CGCCGGGCTG AGAACCTGAA ACGCCGCCTG GAGAATGAGC GGAAGGCAGA GGTCGTCCAA 
GTGATCCGAA ACCCCGCCAA GCTCAAGCGG GCAAAGAAGA AGCAGCTGCG CTCCATTGAG 
AAGCGGGACA CCCTGGCCCT GCTGCAGAAG CAGCCGCCCC AGCAGCCGGC AGCCAAGATC 
TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Association of granulomatosis with polyangiitis (Wegener's) with HLA-DPB1*04 and SEMA6A gene variants: evidence from genome-wide analysis.
Arthritis and rheumatism65(9)2457-68(2013 Sep)
Xie G,Roshandel D,Sherva R,Monach PA,Lu EY,Kung T,Carrington K,Zhang SS,Pulit SL,Ripke S,Carette S,Dellaripa PF,Edberg JC,Hoffman GS,Khalidi N,Langford CA,Mahr AD,St Clair EW,Seo P,Specks U,Spiera RF,Stone JH,Ytterberg SR,Raychaudhuri S,de Bakker PI,Farrer LA,Amos CI,Merkel PA,Siminovitch KA

Expression and differential response to haloperidol treatment of Cyclon/CCDC86 mRNA in schizophrenia patients.
Neurochemistry international62(6)870-2(2013 May)
Chervenkov T,Shishkov R,Tonchev AB

Insights into RNA biology from an atlas of mammalian mRNA-binding proteins.
Cell149(6)1393-406(2012 Jun)
Castello A,Fischer B,Eichelbaum K,Horos R,Beckmann BM,Strein C,Davey NE,Humphreys DT,Preiss T,Steinmetz LM,Krijgsveld J,Hentze MW

The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts.
Molecular cell46(5)674-90(2012 Jun)
Baltz AG,Munschauer M,Schwanh?usser B,Vasile A,Murakawa Y,Schueler M,Youngs N,Penfold-Brown D,Drew K,Milek M,Wyler E,Bonneau R,Selbach M,Dieterich C,Landthaler M

Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study.
Diabetes care33(10)2250-3(2010 Oct)
Bailey SD,Xie C,Do R,Montpetit A,Diaz R,Mohan V,Keavney B,Yusuf S,Gerstein HC,Engert JC,Anand S,