ECSCR cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	ECSCR
Entrez Gene ID	641700
Full Name	endothelial cell surface expressed chemotaxis and apoptosis regulator
Synonyms	ARIA,ECSM2
General protein information	Preferred Names endothelial cell surface expressed chemotaxis and apoptosis regulator Names endothelial cell-specific chemotaxis regulator apoptosis regulator through modulating IAP expression endothelial cell-specific molecule 2
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 5 Map Location: 5q31.2
Summary	The protein encoded by this gene is primarily found in endothelial cells and blood vessels, where it is involved in cell shape changes and EGF-induced cell migration. It can enhance the activation of vascular endothelial growth factor receptor-2/kinase insert domain receptor and also promote the proteolysis of internalized kinase insert domain receptor. This gene may play a role in angiogenesis-related diseases. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2014].
Disorder MIM:	615736

mRNA and Protein(s)

mRNA	Protein	Name
NM_001293739.1	NP_001280668.1	endothelial cell-specific chemotaxis regulator isoform 2 precursor
NM_001077693.3	NP_001071161.1	endothelial cell-specific chemotaxis regulator isoform 1 precursor
NM_001293739.2	NP_001280668.1	endothelial cell-specific chemotaxis regulator isoform 2 precursor
NM_001077693.4	NP_001071161.1	endothelial cell-specific chemotaxis regulator isoform 1 precursor

Pathways from BioSystems

Homologies

Bos taurus (cattle)	ECSCR	NP_001231374.1
Homo sapiens (human)	ECSCR	NP_001071161.1
	LOC100428408	XP_002804583.1
Rattus norvegicus (Norway rat)	Ecscr	XP_006254680.1
Canis lupus familiaris (dog)	ECSCR	XP_005617309.1
Mus musculus (house mouse)	Ecscr	NP_001028313.1

Gene Ontology
Bibliography

Related articles in PubMed

Biomarkers of evasive resistance predict disease progression in cancer patients treated with antiangiogenic therapies.
Pircher A, J?hrer K, Kocher F, Steiner N, Graziadei I, Heidegger I, Pichler R, Leonhartsberger N, Kremser C, Kern J, Untergasser G, Gunsilius E, Hilbe W
Oncotarget7(15)20109-23(2016 Apr)

Favorable prognosis of operable non-small cell lung cancer (NSCLC) patients harboring an increased expression of tumor endothelial markers (TEMs).
Pircher A, Fiegl M, Untergasser G, Heidegger I, Medinger M, Kern J, Hilbe W
Lung cancer (Amsterdam, Netherlands)81(2)252-8(2013 Aug)

Preparation of anti-hECSM2 mouse monoclonal antibodies and their application in the analysis of hECSM2 expression.
Chen L, Ma C, He J, He Y, Wang J, Gou L, Yang J
Monoclonal antibodies in immunodiagnosis and immunotherapy32(4)301-8(2013 Aug)

Endothelial cell-specific chemotaxis receptor (ECSCR) enhances vascular endothelial growth factor (VEGF) receptor-2/kinase insert domain receptor (KDR) activation and promotes proteolysis of internalized KDR.
Kilari S, Remadevi I, Zhao B, Pan J, Miao R, Ramchandran R, North PE, You M, Rahimi N, Wilkinson GA
The Journal of biological chemistry288(15)10265-74(2013 Apr)

Identification of novel splice variants and exons of human endothelial cell-specific chemotaxic regulator (ECSCR) by bioinformatics analysis.
Lu J, Li C, Shi C, Balducci J, Huang H, Ji HL, Chang Y, Huang Y
Computational biology and chemistry4141-50(2012 Dec)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Low expression level of ECSCR is associated with evasive resistance and disease progression in cancer.
Title: Biomarkers of evasive resistance predict disease progression in cancer patients treated with antiangiogenic therapies.

Endothelial cell-specific chemotaxis receptor (ECSCR) enhances vascular endothelial growth factor (VEGF) receptor-2/kinase insert domain receptor (KDR) activation and promotes proteolysis of internalized KDR.
Title: Endothelial cell-specific chemotaxis receptor (ECSCR) enhances vascular endothelial growth factor (VEGF) receptor-2/kinase insert domain receptor (KDR) activation and promotes proteolysis of internalized KDR.

identification of three novel full-length splice variants potentially encoding different protein isoforms
Title: Identification of novel splice variants and exons of human endothelial cell-specific chemotaxic regulator (ECSCR) by bioinformatics analysis.

ECSM2 modulated bFGF-directed endothelial cell motility via the FGF receptor (FGFR)-extracellular regulated kinase (ERK)-focal adhesion kinase (FAK) pathway.
Title: Endothelial cell-specific molecule 2 (ECSM2) localizes to cell-cell junctions and modulates bFGF-directed cell migration via the ERK-FAK pathway.

Knockdown of ARIA in HUVECs significantly reduced endothelial apoptosis without affecting either cell migration or proliferation. ARIA knockdown significantly increased inhibitor of apoptosis cIAP-1 and cIAP-2 protein expression
Title: Identification of ARIA regulating endothelial apoptosis and angiogenesis by modulating proteasomal degradation of cIAP-1 and cIAP-2.

The following ECSCR gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the ECSCR cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu28235	NM_001077693.4 Latest version!	Homo sapiens endothelial cell surface expressed chemotaxis and apoptosis regulator (ECSCR), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
OHu28262	NM_001293739.2 Latest version!	Homo sapiens endothelial cell surface expressed chemotaxis and apoptosis regulator (ECSCR), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$139.30 $199.00
View Old Accession Versions >>
OHu28262	NM_001293739.1	Homo sapiens endothelial cell surface expressed chemotaxis and apoptosis regulator (ECSCR), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$139.30 $199.00
OHu28235	NM_001077693.3	Homo sapiens endothelial cell surface expressed chemotaxis and apoptosis regulator (ECSCR), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

ECSCR ( NM_001077693.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_001071161.1 Homo sapiens endothelial cell surface expressed chemotaxis and apoptosis regulator (ECSCR), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu28235
Clone ID Related Accession (Same CDS sequence)	NM_001077693.3 , NM_001077693.4
Accession Version	NM_001077693.3	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 618bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-10-02
Organism	Homo sapiens(human)
Product	endothelial cell-specific chemotaxis regulator isoform 1 precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from EU025066.1 and AI699314.1. On Jun 17, 2014 this sequence version replaced NM_001077693.2. Transcript Variant: This variant (1) encodes the longer isoform (1). Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## RNAseq introns :: single sample supports all introns SAMEA2467148 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGGCACCG CAGGAGCCAT GCAGCTGTGC TGGGTGATCC TGGGCTTCCT CCTGTTCCGA 
GGCCACAACT CCCAGCCCAC AATGACCCAG ACCTCTAGCT CTCAGGGAGG CCTTGGCGGT 
CTAAGTCTGA CCACAGAGCC AGTTTCTTCC AACCCAGGAT ACATCCCTTC CTCAGAGGCT 
AACAGGCCAA GCCATCTGTC CAGCACTGGT ACCCCAGGCG CAGGTGTCCC CAGCAGTGGA 
AGAGACGGAG GCACAAGCAG AGACACATTT CAAACTGTTC CCCCCAATTC AACCACCATG 
AGCCTGAGCA TGAGGGAAGA TGCGACCATC CTGCCCAGCC CCACGTCAGA GACTGTGCTC 
ACTGTGGCTG CATTTGGTGT TATCAGCTTC ATTGTCATCC TGGTGGTTGT GGTGATCATC 
CTAGTTGGTG TGGTCAGCCT GAGGTTCAAG TGTCGGAAGA GCAAGGAGTC TGAAGATCCC 
CAGAAACCTG GGAGTTCAGG GCTGTCTGAA AGCTGCTCCA CAGCCAATGG AGAGAAAGAC 
AGCATCACCC TTATCTCCAT GAAGAACATC AACATGAATA ATGGCAAACA AAGTCTCTCA 
GCAGAGAAGG TTCTTTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001071161.1
CDS	74..691
Translation	MGTAGAMQLCWVILGFLLFRGHNSQPTMTQTSSSQGGLGGLSLTTEPVSSNPGYIPSSEANRPSHLSSTGTPGAGVPSSGRDGGTSRDTFQTVPPNSTTMSLSMREDATILPSPTSETVLTVAAFGVISFIVILVVVVIILVGVVSLRFKCRKSKESEDPQKPGSSGLSESCSTANGEKDSITLISMKNINMNNGKQSLSAEKVL

Target ORF information:

RefSeq Version	NM_001077693.3
Organism	Homo sapiens(human)
Definition	Homo sapiens endothelial cell surface expressed chemotaxis and apoptosis regulator (ECSCR), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001077693.3

ORF Insert Sequence:

ATGGGCACCG CAGGAGCCAT GCAGCTGTGC TGGGTGATCC TGGGCTTCCT CCTGTTCCGA 
GGCCACAACT CCCAGCCCAC AATGACCCAG ACCTCTAGCT CTCAGGGAGG CCTTGGCGGT 
CTAAGTCTGA CCACAGAGCC AGTTTCTTCC AACCCAGGAT ACATCCCTTC CTCAGAGGCT 
AACAGGCCAA GCCATCTGTC CAGCACTGGT ACCCCAGGCG CAGGTGTCCC CAGCAGTGGA 
AGAGACGGAG GCACAAGCAG AGACACATTT CAAACTGTTC CCCCCAATTC AACCACCATG 
AGCCTGAGCA TGAGGGAAGA TGCGACCATC CTGCCCAGCC CCACGTCAGA GACTGTGCTC 
ACTGTGGCTG CATTTGGTGT TATCAGCTTC ATTGTCATCC TGGTGGTTGT GGTGATCATC 
CTAGTTGGTG TGGTCAGCCT GAGGTTCAAG TGTCGGAAGA GCAAGGAGTC TGAAGATCCC 
CAGAAACCTG GGAGTTCAGG GCTGTCTGAA AGCTGCTCCA CAGCCAATGG AGAGAAAGAC 
AGCATCACCC TTATCTCCAT GAAGAACATC AACATGAATA ATGGCAAACA AAGTCTCTCA 
GCAGAGAAGG TTCTTTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

ECSCR ( NM_001077693.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_001071161.1 Homo sapiens endothelial cell surface expressed chemotaxis and apoptosis regulator (ECSCR), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu28235
Clone ID Related Accession (Same CDS sequence)	NM_001077693.3 , NM_001077693.4
Accession Version	NM_001077693.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 618bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-04-30
Organism	Homo sapiens(human)
Product	endothelial cell-specific chemotaxis regulator isoform 1 precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from EU025066.1 and AI699314.1. On Nov 23, 2018 this sequence version replaced NM_001077693.3. Transcript Variant: This variant (1) encodes the longer isoform (1). Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR5189655.197365.1, DQ462572.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2467148 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000618155.3/ ENSP00000479243.1 RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGGGCACCG CAGGAGCCAT GCAGCTGTGC TGGGTGATCC TGGGCTTCCT CCTGTTCCGA 
GGCCACAACT CCCAGCCCAC AATGACCCAG ACCTCTAGCT CTCAGGGAGG CCTTGGCGGT 
CTAAGTCTGA CCACAGAGCC AGTTTCTTCC AACCCAGGAT ACATCCCTTC CTCAGAGGCT 
AACAGGCCAA GCCATCTGTC CAGCACTGGT ACCCCAGGCG CAGGTGTCCC CAGCAGTGGA 
AGAGACGGAG GCACAAGCAG AGACACATTT CAAACTGTTC CCCCCAATTC AACCACCATG 
AGCCTGAGCA TGAGGGAAGA TGCGACCATC CTGCCCAGCC CCACGTCAGA GACTGTGCTC 
ACTGTGGCTG CATTTGGTGT TATCAGCTTC ATTGTCATCC TGGTGGTTGT GGTGATCATC 
CTAGTTGGTG TGGTCAGCCT GAGGTTCAAG TGTCGGAAGA GCAAGGAGTC TGAAGATCCC 
CAGAAACCTG GGAGTTCAGG GCTGTCTGAA AGCTGCTCCA CAGCCAATGG AGAGAAAGAC 
AGCATCACCC TTATCTCCAT GAAGAACATC AACATGAATA ATGGCAAACA AAGTCTCTCA 
GCAGAGAAGG TTCTTTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001071161.1
CDS	74..691
Translation	MGTAGAMQLCWVILGFLLFRGHNSQPTMTQTSSSQGGLGGLSLTTEPVSSNPGYIPSSEANRPSHLSSTGTPGAGVPSSGRDGGTSRDTFQTVPPNSTTMSLSMREDATILPSPTSETVLTVAAFGVISFIVILVVVVIILVGVVSLRFKCRKSKESEDPQKPGSSGLSESCSTANGEKDSITLISMKNINMNNGKQSLSAEKVL

Target ORF information:

RefSeq Version	NM_001077693.4
Organism	Homo sapiens(human)
Definition	Homo sapiens endothelial cell surface expressed chemotaxis and apoptosis regulator (ECSCR), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001077693.4

ORF Insert Sequence:

ATGGGCACCG CAGGAGCCAT GCAGCTGTGC TGGGTGATCC TGGGCTTCCT CCTGTTCCGA 
GGCCACAACT CCCAGCCCAC AATGACCCAG ACCTCTAGCT CTCAGGGAGG CCTTGGCGGT 
CTAAGTCTGA CCACAGAGCC AGTTTCTTCC AACCCAGGAT ACATCCCTTC CTCAGAGGCT 
AACAGGCCAA GCCATCTGTC CAGCACTGGT ACCCCAGGCG CAGGTGTCCC CAGCAGTGGA 
AGAGACGGAG GCACAAGCAG AGACACATTT CAAACTGTTC CCCCCAATTC AACCACCATG 
AGCCTGAGCA TGAGGGAAGA TGCGACCATC CTGCCCAGCC CCACGTCAGA GACTGTGCTC 
ACTGTGGCTG CATTTGGTGT TATCAGCTTC ATTGTCATCC TGGTGGTTGT GGTGATCATC 
CTAGTTGGTG TGGTCAGCCT GAGGTTCAAG TGTCGGAAGA GCAAGGAGTC TGAAGATCCC 
CAGAAACCTG GGAGTTCAGG GCTGTCTGAA AGCTGCTCCA CAGCCAATGG AGAGAAAGAC 
AGCATCACCC TTATCTCCAT GAAGAACATC AACATGAATA ATGGCAAACA AAGTCTCTCA 
GCAGAGAAGG TTCTTTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

ECSCR ( NM_001293739.1 ) cDNA ORF clone, Homo sapiens(human) -> NP_001280668.1 Homo sapiens endothelial cell surface expressed chemotaxis and apoptosis regulator (ECSCR), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OHu28262
Clone ID Related Accession (Same CDS sequence)	NM_001293739.1 , NM_001293739.2
Accession Version	NM_001293739.1	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 615bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2018-12-03
Organism	Homo sapiens(human)
Product	endothelial cell-specific chemotaxis regulator isoform 2 precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from EU025066.1, BI834795.1, AC188049.2, AC142391.2 and AI699314.1. Transcript Variant: This variant (2) uses an alternate splice site in the 3' terminal exon, compared to variant 1, resulting in an isoform (2) that has a distinct C-terminus and is 1 aa shorter than isoform 1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR5189667.272627.1, SRR5189655.198955.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGGCACCG CAGGAGCCAT GCAGCTGTGC TGGGTGATCC TGGGCTTCCT CCTGTTCCGA 
GGCCACAACT CCCAGCCCAC AATGACCCAG ACCTCTAGCT CTCAGGGAGG CCTTGGCGGT 
CTAAGTCTGA CCACAGAGCC AGTTTCTTCC AACCCAGGAT ACATCCCTTC CTCAGAGGCT 
AACAGGCCAA GCCATCTGTC CAGCACTGGT ACCCCAGGCG CAGGTGTCCC CAGCAGTGGA 
AGAGACGGAG GCACAAGCAG AGACACATTT CAAACTGTTC CCCCCAATTC AACCACCATG 
AGCCTGAGCA TGAGGGAAGA TGCGACCATC CTGCCCAGCC CCACGTCAGA GACTGTGCTC 
ACTGTGGCTG CATTTGGTGT TATCAGCTTC ATTGTCATCC TGGTGGTTGT GGTGATCATC 
CTAGTTGGTG TGGTCAGCCT GAGGTTCAAG TGTCGGAAGA GCAAGGAGTC TGAAGATCCC 
CAGAAACCTG GGAGTTCAGG GCTGTCTGAA AGCTGCTCCA CAGCCAATGG AGAGAAAGAC 
AGCATCACCC TTATCTCCAT GAAGAACATC AACATGAATA ATGGCAAACA AAGTCTCTCA 
GCAGAGAAGA TCTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001280668.1
CDS	74..688
Translation	MGTAGAMQLCWVILGFLLFRGHNSQPTMTQTSSSQGGLGGLSLTTEPVSSNPGYIPSSEANRPSHLSSTGTPGAGVPSSGRDGGTSRDTFQTVPPNSTTMSLSMREDATILPSPTSETVLTVAAFGVISFIVILVVVVIILVGVVSLRFKCRKSKESEDPQKPGSSGLSESCSTANGEKDSITLISMKNINMNNGKQSLSAEKI

Target ORF information:

RefSeq Version	NM_001293739.1
Organism	Homo sapiens(human)
Definition	Homo sapiens endothelial cell surface expressed chemotaxis and apoptosis regulator (ECSCR), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001293739.1

ORF Insert Sequence:

ATGGGCACCG CAGGAGCCAT GCAGCTGTGC TGGGTGATCC TGGGCTTCCT CCTGTTCCGA 
GGCCACAACT CCCAGCCCAC AATGACCCAG ACCTCTAGCT CTCAGGGAGG CCTTGGCGGT 
CTAAGTCTGA CCACAGAGCC AGTTTCTTCC AACCCAGGAT ACATCCCTTC CTCAGAGGCT 
AACAGGCCAA GCCATCTGTC CAGCACTGGT ACCCCAGGCG CAGGTGTCCC CAGCAGTGGA 
AGAGACGGAG GCACAAGCAG AGACACATTT CAAACTGTTC CCCCCAATTC AACCACCATG 
AGCCTGAGCA TGAGGGAAGA TGCGACCATC CTGCCCAGCC CCACGTCAGA GACTGTGCTC 
ACTGTGGCTG CATTTGGTGT TATCAGCTTC ATTGTCATCC TGGTGGTTGT GGTGATCATC 
CTAGTTGGTG TGGTCAGCCT GAGGTTCAAG TGTCGGAAGA GCAAGGAGTC TGAAGATCCC 
CAGAAACCTG GGAGTTCAGG GCTGTCTGAA AGCTGCTCCA CAGCCAATGG AGAGAAAGAC 
AGCATCACCC TTATCTCCAT GAAGAACATC AACATGAATA ATGGCAAACA AAGTCTCTCA 
GCAGAGAAGA TCTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

ECSCR ( NM_001293739.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_001280668.1 Homo sapiens endothelial cell surface expressed chemotaxis and apoptosis regulator (ECSCR), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OHu28262
Clone ID Related Accession (Same CDS sequence)	NM_001293739.1 , NM_001293739.2
Accession Version	NM_001293739.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 615bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-05-30
Organism	Homo sapiens(human)
Product	endothelial cell-specific chemotaxis regulator isoform 2 precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from EU025066.1, BI834795.1, AC188049.2, AC142391.2 and AI699314.1. On May 31, 2019 this sequence version replaced NM_001293739.1. Transcript Variant: This variant (2) uses an alternate splice site in the 3' terminal exon, compared to variant 1, resulting in an isoform (2) that has a distinct C-terminus and is 1 aa shorter than isoform 1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: ERR279862.1278.1, SRR5189667.272627.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGGCACCG CAGGAGCCAT GCAGCTGTGC TGGGTGATCC TGGGCTTCCT CCTGTTCCGA 
GGCCACAACT CCCAGCCCAC AATGACCCAG ACCTCTAGCT CTCAGGGAGG CCTTGGCGGT 
CTAAGTCTGA CCACAGAGCC AGTTTCTTCC AACCCAGGAT ACATCCCTTC CTCAGAGGCT 
AACAGGCCAA GCCATCTGTC CAGCACTGGT ACCCCAGGCG CAGGTGTCCC CAGCAGTGGA 
AGAGACGGAG GCACAAGCAG AGACACATTT CAAACTGTTC CCCCCAATTC AACCACCATG 
AGCCTGAGCA TGAGGGAAGA TGCGACCATC CTGCCCAGCC CCACGTCAGA GACTGTGCTC 
ACTGTGGCTG CATTTGGTGT TATCAGCTTC ATTGTCATCC TGGTGGTTGT GGTGATCATC 
CTAGTTGGTG TGGTCAGCCT GAGGTTCAAG TGTCGGAAGA GCAAGGAGTC TGAAGATCCC 
CAGAAACCTG GGAGTTCAGG GCTGTCTGAA AGCTGCTCCA CAGCCAATGG AGAGAAAGAC 
AGCATCACCC TTATCTCCAT GAAGAACATC AACATGAATA ATGGCAAACA AAGTCTCTCA 
GCAGAGAAGA TCTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001280668.1
CDS	74..688
Translation	MGTAGAMQLCWVILGFLLFRGHNSQPTMTQTSSSQGGLGGLSLTTEPVSSNPGYIPSSEANRPSHLSSTGTPGAGVPSSGRDGGTSRDTFQTVPPNSTTMSLSMREDATILPSPTSETVLTVAAFGVISFIVILVVVVIILVGVVSLRFKCRKSKESEDPQKPGSSGLSESCSTANGEKDSITLISMKNINMNNGKQSLSAEKI

Target ORF information:

RefSeq Version	NM_001293739.2
Organism	Homo sapiens(human)
Definition	Homo sapiens endothelial cell surface expressed chemotaxis and apoptosis regulator (ECSCR), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001293739.2

ORF Insert Sequence:

ATGGGCACCG CAGGAGCCAT GCAGCTGTGC TGGGTGATCC TGGGCTTCCT CCTGTTCCGA 
GGCCACAACT CCCAGCCCAC AATGACCCAG ACCTCTAGCT CTCAGGGAGG CCTTGGCGGT 
CTAAGTCTGA CCACAGAGCC AGTTTCTTCC AACCCAGGAT ACATCCCTTC CTCAGAGGCT 
AACAGGCCAA GCCATCTGTC CAGCACTGGT ACCCCAGGCG CAGGTGTCCC CAGCAGTGGA 
AGAGACGGAG GCACAAGCAG AGACACATTT CAAACTGTTC CCCCCAATTC AACCACCATG 
AGCCTGAGCA TGAGGGAAGA TGCGACCATC CTGCCCAGCC CCACGTCAGA GACTGTGCTC 
ACTGTGGCTG CATTTGGTGT TATCAGCTTC ATTGTCATCC TGGTGGTTGT GGTGATCATC 
CTAGTTGGTG TGGTCAGCCT GAGGTTCAAG TGTCGGAAGA GCAAGGAGTC TGAAGATCCC 
CAGAAACCTG GGAGTTCAGG GCTGTCTGAA AGCTGCTCCA CAGCCAATGG AGAGAAAGAC 
AGCATCACCC TTATCTCCAT GAAGAACATC AACATGAATA ATGGCAAACA AAGTCTCTCA 
GCAGAGAAGA TCTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Biomarkers of evasive resistance predict disease progression in cancer patients treated with antiangiogenic therapies.
Oncotarget7(15)20109-23(2016 Apr)
Pircher A,J?hrer K,Kocher F,Steiner N,Graziadei I,Heidegger I,Pichler R,Leonhartsberger N,Kremser C,Kern J,Untergasser G,Gunsilius E,Hilbe W

Favorable prognosis of operable non-small cell lung cancer (NSCLC) patients harboring an increased expression of tumor endothelial markers (TEMs).
Lung cancer (Amsterdam, Netherlands)81(2)252-8(2013 Aug)
Pircher A,Fiegl M,Untergasser G,Heidegger I,Medinger M,Kern J,Hilbe W

Preparation of anti-hECSM2 mouse monoclonal antibodies and their application in the analysis of hECSM2 expression.
Monoclonal antibodies in immunodiagnosis and immunotherapy32(4)301-8(2013 Aug)
Chen L,Ma C,He J,He Y,Wang J,Gou L,Yang J

Endothelial cell-specific chemotaxis receptor (ECSCR) enhances vascular endothelial growth factor (VEGF) receptor-2/kinase insert domain receptor (KDR) activation and promotes proteolysis of internalized KDR.
The Journal of biological chemistry288(15)10265-74(2013 Apr)
Kilari S,Remadevi I,Zhao B,Pan J,Miao R,Ramchandran R,North PE,You M,Rahimi N,Wilkinson GA

Identification of novel splice variants and exons of human endothelial cell-specific chemotaxic regulator (ECSCR) by bioinformatics analysis.
Computational biology and chemistry4141-50(2012 Dec)
Lu J,Li C,Shi C,Balducci J,Huang H,Ji HL,Chang Y,Huang Y