TAS2R1 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	TAS2R1
Entrez Gene ID	50834
Full Name	taste 2 receptor member 1
Synonyms	T2R1,TRB7
General protein information	Preferred Names taste 2 receptor member 1 Names taste receptor type 2 member 1 taste receptor, family B, member 7 taste receptor, type 2, member 1
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 5 Map Location: 5p15.31
Summary	This gene encodes a member of a family of candidate taste receptors that are members of the G protein-coupled receptor superfamily and that are specifically expressed by taste receptor cells of the tongue and palate epithelia. This intronless taste receptor gene encodes a 7-transmembrane receptor protein, functioning as a bitter taste receptor. This gene is mapped to chromosome 5p15, the location of a genetic locus (PROP) that controls the detection of the bitter compound 6-n-propyl-2-thiouracil. [provided by RefSeq, Jul 2008].
Disorder MIM:	604796

mRNA and Protein(s)

mRNA	Protein	Name
NM_019599.2	NP_062545.1	taste receptor type 2 member 1
NM_019599.3	NP_062545.1	taste receptor type 2 member 1

Pathways from BioSystems

Homologies

Bos taurus (cattle)	TAS2R1	NP_001040101.1
Mus musculus (house mouse)	Tas2r119	NP_065249.2
Rattus norvegicus (Norway rat)	Tas2r119	NP_076483.1
Homo sapiens (human)	TAS2R1	NP_062545.1
Pan troglodytes (chimpanzee)	TAS2R1	NP_001009100.1
Canis lupus familiaris (dog)	TAS2R1	NP_001138977.1
	TAS2R1	XP_001084193.1

Gene Ontology
Bibliography

Related articles in PubMed

Antimitogenic effect of bitter taste receptor agonists on airway smooth muscle cells.
Sharma P, Panebra A, Pera T, Tiegs BC, Hershfeld A, Kenyon LC, Deshpande DA
American journal of physiology. Lung cellular and molecular physiology310(4)L365-76(2016 Feb)

Expression and functional activity of the bitter taste receptors TAS2R1 and TAS2R38 in human keratinocytes.
W?lfle U, Elsholz FA, Kersten A, Haarhaus B, M?ller WE, Schempp CM
Skin pharmacology and physiology28(3)137-46(2015)

Genome-wide association study of HLA-DQB1*06:02 negative essential hypersomnia.
Khor SS, Miyagawa T, Toyoda H, Yamasaki M, Kawamura Y, Tanii H, Okazaki Y, Sasaki T, Lin L, Faraco J, Rico T, Honda Y, Honda M, Mignot E, Tokunaga K
PeerJ1e66(2013)

TAS2R activation promotes airway smooth muscle relaxation despite ?(2)-adrenergic receptor tachyphylaxis.
An SS, Wang WC, Koziol-White CJ, Ahn K, Lee DY, Kurten RC, Panettieri RA Jr, Liggett SB
American journal of physiology. Lung cellular and molecular physiology303(4)L304-11(2012 Aug)

Structural basis of activation of bitter taste receptor T2R1 and comparison with Class A G-protein-coupled receptors (GPCRs).
Singh N, Pydi SP, Upadhyaya J, Chelikani P
The Journal of biological chemistry286(41)36032-41(2011 Oct)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

TAS2R agonists block signaling downstream of phosphatidylinositol 3-kinase
Title: Antimitogenic effect of bitter taste receptor agonists on airway smooth muscle cells.

Expression and functional activity of the bitter taste receptors TAS2R1 and TAS2R38 in human keratinocytes
Title: Expression and functional activity of the bitter taste receptors TAS2R1 and TAS2R38 in human keratinocytes.

Intracellular signaling and cell mechanics using isolated human airway smooth muscle, mouse tracheal responses, and human bronchial responses to characterize TAS2R relaxation in the context of beta(2)AR desensitization.
Title: TAS2R activation promotes airway smooth muscle relaxation despite ?(2)-adrenergic receptor tachyphylaxis.

Structural basis of activation of bitter taste receptor T2R1 and comparison with Class A G-protein-coupled receptors (GPCRs).
Title: Structural basis of activation of bitter taste receptor T2R1 and comparison with Class A G-protein-coupled receptors (GPCRs).

The formation of a short helical segment in intracellular loop II may be necessary for the activation of hTAS2R1.
Title: Structure-function relationships of the human bitter taste receptor hTAS2R1: insights from molecular modeling studies.

The following TAS2R1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the TAS2R1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu29477	NM_019599.3 Latest version!	Homo sapiens taste 2 receptor member 1 (TAS2R1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$99.50-$139.30 $199.00
View Old Accession Versions >>
OHu29477	NM_019599.2	Homo sapiens taste 2 receptor member 1 (TAS2R1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$99.50-$139.30 $199.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

TAS2R1 ( NM_019599.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_062545.1 Homo sapiens taste 2 receptor member 1 (TAS2R1), mRNA.

Price & Availability↑

CloneID	OHu29477
Clone ID Related Accession (Same CDS sequence)	NM_019599.2 , NM_019599.3
Accession Version	NM_019599.2	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 900bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-05-03
Organism	Homo sapiens(human)
Product	taste receptor type 2 member 1
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BC095521.1 and AC034214.5. On Jun 15, 2005 this sequence version replaced NM_019599.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript is intronless :: BC095521.1 [ECO:0000345] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END##

ATGCTAGAGT CTCACCTCAT TATCTATTTT CTTCTTGCAG TGATACAATT TCTTCTTGGG 
ATTTTCACAA ATGGCATCAT TGTGGTGGTG AATGGCATTG ACTTGATCAA GCACAGAAAA 
ATGGCTCCGC TGGATCTCCT TCTTTCTTGT CTGGCAGTTT CTAGAATTTT TCTGCAGTTG 
TTCATCTTCT ACGTTAATGT GATTGTTATC TTCTTCATAG AATTCATCAT GTGTTCTGCG 
AATTGTGCAA TTCTCTTATT TATAAATGAA TTGGAACTTT GGCTTGCCAC ATGGCTCGGC 
GTTTTCTATT GTGCCAAGGT TGCCAGCGTC CGTCACCCAC TCTTCATCTG GTTGAAGATG 
AGGATATCCA AGCTGGTCCC ATGGATGATC CTGGGGTCTC TGCTATATGT ATCTATGATT 
TGTGTTTTCC ATAGCAAATA TGCAGGGTTT ATGGTCCCAT ACTTCCTAAG GAAATTTTTC 
TCCCAAAATG CCACAATTCA AAAAGAAGAT ACACTGGCTA TACAGATTTT CTCTTTTGTT 
GCTGAGTTCT CAGTGCCATT GCTTATCTTC CTTTTTGCTG TTTTGCTCTT GATTTTCTCT 
CTGGGGAGGC ACACCCGGCA AATGAGAAAC ACAGTGGCCG GCAGCAGGGT TCCTGGCAGG 
GGTGCACCCA TCAGCGCGTT GCTGTCTATC CTGTCCTTCC TGATCCTCTA CTTCTCCCAC 
TGCATGATAA AAGTTTTTCT CTCTTCTCTA AAGTTTCACA TCAGAAGGTT CATCTTTCTG 
TTCTTCATCC TTGTGATTGG TATATACCCT TCTGGACACT CTCTCATCTT AATTTTAGGA 
AATCCTAAAT TGAAACAAAA TGCAAAAAAG TTCCTCCTCC ACAGTAAGTG CTGTCAGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_062545.1
CDS	320..1219
Translation	MLESHLIIYFLLAVIQFLLGIFTNGIIVVVNGIDLIKHRKMAPLDLLLSCLAVSRIFLQLFIFYVNVIVIFFIEFIMCSANCAILLFINELELWLATWLGVFYCAKVASVRHPLFIWLKMRISKLVPWMILGSLLYVSMICVFHSKYAGFMVPYFLRKFFSQNATIQKEDTLAIQIFSFVAEFSVPLLIFLFAVLLLIFSLGRHTRQMRNTVAGSRVPGRGAPISALLSILSFLILYFSHCMIKVFLSSLKFHIRRFIFLFFILVIGIYPSGHSLILILGNPKLKQNAKKFLLHSKCCQ

Target ORF information:

RefSeq Version	NM_019599.2
Organism	Homo sapiens(human)
Definition	Homo sapiens taste 2 receptor member 1 (TAS2R1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_019599.2

ORF Insert Sequence:

ATGCTAGAGT CTCACCTCAT TATCTATTTT CTTCTTGCAG TGATACAATT TCTTCTTGGG 
ATTTTCACAA ATGGCATCAT TGTGGTGGTG AATGGCATTG ACTTGATCAA GCACAGAAAA 
ATGGCTCCGC TGGATCTCCT TCTTTCTTGT CTGGCAGTTT CTAGAATTTT TCTGCAGTTG 
TTCATCTTCT ACGTTAATGT GATTGTTATC TTCTTCATAG AATTCATCAT GTGTTCTGCG 
AATTGTGCAA TTCTCTTATT TATAAATGAA TTGGAACTTT GGCTTGCCAC ATGGCTCGGC 
GTTTTCTATT GTGCCAAGGT TGCCAGCGTC CGTCACCCAC TCTTCATCTG GTTGAAGATG 
AGGATATCCA AGCTGGTCCC ATGGATGATC CTGGGGTCTC TGCTATATGT ATCTATGATT 
TGTGTTTTCC ATAGCAAATA TGCAGGGTTT ATGGTCCCAT ACTTCCTAAG GAAATTTTTC 
TCCCAAAATG CCACAATTCA AAAAGAAGAT ACACTGGCTA TACAGATTTT CTCTTTTGTT 
GCTGAGTTCT CAGTGCCATT GCTTATCTTC CTTTTTGCTG TTTTGCTCTT GATTTTCTCT 
CTGGGGAGGC ACACCCGGCA AATGAGAAAC ACAGTGGCCG GCAGCAGGGT TCCTGGCAGG 
GGTGCACCCA TCAGCGCGTT GCTGTCTATC CTGTCCTTCC TGATCCTCTA CTTCTCCCAC 
TGCATGATAA AAGTTTTTCT CTCTTCTCTA AAGTTTCACA TCAGAAGGTT CATCTTTCTG 
TTCTTCATCC TTGTGATTGG TATATACCCT TCTGGACACT CTCTCATCTT AATTTTAGGA 
AATCCTAAAT TGAAACAAAA TGCAAAAAAG TTCCTCCTCC ACAGTAAGTG CTGTCAGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

TAS2R1 ( NM_019599.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_062545.1 Homo sapiens taste 2 receptor member 1 (TAS2R1), mRNA.

Price & Availability↑

CloneID	OHu29477
Clone ID Related Accession (Same CDS sequence)	NM_019599.2 , NM_019599.3
Accession Version	NM_019599.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 900bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-11-20
Organism	Homo sapiens(human)
Product	taste receptor type 2 member 1
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AC034214.5. On Nov 21, 2019 this sequence version replaced NM_019599.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript is intronless :: BC095521.1 [ECO:0000345] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END##

ATGCTAGAGT CTCACCTCAT TATCTATTTT CTTCTTGCAG TGATACAATT TCTTCTTGGG 
ATTTTCACAA ATGGCATCAT TGTGGTGGTG AATGGCATTG ACTTGATCAA GCACAGAAAA 
ATGGCTCCGC TGGATCTCCT TCTTTCTTGT CTGGCAGTTT CTAGAATTTT TCTGCAGTTG 
TTCATCTTCT ACGTTAATGT GATTGTTATC TTCTTCATAG AATTCATCAT GTGTTCTGCG 
AATTGTGCAA TTCTCTTATT TATAAATGAA TTGGAACTTT GGCTTGCCAC ATGGCTCGGC 
GTTTTCTATT GTGCCAAGGT TGCCAGCGTC CGTCACCCAC TCTTCATCTG GTTGAAGATG 
AGGATATCCA AGCTGGTCCC ATGGATGATC CTGGGGTCTC TGCTATATGT ATCTATGATT 
TGTGTTTTCC ATAGCAAATA TGCAGGGTTT ATGGTCCCAT ACTTCCTAAG GAAATTTTTC 
TCCCAAAATG CCACAATTCA AAAAGAAGAT ACACTGGCTA TACAGATTTT CTCTTTTGTT 
GCTGAGTTCT CAGTGCCATT GCTTATCTTC CTTTTTGCTG TTTTGCTCTT GATTTTCTCT 
CTGGGGAGGC ACACCCGGCA AATGAGAAAC ACAGTGGCCG GCAGCAGGGT TCCTGGCAGG 
GGTGCACCCA TCAGCGCGTT GCTGTCTATC CTGTCCTTCC TGATCCTCTA CTTCTCCCAC 
TGCATGATAA AAGTTTTTCT CTCTTCTCTA AAGTTTCACA TCAGAAGGTT CATCTTTCTG 
TTCTTCATCC TTGTGATTGG TATATACCCT TCTGGACACT CTCTCATCTT AATTTTAGGA 
AATCCTAAAT TGAAACAAAA TGCAAAAAAG TTCCTCCTCC ACAGTAAGTG CTGTCAGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_062545.1
CDS	320..1219
Translation	MLESHLIIYFLLAVIQFLLGIFTNGIIVVVNGIDLIKHRKMAPLDLLLSCLAVSRIFLQLFIFYVNVIVIFFIEFIMCSANCAILLFINELELWLATWLGVFYCAKVASVRHPLFIWLKMRISKLVPWMILGSLLYVSMICVFHSKYAGFMVPYFLRKFFSQNATIQKEDTLAIQIFSFVAEFSVPLLIFLFAVLLLIFSLGRHTRQMRNTVAGSRVPGRGAPISALLSILSFLILYFSHCMIKVFLSSLKFHIRRFIFLFFILVIGIYPSGHSLILILGNPKLKQNAKKFLLHSKCCQ

Target ORF information:

RefSeq Version	NM_019599.3
Organism	Homo sapiens(human)
Definition	Homo sapiens taste 2 receptor member 1 (TAS2R1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_019599.3

ORF Insert Sequence:

ATGCTAGAGT CTCACCTCAT TATCTATTTT CTTCTTGCAG TGATACAATT TCTTCTTGGG 
ATTTTCACAA ATGGCATCAT TGTGGTGGTG AATGGCATTG ACTTGATCAA GCACAGAAAA 
ATGGCTCCGC TGGATCTCCT TCTTTCTTGT CTGGCAGTTT CTAGAATTTT TCTGCAGTTG 
TTCATCTTCT ACGTTAATGT GATTGTTATC TTCTTCATAG AATTCATCAT GTGTTCTGCG 
AATTGTGCAA TTCTCTTATT TATAAATGAA TTGGAACTTT GGCTTGCCAC ATGGCTCGGC 
GTTTTCTATT GTGCCAAGGT TGCCAGCGTC CGTCACCCAC TCTTCATCTG GTTGAAGATG 
AGGATATCCA AGCTGGTCCC ATGGATGATC CTGGGGTCTC TGCTATATGT ATCTATGATT 
TGTGTTTTCC ATAGCAAATA TGCAGGGTTT ATGGTCCCAT ACTTCCTAAG GAAATTTTTC 
TCCCAAAATG CCACAATTCA AAAAGAAGAT ACACTGGCTA TACAGATTTT CTCTTTTGTT 
GCTGAGTTCT CAGTGCCATT GCTTATCTTC CTTTTTGCTG TTTTGCTCTT GATTTTCTCT 
CTGGGGAGGC ACACCCGGCA AATGAGAAAC ACAGTGGCCG GCAGCAGGGT TCCTGGCAGG 
GGTGCACCCA TCAGCGCGTT GCTGTCTATC CTGTCCTTCC TGATCCTCTA CTTCTCCCAC 
TGCATGATAA AAGTTTTTCT CTCTTCTCTA AAGTTTCACA TCAGAAGGTT CATCTTTCTG 
TTCTTCATCC TTGTGATTGG TATATACCCT TCTGGACACT CTCTCATCTT AATTTTAGGA 
AATCCTAAAT TGAAACAAAA TGCAAAAAAG TTCCTCCTCC ACAGTAAGTG CTGTCAGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Antimitogenic effect of bitter taste receptor agonists on airway smooth muscle cells.
American journal of physiology. Lung cellular and molecular physiology310(4)L365-76(2016 Feb)
Sharma P,Panebra A,Pera T,Tiegs BC,Hershfeld A,Kenyon LC,Deshpande DA

Expression and functional activity of the bitter taste receptors TAS2R1 and TAS2R38 in human keratinocytes.
Skin pharmacology and physiology28(3)137-46(2015)
W?lfle U,Elsholz FA,Kersten A,Haarhaus B,M?ller WE,Schempp CM

Genome-wide association study of HLA-DQB1*06:02 negative essential hypersomnia.
PeerJ1e66(2013)
Khor SS,Miyagawa T,Toyoda H,Yamasaki M,Kawamura Y,Tanii H,Okazaki Y,Sasaki T,Lin L,Faraco J,Rico T,Honda Y,Honda M,Mignot E,Tokunaga K

TAS2R activation promotes airway smooth muscle relaxation despite ?(2)-adrenergic receptor tachyphylaxis.
American journal of physiology. Lung cellular and molecular physiology303(4)L304-11(2012 Aug)
An SS,Wang WC,Koziol-White CJ,Ahn K,Lee DY,Kurten RC,Panettieri RA Jr,Liggett SB

Structural basis of activation of bitter taste receptor T2R1 and comparison with Class A G-protein-coupled receptors (GPCRs).
The Journal of biological chemistry286(41)36032-41(2011 Oct)
Singh N,Pydi SP,Upadhyaya J,Chelikani P