NDUFB9 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	NDUFB9
Entrez Gene ID	4715
Full Name	NADH:ubiquinone oxidoreductase subunit B9
Synonyms	B22,CI-B22,LYRM3,UQOR22
General protein information	Preferred Names NADH:ubiquinone oxidoreductase subunit B9 Names NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9 LYR motif-containing protein 3 NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 9, 22kDa NADH-ubiquinone oxidoreductase B22 subunit complex I B22 subunit
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 8 Map Location: 8q24.13
Summary	The protein encoded by this gene is a subunit of the mitochondrial oxidative phosphorylation complex I (nicotinamide adenine dinucleotide: ubiquinone oxidoreductase). Complex I is localized to the inner mitochondrial membrane and functions to dehydrogenate nicotinamide adenine dinucleotide and to shuttle electrons to coenzyme Q. Complex I deficiency is the most common defect found in oxidative phosphorylation disorders and results in a range of conditions, including lethal neonatal disease, hypertrophic cardiomyopathy, liver disease, and adult-onset neurodegenerative disorders. Pseudogenes of this gene are found on chromosomes five, seven and eight. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2015].
Disorder MIM:	601445
Disorder Html:	?Mitochondrial complex I deficiency, 252010 (3)

mRNA and Protein(s)

mRNA	Protein	Name
NM_001311168.1	NP_001298097.1	NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9 isoform 4
NM_005005.2	NP_004996.1	NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9 isoform 1
NM_001278646.1	NP_001265575.1	NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9 isoform 3
NM_001278645.1	NP_001265574.1	NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9 isoform 2
NM_005005.3	NP_004996.1	NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9 isoform 1

Pathways from BioSystems

Homologies

Pan troglodytes (chimpanzee)	NDUFB9	NP_001065267.1
Canis lupus familiaris (dog)	NDUFB9	XP_005627982.1
Rattus norvegicus (Norway rat)	Ndufb9	NP_001120766.1
Bos taurus (cattle)	NDUFB9	NP_786977.1
Mus musculus (house mouse)	Ndufb9	NP_075661.1
	LOC711387	XP_001100168.2
Gallus gallus (chicken)	NDUFB9	XP_418444.3
Danio rerio (zebrafish)	ndufb9	NP_001017880.1
Drosophila melanogaster (fruit fly)	CG9306	NP_609642.1
Caenorhabditis elegans (roundworm)	C16A3.5	NP_498396.1
Homo sapiens (human)	NDUFB9	NP_004996.1
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP009865	XP_318983.3
Xenopus tropicalis (tropical clawed frog)	ndufb9	NP_001072252.1

Gene Ontology
Bibliography

Related articles in PubMed

Accessory subunits are integral for assembly and function of human mitochondrial complex I.
Stroud DA, Surgenor EE, Formosa LE, Reljic B, Frazier AE, Dibley MG, Osellame LD, Stait T, Beilharz TH, Thorburn DR, Salim A, Ryan MT
Nature538(7623)123-126(2016 Oct)

Down-Regulation of NDUFB9 Promotes Breast Cancer Cell Proliferation, Metastasis by Mediating Mitochondrial Metabolism.
Li LD, Sun HF, Liu XX, Gao SP, Jiang HL, Hu X, Jin W
PloS one10(12)e0144441(2015)

Mutation screening of 75 candidate genes in 152 complex I deficiency cases identifies pathogenic variants in 16 genes including NDUFB9.
Haack TB, Madignier F, Herzer M, Lamantea E, Danhauser K, Invernizzi F, Koch J, Freitag M, Drost R, Hillier I, Haberberger B, Mayr JA, Ahting U, Tiranti V, R?tig A, Iuso A, Horvath R, Tesarova M, Baric I, Uziel G, Rolinski B, Sperl W, Meitinger T, Zeviani M, Freisinger P, Prokisch H
Journal of medical genetics49(2)83-9(2012 Feb)

Proteome analysis of the thalamus and cerebrospinal fluid reveals glycolysis dysfunction and potential biomarkers candidates for schizophrenia.
Martins-de-Souza D, Maccarrone G, Wobrock T, Zerr I, Gormanns P, Reckow S, Falkai P, Schmitt A, Turck CW
Journal of psychiatric research44(16)1176-89(2010 Dec)

The subunit composition of the human NADH dehydrogenase obtained by rapid one-step immunopurification.
Murray J, Zhang B, Taylor SW, Oglesbee D, Fahy E, Marusich MF, Ghosh SS, Capaldi RA
The Journal of biological chemistry278(16)13619-22(2003 Apr)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Down-Regulation of NDUFB9 Promotes Breast Cancer Cell Proliferation, Metastasis by Mediating Mitochondrial Metabolism.
Title: Down-Regulation of NDUFB9 Promotes Breast Cancer Cell Proliferation, Metastasis by Mediating Mitochondrial Metabolism.

Mutant NDUFB9 is a new cause of complex I deficiency.
Title: Mutation screening of 75 candidate genes in 152 complex I deficiency cases identifies pathogenic variants in 16 genes including NDUFB9.

This protein has been found differentially expressed in thalami from patients with schizophrenia.
Title: Proteome analysis of the thalamus and cerebrospinal fluid reveals glycolysis dysfunction and potential biomarkers candidates for schizophrenia.

Observational study of gene-disease association. (HuGE Navigator)
Title: Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression.

Observational study of gene-disease association. (HuGE Navigator)
Title: Polymorphisms in mitochondrial genes and prostate cancer risk.

The following NDUFB9 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the NDUFB9 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu30747	NM_005005.3 Latest version!	Homo sapiens NADH:ubiquinone oxidoreductase subunit B9 (NDUFB9), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
OHu08344	NM_001278646.1 Latest version!	Homo sapiens NADH:ubiquinone oxidoreductase subunit B9 (NDUFB9), transcript variant 3, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$69.30 $99.00
OHu08538	NM_001278645.1 Latest version!	Homo sapiens NADH:ubiquinone oxidoreductase subunit B9 (NDUFB9), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$69.30 $99.00
OHu59233	NM_001311168.1 Latest version!	Homo sapiens NADH:ubiquinone oxidoreductase subunit B9 (NDUFB9), transcript variant 4, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$69.30 $99.00
View Old Accession Versions >>
OHu30747	NM_005005.2	Homo sapiens NADH:ubiquinone oxidoreductase subunit B9 (NDUFB9), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
Hide Old Accession Versions >>

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***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

NDUFB9 ( NM_005005.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_004996.1 Homo sapiens NADH:ubiquinone oxidoreductase subunit B9 (NDUFB9), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu30747
Clone ID Related Accession (Same CDS sequence)	NM_005005.2 , NM_005005.3
Accession Version	NM_005005.2	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 540bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-10-01
Organism	Homo sapiens(human)
Product	NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9 isoform 1
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AI907018.1, AF261090.1 and BQ685604.1. This sequence is a reference standard in the RefSeqGene project. On Apr 7, 2007 this sequence version replaced NM_005005.1. Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1). Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BQ685604.1, AF261090.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## gene product(s) localized to mito. :: reported by MitoCarta ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGGCGTTCT TGGCGTCGGG ACCCTACCTG ACCCATCAGC AAAAGGTGTT GCGGCTTTAT 
AAGCGGGCGC TACGCCACCT CGAGTCGTGG TGCGTCCAGA GAGACAAATA CCGATACTTT 
GCTTGTTTGA TGAGAGCCCG GTTTGAAGAA CATAAGAATG AAAAGGATAT GGCGAAGGCC 
ACCCAGCTGC TGAAGGAGGC CGAGGAAGAA TTCTGGTACC GTCAGCATCC ACAGCCATAC 
ATCTTCCCTG ACTCTCCTGG GGGCACCTCC TATGAGAGAT ACGATTGCTA CAAGGTCCCA 
GAATGGTGCT TAGATGACTG GCATCCTTCT GAGAAGGCAA TGTATCCTGA TTACTTTGCC 
AAGAGAGAAC AGTGGAAGAA ACTGCGGAGG GAAAGCTGGG AACGAGAGGT TAAGCAGCTG 
CAGGAGGAAA CGCCACCTGG TGGTCCTTTA ACTGAAGCTT TGCCCCCTGC CCGAAAGGAA 
GGTGATTTGC CCCCACTGTG GTGGTATATT GTGACCAGAC CCCGGGAGCG GCCCATGTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_004996.1
CDS	86..625
Translation	MAFLASGPYLTHQQKVLRLYKRALRHLESWCVQRDKYRYFACLMRARFEEHKNEKDMAKATQLLKEAEEEFWYRQHPQPYIFPDSPGGTSYERYDCYKVPEWCLDDWHPSEKAMYPDYFAKREQWKKLRRESWEREVKQLQEETPPGGPLTEALPPARKEGDLPPLWWYIVTRPRERPM

Target ORF information:

RefSeq Version	NM_005005.2
Organism	Homo sapiens(human)
Definition	Homo sapiens NADH:ubiquinone oxidoreductase subunit B9 (NDUFB9), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_005005.2

ORF Insert Sequence:

ATGGCGTTCT TGGCGTCGGG ACCCTACCTG ACCCATCAGC AAAAGGTGTT GCGGCTTTAT 
AAGCGGGCGC TACGCCACCT CGAGTCGTGG TGCGTCCAGA GAGACAAATA CCGATACTTT 
GCTTGTTTGA TGAGAGCCCG GTTTGAAGAA CATAAGAATG AAAAGGATAT GGCGAAGGCC 
ACCCAGCTGC TGAAGGAGGC CGAGGAAGAA TTCTGGTACC GTCAGCATCC ACAGCCATAC 
ATCTTCCCTG ACTCTCCTGG GGGCACCTCC TATGAGAGAT ACGATTGCTA CAAGGTCCCA 
GAATGGTGCT TAGATGACTG GCATCCTTCT GAGAAGGCAA TGTATCCTGA TTACTTTGCC 
AAGAGAGAAC AGTGGAAGAA ACTGCGGAGG GAAAGCTGGG AACGAGAGGT TAAGCAGCTG 
CAGGAGGAAA CGCCACCTGG TGGTCCTTTA ACTGAAGCTT TGCCCCCTGC CCGAAAGGAA 
GGTGATTTGC CCCCACTGTG GTGGTATATT GTGACCAGAC CCCGGGAGCG GCCCATGTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

NDUFB9 ( NM_005005.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_004996.1 Homo sapiens NADH:ubiquinone oxidoreductase subunit B9 (NDUFB9), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu30747
Clone ID Related Accession (Same CDS sequence)	NM_005005.2 , NM_005005.3
Accession Version	NM_005005.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 540bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-29
Organism	Homo sapiens(human)
Product	NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9 isoform 1
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AI907018.1 and AF261090.1. This sequence is a reference standard in the RefSeqGene project. On Nov 22, 2018 this sequence version replaced NM_005005.2. Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1). Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1660805.78573.1, SRR5189661.147724.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## gene product(s) localized to mito. :: reported by MitoCarta MANE Ensembl match :: ENST00000276689.8/ ENSP00000276689.3 RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGGCGTTCT TGGCGTCGGG ACCCTACCTG ACCCATCAGC AAAAGGTGTT GCGGCTTTAT 
AAGCGGGCGC TACGCCACCT CGAGTCGTGG TGCGTCCAGA GAGACAAATA CCGATACTTT 
GCTTGTTTGA TGAGAGCCCG GTTTGAAGAA CATAAGAATG AAAAGGATAT GGCGAAGGCC 
ACCCAGCTGC TGAAGGAGGC CGAGGAAGAA TTCTGGTACC GTCAGCATCC ACAGCCATAC 
ATCTTCCCTG ACTCTCCTGG GGGCACCTCC TATGAGAGAT ACGATTGCTA CAAGGTCCCA 
GAATGGTGCT TAGATGACTG GCATCCTTCT GAGAAGGCAA TGTATCCTGA TTACTTTGCC 
AAGAGAGAAC AGTGGAAGAA ACTGCGGAGG GAAAGCTGGG AACGAGAGGT TAAGCAGCTG 
CAGGAGGAAA CGCCACCTGG TGGTCCTTTA ACTGAAGCTT TGCCCCCTGC CCGAAAGGAA 
GGTGATTTGC CCCCACTGTG GTGGTATATT GTGACCAGAC CCCGGGAGCG GCCCATGTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_004996.1
CDS	65..604
Translation	MAFLASGPYLTHQQKVLRLYKRALRHLESWCVQRDKYRYFACLMRARFEEHKNEKDMAKATQLLKEAEEEFWYRQHPQPYIFPDSPGGTSYERYDCYKVPEWCLDDWHPSEKAMYPDYFAKREQWKKLRRESWEREVKQLQEETPPGGPLTEALPPARKEGDLPPLWWYIVTRPRERPM

Target ORF information:

RefSeq Version	NM_005005.3
Organism	Homo sapiens(human)
Definition	Homo sapiens NADH:ubiquinone oxidoreductase subunit B9 (NDUFB9), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_005005.3

ORF Insert Sequence:

ATGGCGTTCT TGGCGTCGGG ACCCTACCTG ACCCATCAGC AAAAGGTGTT GCGGCTTTAT 
AAGCGGGCGC TACGCCACCT CGAGTCGTGG TGCGTCCAGA GAGACAAATA CCGATACTTT 
GCTTGTTTGA TGAGAGCCCG GTTTGAAGAA CATAAGAATG AAAAGGATAT GGCGAAGGCC 
ACCCAGCTGC TGAAGGAGGC CGAGGAAGAA TTCTGGTACC GTCAGCATCC ACAGCCATAC 
ATCTTCCCTG ACTCTCCTGG GGGCACCTCC TATGAGAGAT ACGATTGCTA CAAGGTCCCA 
GAATGGTGCT TAGATGACTG GCATCCTTCT GAGAAGGCAA TGTATCCTGA TTACTTTGCC 
AAGAGAGAAC AGTGGAAGAA ACTGCGGAGG GAAAGCTGGG AACGAGAGGT TAAGCAGCTG 
CAGGAGGAAA CGCCACCTGG TGGTCCTTTA ACTGAAGCTT TGCCCCCTGC CCGAAAGGAA 
GGTGATTTGC CCCCACTGTG GTGGTATATT GTGACCAGAC CCCGGGAGCG GCCCATGTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

NDUFB9 ( NM_001278646.1 ) cDNA ORF clone, Homo sapiens(human) -> NP_001265575.1 Homo sapiens NADH:ubiquinone oxidoreductase subunit B9 (NDUFB9), transcript variant 3, mRNA.

Price & Availability↑

CloneID	OHu08344
Clone ID Related Accession (Same CDS sequence)	NM_001278646.1
Accession Version	NM_001278646.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 411bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2018-12-15
Organism	Homo sapiens(human)
Product	NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9 isoform 3
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AC090198.7, BG703246.1 and BG991068.1. Transcript Variant: This variant (3) differs in the 5' UTR and uses a downstream start codon compared to variant 1. It encodes isoform 3, which has a shorter N-terminus compared to isoform 1. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1163658.347375.1, CD176111.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1968540, SAMEA1968832 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## gene product(s) localized to mito. :: reported by MitoCarta ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGAGAGCCC GGTTTGAAGA ACATAAGAAT GAAAAGGATA TGGCGAAGGC CACCCAGCTG 
CTGAAGGAGG CCGAGGAAGA ATTCTGGTAC CGTCAGCATC CACAGCCATA CATCTTCCCT 
GACTCTCCTG GGGGCACCTC CTATGAGAGA TACGATTGCT ACAAGGTCCC AGAATGGTGC 
TTAGATGACT GGCATCCTTC TGAGAAGGCA ATGTATCCTG ATTACTTTGC CAAGAGAGAA 
CAGTGGAAGA AACTGCGGAG GGAAAGCTGG GAACGAGAGG TTAAGCAGCT GCAGGAGGAA 
ACGCCACCTG GTGGTCCTTT AACTGAAGCT TTGCCCCCTG CCCGAAAGGA AGGTGATTTG 
CCCCCACTGT GGTGGTATAT TGTGACCAGA CCCCGGGAGC GGCCCATGTA G

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001265575.1
CDS	213..623
Translation	MRARFEEHKNEKDMAKATQLLKEAEEEFWYRQHPQPYIFPDSPGGTSYERYDCYKVPEWCLDDWHPSEKAMYPDYFAKREQWKKLRRESWEREVKQLQEETPPGGPLTEALPPARKEGDLPPLWWYIVTRPRERPM

Target ORF information:

RefSeq Version	NM_001278646.1
Organism	Homo sapiens(human)
Definition	Homo sapiens NADH:ubiquinone oxidoreductase subunit B9 (NDUFB9), transcript variant 3, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001278646.1

ORF Insert Sequence:

ATGAGAGCCC GGTTTGAAGA ACATAAGAAT GAAAAGGATA TGGCGAAGGC CACCCAGCTG 
CTGAAGGAGG CCGAGGAAGA ATTCTGGTAC CGTCAGCATC CACAGCCATA CATCTTCCCT 
GACTCTCCTG GGGGCACCTC CTATGAGAGA TACGATTGCT ACAAGGTCCC AGAATGGTGC 
TTAGATGACT GGCATCCTTC TGAGAAGGCA ATGTATCCTG ATTACTTTGC CAAGAGAGAA 
CAGTGGAAGA AACTGCGGAG GGAAAGCTGG GAACGAGAGG TTAAGCAGCT GCAGGAGGAA 
ACGCCACCTG GTGGTCCTTT AACTGAAGCT TTGCCCCCTG CCCGAAAGGA AGGTGATTTG 
CCCCCACTGT GGTGGTATAT TGTGACCAGA CCCCGGGAGC GGCCCATGTA G

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

NDUFB9 ( NM_001278645.1 ) cDNA ORF clone, Homo sapiens(human) -> NP_001265574.1 Homo sapiens NADH:ubiquinone oxidoreductase subunit B9 (NDUFB9), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OHu08538
Clone ID Related Accession (Same CDS sequence)	NM_001278645.1
Accession Version	NM_001278645.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 372bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2018-12-15
Organism	Homo sapiens(human)
Product	NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9 isoform 2
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AC090198.7, CN410734.1 and BG991068.1. Transcript Variant:This variant (2) differs in the 5' UTR and uses a downstream start codon compared to variant 1. It encodes isoform 2, which has a shorter N-terminus compared to isoform 1. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: CN410734.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2153980, SAMEA2159931 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## gene product(s) localized to mito. :: reported by MitoCarta ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGGCGAAGG CCACCCAGCT GCTGAAGGAG GCCGAGGAAG AATTCTGGTA CCGTCAGCAT 
CCACAGCCAT ACATCTTCCC TGACTCTCCT GGGGGCACCT CCTATGAGAG ATACGATTGC 
TACAAGGTCC CAGAATGGTG CTTAGATGAC TGGCATCCTT CTGAGAAGGC AATGTATCCT 
GATTACTTTG CCAAGAGAGA ACAGTGGAAG AAACTGCGGA GGGAAAGCTG GGAACGAGAG 
GTTAAGCAGC TGCAGGAGGA AACGCCACCT GGTGGTCCTT TAACTGAAGC TTTGCCCCCT 
GCCCGAAAGG AAGGTGATTT GCCCCCACTG TGGTGGTATA TTGTGACCAG ACCCCGGGAG 
CGGCCCATGT AG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001265574.1
CDS	219..590
Translation	MAKATQLLKEAEEEFWYRQHPQPYIFPDSPGGTSYERYDCYKVPEWCLDDWHPSEKAMYPDYFAKREQWKKLRRESWEREVKQLQEETPPGGPLTEALPPARKEGDLPPLWWYIVTRPRERPM

Target ORF information:

RefSeq Version	NM_001278645.1
Organism	Homo sapiens(human)
Definition	Homo sapiens NADH:ubiquinone oxidoreductase subunit B9 (NDUFB9), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001278645.1

ORF Insert Sequence:

ATGGCGAAGG CCACCCAGCT GCTGAAGGAG GCCGAGGAAG AATTCTGGTA CCGTCAGCAT 
CCACAGCCAT ACATCTTCCC TGACTCTCCT GGGGGCACCT CCTATGAGAG ATACGATTGC 
TACAAGGTCC CAGAATGGTG CTTAGATGAC TGGCATCCTT CTGAGAAGGC AATGTATCCT 
GATTACTTTG CCAAGAGAGA ACAGTGGAAG AAACTGCGGA GGGAAAGCTG GGAACGAGAG 
GTTAAGCAGC TGCAGGAGGA AACGCCACCT GGTGGTCCTT TAACTGAAGC TTTGCCCCCT 
GCCCGAAAGG AAGGTGATTT GCCCCCACTG TGGTGGTATA TTGTGACCAG ACCCCGGGAG 
CGGCCCATGT AG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

NDUFB9 ( NM_001311168.1 ) cDNA ORF clone, Homo sapiens(human) -> NP_001298097.1 Homo sapiens NADH:ubiquinone oxidoreductase subunit B9 (NDUFB9), transcript variant 4, mRNA.

Price & Availability↑

CloneID	OHu59233
Clone ID Related Accession (Same CDS sequence)	NM_001311168.1
Accession Version	NM_001311168.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 507bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2018-12-15
Organism	Homo sapiens(human)
Product	NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9 isoform 4
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AI907018.1, DB504123.1, AF044956.1 and BQ685604.1. Transcript Variant: This variant (4) uses an alternate in-frame splice site in the 5' coding region compared to variant 1. It encodes isoform 4, which is shorter than isoform 1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BF206989.1, SRR1163657.168547.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## gene product(s) localized to mito. :: reported by MitoCarta ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGGCGTTCT TGGCGTCGGG ACCCTACCTG ACCCATCAGC AAAAGGTGTT GCGGCTTTAT 
AAGCGGGCGC TACGCCACCT CGAGTCGTGG TGCGTCCAGA GAGCCCGGTT TGAAGAACAT 
AAGAATGAAA AGGATATGGC GAAGGCCACC CAGCTGCTGA AGGAGGCCGA GGAAGAATTC 
TGGTACCGTC AGCATCCACA GCCATACATC TTCCCTGACT CTCCTGGGGG CACCTCCTAT 
GAGAGATACG ATTGCTACAA GGTCCCAGAA TGGTGCTTAG ATGACTGGCA TCCTTCTGAG 
AAGGCAATGT ATCCTGATTA CTTTGCCAAG AGAGAACAGT GGAAGAAACT GCGGAGGGAA 
AGCTGGGAAC GAGAGGTTAA GCAGCTGCAG GAGGAAACGC CACCTGGTGG TCCTTTAACT 
GAAGCTTTGC CCCCTGCCCG AAAGGAAGGT GATTTGCCCC CACTGTGGTG GTATATTGTG 
ACCAGACCCC GGGAGCGGCC CATGTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001298097.1
CDS	86..592
Translation	MAFLASGPYLTHQQKVLRLYKRALRHLESWCVQRARFEEHKNEKDMAKATQLLKEAEEEFWYRQHPQPYIFPDSPGGTSYERYDCYKVPEWCLDDWHPSEKAMYPDYFAKREQWKKLRRESWEREVKQLQEETPPGGPLTEALPPARKEGDLPPLWWYIVTRPRERPM

Target ORF information:

RefSeq Version	NM_001311168.1
Organism	Homo sapiens(human)
Definition	Homo sapiens NADH:ubiquinone oxidoreductase subunit B9 (NDUFB9), transcript variant 4, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001311168.1

ORF Insert Sequence:

ATGGCGTTCT TGGCGTCGGG ACCCTACCTG ACCCATCAGC AAAAGGTGTT GCGGCTTTAT 
AAGCGGGCGC TACGCCACCT CGAGTCGTGG TGCGTCCAGA GAGCCCGGTT TGAAGAACAT 
AAGAATGAAA AGGATATGGC GAAGGCCACC CAGCTGCTGA AGGAGGCCGA GGAAGAATTC 
TGGTACCGTC AGCATCCACA GCCATACATC TTCCCTGACT CTCCTGGGGG CACCTCCTAT 
GAGAGATACG ATTGCTACAA GGTCCCAGAA TGGTGCTTAG ATGACTGGCA TCCTTCTGAG 
AAGGCAATGT ATCCTGATTA CTTTGCCAAG AGAGAACAGT GGAAGAAACT GCGGAGGGAA 
AGCTGGGAAC GAGAGGTTAA GCAGCTGCAG GAGGAAACGC CACCTGGTGG TCCTTTAACT 
GAAGCTTTGC CCCCTGCCCG AAAGGAAGGT GATTTGCCCC CACTGTGGTG GTATATTGTG 
ACCAGACCCC GGGAGCGGCC CATGTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Accessory subunits are integral for assembly and function of human mitochondrial complex I.
Nature538(7623)123-126(2016 Oct)
Stroud DA,Surgenor EE,Formosa LE,Reljic B,Frazier AE,Dibley MG,Osellame LD,Stait T,Beilharz TH,Thorburn DR,Salim A,Ryan MT

Down-Regulation of NDUFB9 Promotes Breast Cancer Cell Proliferation, Metastasis by Mediating Mitochondrial Metabolism.
PloS one10(12)e0144441(2015)
Li LD,Sun HF,Liu XX,Gao SP,Jiang HL,Hu X,Jin W

Mutation screening of 75 candidate genes in 152 complex I deficiency cases identifies pathogenic variants in 16 genes including NDUFB9.
Journal of medical genetics49(2)83-9(2012 Feb)
Haack TB,Madignier F,Herzer M,Lamantea E,Danhauser K,Invernizzi F,Koch J,Freitag M,Drost R,Hillier I,Haberberger B,Mayr JA,Ahting U,Tiranti V,R?tig A,Iuso A,Horvath R,Tesarova M,Baric I,Uziel G,Rolinski B,Sperl W,Meitinger T,Zeviani M,Freisinger P,Prokisch H

Proteome analysis of the thalamus and cerebrospinal fluid reveals glycolysis dysfunction and potential biomarkers candidates for schizophrenia.
Journal of psychiatric research44(16)1176-89(2010 Dec)
Martins-de-Souza D,Maccarrone G,Wobrock T,Zerr I,Gormanns P,Reckow S,Falkai P,Schmitt A,Turck CW

The subunit composition of the human NADH dehydrogenase obtained by rapid one-step immunopurification.
The Journal of biological chemistry278(16)13619-22(2003 Apr)
Murray J,Zhang B,Taylor SW,Oglesbee D,Fahy E,Marusich MF,Ghosh SS,Capaldi RA

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NDUFB9 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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