KPNA4 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	KPNA4
Entrez Gene ID	3840
Full Name	karyopherin subunit alpha 4
Synonyms	IPOA3,QIP1,SRP3
General protein information	Preferred Names karyopherin subunit alpha 4 Names importin subunit alpha-3 importin alpha Q1 importin subunit alpha-4 karyopherin alpha 4 (importin alpha 3)
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 3 Map Location: 3q25.33
Summary	The nuclear import of karyophilic proteins is directed by short amino acid sequences termed nuclear localization signals (NLSs). Karyopherins, or importins, are cytoplasmic proteins that recognize NLSs and dock NLS-containing proteins to the nuclear pore complex. The protein encoded by this gene shares the sequence similarity with Xenopus importin-alpha and Saccharomyces cerevisiae Srp1. This protein is found to interact with the NLSs of DNA helicase Q1 and SV40 T antigen. [provided by RefSeq, Jul 2008].
Disorder MIM:	602970

mRNA and Protein(s)

mRNA	Protein	Name
NM_002268.4	NP_002259.1	importin subunit alpha-3
NM_002268.5	NP_002259.1	importin subunit alpha-3

Pathways from BioSystems

Homologies

Mus musculus (house mouse)	Kpna4	NP_032493.1
Gallus gallus (chicken)	KPNA4	NP_001007964.1
	KPNA4	XP_001097222.1
Xenopus tropicalis (tropical clawed frog)	kpna4	XP_002933281.2
Rattus norvegicus (Norway rat)	Kpna4	NP_001014793.1
Drosophila melanogaster (fruit fly)	Kap-alpha3	NP_001163572.1
Caenorhabditis elegans (roundworm)	ima-3	NP_501227.1
Pan troglodytes (chimpanzee)	KPNA4	XP_526365.2
Canis lupus familiaris (dog)	KPNA4	XP_005639922.1
Danio rerio (zebrafish)	kpna4	NP_958462.1
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP001273	XP_321878.4
Homo sapiens (human)	KPNA4	NP_002259.1
Bos taurus (cattle)	KPNA4	NP_001152788.1

Gene Ontology
Bibliography

Related articles in PubMed

Three-dimensional context rather than NLS amino acid sequence determines importin ? subtype specificity for RCC1.
Sankhala RS, Lokareddy RK, Begum S, Pumroy RA, Gillilan RE, Cingolani G
Nature communications8(1)979(2017 Oct)

Japanese Encephalitis Virus NS5 Inhibits Type I Interferon (IFN) Production by Blocking the Nuclear Translocation of IFN Regulatory Factor 3 and NF-?B.
Ye J, Chen Z, Li Y, Zhao Z, He W, Zohaib A, Song Y, Deng C, Zhang B, Chen H, Cao S
Journal of virology91(8)(2017 Apr)

MicroRNA-567 dysregulation contributes to carcinogenesis of breast cancer, targeting tumor cell proliferation, and migration.
Bertoli G, Cava C, Diceglie C, Martelli C, Rizzo G, Piccotti F, Ottobrini L, Castiglioni I
Breast cancer research and treatment161(3)605-616(2017 02)

Development of a pipeline for automated, high-throughput analysis of paraspeckle proteins reveals specific roles for importin ? proteins.
Major AT, Miyamoto Y, Lo CY, Jans DA, Loveland KL
Scientific reports743323(2017 Feb)

An organelle-specific protein landscape identifies novel diseases and molecular mechanisms.
Boldt K, van Reeuwijk J, Lu Q, Koutroumpas K, Nguyen TM, Texier Y, van Beersum SE, Horn N, Willer JR, Mans DA, Dougherty G, Lamers IJ, Coene KL, Arts HH, Betts MJ, Beyer T, Bolat E, Gloeckner CJ, Haidari K, Hetterschijt L, Iaconis D, Jenkins D, Klose F, Knapp B, Latour B, Letteboer SJ, Marcelis CL, Mitic D, Morleo M, Oud MM, Riemersma M, Rix S, Terhal PA, Toedt G, van Dam TJ, de Vrieze E, Wissinger Y, Wu KM, Apic G, Beales PL, Blacque OE, Gibson TJ, Huynen MA, Katsanis N, Kremer H, Omran H, van Wijk E, Wolfrum U, Kepes F, Davis EE, Franco B, Giles RH, Ueffing M, Russell RB, Roepman R,
Nature communications711491(2016 May)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

These results suggest that the Japanese encephalitis virus NS5 inhibits the induction of type I interferon by targeting KPNA3 and KPNA4.
Title: Japanese Encephalitis Virus NS5 Inhibits Type I Interferon (IFN) Production by Blocking the Nuclear Translocation of IFN Regulatory Factor 3 and NF-?B.

Our results suggest a potential role of Hsa-miR-567 as a novel prognostic biomarker for BC and as regulator of KPNA4.
Title: MicroRNA-567 dysregulation contributes to carcinogenesis of breast cancer, targeting tumor cell proliferation, and migration.

Karyopherin alpha 3 and karyopherin alpha 4 proteins mediate the nuclear import of methyl-CpG binding protein 2.
Title: Karyopherin ? 3 and karyopherin ? 4 proteins mediate the nuclear import of methyl-CpG binding protein 2.

Our results showed that miR-181 family expression was closely correlated with TCGA subtypes and patients' overall survival, indicating that miR-181b.
Title: Upregulation of miR-181s reverses mesenchymal transition by targeting KPNA4 in glioblastoma.

miR-223 downregulation promotes glomerular endothelial cell activation by upregulating importin alpha4 and alpha5 in IgA nephropathy
Title: MiR-223 downregulation promotes glomerular endothelial cell activation by upregulating importin ?4 and ?5 in IgA nephropathy.

The following KPNA4 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the KPNA4 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu11782	NM_002268.5 Latest version!	Homo sapiens karyopherin subunit alpha 4 (KPNA4), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$189.50-$265.30 $379.00
View Old Accession Versions >>
OHu11782	NM_002268.4	Homo sapiens karyopherin subunit alpha 4 (KPNA4), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$189.50-$265.30 $379.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

KPNA4 ( NM_002268.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_002259.1 Homo sapiens karyopherin subunit alpha 4 (KPNA4), mRNA.

Price & Availability↑

CloneID	OHu11782
Clone ID Related Accession (Same CDS sequence)	NM_002268.4 , NM_002268.5
Accession Version	NM_002268.4	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1566bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-12-10
Organism	Homo sapiens(human)
Product	importin subunit alpha-3
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BC034493.2 and AC078868.14. On or before Jul 3, 2011 this sequence version replaced XR_108508.1, XR_113535.1, XR_112567.1, NM_002268.3. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC034493.2, SRR1660807.259939.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGCGGACA ACGAGAAACT GGACAACCAA CGGCTCAAGA ATTTCAAGAA CAAAGGCCGC 
GACTTGGAGA CTATGAGAAG ACAACGAAAT GAAGTTGTAG TTGAATTAAG GAAGAATAAA 
AGAGATGAAC ATCTCTTAAA GAGAAGGAAT GTACCACATG AAGATATCTG TGAAGACTCT 
GATATAGATG GTGATTATAG AGTGCAAAAT ACCTCTCTAG AAGCTATTGT TCAAAATGCT 
TCAAGTGATA ACCAAGGAAT TCAATTAAGT GCAGTTCAAG CTGCTAGGAA GCTTTTGTCC 
AGTGATCGAA ATCCACCAAT TGATGACTTA ATAAAATCTG GAATATTGCC CATTTTAGTC 
CATTGTCTTG AAAGAGATGA CAATCCTTCT TTACAGTTTG AAGCTGCATG GGCTTTGACA 
AACATTGCAT CTGGAACTTC TGAACAAACT CAAGCAGTAG TTCAGTCCAA TGCTGTGCCA 
CTTTTCCTGA GGCTTCTCCA TTCACCCCAT CAGAATGTCT GTGAGCAAGC AGTGTGGGCA 
TTGGGAAATA TCATAGGTGA TGGGCCCCAG TGTAGAGATT ATGTCATAAG TCTTGGAGTT 
GTGAAACCTT TACTTTCCTT CATAAGTCCA TCTATTCCTA TAACATTCTT AAGAAATGTT 
ACTTGGGTTA TGGTCAACTT ATGTCGCCAC AAAGACCCAC CACCACCAAT GGAAACCATT 
CAGGAGATTC TTCCAGCCCT TTGTGTTTTA ATTCATCACA CAGATGTAAA TATACTGGTA 
GACACAGTCT GGGCCCTCTC TTACCTTACT GATGCTGGCA ATGAACAAAT ACAGATGGTA 
ATAGACTCTG GAATAGTTCC TCATTTGGTT CCTCTGCTCA GCCACCAGGA AGTTAAAGTT 
CAGACTGCTG CACTTAGAGC TGTGGGCAAC ATTGTTACTG GAACTGATGA GCAAACACAA 
GTAGTTTTGA ACTGTGATGC TCTTTCACAC TTCCCAGCAC TCCTGACACA TCCCAAAGAG 
AAAATTAATA AAGAAGCAGT GTGGTTCCTC TCCAACATCA CTGCAGGAAA TCAGCAGCAG 
GTACAGGCAG TAATTGATGC CAATCTTGTA CCAATGATAA TACACCTTTT GGATAAGGGG 
GATTTTGGCA CTCAAAAAGA AGCTGCTTGG GCCATAAGTA ACTTAACAAT TAGTGGAAGG 
AAAGATCAAG TGGCTTACCT TATCCAACAA AATGTTATCC CACCTTTTTG CAACTTGCTG 
ACTGTAAAAG ATGCACAAGT TGTGCAAGTA GTACTCGATG GACTAAGTAA TATATTAAAA 
ATGGCTGAAG ATGAGGCAGA AACCATAGGC AATCTTATAG AAGAATGTGG AGGGCTGGAG 
AAAATTGAAC AACTTCAAAA TCATGAAAAT GAAGACATCT ACAAATTGGC CTATGAGATC 
ATTGATCAGT TCTTCTCTTC AGATGATATT GATGAAGACC CTAGCCTTGT TCCAGAGGCA 
ATTCAAGGCG GAACATTTGG TTTCAATTCA TCTGCCAATG TACCAACAGA AGGGTTCCAG 
TTTTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_002259.1
CDS	307..1872
Translation	MADNEKLDNQRLKNFKNKGRDLETMRRQRNEVVVELRKNKRDEHLLKRRNVPHEDICEDSDIDGDYRVQNTSLEAIVQNASSDNQGIQLSAVQAARKLLSSDRNPPIDDLIKSGILPILVHCLERDDNPSLQFEAAWALTNIASGTSEQTQAVVQSNAVPLFLRLLHSPHQNVCEQAVWALGNIIGDGPQCRDYVISLGVVKPLLSFISPSIPITFLRNVTWVMVNLCRHKDPPPPMETIQEILPALCVLIHHTDVNILVDTVWALSYLTDAGNEQIQMVIDSGIVPHLVPLLSHQEVKVQTAALRAVGNIVTGTDEQTQVVLNCDALSHFPALLTHPKEKINKEAVWFLSNITAGNQQQVQAVIDANLVPMIIHLLDKGDFGTQKEAAWAISNLTISGRKDQVAYLIQQNVIPPFCNLLTVKDAQVVQVVLDGLSNILKMAEDEAETIGNLIEECGGLEKIEQLQNHENEDIYKLAYEIIDQFFSSDDIDEDPSLVPEAIQGGTFGFNSSANVPTEGFQF

Target ORF information:

RefSeq Version	NM_002268.4
Organism	Homo sapiens(human)
Definition	Homo sapiens karyopherin subunit alpha 4 (KPNA4), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_002268.4

ORF Insert Sequence:

ATGGCGGACA ACGAGAAACT GGACAACCAA CGGCTCAAGA ATTTCAAGAA CAAAGGCCGC 
GACTTGGAGA CTATGAGAAG ACAACGAAAT GAAGTTGTAG TTGAATTAAG GAAGAATAAA 
AGAGATGAAC ATCTCTTAAA GAGAAGGAAT GTACCACATG AAGATATCTG TGAAGACTCT 
GATATAGATG GTGATTATAG AGTGCAAAAT ACCTCTCTAG AAGCTATTGT TCAAAATGCT 
TCAAGTGATA ACCAAGGAAT TCAATTAAGT GCAGTTCAAG CTGCTAGGAA GCTTTTGTCC 
AGTGATCGAA ATCCACCAAT TGATGACTTA ATAAAATCTG GAATATTGCC CATTTTAGTC 
CATTGTCTTG AAAGAGATGA CAATCCTTCT TTACAGTTTG AAGCTGCATG GGCTTTGACA 
AACATTGCAT CTGGAACTTC TGAACAAACT CAAGCAGTAG TTCAGTCCAA TGCTGTGCCA 
CTTTTCCTGA GGCTTCTCCA TTCACCCCAT CAGAATGTCT GTGAGCAAGC AGTGTGGGCA 
TTGGGAAATA TCATAGGTGA TGGGCCCCAG TGTAGAGATT ATGTCATAAG TCTTGGAGTT 
GTGAAACCTT TACTTTCCTT CATAAGTCCA TCTATTCCTA TAACATTCTT AAGAAATGTT 
ACTTGGGTTA TGGTCAACTT ATGTCGCCAC AAAGACCCAC CACCACCAAT GGAAACCATT 
CAGGAGATTC TTCCAGCCCT TTGTGTTTTA ATTCATCACA CAGATGTAAA TATACTGGTA 
GACACAGTCT GGGCCCTCTC TTACCTTACT GATGCTGGCA ATGAACAAAT ACAGATGGTA 
ATAGACTCTG GAATAGTTCC TCATTTGGTT CCTCTGCTCA GCCACCAGGA AGTTAAAGTT 
CAGACTGCTG CACTTAGAGC TGTGGGCAAC ATTGTTACTG GAACTGATGA GCAAACACAA 
GTAGTTTTGA ACTGTGATGC TCTTTCACAC TTCCCAGCAC TCCTGACACA TCCCAAAGAG 
AAAATTAATA AAGAAGCAGT GTGGTTCCTC TCCAACATCA CTGCAGGAAA TCAGCAGCAG 
GTACAGGCAG TAATTGATGC CAATCTTGTA CCAATGATAA TACACCTTTT GGATAAGGGG 
GATTTTGGCA CTCAAAAAGA AGCTGCTTGG GCCATAAGTA ACTTAACAAT TAGTGGAAGG 
AAAGATCAAG TGGCTTACCT TATCCAACAA AATGTTATCC CACCTTTTTG CAACTTGCTG 
ACTGTAAAAG ATGCACAAGT TGTGCAAGTA GTACTCGATG GACTAAGTAA TATATTAAAA 
ATGGCTGAAG ATGAGGCAGA AACCATAGGC AATCTTATAG AAGAATGTGG AGGGCTGGAG 
AAAATTGAAC AACTTCAAAA TCATGAAAAT GAAGACATCT ACAAATTGGC CTATGAGATC 
ATTGATCAGT TCTTCTCTTC AGATGATATT GATGAAGACC CTAGCCTTGT TCCAGAGGCA 
ATTCAAGGCG GAACATTTGG TTTCAATTCA TCTGCCAATG TACCAACAGA AGGGTTCCAG 
TTTTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

KPNA4 ( NM_002268.5 ) cDNA ORF clone, Homo sapiens(human) -> NP_002259.1 Homo sapiens karyopherin subunit alpha 4 (KPNA4), mRNA.

Price & Availability↑

CloneID	OHu11782
Clone ID Related Accession (Same CDS sequence)	NM_002268.4 , NM_002268.5
Accession Version	NM_002268.5 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1566bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-07-05
Organism	Homo sapiens(human)
Product	importin subunit alpha-3
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BC034493.2 and AC078868.14. On Nov 23, 2018 this sequence version replaced NM_002268.4. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1660807.259939.1, SRR1660807.245511.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000334256.9/ ENSP00000334373.4 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGGCGGACA ACGAGAAACT GGACAACCAA CGGCTCAAGA ATTTCAAGAA CAAAGGCCGC 
GACTTGGAGA CTATGAGAAG ACAACGAAAT GAAGTTGTAG TTGAATTAAG GAAGAATAAA 
AGAGATGAAC ATCTCTTAAA GAGAAGGAAT GTACCACATG AAGATATCTG TGAAGACTCT 
GATATAGATG GTGATTATAG AGTGCAAAAT ACCTCTCTAG AAGCTATTGT TCAAAATGCT 
TCAAGTGATA ACCAAGGAAT TCAATTAAGT GCAGTTCAAG CTGCTAGGAA GCTTTTGTCC 
AGTGATCGAA ATCCACCAAT TGATGACTTA ATAAAATCTG GAATATTGCC CATTTTAGTC 
CATTGTCTTG AAAGAGATGA CAATCCTTCT TTACAGTTTG AAGCTGCATG GGCTTTGACA 
AACATTGCAT CTGGAACTTC TGAACAAACT CAAGCAGTAG TTCAGTCCAA TGCTGTGCCA 
CTTTTCCTGA GGCTTCTCCA TTCACCCCAT CAGAATGTCT GTGAGCAAGC AGTGTGGGCA 
TTGGGAAATA TCATAGGTGA TGGGCCCCAG TGTAGAGATT ATGTCATAAG TCTTGGAGTT 
GTGAAACCTT TACTTTCCTT CATAAGTCCA TCTATTCCTA TAACATTCTT AAGAAATGTT 
ACTTGGGTTA TGGTCAACTT ATGTCGCCAC AAAGACCCAC CACCACCAAT GGAAACCATT 
CAGGAGATTC TTCCAGCCCT TTGTGTTTTA ATTCATCACA CAGATGTAAA TATACTGGTA 
GACACAGTCT GGGCCCTCTC TTACCTTACT GATGCTGGCA ATGAACAAAT ACAGATGGTA 
ATAGACTCTG GAATAGTTCC TCATTTGGTT CCTCTGCTCA GCCACCAGGA AGTTAAAGTT 
CAGACTGCTG CACTTAGAGC TGTGGGCAAC ATTGTTACTG GAACTGATGA GCAAACACAA 
GTAGTTTTGA ACTGTGATGC TCTTTCACAC TTCCCAGCAC TCCTGACACA TCCCAAAGAG 
AAAATTAATA AAGAAGCAGT GTGGTTCCTC TCCAACATCA CTGCAGGAAA TCAGCAGCAG 
GTACAGGCAG TAATTGATGC CAATCTTGTA CCAATGATAA TACACCTTTT GGATAAGGGG 
GATTTTGGCA CTCAAAAAGA AGCTGCTTGG GCCATAAGTA ACTTAACAAT TAGTGGAAGG 
AAAGATCAAG TGGCTTACCT TATCCAACAA AATGTTATCC CACCTTTTTG CAACTTGCTG 
ACTGTAAAAG ATGCACAAGT TGTGCAAGTA GTACTCGATG GACTAAGTAA TATATTAAAA 
ATGGCTGAAG ATGAGGCAGA AACCATAGGC AATCTTATAG AAGAATGTGG AGGGCTGGAG 
AAAATTGAAC AACTTCAAAA TCATGAAAAT GAAGACATCT ACAAATTGGC CTATGAGATC 
ATTGATCAGT TCTTCTCTTC AGATGATATT GATGAAGACC CTAGCCTTGT TCCAGAGGCA 
ATTCAAGGCG GAACATTTGG TTTCAATTCA TCTGCCAATG TACCAACAGA AGGGTTCCAG 
TTTTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_002259.1
CDS	290..1855
Translation	MADNEKLDNQRLKNFKNKGRDLETMRRQRNEVVVELRKNKRDEHLLKRRNVPHEDICEDSDIDGDYRVQNTSLEAIVQNASSDNQGIQLSAVQAARKLLSSDRNPPIDDLIKSGILPILVHCLERDDNPSLQFEAAWALTNIASGTSEQTQAVVQSNAVPLFLRLLHSPHQNVCEQAVWALGNIIGDGPQCRDYVISLGVVKPLLSFISPSIPITFLRNVTWVMVNLCRHKDPPPPMETIQEILPALCVLIHHTDVNILVDTVWALSYLTDAGNEQIQMVIDSGIVPHLVPLLSHQEVKVQTAALRAVGNIVTGTDEQTQVVLNCDALSHFPALLTHPKEKINKEAVWFLSNITAGNQQQVQAVIDANLVPMIIHLLDKGDFGTQKEAAWAISNLTISGRKDQVAYLIQQNVIPPFCNLLTVKDAQVVQVVLDGLSNILKMAEDEAETIGNLIEECGGLEKIEQLQNHENEDIYKLAYEIIDQFFSSDDIDEDPSLVPEAIQGGTFGFNSSANVPTEGFQF

Target ORF information:

RefSeq Version	NM_002268.5
Organism	Homo sapiens(human)
Definition	Homo sapiens karyopherin subunit alpha 4 (KPNA4), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_002268.5

ORF Insert Sequence:

ATGGCGGACA ACGAGAAACT GGACAACCAA CGGCTCAAGA ATTTCAAGAA CAAAGGCCGC 
GACTTGGAGA CTATGAGAAG ACAACGAAAT GAAGTTGTAG TTGAATTAAG GAAGAATAAA 
AGAGATGAAC ATCTCTTAAA GAGAAGGAAT GTACCACATG AAGATATCTG TGAAGACTCT 
GATATAGATG GTGATTATAG AGTGCAAAAT ACCTCTCTAG AAGCTATTGT TCAAAATGCT 
TCAAGTGATA ACCAAGGAAT TCAATTAAGT GCAGTTCAAG CTGCTAGGAA GCTTTTGTCC 
AGTGATCGAA ATCCACCAAT TGATGACTTA ATAAAATCTG GAATATTGCC CATTTTAGTC 
CATTGTCTTG AAAGAGATGA CAATCCTTCT TTACAGTTTG AAGCTGCATG GGCTTTGACA 
AACATTGCAT CTGGAACTTC TGAACAAACT CAAGCAGTAG TTCAGTCCAA TGCTGTGCCA 
CTTTTCCTGA GGCTTCTCCA TTCACCCCAT CAGAATGTCT GTGAGCAAGC AGTGTGGGCA 
TTGGGAAATA TCATAGGTGA TGGGCCCCAG TGTAGAGATT ATGTCATAAG TCTTGGAGTT 
GTGAAACCTT TACTTTCCTT CATAAGTCCA TCTATTCCTA TAACATTCTT AAGAAATGTT 
ACTTGGGTTA TGGTCAACTT ATGTCGCCAC AAAGACCCAC CACCACCAAT GGAAACCATT 
CAGGAGATTC TTCCAGCCCT TTGTGTTTTA ATTCATCACA CAGATGTAAA TATACTGGTA 
GACACAGTCT GGGCCCTCTC TTACCTTACT GATGCTGGCA ATGAACAAAT ACAGATGGTA 
ATAGACTCTG GAATAGTTCC TCATTTGGTT CCTCTGCTCA GCCACCAGGA AGTTAAAGTT 
CAGACTGCTG CACTTAGAGC TGTGGGCAAC ATTGTTACTG GAACTGATGA GCAAACACAA 
GTAGTTTTGA ACTGTGATGC TCTTTCACAC TTCCCAGCAC TCCTGACACA TCCCAAAGAG 
AAAATTAATA AAGAAGCAGT GTGGTTCCTC TCCAACATCA CTGCAGGAAA TCAGCAGCAG 
GTACAGGCAG TAATTGATGC CAATCTTGTA CCAATGATAA TACACCTTTT GGATAAGGGG 
GATTTTGGCA CTCAAAAAGA AGCTGCTTGG GCCATAAGTA ACTTAACAAT TAGTGGAAGG 
AAAGATCAAG TGGCTTACCT TATCCAACAA AATGTTATCC CACCTTTTTG CAACTTGCTG 
ACTGTAAAAG ATGCACAAGT TGTGCAAGTA GTACTCGATG GACTAAGTAA TATATTAAAA 
ATGGCTGAAG ATGAGGCAGA AACCATAGGC AATCTTATAG AAGAATGTGG AGGGCTGGAG 
AAAATTGAAC AACTTCAAAA TCATGAAAAT GAAGACATCT ACAAATTGGC CTATGAGATC 
ATTGATCAGT TCTTCTCTTC AGATGATATT GATGAAGACC CTAGCCTTGT TCCAGAGGCA 
ATTCAAGGCG GAACATTTGG TTTCAATTCA TCTGCCAATG TACCAACAGA AGGGTTCCAG 
TTTTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Three-dimensional context rather than NLS amino acid sequence determines importin ? subtype specificity for RCC1.
Nature communications8(1)979(2017 Oct)
Sankhala RS,Lokareddy RK,Begum S,Pumroy RA,Gillilan RE,Cingolani G

Japanese Encephalitis Virus NS5 Inhibits Type I Interferon (IFN) Production by Blocking the Nuclear Translocation of IFN Regulatory Factor 3 and NF-?B.
Journal of virology91(8)(2017 Apr)
Ye J,Chen Z,Li Y,Zhao Z,He W,Zohaib A,Song Y,Deng C,Zhang B,Chen H,Cao S

MicroRNA-567 dysregulation contributes to carcinogenesis of breast cancer, targeting tumor cell proliferation, and migration.
Breast cancer research and treatment161(3)605-616(2017 02)
Bertoli G,Cava C,Diceglie C,Martelli C,Rizzo G,Piccotti F,Ottobrini L,Castiglioni I

Development of a pipeline for automated, high-throughput analysis of paraspeckle proteins reveals specific roles for importin ? proteins.
Scientific reports743323(2017 Feb)
Major AT,Miyamoto Y,Lo CY,Jans DA,Loveland KL

An organelle-specific protein landscape identifies novel diseases and molecular mechanisms.
Nature communications711491(2016 May)
Boldt K,van Reeuwijk J,Lu Q,Koutroumpas K,Nguyen TM,Texier Y,van Beersum SE,Horn N,Willer JR,Mans DA,Dougherty G,Lamers IJ,Coene KL,Arts HH,Betts MJ,Beyer T,Bolat E,Gloeckner CJ,Haidari K,Hetterschijt L,Iaconis D,Jenkins D,Klose F,Knapp B,Latour B,Letteboer SJ,Marcelis CL,Mitic D,Morleo M,Oud MM,Riemersma M,Rix S,Terhal PA,Toedt G,van Dam TJ,de Vrieze E,Wissinger Y,Wu KM,Apic G,Beales PL,Blacque OE,Gibson TJ,Huynen MA,Katsanis N,Kremer H,Omran H,van Wijk E,Wolfrum U,Kepes F,Davis EE,Franco B,Giles RH,Ueffing M,Russell RB,Roepman R,

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KPNA4 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

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