MPEG1 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	MPEG1
Entrez Gene ID	219972
Full Name	macrophage expressed 1
Synonyms	MPG1,MPS1,Mpg-1
General protein information	Preferred Names macrophage expressed 1 Names macrophage-expressed gene 1 protein macrophage expressed gene 1 macrophage gene 1 protein perforin 2
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 11 Map Location: 11q12.1
Disorder MIM:	610390

mRNA and Protein(s)

mRNA	Protein	Name
NM_001039396.2	NP_001034485.1	macrophage-expressed gene 1 protein precursor
NM_001039396.1	NP_001034485.1	macrophage-expressed gene 1 protein precursor

Pathways from BioSystems

Homologies

Pan troglodytes (chimpanzee)	MPEG1	XP_508450.1
Mus musculus (house mouse)	Mpeg1	NP_034951.1
Canis lupus familiaris (dog)	MPEG1	XP_533169.1
Homo sapiens (human)	MPEG1	NP_001034485.1
Rattus norvegicus (Norway rat)	Mpeg1	NP_072139.1
Danio rerio (zebrafish)	zgc:110354	NP_001018422.1
Danio rerio (zebrafish)	si:ch211-247l22.3	NP_001116782.1
Gallus gallus (chicken)	MPEG1	XP_003641422.1
Danio rerio (zebrafish)	mpeg1	NP_997902.1
Bos taurus (cattle)	MPEG1	NP_001039929.1

Gene Ontology
Bibliography

Related articles in PubMed

Regulation of expression and trafficking of perforin-2 by LPS and TNF-?.
Xiong P, Shiratsuchi M, Matsushima T, Liao J, Tanaka E, Nakashima Y, Takayanagi R, Ogawa Y
Cellular immunology3201-10(2017 Oct)

Perforin-2/Mpeg1 and other pore-forming proteins throughout evolution.
McCormack R, Podack ER
Journal of leukocyte biology98(5)761-8(2015 Nov)

Enteric pathogens deploy cell cycle inhibiting factors to block the bactericidal activity of Perforin-2.
McCormack RM, Lyapichev K, Olsson ML, Podack ER, Munson GP
eLife4(2015 Sep)

Perforin-2 is essential for intracellular defense of parenchymal cells and phagocytes against pathogenic bacteria.
McCormack RM, de Armas LR, Shiratsuchi M, Fiorentino DG, Olsson ML, Lichtenheld MG, Morales A, Lyapichev K, Gonzalez LE, Strbo N, Sukumar N, Stojadinovic O, Plano GV, Munson GP, Tomic-Canic M, Kirsner RS, Russell DG, Podack ER
eLife4(2015 Sep)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

these data provide the evidence that membrane-bound and secretory isoforms of perforin-2 are present in human macrophages and may play important roles in immune defense
Title: Regulation of expression and trafficking of perforin-2 by LPS and TNF-?.

the impact of Perforin-2/macrophage-expressed protein 1 from the earliest multicellular organisms to modern vertebrates, as well as review the development of other membrane attack complexes of complement and Perforin domain member proteins
Title: Perforin-2/Mpeg1 and other pore-forming proteins throughout evolution.

Collectively, these studies further underscore the biological significance of Perforin-2 and elucidate critical molecular events that culminate in Perforin-2-dependent killing of both intracellular and extracellular, cell-adherent bacteria.
Title: Enteric pathogens deploy cell cycle inhibiting factors to block the bactericidal activity of Perforin-2.

Knockdown of perforin-2 in macrophages did not alter the invasion of host cells but did result in chlamydial growth that closely mirrored that detected in HeLa cells.
Title: Perforin-2 restricts growth of Chlamydia trachomatis in macrophages.

The following MPEG1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the MPEG1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu02177	NM_001039396.2 Latest version!	Homo sapiens macrophage expressed 1 (MPEG1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$189.50-$265.30 $379.00
View Old Accession Versions >>
OHu02177	NM_001039396.1	Homo sapiens macrophage expressed 1 (MPEG1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$189.50-$265.30 $379.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

MPEG1 ( NM_001039396.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_001034485.1 Homo sapiens macrophage expressed 1 (MPEG1), mRNA.

Price & Availability↑

CloneID	OHu02177
Clone ID Related Accession (Same CDS sequence)	NM_001039396.2 , NM_001039396.1
Accession Version	NM_001039396.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2151bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2020-01-01
Organism	Homo sapiens(human)
Product	macrophage-expressed gene 1 protein precursor
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from DA946058.1, BC104997.1, AP002358.3 and AW205154.1. On May 17, 2019 this sequence version replaced NM_001039396.1. ##Evidence-Data-START## Transcript is intronless :: SRR1803616.267486.1, AK097881.1 [ECO:0000345] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000361050.4/ ENSP00000354335.3 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END##

ATGAACAACT TCAGGGCCAC CATCCTCTTC TGGGCAGCGG CAGCATGGGC TAAATCAGGC 
AAGCCTTCGG GAGAGATGGA CGAAGTTGGA GTTCAAAAAT GCAAGAATGC CTTGAAACTA 
CCTGTCCTGG AAGTCCTACC TGGAGGGGGC TGGGACAATC TGCGGAATGT GGACATGGGA 
CGAGTTATGG AATTGACTTA CTCCAACTGC AGGACAACAG AGGATGGACA GTATATCATC 
CCTGATGAAA TCTTCACCAT TCCCCAGAAA CAGAGCAACC TGGAGATGAA CTCAGAAATC 
CTGGAATCCT GGGCAAATTA CCAGAGTAGC ACCTCCTACT CCATCAACAC AGAACTCTCT 
CTTTTTTCCA AAGTCAATGG CAAGTTTTCC ACTGAGTTCC AGAGGATGAA GACCCTCCAA 
GTGAAGGACC AAGCTATAAC TACCCGAGTT CAGGTAAGAA ACCTCGTCTA CACAGTCAAA 
ATCAACCCAA CTTTAGAGCT AAGCTCAGGT TTTAGGAAGG AACTCCTTGA CATCTCTGAC 
CGTCTAGAGA ACAACCAGAC GAGGATGGCC ACCTACCTGG CAGAACTCCT GGTGCTCAAC 
TATGGCACCC ACGTCACCAC CAGTGTCGAC GCTGGGGCTG CTCTTATTCA GGAGGACCAC 
CTCAGGGCCT CCTTCCTCCA AGACAGCCAG AGCAGTCGTA GTGCCGTGAC CGCCTCTGCT 
GGACTTGCCT TTCAAAACAC CGTGAACTTC AAATTTGAGG AAAACTATAC CTCGCAGAAT 
GTCCTCACCA AGAGCTACCT CTCAAACCGA ACCAACTCCA GGGTGCAGAG CATTGGAGGG 
GTTCCTTTTT ACCCAGGCAT CACCCTCCAG GCCTGGCAGC AGGGTATCAC CAACCACCTG 
GTGGCCATCG ACCGCTCTGG CCTGCCGCTG CATTTCTTCA TCAACCCCAA CATGCTACCT 
GACTTGCCAG GCCCCCTGGT GAAGAAGGTG TCAAAGACAG TGGAAACTGC TGTGAAGCGC 
TATTATACAT TCAACACCTA CCCTGGCTGC ACAGATCTCA ATTCTCCCAA CTTCAATTTT 
CAGGCCAACA CGGATGATGG CTCCTGCGAG GGGAAAATGA CCAACTTCTC TTTCGGTGGG 
GTTTATCAGG AATGCACTCA GCTCTCAGGG AATAGGGATG TCCTCCTCTG CCAAAAGTTG 
GAGCAGAAGA ATCCACTCAC TGGTGATTTC TCCTGCCCCT CTGGCTACTC CCCGGTGCAC 
CTGTTATCCC AGATCCACGA GGAGGGTTAC AACCACCTGG AGTGTCATCG AAAGTGCACT 
CTCCTCGTCT TCTGCAAGAC CGTGTGTGAA GATGTGTTCC AGGTGGCAAA AGCTGAATTT 
AGGGCTTTTT GGTGTGTGGC CAGCAGCCAA GTACCTGAAA ACTCAGGACT GCTTTTTGGG 
GGCCTCTTCA GCAGCAAGAG CATAAACCCC ATGACAAATG CACAGTCATG CCCAGCCGGC 
TACTTTCCAC TGAGACTCTT TGAAAACCTC AAGGTATGTG TTTCTCAGGA CTATGAGTTG 
GGAAGCAGGT TTGCGGTCCC CTTTGGCGGG TTCTTTAGCT GCACAGTTGG GAACCCCCTG 
GTAGATCCTG CTATATCCAG AGATTTAGGG GCACCGTCTC TGAAAAAGTG CCCCGGGGGC 
TTCAGCCAGC ACCCAGCCCT CATCAGCGAT GGATGCCAAG TGTCCTATTG CGTCAAATCC 
GGGCTCTTCA CAGGAGGGTC CCTGCCCCCT GCCAGGCTCC CACCTTTCAC CCGGCCACCC 
CTCATGAGTC AGGCTGCCAC CAATACTGTC ATAGTGACCA ATTCTGAGAA TGCGAGATCC 
TGGATTAAAG ACTCCCAGAC CCACCAGTGG AGGCTGGGAG AACCGATAGA GCTGCGGAGG 
GCCATGAATG TCATCCATGG GGATGGTGGT GGTCTGTCAG GAGGGGCTGC AGCTGGGGTC 
ACAGTGGGGG TCACCACCAT TCTGGCTGTT GTTATCACCT TGGCCATCTA CGGCACCCGG 
AAGTTCAAGA AGAAAGCATA TCAGGCAATT GAGGAAAGGC AGAGTTTGGT TCCAGGCACT 
GCAGCAACTG GAGACACCAC TTACCAAGAG CAGGGGCAGA GTCCAGCTTA A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001034485.1
CDS	63..2213
Translation	MNNFRATILFWAAAAWAKSGKPSGEMDEVGVQKCKNALKLPVLEVLPGGGWDNLRNVDMGRVMELTYSNCRTTEDGQYIIPDEIFTIPQKQSNLEMNSEILESWANYQSSTSYSINTELSLFSKVNGKFSTEFQRMKTLQVKDQAITTRVQVRNLVYTVKINPTLELSSGFRKELLDISDRLENNQTRMATYLAELLVLNYGTHVTTSVDAGAALIQEDHLRASFLQDSQSSRSAVTASAGLAFQNTVNFKFEENYTSQNVLTKSYLSNRTNSRVQSIGGVPFYPGITLQAWQQGITNHLVAIDRSGLPLHFFINPNMLPDLPGPLVKKVSKTVETAVKRYYTFNTYPGCTDLNSPNFNFQANTDDGSCEGKMTNFSFGGVYQECTQLSGNRDVLLCQKLEQKNPLTGDFSCPSGYSPVHLLSQIHEEGYNHLECHRKCTLLVFCKTVCEDVFQVAKAEFRAFWCVASSQVPENSGLLFGGLFSSKSINPMTNAQSCPAGYFPLRLFENLKVCVSQDYELGSRFAVPFGGFFSCTVGNPLVDPAISRDLGAPSLKKCPGGFSQHPALISDGCQVSYCVKSGLFTGGSLPPARLPPFTRPPLMSQAATNTVIVTNSENARSWIKDSQTHQWRLGEPIELRRAMNVIHGDGGGLSGGAAAGVTVGVTTILAVVITLAIYGTRKFKKKAYQAIEERQSLVPGTAATGDTTYQEQGQSPA

Target ORF information:

RefSeq Version	NM_001039396.2
Organism	Homo sapiens(human)
Definition	Homo sapiens macrophage expressed 1 (MPEG1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001039396.2

ORF Insert Sequence:

ATGAACAACT TCAGGGCCAC CATCCTCTTC TGGGCAGCGG CAGCATGGGC TAAATCAGGC 
AAGCCTTCGG GAGAGATGGA CGAAGTTGGA GTTCAAAAAT GCAAGAATGC CTTGAAACTA 
CCTGTCCTGG AAGTCCTACC TGGAGGGGGC TGGGACAATC TGCGGAATGT GGACATGGGA 
CGAGTTATGG AATTGACTTA CTCCAACTGC AGGACAACAG AGGATGGACA GTATATCATC 
CCTGATGAAA TCTTCACCAT TCCCCAGAAA CAGAGCAACC TGGAGATGAA CTCAGAAATC 
CTGGAATCCT GGGCAAATTA CCAGAGTAGC ACCTCCTACT CCATCAACAC AGAACTCTCT 
CTTTTTTCCA AAGTCAATGG CAAGTTTTCC ACTGAGTTCC AGAGGATGAA GACCCTCCAA 
GTGAAGGACC AAGCTATAAC TACCCGAGTT CAGGTAAGAA ACCTCGTCTA CACAGTCAAA 
ATCAACCCAA CTTTAGAGCT AAGCTCAGGT TTTAGGAAGG AACTCCTTGA CATCTCTGAC 
CGTCTAGAGA ACAACCAGAC GAGGATGGCC ACCTACCTGG CAGAACTCCT GGTGCTCAAC 
TATGGCACCC ACGTCACCAC CAGTGTCGAC GCTGGGGCTG CTCTTATTCA GGAGGACCAC 
CTCAGGGCCT CCTTCCTCCA AGACAGCCAG AGCAGTCGTA GTGCCGTGAC CGCCTCTGCT 
GGACTTGCCT TTCAAAACAC CGTGAACTTC AAATTTGAGG AAAACTATAC CTCGCAGAAT 
GTCCTCACCA AGAGCTACCT CTCAAACCGA ACCAACTCCA GGGTGCAGAG CATTGGAGGG 
GTTCCTTTTT ACCCAGGCAT CACCCTCCAG GCCTGGCAGC AGGGTATCAC CAACCACCTG 
GTGGCCATCG ACCGCTCTGG CCTGCCGCTG CATTTCTTCA TCAACCCCAA CATGCTACCT 
GACTTGCCAG GCCCCCTGGT GAAGAAGGTG TCAAAGACAG TGGAAACTGC TGTGAAGCGC 
TATTATACAT TCAACACCTA CCCTGGCTGC ACAGATCTCA ATTCTCCCAA CTTCAATTTT 
CAGGCCAACA CGGATGATGG CTCCTGCGAG GGGAAAATGA CCAACTTCTC TTTCGGTGGG 
GTTTATCAGG AATGCACTCA GCTCTCAGGG AATAGGGATG TCCTCCTCTG CCAAAAGTTG 
GAGCAGAAGA ATCCACTCAC TGGTGATTTC TCCTGCCCCT CTGGCTACTC CCCGGTGCAC 
CTGTTATCCC AGATCCACGA GGAGGGTTAC AACCACCTGG AGTGTCATCG AAAGTGCACT 
CTCCTCGTCT TCTGCAAGAC CGTGTGTGAA GATGTGTTCC AGGTGGCAAA AGCTGAATTT 
AGGGCTTTTT GGTGTGTGGC CAGCAGCCAA GTACCTGAAA ACTCAGGACT GCTTTTTGGG 
GGCCTCTTCA GCAGCAAGAG CATAAACCCC ATGACAAATG CACAGTCATG CCCAGCCGGC 
TACTTTCCAC TGAGACTCTT TGAAAACCTC AAGGTATGTG TTTCTCAGGA CTATGAGTTG 
GGAAGCAGGT TTGCGGTCCC CTTTGGCGGG TTCTTTAGCT GCACAGTTGG GAACCCCCTG 
GTAGATCCTG CTATATCCAG AGATTTAGGG GCACCGTCTC TGAAAAAGTG CCCCGGGGGC 
TTCAGCCAGC ACCCAGCCCT CATCAGCGAT GGATGCCAAG TGTCCTATTG CGTCAAATCC 
GGGCTCTTCA CAGGAGGGTC CCTGCCCCCT GCCAGGCTCC CACCTTTCAC CCGGCCACCC 
CTCATGAGTC AGGCTGCCAC CAATACTGTC ATAGTGACCA ATTCTGAGAA TGCGAGATCC 
TGGATTAAAG ACTCCCAGAC CCACCAGTGG AGGCTGGGAG AACCGATAGA GCTGCGGAGG 
GCCATGAATG TCATCCATGG GGATGGTGGT GGTCTGTCAG GAGGGGCTGC AGCTGGGGTC 
ACAGTGGGGG TCACCACCAT TCTGGCTGTT GTTATCACCT TGGCCATCTA CGGCACCCGG 
AAGTTCAAGA AGAAAGCATA TCAGGCAATT GAGGAAAGGC AGAGTTTGGT TCCAGGCACT 
GCAGCAACTG GAGACACCAC TTACCAAGAG CAGGGGCAGA GTCCAGCTTA A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

MPEG1 ( NM_001039396.1 ) cDNA ORF clone, Homo sapiens(human) -> NP_001034485.1 Homo sapiens macrophage expressed 1 (MPEG1), mRNA.

Price & Availability↑

CloneID	OHu02177
Clone ID Related Accession (Same CDS sequence)	NM_001039396.2 , NM_001039396.1
Accession Version	NM_001039396.1	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2151bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-02-16
Organism	Homo sapiens(human)
Product	macrophage-expressed gene 1 protein precursor
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from DA946058.1, BC104997.1, AP002358.3 and AW205154.1. On or before Mar 20, 2007 this sequence version replaced XM_166227.7, XM_943258.2.

ATGAACAACT TCAGGGCCAC CATCCTCTTC TGGGCAGCGG CAGCATGGGC TAAATCAGGC 
AAGCCTTCGG GAGAGATGGA CGAAGTTGGA GTTCAAAAAT GCAAGAATGC CTTGAAACTA 
CCTGTCCTGG AAGTCCTACC TGGAGGGGGC TGGGACAATC TGCGGAATGT GGACATGGGA 
CGAGTTATGG AATTGACTTA CTCCAACTGC AGGACAACAG AGGATGGACA GTATATCATC 
CCTGATGAAA TCTTCACCAT TCCCCAGAAA CAGAGCAACC TGGAGATGAA CTCAGAAATC 
CTGGAATCCT GGGCAAATTA CCAGAGTAGC ACCTCCTACT CCATCAACAC AGAACTCTCT 
CTTTTTTCCA AAGTCAATGG CAAGTTTTCC ACTGAGTTCC AGAGGATGAA GACCCTCCAA 
GTGAAGGACC AAGCTATAAC TACCCGAGTT CAGGTAAGAA ACCTCGTCTA CACAGTCAAA 
ATCAACCCAA CTTTAGAGCT AAGCTCAGGT TTTAGGAAGG AACTCCTTGA CATCTCTGAC 
CGTCTAGAGA ACAACCAGAC GAGGATGGCC ACCTACCTGG CAGAACTCCT GGTGCTCAAC 
TATGGCACCC ACGTCACCAC CAGTGTCGAC GCTGGGGCTG CTCTTATTCA GGAGGACCAC 
CTCAGGGCCT CCTTCCTCCA AGACAGCCAG AGCAGTCGTA GTGCCGTGAC CGCCTCTGCT 
GGACTTGCCT TTCAAAACAC CGTGAACTTC AAATTTGAGG AAAACTATAC CTCGCAGAAT 
GTCCTCACCA AGAGCTACCT CTCAAACCGA ACCAACTCCA GGGTGCAGAG CATTGGAGGG 
GTTCCTTTTT ACCCAGGCAT CACCCTCCAG GCCTGGCAGC AGGGTATCAC CAACCACCTG 
GTGGCCATCG ACCGCTCTGG CCTGCCGCTG CATTTCTTCA TCAACCCCAA CATGCTACCT 
GACTTGCCAG GCCCCCTGGT GAAGAAGGTG TCAAAGACAG TGGAAACTGC TGTGAAGCGC 
TATTATACAT TCAACACCTA CCCTGGCTGC ACAGATCTCA ATTCTCCCAA CTTCAATTTT 
CAGGCCAACA CGGATGATGG CTCCTGCGAG GGGAAAATGA CCAACTTCTC TTTCGGTGGG 
GTTTATCAGG AATGCACTCA GCTCTCAGGG AATAGGGATG TCCTCCTCTG CCAAAAGTTG 
GAGCAGAAGA ATCCACTCAC TGGTGATTTC TCCTGCCCCT CTGGCTACTC CCCGGTGCAC 
CTGTTATCCC AGATCCACGA GGAGGGTTAC AACCACCTGG AGTGTCATCG AAAGTGCACT 
CTCCTCGTCT TCTGCAAGAC CGTGTGTGAA GATGTGTTCC AGGTGGCAAA AGCTGAATTT 
AGGGCTTTTT GGTGTGTGGC CAGCAGCCAA GTACCTGAAA ACTCAGGACT GCTTTTTGGG 
GGCCTCTTCA GCAGCAAGAG CATAAACCCC ATGACAAATG CACAGTCATG CCCAGCCGGC 
TACTTTCCAC TGAGACTCTT TGAAAACCTC AAGGTATGTG TTTCTCAGGA CTATGAGTTG 
GGAAGCAGGT TTGCGGTCCC CTTTGGCGGG TTCTTTAGCT GCACAGTTGG GAACCCCCTG 
GTAGATCCTG CTATATCCAG AGATTTAGGG GCACCGTCTC TGAAAAAGTG CCCCGGGGGC 
TTCAGCCAGC ACCCAGCCCT CATCAGCGAT GGATGCCAAG TGTCCTATTG CGTCAAATCC 
GGGCTCTTCA CAGGAGGGTC CCTGCCCCCT GCCAGGCTCC CACCTTTCAC CCGGCCACCC 
CTCATGAGTC AGGCTGCCAC CAATACTGTC ATAGTGACCA ATTCTGAGAA TGCGAGATCC 
TGGATTAAAG ACTCCCAGAC CCACCAGTGG AGGCTGGGAG AACCGATAGA GCTGCGGAGG 
GCCATGAATG TCATCCATGG GGATGGTGGT GGTCTGTCAG GAGGGGCTGC AGCTGGGGTC 
ACAGTGGGGG TCACCACCAT TCTGGCTGTT GTTATCACCT TGGCCATCTA CGGCACCCGG 
AAGTTCAAGA AGAAAGCATA TCAGGCAATT GAGGAAAGGC AGAGTTTGGT TCCAGGCACT 
GCAGCAACTG GAGACACCAC TTACCAAGAG CAGGGGCAGA GTCCAGCTTA A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001034485.1
CDS	157..2307
Translation	MNNFRATILFWAAAAWAKSGKPSGEMDEVGVQKCKNALKLPVLEVLPGGGWDNLRNVDMGRVMELTYSNCRTTEDGQYIIPDEIFTIPQKQSNLEMNSEILESWANYQSSTSYSINTELSLFSKVNGKFSTEFQRMKTLQVKDQAITTRVQVRNLVYTVKINPTLELSSGFRKELLDISDRLENNQTRMATYLAELLVLNYGTHVTTSVDAGAALIQEDHLRASFLQDSQSSRSAVTASAGLAFQNTVNFKFEENYTSQNVLTKSYLSNRTNSRVQSIGGVPFYPGITLQAWQQGITNHLVAIDRSGLPLHFFINPNMLPDLPGPLVKKVSKTVETAVKRYYTFNTYPGCTDLNSPNFNFQANTDDGSCEGKMTNFSFGGVYQECTQLSGNRDVLLCQKLEQKNPLTGDFSCPSGYSPVHLLSQIHEEGYNHLECHRKCTLLVFCKTVCEDVFQVAKAEFRAFWCVASSQVPENSGLLFGGLFSSKSINPMTNAQSCPAGYFPLRLFENLKVCVSQDYELGSRFAVPFGGFFSCTVGNPLVDPAISRDLGAPSLKKCPGGFSQHPALISDGCQVSYCVKSGLFTGGSLPPARLPPFTRPPLMSQAATNTVIVTNSENARSWIKDSQTHQWRLGEPIELRRAMNVIHGDGGGLSGGAAAGVTVGVTTILAVVITLAIYGTRKFKKKAYQAIEERQSLVPGTAATGDTTYQEQGQSPA

Target ORF information:

RefSeq Version	NM_001039396.1
Organism	Homo sapiens(human)
Definition	Homo sapiens macrophage expressed 1 (MPEG1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001039396.1

ORF Insert Sequence:

ATGAACAACT TCAGGGCCAC CATCCTCTTC TGGGCAGCGG CAGCATGGGC TAAATCAGGC 
AAGCCTTCGG GAGAGATGGA CGAAGTTGGA GTTCAAAAAT GCAAGAATGC CTTGAAACTA 
CCTGTCCTGG AAGTCCTACC TGGAGGGGGC TGGGACAATC TGCGGAATGT GGACATGGGA 
CGAGTTATGG AATTGACTTA CTCCAACTGC AGGACAACAG AGGATGGACA GTATATCATC 
CCTGATGAAA TCTTCACCAT TCCCCAGAAA CAGAGCAACC TGGAGATGAA CTCAGAAATC 
CTGGAATCCT GGGCAAATTA CCAGAGTAGC ACCTCCTACT CCATCAACAC AGAACTCTCT 
CTTTTTTCCA AAGTCAATGG CAAGTTTTCC ACTGAGTTCC AGAGGATGAA GACCCTCCAA 
GTGAAGGACC AAGCTATAAC TACCCGAGTT CAGGTAAGAA ACCTCGTCTA CACAGTCAAA 
ATCAACCCAA CTTTAGAGCT AAGCTCAGGT TTTAGGAAGG AACTCCTTGA CATCTCTGAC 
CGTCTAGAGA ACAACCAGAC GAGGATGGCC ACCTACCTGG CAGAACTCCT GGTGCTCAAC 
TATGGCACCC ACGTCACCAC CAGTGTCGAC GCTGGGGCTG CTCTTATTCA GGAGGACCAC 
CTCAGGGCCT CCTTCCTCCA AGACAGCCAG AGCAGTCGTA GTGCCGTGAC CGCCTCTGCT 
GGACTTGCCT TTCAAAACAC CGTGAACTTC AAATTTGAGG AAAACTATAC CTCGCAGAAT 
GTCCTCACCA AGAGCTACCT CTCAAACCGA ACCAACTCCA GGGTGCAGAG CATTGGAGGG 
GTTCCTTTTT ACCCAGGCAT CACCCTCCAG GCCTGGCAGC AGGGTATCAC CAACCACCTG 
GTGGCCATCG ACCGCTCTGG CCTGCCGCTG CATTTCTTCA TCAACCCCAA CATGCTACCT 
GACTTGCCAG GCCCCCTGGT GAAGAAGGTG TCAAAGACAG TGGAAACTGC TGTGAAGCGC 
TATTATACAT TCAACACCTA CCCTGGCTGC ACAGATCTCA ATTCTCCCAA CTTCAATTTT 
CAGGCCAACA CGGATGATGG CTCCTGCGAG GGGAAAATGA CCAACTTCTC TTTCGGTGGG 
GTTTATCAGG AATGCACTCA GCTCTCAGGG AATAGGGATG TCCTCCTCTG CCAAAAGTTG 
GAGCAGAAGA ATCCACTCAC TGGTGATTTC TCCTGCCCCT CTGGCTACTC CCCGGTGCAC 
CTGTTATCCC AGATCCACGA GGAGGGTTAC AACCACCTGG AGTGTCATCG AAAGTGCACT 
CTCCTCGTCT TCTGCAAGAC CGTGTGTGAA GATGTGTTCC AGGTGGCAAA AGCTGAATTT 
AGGGCTTTTT GGTGTGTGGC CAGCAGCCAA GTACCTGAAA ACTCAGGACT GCTTTTTGGG 
GGCCTCTTCA GCAGCAAGAG CATAAACCCC ATGACAAATG CACAGTCATG CCCAGCCGGC 
TACTTTCCAC TGAGACTCTT TGAAAACCTC AAGGTATGTG TTTCTCAGGA CTATGAGTTG 
GGAAGCAGGT TTGCGGTCCC CTTTGGCGGG TTCTTTAGCT GCACAGTTGG GAACCCCCTG 
GTAGATCCTG CTATATCCAG AGATTTAGGG GCACCGTCTC TGAAAAAGTG CCCCGGGGGC 
TTCAGCCAGC ACCCAGCCCT CATCAGCGAT GGATGCCAAG TGTCCTATTG CGTCAAATCC 
GGGCTCTTCA CAGGAGGGTC CCTGCCCCCT GCCAGGCTCC CACCTTTCAC CCGGCCACCC 
CTCATGAGTC AGGCTGCCAC CAATACTGTC ATAGTGACCA ATTCTGAGAA TGCGAGATCC 
TGGATTAAAG ACTCCCAGAC CCACCAGTGG AGGCTGGGAG AACCGATAGA GCTGCGGAGG 
GCCATGAATG TCATCCATGG GGATGGTGGT GGTCTGTCAG GAGGGGCTGC AGCTGGGGTC 
ACAGTGGGGG TCACCACCAT TCTGGCTGTT GTTATCACCT TGGCCATCTA CGGCACCCGG 
AAGTTCAAGA AGAAAGCATA TCAGGCAATT GAGGAAAGGC AGAGTTTGGT TCCAGGCACT 
GCAGCAACTG GAGACACCAC TTACCAAGAG CAGGGGCAGA GTCCAGCTTA A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Regulation of expression and trafficking of perforin-2 by LPS and TNF-?.
Cellular immunology3201-10(2017 Oct)
Xiong P,Shiratsuchi M,Matsushima T,Liao J,Tanaka E,Nakashima Y,Takayanagi R,Ogawa Y

Perforin-2/Mpeg1 and other pore-forming proteins throughout evolution.
Journal of leukocyte biology98(5)761-8(2015 Nov)
McCormack R,Podack ER

Enteric pathogens deploy cell cycle inhibiting factors to block the bactericidal activity of Perforin-2.
eLife4(2015 Sep)
McCormack RM,Lyapichev K,Olsson ML,Podack ER,Munson GP

Perforin-2 is essential for intracellular defense of parenchymal cells and phagocytes against pathogenic bacteria.
eLife4(2015 Sep)
McCormack RM,de Armas LR,Shiratsuchi M,Fiorentino DG,Olsson ML,Lichtenheld MG,Morales A,Lyapichev K,Gonzalez LE,Strbo N,Sukumar N,Stojadinovic O,Plano GV,Munson GP,Tomic-Canic M,Kirsner RS,Russell DG,Podack ER

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MPEG1 cDNA ORF clone, Homo sapiens(human)

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