CSN1S1 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	CSN1S1
Entrez Gene ID	1446
Full Name	casein alpha s1
Synonyms	CASA,CSN1
General protein information	Preferred Names casein alpha s1 Names alpha-S1-casein casein, alpha
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 4 Map Location: 4q13.3
Disorder MIM:	115450

mRNA and Protein(s)

mRNA	Protein	Name
NM_001890.1	NP_001881.1	alpha-S1-casein isoform 1 precursor
XM_006714089.2	XP_006714152.1	alpha-S1-casein isoform X1
NM_001025104.1	NP_001020275.1	alpha-S1-casein isoform 2 precursor
XM_006714091.2	XP_006714154.1	alpha-S1-casein isoform X3
NM_001890.2	NP_001881.1	alpha-S1-casein isoform 1 precursor
NM_001025104.2	NP_001020275.1	alpha-S1-casein isoform 2 precursor
XM_006714090.2	XP_006714153.1	alpha-S1-casein isoform X2

Pathways from BioSystems

Homologies

Homo sapiens (human)	CSN1S1	NP_001881.1
Pan troglodytes (chimpanzee)	CSN1S1	XP_517254.2

Gene Ontology
Bibliography

Related articles in PubMed

Ser71 of ?S1-Casein is Phosphorylated in Breast Milk-Evidence from Targeted Mass Analysis.
K?nig S, Altendorfer I, Saenger T, Bleck E, Vordenb?umen S, Schneider M, Jose J
Molecular nutrition & food research61(12)(2017 Dec)

Insulin autoantibodies with high affinity to the bovine milk protein alpha casein.
Adler K, Mueller DB, Achenbach P, Krause S, Heninger AK, Ziegler AG, Bonifacio E
Clinical and experimental immunology164(1)42-9(2011 Apr)

Casein ? s1 is expressed by human monocytes and upregulates the production of GM-CSF via p38 MAPK.
Vordenb?umen S, Braukmann A, Petermann K, Scharf A, Bleck E, von Mikecz A, Jose J, Schneider M
Journal of immunology (Baltimore, Md. : 1950)186(1)592-601(2011 Jan)

Human colostrum: identification of minor proteins in the aqueous phase by proteomics.
Palmer DJ, Kelly VC, Smit AM, Kuy S, Knight CG, Cooper GJ
Proteomics6(7)2208-16(2006 Apr)

Evidence of a novel biomarker, alphas1-Casein, a milk protein, in benign prostate hyperplasia.
Xu K, Ling MT, Wang X, Wong YC
Prostate cancer and prostatic diseases9(3)293-7(2006)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Results suggest that autoimmunity to insulin can occur infrequently via cross-reactivity to food protein alpha casein.
Title: Insulin autoantibodies with high affinity to the bovine milk protein alpha casein.

Casein alpha s1 is expressed in human monocytes and stimulates expression of proinflammatory cytokine granulocyte-macrophage colony-stimulating factor (GM-CSF) via an immunomodulatory role beyond the nutritional function of CSN1S1 in milk.
Title: Casein ? s1 is expressed by human monocytes and upregulates the production of GM-CSF via p38 MAPK.

alphas1-Casein may be a potential biomarker for early identification of BPH patients.
Title: Evidence of a novel biomarker, alphas1-Casein, a milk protein, in benign prostate hyperplasia.

The following CSN1S1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the CSN1S1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu03733	NM_001890.2 Latest version!	Homo sapiens casein alpha s1 (CSN1S1), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
OHu04322	NM_001025104.2 Latest version!	Homo sapiens casein alpha s1 (CSN1S1), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$69.30 $99.00
OHu38711	XM_006714089.2 Latest version!	Homo sapiens casein alpha s1 (CSN1S1), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$69.30 $99.00
OHu38712	XM_006714090.2 Latest version!	Homo sapiens casein alpha s1 (CSN1S1), transcript variant X2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$69.30 $99.00
OHu38713	XM_006714091.2 Latest version!	Homo sapiens casein alpha s1 (CSN1S1), transcript variant X3, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$69.30 $99.00
View Old Accession Versions >>
OHu03733	NM_001890.1	Homo sapiens casein alpha s1 (CSN1S1), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
OHu04322	NM_001025104.1	Homo sapiens casein alpha s1 (CSN1S1), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$69.30 $99.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

CSN1S1 ( NM_001890.1 ) cDNA ORF clone, Homo sapiens(human) -> NP_001881.1 Homo sapiens casein alpha s1 (CSN1S1), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu03733
Clone ID Related Accession (Same CDS sequence)	NM_001890.1 , NM_001890.2
Accession Version	NM_001890.1	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 558bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-09-30
Organism	Homo sapiens(human)
Product	alpha-S1-casein isoform 1 precursor
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from X78416.1. Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1). ##Evidence-Data-START## Transcript exon combination :: X78416.1, U23157.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2142680, SAMN02400288 [ECO:0000348] ##Evidence-Data-END##

ATGAGGCTTC TCATTCTCAC CTGTCTTGTG GCTGTTGCTC TTGCCAGGCC TAAACTTCCT 
CTTAGATACC CAGAACGCCT TCAGAATCCA TCAGAGAGCA GTGAGCCTAT ACCATTAGAA 
TCAAGAGAGG AATACATGAA TGGTATGAAC AGGCAGAGAA ACATTCTGAG AGAAAAACAG 
ACTGATGAAA TCAAGGATAC TAGGAATGAG TCTACTCAGA ACTGTGTTGT GGCAGAGCCT 
GAGAAGATGG AATCCAGCAT CAGTTCATCG AGTGAGGAAA TGTCTCTCAG TAAGTGTGCG 
GAACAGTTTT GTAGACTGAA CGAATACAAC CAACTTCAGC TGCAAGCTGC CCATGCCCAG 
GAGCAAATTC GCAGAATGAA TGAAAACAGC CATGTCCAAG TGCCTTTCCA GCAGCTCAAC 
CAACTTGCTG CCTACCCCTA TGCTGTTTGG TACTATCCAC AAATCATGCA GTATGTTCCT 
TTCCCACCGT TTTCCGACAT CTCCAATCCC ACTGCTCATG AAAATTATGA AAAAAATAAC 
GTCATGCTAC AGTGGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001881.1
CDS	50..607
Translation	MRLLILTCLVAVALARPKLPLRYPERLQNPSESSEPIPLESREEYMNGMNRQRNILREKQTDEIKDTRNESTQNCVVAEPEKMESSISSSSEEMSLSKCAEQFCRLNEYNQLQLQAAHAQEQIRRMNENSHVQVPFQQLNQLAAYPYAVWYYPQIMQYVPFPPFSDISNPTAHENYEKNNVMLQW

Target ORF information:

RefSeq Version	NM_001890.1
Organism	Homo sapiens(human)
Definition	Homo sapiens casein alpha s1 (CSN1S1), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001890.1

ORF Insert Sequence:

ATGAGGCTTC TCATTCTCAC CTGTCTTGTG GCTGTTGCTC TTGCCAGGCC TAAACTTCCT 
CTTAGATACC CAGAACGCCT TCAGAATCCA TCAGAGAGCA GTGAGCCTAT ACCATTAGAA 
TCAAGAGAGG AATACATGAA TGGTATGAAC AGGCAGAGAA ACATTCTGAG AGAAAAACAG 
ACTGATGAAA TCAAGGATAC TAGGAATGAG TCTACTCAGA ACTGTGTTGT GGCAGAGCCT 
GAGAAGATGG AATCCAGCAT CAGTTCATCG AGTGAGGAAA TGTCTCTCAG TAAGTGTGCG 
GAACAGTTTT GTAGACTGAA CGAATACAAC CAACTTCAGC TGCAAGCTGC CCATGCCCAG 
GAGCAAATTC GCAGAATGAA TGAAAACAGC CATGTCCAAG TGCCTTTCCA GCAGCTCAAC 
CAACTTGCTG CCTACCCCTA TGCTGTTTGG TACTATCCAC AAATCATGCA GTATGTTCCT 
TTCCCACCGT TTTCCGACAT CTCCAATCCC ACTGCTCATG AAAATTATGA AAAAAATAAC 
GTCATGCTAC AGTGGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

CSN1S1 ( NM_001890.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_001881.1 Homo sapiens casein alpha s1 (CSN1S1), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu03733
Clone ID Related Accession (Same CDS sequence)	NM_001890.1 , NM_001890.2
Accession Version	NM_001890.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 558bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-30
Organism	Homo sapiens(human)
Product	alpha-S1-casein isoform 1 precursor
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AC108941.4 and X78416.1. On Nov 23, 2018 this sequence version replaced NM_001890.1. Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1). Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: X78416.1, U23157.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2142680, SAMN02400288 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000246891.9/ ENSP00000246891.4 RefSeq Select criteria :: based on expression, longest protein ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGAGGCTTC TCATTCTCAC CTGTCTTGTG GCTGTTGCTC TTGCCAGGCC TAAACTTCCT 
CTTAGATACC CAGAACGCCT TCAGAATCCA TCAGAGAGCA GTGAGCCTAT ACCATTAGAA 
TCAAGAGAGG AATACATGAA TGGTATGAAC AGGCAGAGAA ACATTCTGAG AGAAAAACAG 
ACTGATGAAA TCAAGGATAC TAGGAATGAG TCTACTCAGA ACTGTGTTGT GGCAGAGCCT 
GAGAAGATGG AATCCAGCAT CAGTTCATCG AGTGAGGAAA TGTCTCTCAG TAAGTGTGCG 
GAACAGTTTT GTAGACTGAA CGAATACAAC CAACTTCAGC TGCAAGCTGC CCATGCCCAG 
GAGCAAATTC GCAGAATGAA TGAAAACAGC CATGTCCAAG TGCCTTTCCA GCAGCTCAAC 
CAACTTGCTG CCTACCCCTA TGCTGTTTGG TACTATCCAC AAATCATGCA GTATGTTCCT 
TTCCCACCGT TTTCCGACAT CTCCAATCCC ACTGCTCATG AAAATTATGA AAAAAATAAC 
GTCATGCTAC AGTGGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001881.1
CDS	63..620
Translation	MRLLILTCLVAVALARPKLPLRYPERLQNPSESSEPIPLESREEYMNGMNRQRNILREKQTDEIKDTRNESTQNCVVAEPEKMESSISSSSEEMSLSKCAEQFCRLNEYNQLQLQAAHAQEQIRRMNENSHVQVPFQQLNQLAAYPYAVWYYPQIMQYVPFPPFSDISNPTAHENYEKNNVMLQW

Target ORF information:

RefSeq Version	NM_001890.2
Organism	Homo sapiens(human)
Definition	Homo sapiens casein alpha s1 (CSN1S1), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001890.2

ORF Insert Sequence:

ATGAGGCTTC TCATTCTCAC CTGTCTTGTG GCTGTTGCTC TTGCCAGGCC TAAACTTCCT 
CTTAGATACC CAGAACGCCT TCAGAATCCA TCAGAGAGCA GTGAGCCTAT ACCATTAGAA 
TCAAGAGAGG AATACATGAA TGGTATGAAC AGGCAGAGAA ACATTCTGAG AGAAAAACAG 
ACTGATGAAA TCAAGGATAC TAGGAATGAG TCTACTCAGA ACTGTGTTGT GGCAGAGCCT 
GAGAAGATGG AATCCAGCAT CAGTTCATCG AGTGAGGAAA TGTCTCTCAG TAAGTGTGCG 
GAACAGTTTT GTAGACTGAA CGAATACAAC CAACTTCAGC TGCAAGCTGC CCATGCCCAG 
GAGCAAATTC GCAGAATGAA TGAAAACAGC CATGTCCAAG TGCCTTTCCA GCAGCTCAAC 
CAACTTGCTG CCTACCCCTA TGCTGTTTGG TACTATCCAC AAATCATGCA GTATGTTCCT 
TTCCCACCGT TTTCCGACAT CTCCAATCCC ACTGCTCATG AAAATTATGA AAAAAATAAC 
GTCATGCTAC AGTGGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

CSN1S1 ( NM_001025104.1 ) cDNA ORF clone, Homo sapiens(human) -> NP_001020275.1 Homo sapiens casein alpha s1 (CSN1S1), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OHu04322
Clone ID Related Accession (Same CDS sequence)	NM_001025104.1 , NM_001025104.2
Accession Version	NM_001025104.1	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 531bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2018-07-21
Organism	Homo sapiens(human)
Product	alpha-S1-casein isoform 2 precursor
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from X78416.1 and BG217918.1. Transcript Variant: This variant (2) lacks an in-frame exon, compared to variant 1, and encodes a shorter isoform (2), compared to isoform 1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## RNAseq introns :: single sample supports all introns SAMEA2142680, SAMN02400289 [ECO:0000348] ##Evidence-Data-END##

ATGAGGCTTC TCATTCTCAC CTGTCTTGTG GCTGTTGCTC TTGCCAGGCC TAAACTTCCT 
CTTAGATACC CAGAACGCCT TCAGAATCCA TCAGAGAGCA GTGAGCCTAT ACCATTAGAA 
TCAAGAGAGG AATACATGAA TGGTATGAAC AGGAGAAACA TTCTGAGAGA AAAACAGACT 
GATGAAATCA AGGATACTAG GAATGAGTCT ACTCAGAACT GTGTTGTGGC AGAGCCTGAG 
AAGATGGAAT CCAGCATCAG TTCATCGAGT GAGGAACAGT TTTGTAGACT GAACGAATAC 
AACCAACTTC AGCTGCAAGC TGCCCATGCC CAGGAGCAAA TTCGCAGAAT GAATGAAAAC 
AGCCATGTCC AAGTGCCTTT CCAGCAGCTC AACCAACTTG CTGCCTACCC CTATGCTGTT 
TGGTACTATC CACAAATCAT GCAGTATGTT CCTTTCCCAC CGTTTTCCGA CATCTCCAAT 
CCCACTGCTC ATGAAAATTA TGAAAAAAAT AACGTCATGC TACAGTGGTG A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001020275.1
CDS	50..580
Translation	MRLLILTCLVAVALARPKLPLRYPERLQNPSESSEPIPLESREEYMNGMNRRNILREKQTDEIKDTRNESTQNCVVAEPEKMESSISSSSEEQFCRLNEYNQLQLQAAHAQEQIRRMNENSHVQVPFQQLNQLAAYPYAVWYYPQIMQYVPFPPFSDISNPTAHENYEKNNVMLQW

Target ORF information:

RefSeq Version	NM_001025104.1
Organism	Homo sapiens(human)
Definition	Homo sapiens casein alpha s1 (CSN1S1), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001025104.1

ORF Insert Sequence:

ATGAGGCTTC TCATTCTCAC CTGTCTTGTG GCTGTTGCTC TTGCCAGGCC TAAACTTCCT 
CTTAGATACC CAGAACGCCT TCAGAATCCA TCAGAGAGCA GTGAGCCTAT ACCATTAGAA 
TCAAGAGAGG AATACATGAA TGGTATGAAC AGGAGAAACA TTCTGAGAGA AAAACAGACT 
GATGAAATCA AGGATACTAG GAATGAGTCT ACTCAGAACT GTGTTGTGGC AGAGCCTGAG 
AAGATGGAAT CCAGCATCAG TTCATCGAGT GAGGAACAGT TTTGTAGACT GAACGAATAC 
AACCAACTTC AGCTGCAAGC TGCCCATGCC CAGGAGCAAA TTCGCAGAAT GAATGAAAAC 
AGCCATGTCC AAGTGCCTTT CCAGCAGCTC AACCAACTTG CTGCCTACCC CTATGCTGTT 
TGGTACTATC CACAAATCAT GCAGTATGTT CCTTTCCCAC CGTTTTCCGA CATCTCCAAT 
CCCACTGCTC ATGAAAATTA TGAAAAAAAT AACGTCATGC TACAGTGGTG A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

CSN1S1 ( NM_001025104.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_001020275.1 Homo sapiens casein alpha s1 (CSN1S1), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OHu04322
Clone ID Related Accession (Same CDS sequence)	NM_001025104.1 , NM_001025104.2
Accession Version	NM_001025104.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 531bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-09-27
Organism	Homo sapiens(human)
Product	alpha-S1-casein isoform 2 precursor
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AC108941.4, X78416.1 and BG217918.1. On May 31, 2019 this sequence version replaced NM_001025104.1. Transcript Variant: This variant (2) lacks an in-frame exon, compared to variant 1, and encodes a shorter isoform (2), compared to isoform 1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## RNAseq introns :: single sample supports all introns SAMEA2142680, SAMN02400289 [ECO:0000348] ##Evidence-Data-END##

ATGAGGCTTC TCATTCTCAC CTGTCTTGTG GCTGTTGCTC TTGCCAGGCC TAAACTTCCT 
CTTAGATACC CAGAACGCCT TCAGAATCCA TCAGAGAGCA GTGAGCCTAT ACCATTAGAA 
TCAAGAGAGG AATACATGAA TGGTATGAAC AGGAGAAACA TTCTGAGAGA AAAACAGACT 
GATGAAATCA AGGATACTAG GAATGAGTCT ACTCAGAACT GTGTTGTGGC AGAGCCTGAG 
AAGATGGAAT CCAGCATCAG TTCATCGAGT GAGGAACAGT TTTGTAGACT GAACGAATAC 
AACCAACTTC AGCTGCAAGC TGCCCATGCC CAGGAGCAAA TTCGCAGAAT GAATGAAAAC 
AGCCATGTCC AAGTGCCTTT CCAGCAGCTC AACCAACTTG CTGCCTACCC CTATGCTGTT 
TGGTACTATC CACAAATCAT GCAGTATGTT CCTTTCCCAC CGTTTTCCGA CATCTCCAAT 
CCCACTGCTC ATGAAAATTA TGAAAAAAAT AACGTCATGC TACAGTGGTG A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001020275.1
CDS	63..593
Translation	MRLLILTCLVAVALARPKLPLRYPERLQNPSESSEPIPLESREEYMNGMNRRNILREKQTDEIKDTRNESTQNCVVAEPEKMESSISSSSEEQFCRLNEYNQLQLQAAHAQEQIRRMNENSHVQVPFQQLNQLAAYPYAVWYYPQIMQYVPFPPFSDISNPTAHENYEKNNVMLQW

Target ORF information:

RefSeq Version	NM_001025104.2
Organism	Homo sapiens(human)
Definition	Homo sapiens casein alpha s1 (CSN1S1), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001025104.2

ORF Insert Sequence:

ATGAGGCTTC TCATTCTCAC CTGTCTTGTG GCTGTTGCTC TTGCCAGGCC TAAACTTCCT 
CTTAGATACC CAGAACGCCT TCAGAATCCA TCAGAGAGCA GTGAGCCTAT ACCATTAGAA 
TCAAGAGAGG AATACATGAA TGGTATGAAC AGGAGAAACA TTCTGAGAGA AAAACAGACT 
GATGAAATCA AGGATACTAG GAATGAGTCT ACTCAGAACT GTGTTGTGGC AGAGCCTGAG 
AAGATGGAAT CCAGCATCAG TTCATCGAGT GAGGAACAGT TTTGTAGACT GAACGAATAC 
AACCAACTTC AGCTGCAAGC TGCCCATGCC CAGGAGCAAA TTCGCAGAAT GAATGAAAAC 
AGCCATGTCC AAGTGCCTTT CCAGCAGCTC AACCAACTTG CTGCCTACCC CTATGCTGTT 
TGGTACTATC CACAAATCAT GCAGTATGTT CCTTTCCCAC CGTTTTCCGA CATCTCCAAT 
CCCACTGCTC ATGAAAATTA TGAAAAAAAT AACGTCATGC TACAGTGGTG A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

CSN1S1 ( XM_006714089.2 ) cDNA ORF clone, Homo sapiens(human) -> XP_006714152.1 Homo sapiens casein alpha s1 (CSN1S1), transcript variant X1, mRNA.

Price & Availability↑

CloneID	OHu38711
Clone ID Related Accession (Same CDS sequence)	XM_006714089.2
Accession Version	XM_006714089.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 555bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-05
Organism	Homo sapiens(human)
Product	alpha-S1-casein isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000004.12) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On Mar 12, 2015 this sequence version replaced XM_006714089.1. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Updated annotation Annotation Name :: Homo sapiens Updated Annotation Release 109.20191205 Annotation Version :: 109.20191205 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.3 Annotation Method :: Best-placed RefSeq; propagated RefSeq model Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGAGGCTTC TCATTCTCAC CTGTCTTGTG GCTGTTGCTC TTGCCAGGCC TAAACTTCCT 
CTTAGATACC CAGAACGCCT TCAGAATCCA TCAGAGAGCA GTGAGCCTAT ACCATTAGAA 
TCAAGAGAGG AATACATGAA TGGTATGAAC AGGAGAAACA TTCTGAGAGA AAAACAGACT 
GATGAAATCA AGGATACTAG GAATGAGTCT ACTCAGAACT GTGTTGTGGC AGAGCCTGAG 
AAGATGGAAT CCAGCATCAG TTCATCGAGT GAGGAAATGT CTCTCAGTAA GTGTGCGGAA 
CAGTTTTGTA GACTGAACGA ATACAACCAA CTTCAGCTGC AAGCTGCCCA TGCCCAGGAG 
CAAATTCGCA GAATGAATGA AAACAGCCAT GTCCAAGTGC CTTTCCAGCA GCTCAACCAA 
CTTGCTGCCT ACCCCTATGC TGTTTGGTAC TATCCACAAA TCATGCAGTA TGTTCCTTTC 
CCACCGTTTT CCGACATCTC CAATCCCACT GCTCATGAAA ATTATGAAAA AAATAACGTC 
ATGCTACAGT GGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_006714152.1
CDS	69..623
Translation	MRLLILTCLVAVALARPKLPLRYPERLQNPSESSEPIPLESREEYMNGMNRRNILREKQTDEIKDTRNESTQNCVVAEPEKMESSISSSSEEMSLSKCAEQFCRLNEYNQLQLQAAHAQEQIRRMNENSHVQVPFQQLNQLAAYPYAVWYYPQIMQYVPFPPFSDISNPTAHENYEKNNVMLQW

Target ORF information:

RefSeq Version	XM_006714089.2
Organism	Homo sapiens(human)
Definition	Homo sapiens casein alpha s1 (CSN1S1), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_006714089.2

ORF Insert Sequence:

ATGAGGCTTC TCATTCTCAC CTGTCTTGTG GCTGTTGCTC TTGCCAGGCC TAAACTTCCT 
CTTAGATACC CAGAACGCCT TCAGAATCCA TCAGAGAGCA GTGAGCCTAT ACCATTAGAA 
TCAAGAGAGG AATACATGAA TGGTATGAAC AGGAGAAACA TTCTGAGAGA AAAACAGACT 
GATGAAATCA AGGATACTAG GAATGAGTCT ACTCAGAACT GTGTTGTGGC AGAGCCTGAG 
AAGATGGAAT CCAGCATCAG TTCATCGAGT GAGGAAATGT CTCTCAGTAA GTGTGCGGAA 
CAGTTTTGTA GACTGAACGA ATACAACCAA CTTCAGCTGC AAGCTGCCCA TGCCCAGGAG 
CAAATTCGCA GAATGAATGA AAACAGCCAT GTCCAAGTGC CTTTCCAGCA GCTCAACCAA 
CTTGCTGCCT ACCCCTATGC TGTTTGGTAC TATCCACAAA TCATGCAGTA TGTTCCTTTC 
CCACCGTTTT CCGACATCTC CAATCCCACT GCTCATGAAA ATTATGAAAA AAATAACGTC 
ATGCTACAGT GGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

CSN1S1 ( XM_006714090.2 ) cDNA ORF clone, Homo sapiens(human) -> XP_006714153.1 Homo sapiens casein alpha s1 (CSN1S1), transcript variant X2, mRNA.

Price & Availability↑

CloneID	OHu38712
Clone ID Related Accession (Same CDS sequence)	XM_006714090.2
Accession Version	XM_006714090.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 534bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-05
Organism	Homo sapiens(human)
Product	alpha-S1-casein isoform X2
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000004.12) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On Mar 12, 2015 this sequence version replaced XM_006714090.1. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Updated annotation Annotation Name :: Homo sapiens Updated Annotation Release 109.20191205 Annotation Version :: 109.20191205 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.3 Annotation Method :: Best-placed RefSeq; propagated RefSeq model Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGAGGCTTC TCATTCTCAC CTGTCTTGTG GCTGTTGCTC TTGCCAGGCC TAAACTTCCT 
CTTAGATACC CAGAACGCCT TCAGAATCCA TCAGAGAGCA GTGAGCCTAT ACCATTAGAA 
TCAAGAGAGG AATACATGAA TGGTATGAAC AGGCAGAGAA ACATTCTGAG AGAAAAACAG 
ACTGATGAAA TCAAGAACTG TGTTGTGGCA GAGCCTGAGA AGATGGAATC CAGCATCAGT 
TCATCGAGTG AGGAAATGTC TCTCAGTAAG TGTGCGGAAC AGTTTTGTAG ACTGAACGAA 
TACAACCAAC TTCAGCTGCA AGCTGCCCAT GCCCAGGAGC AAATTCGCAG AATGAATGAA 
AACAGCCATG TCCAAGTGCC TTTCCAGCAG CTCAACCAAC TTGCTGCCTA CCCCTATGCT 
GTTTGGTACT ATCCACAAAT CATGCAGTAT GTTCCTTTCC CACCGTTTTC CGACATCTCC 
AATCCCACTG CTCATGAAAA TTATGAAAAA AATAACGTCA TGCTACAGTG GTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_006714153.1
CDS	69..602
Translation	MRLLILTCLVAVALARPKLPLRYPERLQNPSESSEPIPLESREEYMNGMNRQRNILREKQTDEIKNCVVAEPEKMESSISSSSEEMSLSKCAEQFCRLNEYNQLQLQAAHAQEQIRRMNENSHVQVPFQQLNQLAAYPYAVWYYPQIMQYVPFPPFSDISNPTAHENYEKNNVMLQW

Target ORF information:

RefSeq Version	XM_006714090.2
Organism	Homo sapiens(human)
Definition	Homo sapiens casein alpha s1 (CSN1S1), transcript variant X2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_006714090.2

ORF Insert Sequence:

ATGAGGCTTC TCATTCTCAC CTGTCTTGTG GCTGTTGCTC TTGCCAGGCC TAAACTTCCT 
CTTAGATACC CAGAACGCCT TCAGAATCCA TCAGAGAGCA GTGAGCCTAT ACCATTAGAA 
TCAAGAGAGG AATACATGAA TGGTATGAAC AGGCAGAGAA ACATTCTGAG AGAAAAACAG 
ACTGATGAAA TCAAGAACTG TGTTGTGGCA GAGCCTGAGA AGATGGAATC CAGCATCAGT 
TCATCGAGTG AGGAAATGTC TCTCAGTAAG TGTGCGGAAC AGTTTTGTAG ACTGAACGAA 
TACAACCAAC TTCAGCTGCA AGCTGCCCAT GCCCAGGAGC AAATTCGCAG AATGAATGAA 
AACAGCCATG TCCAAGTGCC TTTCCAGCAG CTCAACCAAC TTGCTGCCTA CCCCTATGCT 
GTTTGGTACT ATCCACAAAT CATGCAGTAT GTTCCTTTCC CACCGTTTTC CGACATCTCC 
AATCCCACTG CTCATGAAAA TTATGAAAAA AATAACGTCA TGCTACAGTG GTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

CSN1S1 ( XM_006714091.2 ) cDNA ORF clone, Homo sapiens(human) -> XP_006714154.1 Homo sapiens casein alpha s1 (CSN1S1), transcript variant X3, mRNA.

Price & Availability↑

CloneID	OHu38713
Clone ID Related Accession (Same CDS sequence)	XM_006714091.2
Accession Version	XM_006714091.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 531bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-05
Organism	Homo sapiens(human)
Product	alpha-S1-casein isoform X3
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000004.12) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On Mar 12, 2015 this sequence version replaced XM_006714091.1. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Updated annotation Annotation Name :: Homo sapiens Updated Annotation Release 109.20191205 Annotation Version :: 109.20191205 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.3 Annotation Method :: Best-placed RefSeq; propagated RefSeq model Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGAGGCTTC TCATTCTCAC CTGTCTTGTG GCTGTTGCTC TTGCCAGGCC TAAACTTCCT 
CTTAGATACC CAGAACGCCT TCAGAATCCA TCAGAGAGCA GTGAGCCTAT ACCATTAGAA 
TCAAGAGAGG AATACATGAA TGGTATGAAC AGGAGAAACA TTCTGAGAGA AAAACAGACT 
GATGAAATCA AGAACTGTGT TGTGGCAGAG CCTGAGAAGA TGGAATCCAG CATCAGTTCA 
TCGAGTGAGG AAATGTCTCT CAGTAAGTGT GCGGAACAGT TTTGTAGACT GAACGAATAC 
AACCAACTTC AGCTGCAAGC TGCCCATGCC CAGGAGCAAA TTCGCAGAAT GAATGAAAAC 
AGCCATGTCC AAGTGCCTTT CCAGCAGCTC AACCAACTTG CTGCCTACCC CTATGCTGTT 
TGGTACTATC CACAAATCAT GCAGTATGTT CCTTTCCCAC CGTTTTCCGA CATCTCCAAT 
CCCACTGCTC ATGAAAATTA TGAAAAAAAT AACGTCATGC TACAGTGGTG A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_006714154.1
CDS	69..599
Translation	MRLLILTCLVAVALARPKLPLRYPERLQNPSESSEPIPLESREEYMNGMNRRNILREKQTDEIKNCVVAEPEKMESSISSSSEEMSLSKCAEQFCRLNEYNQLQLQAAHAQEQIRRMNENSHVQVPFQQLNQLAAYPYAVWYYPQIMQYVPFPPFSDISNPTAHENYEKNNVMLQW

Target ORF information:

RefSeq Version	XM_006714091.2
Organism	Homo sapiens(human)
Definition	Homo sapiens casein alpha s1 (CSN1S1), transcript variant X3, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_006714091.2

ORF Insert Sequence:

ATGAGGCTTC TCATTCTCAC CTGTCTTGTG GCTGTTGCTC TTGCCAGGCC TAAACTTCCT 
CTTAGATACC CAGAACGCCT TCAGAATCCA TCAGAGAGCA GTGAGCCTAT ACCATTAGAA 
TCAAGAGAGG AATACATGAA TGGTATGAAC AGGAGAAACA TTCTGAGAGA AAAACAGACT 
GATGAAATCA AGAACTGTGT TGTGGCAGAG CCTGAGAAGA TGGAATCCAG CATCAGTTCA 
TCGAGTGAGG AAATGTCTCT CAGTAAGTGT GCGGAACAGT TTTGTAGACT GAACGAATAC 
AACCAACTTC AGCTGCAAGC TGCCCATGCC CAGGAGCAAA TTCGCAGAAT GAATGAAAAC 
AGCCATGTCC AAGTGCCTTT CCAGCAGCTC AACCAACTTG CTGCCTACCC CTATGCTGTT 
TGGTACTATC CACAAATCAT GCAGTATGTT CCTTTCCCAC CGTTTTCCGA CATCTCCAAT 
CCCACTGCTC ATGAAAATTA TGAAAAAAAT AACGTCATGC TACAGTGGTG A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Ser71 of ?S1-Casein is Phosphorylated in Breast Milk-Evidence from Targeted Mass Analysis.
Molecular nutrition & food research61(12)(2017 Dec)
K?nig S,Altendorfer I,Saenger T,Bleck E,Vordenb?umen S,Schneider M,Jose J

Insulin autoantibodies with high affinity to the bovine milk protein alpha casein.
Clinical and experimental immunology164(1)42-9(2011 Apr)
Adler K,Mueller DB,Achenbach P,Krause S,Heninger AK,Ziegler AG,Bonifacio E

Casein ? s1 is expressed by human monocytes and upregulates the production of GM-CSF via p38 MAPK.
Journal of immunology (Baltimore, Md. : 1950)186(1)592-601(2011 Jan)
Vordenb?umen S,Braukmann A,Petermann K,Scharf A,Bleck E,von Mikecz A,Jose J,Schneider M

Human colostrum: identification of minor proteins in the aqueous phase by proteomics.
Proteomics6(7)2208-16(2006 Apr)
Palmer DJ,Kelly VC,Smit AM,Kuy S,Knight CG,Cooper GJ

Evidence of a novel biomarker, alphas1-Casein, a milk protein, in benign prostate hyperplasia.
Prostate cancer and prostatic diseases9(3)293-7(2006)
Xu K,Ling MT,Wang X,Wong YC

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CSN1S1 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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