FOXR2 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	FOXR2
Entrez Gene ID	139628
Full Name	forkhead box R2
Synonyms	FOXN6
General protein information	Preferred Names forkhead box R2 Names forkhead box protein R2 forkhead box protein N6
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: X Map Location: Xp11.21
Disorder MIM:	300949

mRNA and Protein(s)

mRNA	Protein	Name
NM_198451.4	NP_940853.1	forkhead box protein R2
NM_198451.3	NP_940853.1	forkhead box protein R2

Pathways from BioSystems

Homologies

Pan troglodytes (chimpanzee)	FOXR2	XP_529000.1
	FOXR2	XP_001093505.1
Canis lupus familiaris (dog)	FOXR2	XP_003435531.1
Bos taurus (cattle)	FOXR2	NP_001193489.1
Mus musculus (house mouse)	Foxr2	NP_001030066.1
Rattus norvegicus (Norway rat)	Foxr2	XP_006256839.1
Homo sapiens (human)	FOXR2	NP_940853.1

Gene Ontology
Bibliography

Related articles in PubMed

FOXR2 Promotes the Proliferation, Invasion, and Epithelial-Mesenchymal Transition in Human Colorectal Cancer Cells.
Lu SQ, Qiu Y, Dai WJ, Zhang XY
Oncology research25(5)681-689(2017 May)

miR-202 Suppresses Cell Proliferation by Targeting FOXR2 in Endometrial Adenocarcinoma.
Deng X, Hou C, Liang Z, Wang H, Zhu L, Xu H
Disease markers20172827435(2017)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

our data suggested that FOXR2 significantly promoted proliferation, invasion, and EMT of CRC cells. All these findings provided evidence for the role of FOXR2 as an oncogene in CRC development.
Title: FOXR2 Promotes the Proliferation, Invasion, and Epithelial-Mesenchymal Transition in Human Colorectal Cancer Cells.

Knockdown of FOXR2 significantly down-regulated the protein expression levels of beta-catenin.
Title: Knockdown of FOXR2 suppresses the tumorigenesis, growth and metastasis of prostate cancer.

FOXR2 is frequently upregulated in hepatocellular carcinoma specimens compared with neighboring non-cancerous tissues in both messenger RNA and protein. It promoted cell growth and colony formation, and it facilitated tumor xenograft growth. beta-catenin, Skp2, c-Myc, and Gli-1 are the potential downstream effectors of FOXR2.
Title: FOXR2 contributes to cell proliferation and malignancy in human hepatocellular carcinoma.

FOXR2 acts with MYC to promote cancer cell proliferation, which is a potential tumor-specific target for therapeutic intervention against MYC-driven cancers.
Title: FOXR2 Interacts with MYC to Promote Its Transcriptional Activities and Tumorigenesis.

we observed that the highly expressed FOXR2 in breast and overexpression of FOXR2 was positively associated with the progression and poor prognosis in patients with breast cancer, which indicated that FOXR2 might serve as a valuable prognosis biomarker for breast cancer individuals.
Title: High expression of FOXR2 in breast cancer correlates with poor prognosis.

The following FOXR2 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the FOXR2 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu21454	NM_198451.4 Latest version!	Homo sapiens forkhead box R2 (FOXR2), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$99.50-$139.30 $199.00
View Old Accession Versions >>
OHu21454	NM_198451.3	Homo sapiens forkhead box R2 (FOXR2), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$99.50-$139.30 $199.00
Hide Old Accession Versions >>

ORF Online Only Promotion

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

FOXR2 ( NM_198451.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_940853.1 Homo sapiens forkhead box R2 (FOXR2), mRNA.

Price & Availability↑

CloneID	OHu21454
Clone ID Related Accession (Same CDS sequence)	NM_198451.4 , NM_198451.3
Accession Version	NM_198451.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 936bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-10-13
Organism	Homo sapiens(human)
Product	forkhead box protein R2
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from BC012934.2 and AL159987.19. This sequence is a reference standard in the RefSeqGene project. On May 17, 2019 this sequence version replaced NM_198451.3. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript is intronless :: BC012934.2 [ECO:0000345] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000339140.5/ ENSP00000427329.2 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGGACTTAA AACTAAAAGA CTGTGAATTT TGGTATAGTC TCCATGGCCA GGTCCCAGGG 
CTGCTGGACT GGGACATGAG GAATGAGTTA TTTCTGCCTT GTACCACAGA CCAGTGCTCT 
TTAGCTGAGC AAATCCTTGC CAAATACAGA GTCGGAGTAA TGAAGCCCCC AGAAATGCCT 
CAGAAGAGGA GACCCAGTCC TGATGGAGAT GGTCCTCCCT GTGAACCCAA TCTGTGGATG 
TGGGTGGACC CCAATATCCT GTGCCCCCTT GGCAGCCAGG AGGCCCCAAA GCCCAGTGGA 
AAAGAGGATC TGACAAACAT TTCTCCTTTC CCTCAGCCCC CACAAAAAGA CGAAGGGTCT 
AACTGCTCAG AGGACAAAGT GGTAGAGTCT CTGCCATCTT CCTCCAGTGA GCAGTCTCCT 
TTACAGAAGC AGGGTATCCA TTCCCCCAGT GACTTTGAGC TCACAGAAGA GGAGGCTGAG 
GAACCAGACG ACAACTCCCT CCAGTCCCCT GAAATGAAAT GTTACCAGAG CCAGAAACTA 
TGGCAAATCA ACAACCAAGA GAAGTCCTGG CAAAGGCCCC CTCTCAATTG TAGCCACCTT 
ATTGCCCTAG CATTAAGAAA CAACCCCCAC TGTGGCCTCA GTGTGCAGGA GATCTACAAT 
TTCACCCGAC AGCATTTCCC CTTTTTCTGG ACAGCTCCGG ATGGCTGGAA GAGCACCATT 
CATTACAACC TCTGCTTCCT GGACAGCTTT GAGAAGGTGC CAGACAGCCT TAAGGATGAA 
GATAATGCAA GACCTCGCTC TTGCCTTTGG AAGCTCACTA AGGAGGGGCA CCGCCGCTTT 
TGGGAGGAGA CTCGTGTCTT AGCCTTTGCT CAAAGGGAGA GAATCCAAGA GTGCATGAGT 
CAGCCAGAGT TGTTGACCTC TCTCTTTGAT CTTTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_940853.1
CDS	313..1248
Translation	MDLKLKDCEFWYSLHGQVPGLLDWDMRNELFLPCTTDQCSLAEQILAKYRVGVMKPPEMPQKRRPSPDGDGPPCEPNLWMWVDPNILCPLGSQEAPKPSGKEDLTNISPFPQPPQKDEGSNCSEDKVVESLPSSSSEQSPLQKQGIHSPSDFELTEEEAEEPDDNSLQSPEMKCYQSQKLWQINNQEKSWQRPPLNCSHLIALALRNNPHCGLSVQEIYNFTRQHFPFFWTAPDGWKSTIHYNLCFLDSFEKVPDSLKDEDNARPRSCLWKLTKEGHRRFWEETRVLAFAQRERIQECMSQPELLTSLFDL

Target ORF information:

RefSeq Version	NM_198451.4
Organism	Homo sapiens(human)
Definition	Homo sapiens forkhead box R2 (FOXR2), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_198451.4

ORF Insert Sequence:

ATGGACTTAA AACTAAAAGA CTGTGAATTT TGGTATAGTC TCCATGGCCA GGTCCCAGGG 
CTGCTGGACT GGGACATGAG GAATGAGTTA TTTCTGCCTT GTACCACAGA CCAGTGCTCT 
TTAGCTGAGC AAATCCTTGC CAAATACAGA GTCGGAGTAA TGAAGCCCCC AGAAATGCCT 
CAGAAGAGGA GACCCAGTCC TGATGGAGAT GGTCCTCCCT GTGAACCCAA TCTGTGGATG 
TGGGTGGACC CCAATATCCT GTGCCCCCTT GGCAGCCAGG AGGCCCCAAA GCCCAGTGGA 
AAAGAGGATC TGACAAACAT TTCTCCTTTC CCTCAGCCCC CACAAAAAGA CGAAGGGTCT 
AACTGCTCAG AGGACAAAGT GGTAGAGTCT CTGCCATCTT CCTCCAGTGA GCAGTCTCCT 
TTACAGAAGC AGGGTATCCA TTCCCCCAGT GACTTTGAGC TCACAGAAGA GGAGGCTGAG 
GAACCAGACG ACAACTCCCT CCAGTCCCCT GAAATGAAAT GTTACCAGAG CCAGAAACTA 
TGGCAAATCA ACAACCAAGA GAAGTCCTGG CAAAGGCCCC CTCTCAATTG TAGCCACCTT 
ATTGCCCTAG CATTAAGAAA CAACCCCCAC TGTGGCCTCA GTGTGCAGGA GATCTACAAT 
TTCACCCGAC AGCATTTCCC CTTTTTCTGG ACAGCTCCGG ATGGCTGGAA GAGCACCATT 
CATTACAACC TCTGCTTCCT GGACAGCTTT GAGAAGGTGC CAGACAGCCT TAAGGATGAA 
GATAATGCAA GACCTCGCTC TTGCCTTTGG AAGCTCACTA AGGAGGGGCA CCGCCGCTTT 
TGGGAGGAGA CTCGTGTCTT AGCCTTTGCT CAAAGGGAGA GAATCCAAGA GTGCATGAGT 
CAGCCAGAGT TGTTGACCTC TCTCTTTGAT CTTTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

FOXR2 ( NM_198451.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_940853.1 Homo sapiens forkhead box R2 (FOXR2), mRNA.

Price & Availability↑

CloneID	OHu21454
Clone ID Related Accession (Same CDS sequence)	NM_198451.4 , NM_198451.3
Accession Version	NM_198451.3	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 936bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-02-21
Organism	Homo sapiens(human)
Product	forkhead box protein R2
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from BC012934.2 and AL159987.19. This sequence is a reference standard in the RefSeqGene project. On May 20, 2010 this sequence version replaced NM_198451.2. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. COMPLETENESS: complete on the 3' end.

ATGGACTTAA AACTAAAAGA CTGTGAATTT TGGTATAGTC TCCATGGCCA GGTCCCAGGG 
CTGCTGGACT GGGACATGAG GAATGAGTTA TTTCTGCCTT GTACCACAGA CCAGTGCTCT 
TTAGCTGAGC AAATCCTTGC CAAATACAGA GTCGGAGTAA TGAAGCCCCC AGAAATGCCT 
CAGAAGAGGA GACCCAGTCC TGATGGAGAT GGTCCTCCCT GTGAACCCAA TCTGTGGATG 
TGGGTGGACC CCAATATCCT GTGCCCCCTT GGCAGCCAGG AGGCCCCAAA GCCCAGTGGA 
AAAGAGGATC TGACAAACAT TTCTCCTTTC CCTCAGCCCC CACAAAAAGA CGAAGGGTCT 
AACTGCTCAG AGGACAAAGT GGTAGAGTCT CTGCCATCTT CCTCCAGTGA GCAGTCTCCT 
TTACAGAAGC AGGGTATCCA TTCCCCCAGT GACTTTGAGC TCACAGAAGA GGAGGCTGAG 
GAACCAGACG ACAACTCCCT CCAGTCCCCT GAAATGAAAT GTTACCAGAG CCAGAAACTA 
TGGCAAATCA ACAACCAAGA GAAGTCCTGG CAAAGGCCCC CTCTCAATTG TAGCCACCTT 
ATTGCCCTAG CATTAAGAAA CAACCCCCAC TGTGGCCTCA GTGTGCAGGA GATCTACAAT 
TTCACCCGAC AGCATTTCCC CTTTTTCTGG ACAGCTCCGG ATGGCTGGAA GAGCACCATT 
CATTACAACC TCTGCTTCCT GGACAGCTTT GAGAAGGTGC CAGACAGCCT TAAGGATGAA 
GATAATGCAA GACCTCGCTC TTGCCTTTGG AAGCTCACTA AGGAGGGGCA CCGCCGCTTT 
TGGGAGGAGA CTCGTGTCTT AGCCTTTGCT CAAAGGGAGA GAATCCAAGA GTGCATGAGT 
CAGCCAGAGT TGTTGACCTC TCTCTTTGAT CTTTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_940853.1
CDS	313..1248
Translation	MDLKLKDCEFWYSLHGQVPGLLDWDMRNELFLPCTTDQCSLAEQILAKYRVGVMKPPEMPQKRRPSPDGDGPPCEPNLWMWVDPNILCPLGSQEAPKPSGKEDLTNISPFPQPPQKDEGSNCSEDKVVESLPSSSSEQSPLQKQGIHSPSDFELTEEEAEEPDDNSLQSPEMKCYQSQKLWQINNQEKSWQRPPLNCSHLIALALRNNPHCGLSVQEIYNFTRQHFPFFWTAPDGWKSTIHYNLCFLDSFEKVPDSLKDEDNARPRSCLWKLTKEGHRRFWEETRVLAFAQRERIQECMSQPELLTSLFDL

Target ORF information:

RefSeq Version	NM_198451.3
Organism	Homo sapiens(human)
Definition	Homo sapiens forkhead box R2 (FOXR2), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_198451.3

ORF Insert Sequence:

ATGGACTTAA AACTAAAAGA CTGTGAATTT TGGTATAGTC TCCATGGCCA GGTCCCAGGG 
CTGCTGGACT GGGACATGAG GAATGAGTTA TTTCTGCCTT GTACCACAGA CCAGTGCTCT 
TTAGCTGAGC AAATCCTTGC CAAATACAGA GTCGGAGTAA TGAAGCCCCC AGAAATGCCT 
CAGAAGAGGA GACCCAGTCC TGATGGAGAT GGTCCTCCCT GTGAACCCAA TCTGTGGATG 
TGGGTGGACC CCAATATCCT GTGCCCCCTT GGCAGCCAGG AGGCCCCAAA GCCCAGTGGA 
AAAGAGGATC TGACAAACAT TTCTCCTTTC CCTCAGCCCC CACAAAAAGA CGAAGGGTCT 
AACTGCTCAG AGGACAAAGT GGTAGAGTCT CTGCCATCTT CCTCCAGTGA GCAGTCTCCT 
TTACAGAAGC AGGGTATCCA TTCCCCCAGT GACTTTGAGC TCACAGAAGA GGAGGCTGAG 
GAACCAGACG ACAACTCCCT CCAGTCCCCT GAAATGAAAT GTTACCAGAG CCAGAAACTA 
TGGCAAATCA ACAACCAAGA GAAGTCCTGG CAAAGGCCCC CTCTCAATTG TAGCCACCTT 
ATTGCCCTAG CATTAAGAAA CAACCCCCAC TGTGGCCTCA GTGTGCAGGA GATCTACAAT 
TTCACCCGAC AGCATTTCCC CTTTTTCTGG ACAGCTCCGG ATGGCTGGAA GAGCACCATT 
CATTACAACC TCTGCTTCCT GGACAGCTTT GAGAAGGTGC CAGACAGCCT TAAGGATGAA 
GATAATGCAA GACCTCGCTC TTGCCTTTGG AAGCTCACTA AGGAGGGGCA CCGCCGCTTT 
TGGGAGGAGA CTCGTGTCTT AGCCTTTGCT CAAAGGGAGA GAATCCAAGA GTGCATGAGT 
CAGCCAGAGT TGTTGACCTC TCTCTTTGAT CTTTGA