FUNDC1 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	FUNDC1
Entrez Gene ID	139341
Full Name	FUN14 domain containing 1
General protein information	Preferred Names FUN14 domain containing 1 Names FUN14 domain-containing protein 1
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: X Map Location: Xp11.3
Summary	This gene encodes a protein with a FUN14 superfamily domain. The function of the encoded protein is not known. [provided by RefSeq, Sep 2011].
Disorder MIM:	300871

mRNA and Protein(s)

mRNA	Protein	Name
NM_173794.3	NP_776155.1	FUN14 domain-containing protein 1
NM_173794.4	NP_776155.1	FUN14 domain-containing protein 1

Pathways from BioSystems

Homologies

Mus musculus (house mouse)	Fundc1	NP_082334.1
Rattus norvegicus (Norway rat)	Fundc1	NP_001020198.1
Xenopus tropicalis (tropical clawed frog)	fundc1	NP_001120476.1
Homo sapiens (human)	FUNDC1	NP_776155.1
	FUNDC1	XP_001083529.1
Bos taurus (cattle)	FUNDC1	NP_001098452.1
Gallus gallus (chicken)	FUNDC1	NP_001263292.1
Danio rerio (zebrafish)	fundc1	NP_001002711.2
Pan troglodytes (chimpanzee)	FUNDC1	XP_001139861.1
Canis lupus familiaris (dog)	LOC491842	XP_548961.2

Gene Ontology
Bibliography

Related articles in PubMed

High expression of FUNDC1 predicts poor prognostic outcomes and is a promising target to improve chemoradiotherapy effects in patients with cervical cancer.
Hou H, Er P, Cheng J, Chen X, Ding X, Wang Y, Chen X, Yuan Z, Pang Q, Wang P, Qian D
Cancer medicine6(8)1871-1881(2017 Aug)

Mitochondrial E3 ligase MARCH5 regulates FUNDC1 to fine-tune hypoxic mitophagy.
Chen Z, Liu L, Cheng Q, Li Y, Wu H, Zhang W, Wang Y, Sehgal SA, Siraj S, Wang X, Wang J, Zhu Y, Chen Q
EMBO reports18(3)495-509(2017 03)

Structural insights into the recognition of phosphorylated FUNDC1 by LC3B in mitophagy.
Lv M, Wang C, Li F, Peng J, Wen B, Gong Q, Shi Y, Tang Y
Protein & cell8(1)25-38(2017 Jan)

Structural basis for the phosphorylation of FUNDC1 LIR as a molecular switch of mitophagy.
Kuang Y, Ma K, Zhou C, Ding P, Zhu Y, Chen Q, Xia B
Autophagy12(12)2363-2373(2016 Dec)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

MARCH5 directly interacts with FUNDC1 to mediate its ubiquitylation at lysine 119 for subsequent degradation.
Title: Mitochondrial E3 ligase MARCH5 regulates FUNDC1 to fine-tune hypoxic mitophagy.

structural and biochemical results reveal a working model for the specific recognition of FUNDC1 by LC3B and imply that the reversible phosphorylation modification of mitophagy receptors may be a switch for selective mitophagy.
Title: Structural insights into the recognition of phosphorylated FUNDC1 by LC3B in mitophagy.

phosphorylation of Tyr18 of FUNDC1 serves as a molecular switch for mitophagy.
Title: Structural basis for the phosphorylation of FUNDC1 LIR as a molecular switch of mitophagy.

FUNDC1 integrates mitochondrial fission and mitophagy at the interface of the endoplasmic reticulum-mitochondrial contact site by working in concert with DRP1 and calnexin under hypoxic conditions in mammalian cells.
Title: FUNDC1 regulates mitochondrial dynamics at the ER-mitochondrial contact site under hypoxic?conditions.

FUNDC1 regulates both mitochondrial fission or fusion and mitophagy.
Title: Mitophagy receptor FUNDC1 regulates mitochondrial dynamics and mitophagy.

The following FUNDC1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the FUNDC1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu19682	NM_173794.4 Latest version!	Homo sapiens FUN14 domain containing 1 (FUNDC1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
View Old Accession Versions >>
OHu19682	NM_173794.3	Homo sapiens FUN14 domain containing 1 (FUNDC1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
Hide Old Accession Versions >>

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

FUNDC1 ( NM_173794.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_776155.1 Homo sapiens FUN14 domain containing 1 (FUNDC1), mRNA.

Price & Availability↑

CloneID	OHu19682
Clone ID Related Accession (Same CDS sequence)	NM_173794.3 , NM_173794.4
Accession Version	NM_173794.3	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 468bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-11-19
Organism	Homo sapiens(human)
Product	FUN14 domain-containing protein 1
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BM837991.1, BG213042.1 and BC035015.2. This sequence is a reference standard in the RefSeqGene project. On Dec 9, 2008 this sequence version replaced NM_173794.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1163655.613246.1, SRR1163658.550631.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGCGACCC GGAACCCCCC TCCCCAAGAC TATGAAAGTG ATGACGACTC TTATGAAGTG 
TTGGATTTAA CTGAGTATGC AAGAAGACAC CAGTGGTGGA ATCGAGTGTT TGGCCACAGT 
TCGGGACCTA TGGTAGAAAA ATACTCAGTA GCTACCCAGA TTGTAATGGG TGGCGTTACT 
GGCTGGTGTG CAGGATTTCT GTTCCAGAAA GTTGGAAAAC TTGCAGCAAC TGCAGTAGGT 
GGTGGCTTTC TTCTTCTTCA GATTGCTAGT CATAGTGGCT ATGTGCAGAT TGACTGGAAG 
AGAGTTGAAA AAGATGTAAA TAAAGCAAAA AGACAGATTA AGAAACGAGC GAACAAAGCA 
GCACCTGAAA TCAACAATTT AATTGAAGAA GCAACAGAAT TTATCAAGCA GAACATTGTG 
ATATCCAGTG GATTTGTGGG AGGCTTTTTG CTCGGACTTG CATCTTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_776155.1
CDS	144..611
Translation	MATRNPPPQDYESDDDSYEVLDLTEYARRHQWWNRVFGHSSGPMVEKYSVATQIVMGGVTGWCAGFLFQKVGKLAATAVGGGFLLLQIASHSGYVQIDWKRVEKDVNKAKRQIKKRANKAAPEINNLIEEATEFIKQNIVISSGFVGGFLLGLAS

Target ORF information:

RefSeq Version	NM_173794.3
Organism	Homo sapiens(human)
Definition	Homo sapiens FUN14 domain containing 1 (FUNDC1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_173794.3

ORF Insert Sequence:

ATGGCGACCC GGAACCCCCC TCCCCAAGAC TATGAAAGTG ATGACGACTC TTATGAAGTG 
TTGGATTTAA CTGAGTATGC AAGAAGACAC CAGTGGTGGA ATCGAGTGTT TGGCCACAGT 
TCGGGACCTA TGGTAGAAAA ATACTCAGTA GCTACCCAGA TTGTAATGGG TGGCGTTACT 
GGCTGGTGTG CAGGATTTCT GTTCCAGAAA GTTGGAAAAC TTGCAGCAAC TGCAGTAGGT 
GGTGGCTTTC TTCTTCTTCA GATTGCTAGT CATAGTGGCT ATGTGCAGAT TGACTGGAAG 
AGAGTTGAAA AAGATGTAAA TAAAGCAAAA AGACAGATTA AGAAACGAGC GAACAAAGCA 
GCACCTGAAA TCAACAATTT AATTGAAGAA GCAACAGAAT TTATCAAGCA GAACATTGTG 
ATATCCAGTG GATTTGTGGG AGGCTTTTTG CTCGGACTTG CATCTTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

FUNDC1 ( NM_173794.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_776155.1 Homo sapiens FUN14 domain containing 1 (FUNDC1), mRNA.

Price & Availability↑

CloneID	OHu19682
Clone ID Related Accession (Same CDS sequence)	NM_173794.3 , NM_173794.4
Accession Version	NM_173794.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 468bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-29
Organism	Homo sapiens(human)
Product	FUN14 domain-containing protein 1
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BM837991.1, BG213042.1 and BC035015.2. This sequence is a reference standard in the RefSeqGene project. On Nov 22, 2018 this sequence version replaced NM_173794.3. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC035015.2, SRR1660803.28991.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000378045.5/ ENSP00000367284.4 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGGCGACCC GGAACCCCCC TCCCCAAGAC TATGAAAGTG ATGACGACTC TTATGAAGTG 
TTGGATTTAA CTGAGTATGC AAGAAGACAC CAGTGGTGGA ATCGAGTGTT TGGCCACAGT 
TCGGGACCTA TGGTAGAAAA ATACTCAGTA GCTACCCAGA TTGTAATGGG TGGCGTTACT 
GGCTGGTGTG CAGGATTTCT GTTCCAGAAA GTTGGAAAAC TTGCAGCAAC TGCAGTAGGT 
GGTGGCTTTC TTCTTCTTCA GATTGCTAGT CATAGTGGCT ATGTGCAGAT TGACTGGAAG 
AGAGTTGAAA AAGATGTAAA TAAAGCAAAA AGACAGATTA AGAAACGAGC GAACAAAGCA 
GCACCTGAAA TCAACAATTT AATTGAAGAA GCAACAGAAT TTATCAAGCA GAACATTGTG 
ATATCCAGTG GATTTGTGGG AGGCTTTTTG CTCGGACTTG CATCTTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_776155.1
CDS	28..495
Translation	MATRNPPPQDYESDDDSYEVLDLTEYARRHQWWNRVFGHSSGPMVEKYSVATQIVMGGVTGWCAGFLFQKVGKLAATAVGGGFLLLQIASHSGYVQIDWKRVEKDVNKAKRQIKKRANKAAPEINNLIEEATEFIKQNIVISSGFVGGFLLGLAS

Target ORF information:

RefSeq Version	NM_173794.4
Organism	Homo sapiens(human)
Definition	Homo sapiens FUN14 domain containing 1 (FUNDC1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_173794.4

ORF Insert Sequence:

ATGGCGACCC GGAACCCCCC TCCCCAAGAC TATGAAAGTG ATGACGACTC TTATGAAGTG 
TTGGATTTAA CTGAGTATGC AAGAAGACAC CAGTGGTGGA ATCGAGTGTT TGGCCACAGT 
TCGGGACCTA TGGTAGAAAA ATACTCAGTA GCTACCCAGA TTGTAATGGG TGGCGTTACT 
GGCTGGTGTG CAGGATTTCT GTTCCAGAAA GTTGGAAAAC TTGCAGCAAC TGCAGTAGGT 
GGTGGCTTTC TTCTTCTTCA GATTGCTAGT CATAGTGGCT ATGTGCAGAT TGACTGGAAG 
AGAGTTGAAA AAGATGTAAA TAAAGCAAAA AGACAGATTA AGAAACGAGC GAACAAAGCA 
GCACCTGAAA TCAACAATTT AATTGAAGAA GCAACAGAAT TTATCAAGCA GAACATTGTG 
ATATCCAGTG GATTTGTGGG AGGCTTTTTG CTCGGACTTG CATCTTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

High expression of FUNDC1 predicts poor prognostic outcomes and is a promising target to improve chemoradiotherapy effects in patients with cervical cancer.
Cancer medicine6(8)1871-1881(2017 Aug)
Hou H,Er P,Cheng J,Chen X,Ding X,Wang Y,Chen X,Yuan Z,Pang Q,Wang P,Qian D

Mitochondrial E3 ligase MARCH5 regulates FUNDC1 to fine-tune hypoxic mitophagy.
EMBO reports18(3)495-509(2017 03)
Chen Z,Liu L,Cheng Q,Li Y,Wu H,Zhang W,Wang Y,Sehgal SA,Siraj S,Wang X,Wang J,Zhu Y,Chen Q

Structural insights into the recognition of phosphorylated FUNDC1 by LC3B in mitophagy.
Protein & cell8(1)25-38(2017 Jan)
Lv M,Wang C,Li F,Peng J,Wen B,Gong Q,Shi Y,Tang Y

Structural basis for the phosphorylation of FUNDC1 LIR as a molecular switch of mitophagy.
Autophagy12(12)2363-2373(2016 Dec)
Kuang Y,Ma K,Zhou C,Ding P,Zhu Y,Chen Q,Xia B