CHGB cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	CHGB
Entrez Gene ID	1114
Full Name	chromogranin B
Synonyms	SCG1
General protein information	Preferred Names chromogranin B Names secretogranin-1 cgB secretogranin B secretogranin I sgI
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 20 Map Location: 20p12.3
Summary	This gene encodes a tyrosine-sulfated secretory protein abundant in peptidergic endocrine cells and neurons. This protein may serve as a precursor for regulatory peptides. [provided by RefSeq, Jan 2009].
Disorder MIM:	118920

mRNA and Protein(s)

mRNA	Protein	Name
NM_001819.2	NP_001810.2	secretogranin-1 precursor
NM_001819.3	NP_001810.2	secretogranin-1 precursor

Pathways from BioSystems

Homologies

Canis lupus familiaris (dog)	CHGB	XP_534354.3
Gallus gallus (chicken)	CHGB	XP_419377.1
	CHGB	XP_001112965.2
Bos taurus (cattle)	CHGB	NP_851349.1
Rattus norvegicus (Norway rat)	Chgb	NP_036658.2
Mus musculus (house mouse)	Chgb	NP_031720.1
Homo sapiens (human)	CHGB	NP_001810.2
Pan troglodytes (chimpanzee)	CHGB	XP_525418.3

Gene Ontology
Bibliography

Related articles in PubMed

Regulation of circulating chromogranin B levels in heart failure.
Heidrich FM, Melz C, Buechau MS, Pfluecke C, Quick S, Speiser U, Poitz DM, Augstein A, Ruf T, W?ssnig NK, Youssef A, Strasser RH, Wiedemann S
Biomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals1-10(2017 Nov)

Identification of novel genetic loci GAL3ST4 and CHGB involved in susceptibility to leprosy.
Yuan Y, You Y, Wen Y, Liu J, Li H, Zhang Y, Wu N, Liu S, Zhang S, Chen J, Ai J, Zhang W, Zhang Y
Scientific reports7(1)16352(2017 Nov)

Lack of association between the P413L variant of chromogranin B and ALS risk or age at onset: a meta-analysis.
Yang X, Li S, Xing D, Li P, Li C, Qi L, Xu Y, Ren H
Amyotrophic lateral sclerosis & frontotemporal degeneration1-7(2017 Aug)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Compared with chromogranin A, chromogranin B may be more useful during proton pump inhibitor treatment and can detect tumors without liver metastases.
Title: Utility of chromogranin B compared with chromogranin A as a biomarker in Japanese patients with pancreatic neuroendocrine tumors.

our results suggest that genetic variants of CHGB may have sex-specific effects on the risk of schizophrenia and provide useful preliminary information for further study.
Title: Gender-Specific Associations between CHGB Genetic Variants and Schizophrenia in a Korean Population.

Data indicate that measurement of chromogranin A (CgA) alone is sufficient in the management of patients with neuroendocrine tumours (NETs) and that routine additional measurement of chromogranin B (CgB) provides little added value.
Title: Routine measurement of plasma chromogranin B has limited clinical utility in the management of patients with neuroendocrine tumours.

intracellular calcium binding protein Sg1 is increased in early multiple sclerosis (MS) patients compared to relapsing-remitting MS and neurological controls.
Title: Quantitative proteomics suggests decrease in the secretogranin-1 cerebrospinal fluid levels during the disease course of multiple sclerosis.

The polymorphism P413L in the CHGB gene was not associated with sporadic amyotrophic lateral sclerosis in a group of Italian patients.
Title: Lack of relationship between the P413L chromogranin B variant and a SALS Italian cohort.

The following CHGB gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the CHGB cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu17565	NM_001819.3 Latest version!	Homo sapiens chromogranin B (CHGB), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	12-14	$265.30 $379.00
View Old Accession Versions >>
OHu17565	NM_001819.2	Homo sapiens chromogranin B (CHGB), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	12-14	$265.30 $379.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

CHGB ( NM_001819.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_001810.2 Homo sapiens chromogranin B (CHGB), mRNA.

Price & Availability↑

CloneID	OHu17565
Clone ID Related Accession (Same CDS sequence)	NM_001819.2 , NM_001819.3
Accession Version	NM_001819.2	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2034bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-11-11
Organism	Homo sapiens(human)
Product	secretogranin-1 precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DC312240.1, BC000375.2, BP422638.1 and BM681923.1. This sequence is a reference standard in the RefSeqGene project. On Jan 24, 2009 this sequence version replaced NM_001819.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1803614.206048.1, SRR1803611.232123.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGCAGCCAA CGCTGCTTCT CAGCCTCCTG GGAGCCGTGG GGCTGGCGGC TGTCAATTCC 
ATGCCAGTGG ATAACAGGAA CCACAATGAA GGAATGGTGA CTCGCTGCAT CATTGAGGTC 
CTCTCAAATG CCTTGTCGAA GTCCAGCGCT CCACCCATCA CCCCTGAGTG CCGCCAAGTC 
CTGAAGACGA GTAGAAAAGA CGTCAAAGAC AAAGAGACAA CTGAAAATGA AAACACAAAG 
TTTGAAGTAA GATTGTTAAG AGACCCAGCT GATGCCTCGG AAGCCCACGA GTCCTCCAGC 
AGGGGAGAGG CAGGAGCCCC AGGGGAGGAG GACATCCAAG GCCCAACAAA GGCAGACACA 
GAGAAATGGG CAGAGGGAGG CGGGCACAGC CGAGAGCGAG CGGATGAGCC CCAGTGGAGC 
CTCTATCCCT CCGACAGCCA AGTCTCTGAA GAAGTGAAGA CACGCCATTC TGAGAAGAGC 
CAGAGAGAGG ATGAGGAGGA GGAGGAGGGA GAGAACTATC AAAAAGGGGA GCGAGGGGAA 
GATAGCAGTG AAGAGAAACA CCTTGAAGAG CCAGGAGAGA CACAAAACGC TTTTCTCAAT 
GAAAGAAAGC AGGCTTCAGC TATAAAAAAA GAGGAGTTAG TGGCCAGATC GGAAACACAT 
GCTGCCGGGC ATTCTCAGGA GAAGACACAT AGCCGAGAGA AGAGTAGCCA GGAGAGTGGA 
GAGGAGACAG GGAGCCAGGA GAATCACCCC CAGGAGTCTA AAGGCCAACC CCGAAGCCAG 
GAAGAATCTG AGGAAGGTGA GGAAGATGCC ACCTCTGAGG TGGACAAACG ACGCACGAGG 
CCCAGACACC ACCACGGGAG GAGCAGGCCC GACAGGTCCT CTCAAGGAGG GAGTCTTCCC 
TCTGAGGAAA AGGGACACCC CCAGGAGGAA TCTGAGGAGT CAAACGTCAG CATGGCCAGT 
TTAGGGGAAA AGAGGGACCA CCATTCAACC CACTACAGGG CTTCAGAGGA AGAACCTGAA 
TATGGAGAAG AAATAAAGGG TTATCCAGGC GTCCAGGCCC CTGAGGACCT GGAGTGGGAG 
CGCTATAGGG GCAGAGGAAG TGAAGAATAC AGGGCTCCAA GACCTCAGAG TGAGGAGAGT 
TGGGATGAGG AGGACAAGAG AAACTACCCC AGCTTAGAGC TTGATAAGAT GGCACATGGA 
TATGGTGAAG AAAGTGAGGA AGAGAGGGGC CTTGAGCCGG GAAAGGGACG CCATCACAGA 
GGCAGGGGAG GGGAGCCACG TGCCTATTTC ATGTCTGACA CCAGAGAAGA GAAAAGGTTC 
TTGGGTGAAG GACACCACCG TGTCCAAGAA AACCAGATGG ACAAGGCAAG GAGGCATCCA 
CAAGGTGCGT GGAAAGAGCT GGACAGAAAT TATCTCAACT ACGGTGAGGA AGGAGCCCCA 
GGGAAGTGGC AGCAGCAGGG AGACCTGCAG GACACTAAAG AAAACAGGGA GGAAGCTAGG 
TTTCAAGATA AACAATATAG CTCCCATCAC ACAGCTGAAA AGAGGAAGAG ATTAGGGGAA 
CTGTTCAACC CATACTACGA CCCTCTCCAG TGGAAGAGCA GCCATTTTGA AAGAAGAGAC 
AACATGAATG ACAATTTTCT CGAGGGTGAG GAGGAAAATG AGCTGACCTT GAACGAGAAG 
AATTTCTTCC CAGAATACAA CTATGACTGG TGGGAGAAAA AGCCCTTCTC TGAGGATGTG 
AACTGGGGGT ATGAGAAGAG AAACCTCGCC AGGGTCCCCA AGCTGGACCT GAAAAGGCAA 
TATGACAGGG TGGCCCAACT GGACCAGCTC CTTCACTACA GGAAGAAGTC AGCTGAGTTT 
CCAGACTTCT ATGATTCTGA GGAGCCGGTG AGCACCCACC AGGAGGCAGA AAATGAAAAG 
GACAGGGCTG ACCAGACAGT CCTGACAGAG GACGAGAAAA AAGAACTCGA AAACTTGGCT 
GCAATGGATT TGGAACTACA GAAGATAGCT GAGAAATTCA GCCAAAGGGG CTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001810.2
CDS	307..2340
Translation	MQPTLLLSLLGAVGLAAVNSMPVDNRNHNEGMVTRCIIEVLSNALSKSSAPPITPECRQVLKTSRKDVKDKETTENENTKFEVRLLRDPADASEAHESSSRGEAGAPGEEDIQGPTKADTEKWAEGGGHSRERADEPQWSLYPSDSQVSEEVKTRHSEKSQREDEEEEEGENYQKGERGEDSSEEKHLEEPGETQNAFLNERKQASAIKKEELVARSETHAAGHSQEKTHSREKSSQESGEETGSQENHPQESKGQPRSQEESEEGEEDATSEVDKRRTRPRHHHGRSRPDRSSQGGSLPSEEKGHPQEESEESNVSMASLGEKRDHHSTHYRASEEEPEYGEEIKGYPGVQAPEDLEWERYRGRGSEEYRAPRPQSEESWDEEDKRNYPSLELDKMAHGYGEESEEERGLEPGKGRHHRGRGGEPRAYFMSDTREEKRFLGEGHHRVQENQMDKARRHPQGAWKELDRNYLNYGEEGAPGKWQQQGDLQDTKENREEARFQDKQYSSHHTAEKRKRLGELFNPYYDPLQWKSSHFERRDNMNDNFLEGEEENELTLNEKNFFPEYNYDWWEKKPFSEDVNWGYEKRNLARVPKLDLKRQYDRVAQLDQLLHYRKKSAEFPDFYDSEEPVSTHQEAENEKDRADQTVLTEDEKKELENLAAMDLELQKIAEKFSQRG

Target ORF information:

RefSeq Version	NM_001819.2
Organism	Homo sapiens(human)
Definition	Homo sapiens chromogranin B (CHGB), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001819.2

ORF Insert Sequence:

ATGCAGCCAA CGCTGCTTCT CAGCCTCCTG GGAGCCGTGG GGCTGGCGGC TGTCAATTCC 
ATGCCAGTGG ATAACAGGAA CCACAATGAA GGAATGGTGA CTCGCTGCAT CATTGAGGTC 
CTCTCAAATG CCTTGTCGAA GTCCAGCGCT CCACCCATCA CCCCTGAGTG CCGCCAAGTC 
CTGAAGACGA GTAGAAAAGA CGTCAAAGAC AAAGAGACAA CTGAAAATGA AAACACAAAG 
TTTGAAGTAA GATTGTTAAG AGACCCAGCT GATGCCTCGG AAGCCCACGA GTCCTCCAGC 
AGGGGAGAGG CAGGAGCCCC AGGGGAGGAG GACATCCAAG GCCCAACAAA GGCAGACACA 
GAGAAATGGG CAGAGGGAGG CGGGCACAGC CGAGAGCGAG CGGATGAGCC CCAGTGGAGC 
CTCTATCCCT CCGACAGCCA AGTCTCTGAA GAAGTGAAGA CACGCCATTC TGAGAAGAGC 
CAGAGAGAGG ATGAGGAGGA GGAGGAGGGA GAGAACTATC AAAAAGGGGA GCGAGGGGAA 
GATAGCAGTG AAGAGAAACA CCTTGAAGAG CCAGGAGAGA CACAAAACGC TTTTCTCAAT 
GAAAGAAAGC AGGCTTCAGC TATAAAAAAA GAGGAGTTAG TGGCCAGATC GGAAACACAT 
GCTGCCGGGC ATTCTCAGGA GAAGACACAT AGCCGAGAGA AGAGTAGCCA GGAGAGTGGA 
GAGGAGACAG GGAGCCAGGA GAATCACCCC CAGGAGTCTA AAGGCCAACC CCGAAGCCAG 
GAAGAATCTG AGGAAGGTGA GGAAGATGCC ACCTCTGAGG TGGACAAACG ACGCACGAGG 
CCCAGACACC ACCACGGGAG GAGCAGGCCC GACAGGTCCT CTCAAGGAGG GAGTCTTCCC 
TCTGAGGAAA AGGGACACCC CCAGGAGGAA TCTGAGGAGT CAAACGTCAG CATGGCCAGT 
TTAGGGGAAA AGAGGGACCA CCATTCAACC CACTACAGGG CTTCAGAGGA AGAACCTGAA 
TATGGAGAAG AAATAAAGGG TTATCCAGGC GTCCAGGCCC CTGAGGACCT GGAGTGGGAG 
CGCTATAGGG GCAGAGGAAG TGAAGAATAC AGGGCTCCAA GACCTCAGAG TGAGGAGAGT 
TGGGATGAGG AGGACAAGAG AAACTACCCC AGCTTAGAGC TTGATAAGAT GGCACATGGA 
TATGGTGAAG AAAGTGAGGA AGAGAGGGGC CTTGAGCCGG GAAAGGGACG CCATCACAGA 
GGCAGGGGAG GGGAGCCACG TGCCTATTTC ATGTCTGACA CCAGAGAAGA GAAAAGGTTC 
TTGGGTGAAG GACACCACCG TGTCCAAGAA AACCAGATGG ACAAGGCAAG GAGGCATCCA 
CAAGGTGCGT GGAAAGAGCT GGACAGAAAT TATCTCAACT ACGGTGAGGA AGGAGCCCCA 
GGGAAGTGGC AGCAGCAGGG AGACCTGCAG GACACTAAAG AAAACAGGGA GGAAGCTAGG 
TTTCAAGATA AACAATATAG CTCCCATCAC ACAGCTGAAA AGAGGAAGAG ATTAGGGGAA 
CTGTTCAACC CATACTACGA CCCTCTCCAG TGGAAGAGCA GCCATTTTGA AAGAAGAGAC 
AACATGAATG ACAATTTTCT CGAGGGTGAG GAGGAAAATG AGCTGACCTT GAACGAGAAG 
AATTTCTTCC CAGAATACAA CTATGACTGG TGGGAGAAAA AGCCCTTCTC TGAGGATGTG 
AACTGGGGGT ATGAGAAGAG AAACCTCGCC AGGGTCCCCA AGCTGGACCT GAAAAGGCAA 
TATGACAGGG TGGCCCAACT GGACCAGCTC CTTCACTACA GGAAGAAGTC AGCTGAGTTT 
CCAGACTTCT ATGATTCTGA GGAGCCGGTG AGCACCCACC AGGAGGCAGA AAATGAAAAG 
GACAGGGCTG ACCAGACAGT CCTGACAGAG GACGAGAAAA AAGAACTCGA AAACTTGGCT 
GCAATGGATT TGGAACTACA GAAGATAGCT GAGAAATTCA GCCAAAGGGG CTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

CHGB ( NM_001819.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_001810.2 Homo sapiens chromogranin B (CHGB), mRNA.

Price & Availability↑

CloneID	OHu17565
Clone ID Related Accession (Same CDS sequence)	NM_001819.2 , NM_001819.3
Accession Version	NM_001819.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2034bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-09-24
Organism	Homo sapiens(human)
Product	secretogranin-1 precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DC312240.1, BC000375.2, BP422638.1 and BM681923.1. This sequence is a reference standard in the RefSeqGene project. On Nov 22, 2018 this sequence version replaced NM_001819.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1803613.63507.1, SRR1803611.247990.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000378961.9/ ENSP00000368244.4 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGCAGCCAA CGCTGCTTCT CAGCCTCCTG GGAGCCGTGG GGCTGGCGGC TGTCAATTCC 
ATGCCAGTGG ATAACAGGAA CCACAATGAA GGAATGGTGA CTCGCTGCAT CATTGAGGTC 
CTCTCAAATG CCTTGTCGAA GTCCAGCGCT CCACCCATCA CCCCTGAGTG CCGCCAAGTC 
CTGAAGACGA GTAGAAAAGA CGTCAAAGAC AAAGAGACAA CTGAAAATGA AAACACAAAG 
TTTGAAGTAA GATTGTTAAG AGACCCAGCT GATGCCTCGG AAGCCCACGA GTCCTCCAGC 
AGGGGAGAGG CAGGAGCCCC AGGGGAGGAG GACATCCAAG GCCCAACAAA GGCAGACACA 
GAGAAATGGG CAGAGGGAGG CGGGCACAGC CGAGAGCGAG CGGATGAGCC CCAGTGGAGC 
CTCTATCCCT CCGACAGCCA AGTCTCTGAA GAAGTGAAGA CACGCCATTC TGAGAAGAGC 
CAGAGAGAGG ATGAGGAGGA GGAGGAGGGA GAGAACTATC AAAAAGGGGA GCGAGGGGAA 
GATAGCAGTG AAGAGAAACA CCTTGAAGAG CCAGGAGAGA CACAAAACGC TTTTCTCAAT 
GAAAGAAAGC AGGCTTCAGC TATAAAAAAA GAGGAGTTAG TGGCCAGATC GGAAACACAT 
GCTGCCGGGC ATTCTCAGGA GAAGACACAT AGCCGAGAGA AGAGTAGCCA GGAGAGTGGA 
GAGGAGACAG GGAGCCAGGA GAATCACCCC CAGGAGTCTA AAGGCCAACC CCGAAGCCAG 
GAAGAATCTG AGGAAGGTGA GGAAGATGCC ACCTCTGAGG TGGACAAACG ACGCACGAGG 
CCCAGACACC ACCACGGGAG GAGCAGGCCC GACAGGTCCT CTCAAGGAGG GAGTCTTCCC 
TCTGAGGAAA AGGGACACCC CCAGGAGGAA TCTGAGGAGT CAAACGTCAG CATGGCCAGT 
TTAGGGGAAA AGAGGGACCA CCATTCAACC CACTACAGGG CTTCAGAGGA AGAACCTGAA 
TATGGAGAAG AAATAAAGGG TTATCCAGGC GTCCAGGCCC CTGAGGACCT GGAGTGGGAG 
CGCTATAGGG GCAGAGGAAG TGAAGAATAC AGGGCTCCAA GACCTCAGAG TGAGGAGAGT 
TGGGATGAGG AGGACAAGAG AAACTACCCC AGCTTAGAGC TTGATAAGAT GGCACATGGA 
TATGGTGAAG AAAGTGAGGA AGAGAGGGGC CTTGAGCCGG GAAAGGGACG CCATCACAGA 
GGCAGGGGAG GGGAGCCACG TGCCTATTTC ATGTCTGACA CCAGAGAAGA GAAAAGGTTC 
TTGGGTGAAG GACACCACCG TGTCCAAGAA AACCAGATGG ACAAGGCAAG GAGGCATCCA 
CAAGGTGCGT GGAAAGAGCT GGACAGAAAT TATCTCAACT ACGGTGAGGA AGGAGCCCCA 
GGGAAGTGGC AGCAGCAGGG AGACCTGCAG GACACTAAAG AAAACAGGGA GGAAGCTAGG 
TTTCAAGATA AACAATATAG CTCCCATCAC ACAGCTGAAA AGAGGAAGAG ATTAGGGGAA 
CTGTTCAACC CATACTACGA CCCTCTCCAG TGGAAGAGCA GCCATTTTGA AAGAAGAGAC 
AACATGAATG ACAATTTTCT CGAGGGTGAG GAGGAAAATG AGCTGACCTT GAACGAGAAG 
AATTTCTTCC CAGAATACAA CTATGACTGG TGGGAGAAAA AGCCCTTCTC TGAGGATGTG 
AACTGGGGGT ATGAGAAGAG AAACCTCGCC AGGGTCCCCA AGCTGGACCT GAAAAGGCAA 
TATGACAGGG TGGCCCAACT GGACCAGCTC CTTCACTACA GGAAGAAGTC AGCTGAGTTT 
CCAGACTTCT ATGATTCTGA GGAGCCGGTG AGCACCCACC AGGAGGCAGA AAATGAAAAG 
GACAGGGCTG ACCAGACAGT CCTGACAGAG GACGAGAAAA AAGAACTCGA AAACTTGGCT 
GCAATGGATT TGGAACTACA GAAGATAGCT GAGAAATTCA GCCAAAGGGG CTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001810.2
CDS	125..2158
Translation	MQPTLLLSLLGAVGLAAVNSMPVDNRNHNEGMVTRCIIEVLSNALSKSSAPPITPECRQVLKTSRKDVKDKETTENENTKFEVRLLRDPADASEAHESSSRGEAGAPGEEDIQGPTKADTEKWAEGGGHSRERADEPQWSLYPSDSQVSEEVKTRHSEKSQREDEEEEEGENYQKGERGEDSSEEKHLEEPGETQNAFLNERKQASAIKKEELVARSETHAAGHSQEKTHSREKSSQESGEETGSQENHPQESKGQPRSQEESEEGEEDATSEVDKRRTRPRHHHGRSRPDRSSQGGSLPSEEKGHPQEESEESNVSMASLGEKRDHHSTHYRASEEEPEYGEEIKGYPGVQAPEDLEWERYRGRGSEEYRAPRPQSEESWDEEDKRNYPSLELDKMAHGYGEESEEERGLEPGKGRHHRGRGGEPRAYFMSDTREEKRFLGEGHHRVQENQMDKARRHPQGAWKELDRNYLNYGEEGAPGKWQQQGDLQDTKENREEARFQDKQYSSHHTAEKRKRLGELFNPYYDPLQWKSSHFERRDNMNDNFLEGEEENELTLNEKNFFPEYNYDWWEKKPFSEDVNWGYEKRNLARVPKLDLKRQYDRVAQLDQLLHYRKKSAEFPDFYDSEEPVSTHQEAENEKDRADQTVLTEDEKKELENLAAMDLELQKIAEKFSQRG

Target ORF information:

RefSeq Version	NM_001819.3
Organism	Homo sapiens(human)
Definition	Homo sapiens chromogranin B (CHGB), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001819.3

ORF Insert Sequence:

ATGCAGCCAA CGCTGCTTCT CAGCCTCCTG GGAGCCGTGG GGCTGGCGGC TGTCAATTCC 
ATGCCAGTGG ATAACAGGAA CCACAATGAA GGAATGGTGA CTCGCTGCAT CATTGAGGTC 
CTCTCAAATG CCTTGTCGAA GTCCAGCGCT CCACCCATCA CCCCTGAGTG CCGCCAAGTC 
CTGAAGACGA GTAGAAAAGA CGTCAAAGAC AAAGAGACAA CTGAAAATGA AAACACAAAG 
TTTGAAGTAA GATTGTTAAG AGACCCAGCT GATGCCTCGG AAGCCCACGA GTCCTCCAGC 
AGGGGAGAGG CAGGAGCCCC AGGGGAGGAG GACATCCAAG GCCCAACAAA GGCAGACACA 
GAGAAATGGG CAGAGGGAGG CGGGCACAGC CGAGAGCGAG CGGATGAGCC CCAGTGGAGC 
CTCTATCCCT CCGACAGCCA AGTCTCTGAA GAAGTGAAGA CACGCCATTC TGAGAAGAGC 
CAGAGAGAGG ATGAGGAGGA GGAGGAGGGA GAGAACTATC AAAAAGGGGA GCGAGGGGAA 
GATAGCAGTG AAGAGAAACA CCTTGAAGAG CCAGGAGAGA CACAAAACGC TTTTCTCAAT 
GAAAGAAAGC AGGCTTCAGC TATAAAAAAA GAGGAGTTAG TGGCCAGATC GGAAACACAT 
GCTGCCGGGC ATTCTCAGGA GAAGACACAT AGCCGAGAGA AGAGTAGCCA GGAGAGTGGA 
GAGGAGACAG GGAGCCAGGA GAATCACCCC CAGGAGTCTA AAGGCCAACC CCGAAGCCAG 
GAAGAATCTG AGGAAGGTGA GGAAGATGCC ACCTCTGAGG TGGACAAACG ACGCACGAGG 
CCCAGACACC ACCACGGGAG GAGCAGGCCC GACAGGTCCT CTCAAGGAGG GAGTCTTCCC 
TCTGAGGAAA AGGGACACCC CCAGGAGGAA TCTGAGGAGT CAAACGTCAG CATGGCCAGT 
TTAGGGGAAA AGAGGGACCA CCATTCAACC CACTACAGGG CTTCAGAGGA AGAACCTGAA 
TATGGAGAAG AAATAAAGGG TTATCCAGGC GTCCAGGCCC CTGAGGACCT GGAGTGGGAG 
CGCTATAGGG GCAGAGGAAG TGAAGAATAC AGGGCTCCAA GACCTCAGAG TGAGGAGAGT 
TGGGATGAGG AGGACAAGAG AAACTACCCC AGCTTAGAGC TTGATAAGAT GGCACATGGA 
TATGGTGAAG AAAGTGAGGA AGAGAGGGGC CTTGAGCCGG GAAAGGGACG CCATCACAGA 
GGCAGGGGAG GGGAGCCACG TGCCTATTTC ATGTCTGACA CCAGAGAAGA GAAAAGGTTC 
TTGGGTGAAG GACACCACCG TGTCCAAGAA AACCAGATGG ACAAGGCAAG GAGGCATCCA 
CAAGGTGCGT GGAAAGAGCT GGACAGAAAT TATCTCAACT ACGGTGAGGA AGGAGCCCCA 
GGGAAGTGGC AGCAGCAGGG AGACCTGCAG GACACTAAAG AAAACAGGGA GGAAGCTAGG 
TTTCAAGATA AACAATATAG CTCCCATCAC ACAGCTGAAA AGAGGAAGAG ATTAGGGGAA 
CTGTTCAACC CATACTACGA CCCTCTCCAG TGGAAGAGCA GCCATTTTGA AAGAAGAGAC 
AACATGAATG ACAATTTTCT CGAGGGTGAG GAGGAAAATG AGCTGACCTT GAACGAGAAG 
AATTTCTTCC CAGAATACAA CTATGACTGG TGGGAGAAAA AGCCCTTCTC TGAGGATGTG 
AACTGGGGGT ATGAGAAGAG AAACCTCGCC AGGGTCCCCA AGCTGGACCT GAAAAGGCAA 
TATGACAGGG TGGCCCAACT GGACCAGCTC CTTCACTACA GGAAGAAGTC AGCTGAGTTT 
CCAGACTTCT ATGATTCTGA GGAGCCGGTG AGCACCCACC AGGAGGCAGA AAATGAAAAG 
GACAGGGCTG ACCAGACAGT CCTGACAGAG GACGAGAAAA AAGAACTCGA AAACTTGGCT 
GCAATGGATT TGGAACTACA GAAGATAGCT GAGAAATTCA GCCAAAGGGG CTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Regulation of circulating chromogranin B levels in heart failure.
Biomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals1-10(2017 Nov)
Heidrich FM,Melz C,Buechau MS,Pfluecke C,Quick S,Speiser U,Poitz DM,Augstein A,Ruf T,W?ssnig NK,Youssef A,Strasser RH,Wiedemann S

Identification of novel genetic loci GAL3ST4 and CHGB involved in susceptibility to leprosy.
Scientific reports7(1)16352(2017 Nov)
Yuan Y,You Y,Wen Y,Liu J,Li H,Zhang Y,Wu N,Liu S,Zhang S,Chen J,Ai J,Zhang W,Zhang Y

Lack of association between the P413L variant of chromogranin B and ALS risk or age at onset: a meta-analysis.
Amyotrophic lateral sclerosis & frontotemporal degeneration1-7(2017 Aug)
Yang X,Li S,Xing D,Li P,Li C,Qi L,Xu Y,Ren H

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CHGB cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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