ZBTB18 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	ZBTB18
Entrez Gene ID	10472
Full Name	zinc finger and BTB domain containing 18
Synonyms	C2H2-171,MRD22,RP58,TAZ-1,ZNF238
General protein information	Preferred Names zinc finger and BTB domain containing 18 Names zinc finger and BTB domain-containing protein 18 58 kDa repressor protein transcriptional repressor RP58 translin-associated zinc finger protein 1 zinc finger protein 238 zinc finger protein C2H2-171
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 1 Map Location: 1q44
Summary	This gene encodes a C2H2-type zinc finger protein which acts a transcriptional repressor of genes involved in neuronal development. The encoded protein recognizes a specific sequence motif and recruits components of chromatin to target genes. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2013].
Disorder MIM:	608433
Disorder Html:	Mental retardation, autosomal dominant 22, 612337 (3)

mRNA and Protein(s)

mRNA	Protein	Name
NM_006352.4	NP_006343.2	zinc finger and BTB domain-containing protein 18 isoform 2
NM_001278196.1	NP_001265125.1	zinc finger and BTB domain-containing protein 18 isoform 2
NM_205768.2	NP_991331.1	zinc finger and BTB domain-containing protein 18 isoform 1
XM_017000060.1	XP_016855549.1	zinc finger and BTB domain-containing protein 18 isoform X1
XM_005273006.2	XP_005273063.1	zinc finger and BTB domain-containing protein 18 isoform X1

Pathways from BioSystems

Homologies

Homo sapiens (human)	ZBTB18	NP_991331.1
Canis lupus familiaris (dog)	ZBTB18	XP_547497.2
Mus musculus (house mouse)	Zbtb18	NP_001012330.1
Xenopus tropicalis (tropical clawed frog)	zbtb18	NP_001016948.2
Danio rerio (zebrafish)	zbtb18	NP_001076421.1
	ZNF238	XP_002802142.1
Pan troglodytes (chimpanzee)	ZNF238	XP_525117.2
Bos taurus (cattle)	ZBTB18	NP_001071484.1
Rattus norvegicus (Norway rat)	Zfp238	NP_073169.1
Gallus gallus (chicken)	ZNF238	XP_426137.4

Gene Ontology
Bibliography

Related articles in PubMed

Epigenetic Regulation of ZBTB18 Promotes Glioblastoma Progression.
Fedele V, Dai F, Masilamani AP, Heiland DH, Kling E, G?tjens-Sanchez AM, Ferrarese R, Platania L, Soroush D, Kim H, Nelander S, Weyerbrock A, Prinz M, Califano A, Iavarone A, Bredel M, Carro MS
Molecular cancer research : MCR15(8)998-1011(2017 Aug)

A de novo nonsense mutation in ZBTB18 plus a de novo 15q13.3 microdeletion in a 6-year-old female.
Ehmke N, Karge S, Buchmann J, Korinth D, Horn D, Reis O, H??ler F
American journal of medical genetics. Part A173(5)1251-1256(2017 May)

Further evidence that de novo missense and truncating variants in ZBTB18 cause intellectual disability with variable features.
Cohen JS, Srivastava S, Farwell Hagman KD, Shinde DN, Huether R, Darcy D, Wallerstein R, Houge G, Berland S, Monaghan KG, Poretti A, Wilson AL, Chung WK, Fatemi A
Clinical genetics91(5)697-707(2017 May)

Genetic and phenotypic dissection of 1q43q44 microdeletion syndrome and neurodevelopmental phenotypes associated with mutations in ZBTB18 and HNRNPU.
Depienne C, Nava C, Keren B, Heide S, Rastetter A, Passemard S, Chantot-Bastaraud S, Moutard ML, Agrawal PB, VanNoy G, Stoler JM, Amor DJ, Billette de Villemeur T, Doummar D, Alby C, Cormier-Daire V, Garel C, Marzin P, Scheidecker S, de Saint-Martin A, Hirsch E, Korff C, Bottani A, Faivre L, Verloes A, Orzechowski C, Burglen L, Leheup B, Roume J, Andrieux J, Sheth F, Datar C, Parker MJ, Pasquier L, Odent S, Naudion S, Delrue MA, Le Caignec C, Vincent M, Isidor B, Renaldo F, Stewart F, Toutain A, Koehler U, H?ckl B, von St?lpnagel C, Kluger G, M?ller RS, Pal D, Jonson T, Soller M, Verbeek NE, van Haelst MM, de Kovel C, Koeleman B, Monroe G, van Haaften G, , Atti?-Bitach T, Boutaud L, H?ron D, Mignot C
Human genetics136(4)463-479(2017 Apr)

A systems approach reveals that the myogenesis genome network is regulated by the transcriptional repressor RP58.
Yokoyama S, Ito Y, Ueno-Kudoh H, Shimizu H, Uchibe K, Albini S, Mitsuoka K, Miyaki S, Kiso M, Nagai A, Hikata T, Osada T, Fukuda N, Yamashita S, Harada D, Mezzano V, Kasai M, Puri PL, Hayashizaki Y, Okado H, Hashimoto M, Asahara H
Developmental cell17(6)836-48(2009 Dec)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

This report indicates that haploinsufficiency of additional genes beside ZBTB18 causes the high frequency of corpus callosum anomalies in patients with microdeletions of 1q43q44 and underlines the importance of an NGS-based molecular diagnostic in complex phenotypes
Title: A de novo nonsense mutation in ZBTB18 plus a de novo 15q13.3 microdeletion in a 6-year-old female.

De novo missense and truncating variants in ZBTB18 cause intellectual disability.
Title: Further evidence that de novo missense and truncating variants in ZBTB18 cause intellectual disability with variable features.

results confirm and refine the complex genotype-phenotype correlations existing in the 1qter microdeletion syndrome and define more precisely the neurodevelopmental phenotypes associated with genetic alterations of AKT3, ZBTB18 and HNRNPU in humans
Title: Genetic and phenotypic dissection of 1q43q44 microdeletion syndrome and neurodevelopmental phenotypes associated with mutations in ZBTB18 and HNRNPU.

repression of the CR2/CD21 promoter can occur through one of the E-box motifs via recruitment of RP58.
Title: Analysis of tandem E-box motifs within human Complement receptor 2 (CR2/CD21) promoter reveals cell specific roles for RP58, E2A, USF and localized chromatin accessibility.

RP58 may act to favor neuronal differentiation and brain growth by coherently repressing multiple proneurogenic genes in a timely manner.
Title: RP58/ZNF238 directly modulates proneurogenic gene levels and is required for neuronal differentiation and brain expansion.

The following ZBTB18 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the ZBTB18 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu00433	NM_001278196.1 Latest version!	Homo sapiens zinc finger and BTB domain containing 18 (ZBTB18), transcript variant 3, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$189.50-$265.30 $379.00
OHu00433	NM_006352.4 Latest version!	Homo sapiens zinc finger and BTB domain containing 18 (ZBTB18), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$189.50-$265.30 $379.00
OHu17801	NM_205768.2 Latest version!	Homo sapiens zinc finger and BTB domain containing 18 (ZBTB18), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$189.50-$265.30 $379.00
OHu00433	XM_017000060.1 Latest version!	Homo sapiens zinc finger and BTB domain containing 18 (ZBTB18), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$189.50-$265.30 $379.00
OHu00433	XM_005273006.2 Latest version!	Homo sapiens zinc finger and BTB domain containing 18 (ZBTB18), transcript variant X2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$189.50-$265.30 $379.00

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

ZBTB18 ( NM_006352.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_006343.2 Homo sapiens zinc finger and BTB domain containing 18 (ZBTB18), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OHu00433
Clone ID Related Accession (Same CDS sequence)	NM_006352.4 , NM_001278196.1 , XM_017000060.1 , XM_005273006.2
Accession Version	NM_006352.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1569bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-11-15
Organism	Homo sapiens(human)
Product	zinc finger and BTB domain-containing protein 18 isoform 2
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BC078175.1, AJ001388.1 and AL050055.1. On May 16, 2013 this sequence version replaced NM_006352.3. Transcript Variant: This variant (2) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at a downstream in-frame start codon, compared to variant 1. The encoded isoform (2) has a shorter N-terminus, compared to isoform 1. Both variants 2 and 3 encode the same isoform (2). Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript is intronless :: BC078175.1 [ECO:0000345] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGAGTTTC CAGACCATAG TAGACATTTG CTACAGTGTC TGAGCGAGCA GAGACACCAG 
GGTTTTCTTT GTGACTGCAC TGTTCTGGTG GGAGATGCCC AGTTCCGAGC GCACCGAGCT 
GTACTGGCTT CATGCAGCAT GTATTTCCAC CTCTTTTACA AGGACCAGCT GGACAAAAGA 
GACATTGTTC ATCTGAACAG CGACATTGTT ACAGCCCCCG CTTTCGCTCT CCTGCTTGAA 
TTCATGTATG AAGGGAAACT CCAGTTCAAA GACTTGCCCA TTGAAGACGT GCTAGCAGCT 
GCCAGTTATC TCCACATGTA TGACATTGTC AAAGTCTGCA AAAAGAAGCT GAAAGAGAAA 
GCCACCACGG AGGCAGACAG CACCAAAAAG GAAGAAGATG CTTCAAGTTG TTCGGACAAA 
GTCGAGAGTC TCTCCGATGG CAGCAGCCAC ATAGCAGGCG ATTTGCCCAG TGATGAAGAT 
GAAGGAGAAG ATGAAAAATT GAACATCCTG CCCAGCAAAA GGGACTTGGC GGCCGAGCCT 
GGGAACATGT GGATGCGATT GCCCTCAGAC TCAGCAGGCA TCCCCCAGGC TGGCGGAGAG 
GCAGAGCCAC ACGCCACAGC AGCTGGAAAA ACAGTAGCCA GCCCCTGCAG CTCAACAGAG 
TCTTTGTCCC AGAGGTCTGT CACCTCCGTG AGGGATTCGG CAGATGTTGA CTGTGTGCTG 
GACCTGTCTG TCAAGTCCAG CCTTTCAGGA GTTGAAAATC TGAACAGCTC TTATTTCTCT 
TCACAGGACG TGCTGAGAAG CAACCTGGTG CAGGTGAAGG TGGAGAAAGA GGCTTCCTGT 
GATGAGAGTG ATGTTGGCAC TAATGACTAT GACATGGAAC ATAGCACTGT GAAAGAAAGT 
GTGAGCACTA ATAACAGGGT ACAGTATGAG CCGGCCCATC TGGCTCCCCT GAGGGAGGAC 
TCGGTCTTGA GGGAGCTGGA CCGGGAGGAC AAAGCCAGTG ATGATGAGAT GATGACCCCA 
GAGAGCGAGC GTGTCCAGGT GGAGGGAGGC ATGGAGAGCA GTCTGCTCCC CTACGTCTCC 
AACATCCTGA GCCCCGCGGG CCAGATCTTC ATGTGCCCCC TGTGCAACAA GGTCTTCCCC 
AGCCCCCACA TCCTGCAGAT CCACCTGAGC ACGCACTTCC GCGAGCAGGA CGGCATCCGC 
AGCAAGCCCG CCGCCGATGT CAACGTGCCC ACGTGCTCGC TGTGTGGGAA GACTTTCTCT 
TGCATGTACA CCCTCAAGCG CCACGAGAGG ACTCACTCGG GGGAGAAGCC CTACACATGC 
ACCCAGTGCG GCAAGAGCTT CCAGTACTCG CACAACCTGA GCCGCCATGC CGTGGTGCAC 
ACCCGCGAGA AGCCGCACGC CTGCAAGTGG TGCGAGCGCA GGTTCACGCA GTCCGGGGAC 
CTGTACAGAC ACATTCGCAA GTTCCACTGT GAGTTGGTGA ACTCCTTGTC GGTCAAAAGC 
GAAGCACTGA GCTTGCCTAC TGTCAGAGAC TGGACCTTAG AAGATAGCTC TCAAGAACTT 
TGGAAATAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_006343.2
CDS	598..2166
Translation	MEFPDHSRHLLQCLSEQRHQGFLCDCTVLVGDAQFRAHRAVLASCSMYFHLFYKDQLDKRDIVHLNSDIVTAPAFALLLEFMYEGKLQFKDLPIEDVLAAASYLHMYDIVKVCKKKLKEKATTEADSTKKEEDASSCSDKVESLSDGSSHIAGDLPSDEDEGEDEKLNILPSKRDLAAEPGNMWMRLPSDSAGIPQAGGEAEPHATAAGKTVASPCSSTESLSQRSVTSVRDSADVDCVLDLSVKSSLSGVENLNSSYFSSQDVLRSNLVQVKVEKEASCDESDVGTNDYDMEHSTVKESVSTNNRVQYEPAHLAPLREDSVLRELDREDKASDDEMMTPESERVQVEGGMESSLLPYVSNILSPAGQIFMCPLCNKVFPSPHILQIHLSTHFREQDGIRSKPAADVNVPTCSLCGKTFSCMYTLKRHERTHSGEKPYTCTQCGKSFQYSHNLSRHAVVHTREKPHACKWCERRFTQSGDLYRHIRKFHCELVNSLSVKSEALSLPTVRDWTLEDSSQELWK

Target ORF information:

RefSeq Version	NM_006352.4
Organism	Homo sapiens(human)
Definition	Homo sapiens zinc finger and BTB domain containing 18 (ZBTB18), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_006352.4

ORF Insert Sequence:

ATGGAGTTTC CAGACCATAG TAGACATTTG CTACAGTGTC TGAGCGAGCA GAGACACCAG 
GGTTTTCTTT GTGACTGCAC TGTTCTGGTG GGAGATGCCC AGTTCCGAGC GCACCGAGCT 
GTACTGGCTT CATGCAGCAT GTATTTCCAC CTCTTTTACA AGGACCAGCT GGACAAAAGA 
GACATTGTTC ATCTGAACAG CGACATTGTT ACAGCCCCCG CTTTCGCTCT CCTGCTTGAA 
TTCATGTATG AAGGGAAACT CCAGTTCAAA GACTTGCCCA TTGAAGACGT GCTAGCAGCT 
GCCAGTTATC TCCACATGTA TGACATTGTC AAAGTCTGCA AAAAGAAGCT GAAAGAGAAA 
GCCACCACGG AGGCAGACAG CACCAAAAAG GAAGAAGATG CTTCAAGTTG TTCGGACAAA 
GTCGAGAGTC TCTCCGATGG CAGCAGCCAC ATAGCAGGCG ATTTGCCCAG TGATGAAGAT 
GAAGGAGAAG ATGAAAAATT GAACATCCTG CCCAGCAAAA GGGACTTGGC GGCCGAGCCT 
GGGAACATGT GGATGCGATT GCCCTCAGAC TCAGCAGGCA TCCCCCAGGC TGGCGGAGAG 
GCAGAGCCAC ACGCCACAGC AGCTGGAAAA ACAGTAGCCA GCCCCTGCAG CTCAACAGAG 
TCTTTGTCCC AGAGGTCTGT CACCTCCGTG AGGGATTCGG CAGATGTTGA CTGTGTGCTG 
GACCTGTCTG TCAAGTCCAG CCTTTCAGGA GTTGAAAATC TGAACAGCTC TTATTTCTCT 
TCACAGGACG TGCTGAGAAG CAACCTGGTG CAGGTGAAGG TGGAGAAAGA GGCTTCCTGT 
GATGAGAGTG ATGTTGGCAC TAATGACTAT GACATGGAAC ATAGCACTGT GAAAGAAAGT 
GTGAGCACTA ATAACAGGGT ACAGTATGAG CCGGCCCATC TGGCTCCCCT GAGGGAGGAC 
TCGGTCTTGA GGGAGCTGGA CCGGGAGGAC AAAGCCAGTG ATGATGAGAT GATGACCCCA 
GAGAGCGAGC GTGTCCAGGT GGAGGGAGGC ATGGAGAGCA GTCTGCTCCC CTACGTCTCC 
AACATCCTGA GCCCCGCGGG CCAGATCTTC ATGTGCCCCC TGTGCAACAA GGTCTTCCCC 
AGCCCCCACA TCCTGCAGAT CCACCTGAGC ACGCACTTCC GCGAGCAGGA CGGCATCCGC 
AGCAAGCCCG CCGCCGATGT CAACGTGCCC ACGTGCTCGC TGTGTGGGAA GACTTTCTCT 
TGCATGTACA CCCTCAAGCG CCACGAGAGG ACTCACTCGG GGGAGAAGCC CTACACATGC 
ACCCAGTGCG GCAAGAGCTT CCAGTACTCG CACAACCTGA GCCGCCATGC CGTGGTGCAC 
ACCCGCGAGA AGCCGCACGC CTGCAAGTGG TGCGAGCGCA GGTTCACGCA GTCCGGGGAC 
CTGTACAGAC ACATTCGCAA GTTCCACTGT GAGTTGGTGA ACTCCTTGTC GGTCAAAAGC 
GAAGCACTGA GCTTGCCTAC TGTCAGAGAC TGGACCTTAG AAGATAGCTC TCAAGAACTT 
TGGAAATAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

ZBTB18 ( NM_001278196.1 ) cDNA ORF clone, Homo sapiens(human) -> NP_001265125.1 Homo sapiens zinc finger and BTB domain containing 18 (ZBTB18), transcript variant 3, mRNA.

Price & Availability↑

CloneID	OHu00433
Clone ID Related Accession (Same CDS sequence)	NM_006352.4 , NM_001278196.1 , XM_017000060.1 , XM_005273006.2
Accession Version	NM_001278196.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1569bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-11-15
Organism	Homo sapiens(human)
Product	zinc finger and BTB domain-containing protein 18 isoform 2
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AL590483.32, W68199.1, CN409673.1, AJ001388.1, AL050055.1 and BC078175.1. Transcript Variant: This variant (3) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at a downstream in-frame start codon, compared to variant 1. The encoded isoform (2) has a shorter N-terminus, compared to isoform 1. Both variants 2 and 3 encode the same isoform (2). Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1163657.383425.1, SRR1163657.6234.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on conservation, expression ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGGAGTTTC CAGACCATAG TAGACATTTG CTACAGTGTC TGAGCGAGCA GAGACACCAG 
GGTTTTCTTT GTGACTGCAC TGTTCTGGTG GGAGATGCCC AGTTCCGAGC GCACCGAGCT 
GTACTGGCTT CATGCAGCAT GTATTTCCAC CTCTTTTACA AGGACCAGCT GGACAAAAGA 
GACATTGTTC ATCTGAACAG CGACATTGTT ACAGCCCCCG CTTTCGCTCT CCTGCTTGAA 
TTCATGTATG AAGGGAAACT CCAGTTCAAA GACTTGCCCA TTGAAGACGT GCTAGCAGCT 
GCCAGTTATC TCCACATGTA TGACATTGTC AAAGTCTGCA AAAAGAAGCT GAAAGAGAAA 
GCCACCACGG AGGCAGACAG CACCAAAAAG GAAGAAGATG CTTCAAGTTG TTCGGACAAA 
GTCGAGAGTC TCTCCGATGG CAGCAGCCAC ATAGCAGGCG ATTTGCCCAG TGATGAAGAT 
GAAGGAGAAG ATGAAAAATT GAACATCCTG CCCAGCAAAA GGGACTTGGC GGCCGAGCCT 
GGGAACATGT GGATGCGATT GCCCTCAGAC TCAGCAGGCA TCCCCCAGGC TGGCGGAGAG 
GCAGAGCCAC ACGCCACAGC AGCTGGAAAA ACAGTAGCCA GCCCCTGCAG CTCAACAGAG 
TCTTTGTCCC AGAGGTCTGT CACCTCCGTG AGGGATTCGG CAGATGTTGA CTGTGTGCTG 
GACCTGTCTG TCAAGTCCAG CCTTTCAGGA GTTGAAAATC TGAACAGCTC TTATTTCTCT 
TCACAGGACG TGCTGAGAAG CAACCTGGTG CAGGTGAAGG TGGAGAAAGA GGCTTCCTGT 
GATGAGAGTG ATGTTGGCAC TAATGACTAT GACATGGAAC ATAGCACTGT GAAAGAAAGT 
GTGAGCACTA ATAACAGGGT ACAGTATGAG CCGGCCCATC TGGCTCCCCT GAGGGAGGAC 
TCGGTCTTGA GGGAGCTGGA CCGGGAGGAC AAAGCCAGTG ATGATGAGAT GATGACCCCA 
GAGAGCGAGC GTGTCCAGGT GGAGGGAGGC ATGGAGAGCA GTCTGCTCCC CTACGTCTCC 
AACATCCTGA GCCCCGCGGG CCAGATCTTC ATGTGCCCCC TGTGCAACAA GGTCTTCCCC 
AGCCCCCACA TCCTGCAGAT CCACCTGAGC ACGCACTTCC GCGAGCAGGA CGGCATCCGC 
AGCAAGCCCG CCGCCGATGT CAACGTGCCC ACGTGCTCGC TGTGTGGGAA GACTTTCTCT 
TGCATGTACA CCCTCAAGCG CCACGAGAGG ACTCACTCGG GGGAGAAGCC CTACACATGC 
ACCCAGTGCG GCAAGAGCTT CCAGTACTCG CACAACCTGA GCCGCCATGC CGTGGTGCAC 
ACCCGCGAGA AGCCGCACGC CTGCAAGTGG TGCGAGCGCA GGTTCACGCA GTCCGGGGAC 
CTGTACAGAC ACATTCGCAA GTTCCACTGT GAGTTGGTGA ACTCCTTGTC GGTCAAAAGC 
GAAGCACTGA GCTTGCCTAC TGTCAGAGAC TGGACCTTAG AAGATAGCTC TCAAGAACTT 
TGGAAATAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001265125.1
CDS	70..1638
Translation	MEFPDHSRHLLQCLSEQRHQGFLCDCTVLVGDAQFRAHRAVLASCSMYFHLFYKDQLDKRDIVHLNSDIVTAPAFALLLEFMYEGKLQFKDLPIEDVLAAASYLHMYDIVKVCKKKLKEKATTEADSTKKEEDASSCSDKVESLSDGSSHIAGDLPSDEDEGEDEKLNILPSKRDLAAEPGNMWMRLPSDSAGIPQAGGEAEPHATAAGKTVASPCSSTESLSQRSVTSVRDSADVDCVLDLSVKSSLSGVENLNSSYFSSQDVLRSNLVQVKVEKEASCDESDVGTNDYDMEHSTVKESVSTNNRVQYEPAHLAPLREDSVLRELDREDKASDDEMMTPESERVQVEGGMESSLLPYVSNILSPAGQIFMCPLCNKVFPSPHILQIHLSTHFREQDGIRSKPAADVNVPTCSLCGKTFSCMYTLKRHERTHSGEKPYTCTQCGKSFQYSHNLSRHAVVHTREKPHACKWCERRFTQSGDLYRHIRKFHCELVNSLSVKSEALSLPTVRDWTLEDSSQELWK

Target ORF information:

RefSeq Version	NM_001278196.1
Organism	Homo sapiens(human)
Definition	Homo sapiens zinc finger and BTB domain containing 18 (ZBTB18), transcript variant 3, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001278196.1

ORF Insert Sequence:

ATGGAGTTTC CAGACCATAG TAGACATTTG CTACAGTGTC TGAGCGAGCA GAGACACCAG 
GGTTTTCTTT GTGACTGCAC TGTTCTGGTG GGAGATGCCC AGTTCCGAGC GCACCGAGCT 
GTACTGGCTT CATGCAGCAT GTATTTCCAC CTCTTTTACA AGGACCAGCT GGACAAAAGA 
GACATTGTTC ATCTGAACAG CGACATTGTT ACAGCCCCCG CTTTCGCTCT CCTGCTTGAA 
TTCATGTATG AAGGGAAACT CCAGTTCAAA GACTTGCCCA TTGAAGACGT GCTAGCAGCT 
GCCAGTTATC TCCACATGTA TGACATTGTC AAAGTCTGCA AAAAGAAGCT GAAAGAGAAA 
GCCACCACGG AGGCAGACAG CACCAAAAAG GAAGAAGATG CTTCAAGTTG TTCGGACAAA 
GTCGAGAGTC TCTCCGATGG CAGCAGCCAC ATAGCAGGCG ATTTGCCCAG TGATGAAGAT 
GAAGGAGAAG ATGAAAAATT GAACATCCTG CCCAGCAAAA GGGACTTGGC GGCCGAGCCT 
GGGAACATGT GGATGCGATT GCCCTCAGAC TCAGCAGGCA TCCCCCAGGC TGGCGGAGAG 
GCAGAGCCAC ACGCCACAGC AGCTGGAAAA ACAGTAGCCA GCCCCTGCAG CTCAACAGAG 
TCTTTGTCCC AGAGGTCTGT CACCTCCGTG AGGGATTCGG CAGATGTTGA CTGTGTGCTG 
GACCTGTCTG TCAAGTCCAG CCTTTCAGGA GTTGAAAATC TGAACAGCTC TTATTTCTCT 
TCACAGGACG TGCTGAGAAG CAACCTGGTG CAGGTGAAGG TGGAGAAAGA GGCTTCCTGT 
GATGAGAGTG ATGTTGGCAC TAATGACTAT GACATGGAAC ATAGCACTGT GAAAGAAAGT 
GTGAGCACTA ATAACAGGGT ACAGTATGAG CCGGCCCATC TGGCTCCCCT GAGGGAGGAC 
TCGGTCTTGA GGGAGCTGGA CCGGGAGGAC AAAGCCAGTG ATGATGAGAT GATGACCCCA 
GAGAGCGAGC GTGTCCAGGT GGAGGGAGGC ATGGAGAGCA GTCTGCTCCC CTACGTCTCC 
AACATCCTGA GCCCCGCGGG CCAGATCTTC ATGTGCCCCC TGTGCAACAA GGTCTTCCCC 
AGCCCCCACA TCCTGCAGAT CCACCTGAGC ACGCACTTCC GCGAGCAGGA CGGCATCCGC 
AGCAAGCCCG CCGCCGATGT CAACGTGCCC ACGTGCTCGC TGTGTGGGAA GACTTTCTCT 
TGCATGTACA CCCTCAAGCG CCACGAGAGG ACTCACTCGG GGGAGAAGCC CTACACATGC 
ACCCAGTGCG GCAAGAGCTT CCAGTACTCG CACAACCTGA GCCGCCATGC CGTGGTGCAC 
ACCCGCGAGA AGCCGCACGC CTGCAAGTGG TGCGAGCGCA GGTTCACGCA GTCCGGGGAC 
CTGTACAGAC ACATTCGCAA GTTCCACTGT GAGTTGGTGA ACTCCTTGTC GGTCAAAAGC 
GAAGCACTGA GCTTGCCTAC TGTCAGAGAC TGGACCTTAG AAGATAGCTC TCAAGAACTT 
TGGAAATAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

ZBTB18 ( NM_205768.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_991331.1 Homo sapiens zinc finger and BTB domain containing 18 (ZBTB18), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu17801
Clone ID Related Accession (Same CDS sequence)	NM_205768.2
Accession Version	NM_205768.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1596bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-11-14
Organism	Homo sapiens(human)
Product	zinc finger and BTB domain-containing protein 18 isoform 1
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DC377579.1, BC036677.2, BC078175.1, AJ001388.1 and AL050055.1. This sequence is a reference standard in the RefSeqGene project. On Sep 22, 2007 this sequence version replaced NM_205768.1. Transcript Variant: This variant (1) encodes the longer isoform (1). Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC036677.2, AK291408.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1968968, SAMEA2142348 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGTGTCCTA AAGGTTATGA AGACAGTATG GAGTTTCCAG ACCATAGTAG ACATTTGCTA 
CAGTGTCTGA GCGAGCAGAG ACACCAGGGT TTTCTTTGTG ACTGCACTGT TCTGGTGGGA 
GATGCCCAGT TCCGAGCGCA CCGAGCTGTA CTGGCTTCAT GCAGCATGTA TTTCCACCTC 
TTTTACAAGG ACCAGCTGGA CAAAAGAGAC ATTGTTCATC TGAACAGCGA CATTGTTACA 
GCCCCCGCTT TCGCTCTCCT GCTTGAATTC ATGTATGAAG GGAAACTCCA GTTCAAAGAC 
TTGCCCATTG AAGACGTGCT AGCAGCTGCC AGTTATCTCC ACATGTATGA CATTGTCAAA 
GTCTGCAAAA AGAAGCTGAA AGAGAAAGCC ACCACGGAGG CAGACAGCAC CAAAAAGGAA 
GAAGATGCTT CAAGTTGTTC GGACAAAGTC GAGAGTCTCT CCGATGGCAG CAGCCACATA 
GCAGGCGATT TGCCCAGTGA TGAAGATGAA GGAGAAGATG AAAAATTGAA CATCCTGCCC 
AGCAAAAGGG ACTTGGCGGC CGAGCCTGGG AACATGTGGA TGCGATTGCC CTCAGACTCA 
GCAGGCATCC CCCAGGCTGG CGGAGAGGCA GAGCCACACG CCACAGCAGC TGGAAAAACA 
GTAGCCAGCC CCTGCAGCTC AACAGAGTCT TTGTCCCAGA GGTCTGTCAC CTCCGTGAGG 
GATTCGGCAG ATGTTGACTG TGTGCTGGAC CTGTCTGTCA AGTCCAGCCT TTCAGGAGTT 
GAAAATCTGA ACAGCTCTTA TTTCTCTTCA CAGGACGTGC TGAGAAGCAA CCTGGTGCAG 
GTGAAGGTGG AGAAAGAGGC TTCCTGTGAT GAGAGTGATG TTGGCACTAA TGACTATGAC 
ATGGAACATA GCACTGTGAA AGAAAGTGTG AGCACTAATA ACAGGGTACA GTATGAGCCG 
GCCCATCTGG CTCCCCTGAG GGAGGACTCG GTCTTGAGGG AGCTGGACCG GGAGGACAAA 
GCCAGTGATG ATGAGATGAT GACCCCAGAG AGCGAGCGTG TCCAGGTGGA GGGAGGCATG 
GAGAGCAGTC TGCTCCCCTA CGTCTCCAAC ATCCTGAGCC CCGCGGGCCA GATCTTCATG 
TGCCCCCTGT GCAACAAGGT CTTCCCCAGC CCCCACATCC TGCAGATCCA CCTGAGCACG 
CACTTCCGCG AGCAGGACGG CATCCGCAGC AAGCCCGCCG CCGATGTCAA CGTGCCCACG 
TGCTCGCTGT GTGGGAAGAC TTTCTCTTGC ATGTACACCC TCAAGCGCCA CGAGAGGACT 
CACTCGGGGG AGAAGCCCTA CACATGCACC CAGTGCGGCA AGAGCTTCCA GTACTCGCAC 
AACCTGAGCC GCCATGCCGT GGTGCACACC CGCGAGAAGC CGCACGCCTG CAAGTGGTGC 
GAGCGCAGGT TCACGCAGTC CGGGGACCTG TACAGACACA TTCGCAAGTT CCACTGTGAG 
TTGGTGAACT CCTTGTCGGT CAAAAGCGAA GCACTGAGCT TGCCTACTGT CAGAGACTGG 
ACCTTAGAAG ATAGCTCTCA AGAACTTTGG AAATAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_991331.1
CDS	174..1769
Translation	MCPKGYEDSMEFPDHSRHLLQCLSEQRHQGFLCDCTVLVGDAQFRAHRAVLASCSMYFHLFYKDQLDKRDIVHLNSDIVTAPAFALLLEFMYEGKLQFKDLPIEDVLAAASYLHMYDIVKVCKKKLKEKATTEADSTKKEEDASSCSDKVESLSDGSSHIAGDLPSDEDEGEDEKLNILPSKRDLAAEPGNMWMRLPSDSAGIPQAGGEAEPHATAAGKTVASPCSSTESLSQRSVTSVRDSADVDCVLDLSVKSSLSGVENLNSSYFSSQDVLRSNLVQVKVEKEASCDESDVGTNDYDMEHSTVKESVSTNNRVQYEPAHLAPLREDSVLRELDREDKASDDEMMTPESERVQVEGGMESSLLPYVSNILSPAGQIFMCPLCNKVFPSPHILQIHLSTHFREQDGIRSKPAADVNVPTCSLCGKTFSCMYTLKRHERTHSGEKPYTCTQCGKSFQYSHNLSRHAVVHTREKPHACKWCERRFTQSGDLYRHIRKFHCELVNSLSVKSEALSLPTVRDWTLEDSSQELWK

Target ORF information:

RefSeq Version	NM_205768.2
Organism	Homo sapiens(human)
Definition	Homo sapiens zinc finger and BTB domain containing 18 (ZBTB18), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_205768.2

ORF Insert Sequence:

ATGTGTCCTA AAGGTTATGA AGACAGTATG GAGTTTCCAG ACCATAGTAG ACATTTGCTA 
CAGTGTCTGA GCGAGCAGAG ACACCAGGGT TTTCTTTGTG ACTGCACTGT TCTGGTGGGA 
GATGCCCAGT TCCGAGCGCA CCGAGCTGTA CTGGCTTCAT GCAGCATGTA TTTCCACCTC 
TTTTACAAGG ACCAGCTGGA CAAAAGAGAC ATTGTTCATC TGAACAGCGA CATTGTTACA 
GCCCCCGCTT TCGCTCTCCT GCTTGAATTC ATGTATGAAG GGAAACTCCA GTTCAAAGAC 
TTGCCCATTG AAGACGTGCT AGCAGCTGCC AGTTATCTCC ACATGTATGA CATTGTCAAA 
GTCTGCAAAA AGAAGCTGAA AGAGAAAGCC ACCACGGAGG CAGACAGCAC CAAAAAGGAA 
GAAGATGCTT CAAGTTGTTC GGACAAAGTC GAGAGTCTCT CCGATGGCAG CAGCCACATA 
GCAGGCGATT TGCCCAGTGA TGAAGATGAA GGAGAAGATG AAAAATTGAA CATCCTGCCC 
AGCAAAAGGG ACTTGGCGGC CGAGCCTGGG AACATGTGGA TGCGATTGCC CTCAGACTCA 
GCAGGCATCC CCCAGGCTGG CGGAGAGGCA GAGCCACACG CCACAGCAGC TGGAAAAACA 
GTAGCCAGCC CCTGCAGCTC AACAGAGTCT TTGTCCCAGA GGTCTGTCAC CTCCGTGAGG 
GATTCGGCAG ATGTTGACTG TGTGCTGGAC CTGTCTGTCA AGTCCAGCCT TTCAGGAGTT 
GAAAATCTGA ACAGCTCTTA TTTCTCTTCA CAGGACGTGC TGAGAAGCAA CCTGGTGCAG 
GTGAAGGTGG AGAAAGAGGC TTCCTGTGAT GAGAGTGATG TTGGCACTAA TGACTATGAC 
ATGGAACATA GCACTGTGAA AGAAAGTGTG AGCACTAATA ACAGGGTACA GTATGAGCCG 
GCCCATCTGG CTCCCCTGAG GGAGGACTCG GTCTTGAGGG AGCTGGACCG GGAGGACAAA 
GCCAGTGATG ATGAGATGAT GACCCCAGAG AGCGAGCGTG TCCAGGTGGA GGGAGGCATG 
GAGAGCAGTC TGCTCCCCTA CGTCTCCAAC ATCCTGAGCC CCGCGGGCCA GATCTTCATG 
TGCCCCCTGT GCAACAAGGT CTTCCCCAGC CCCCACATCC TGCAGATCCA CCTGAGCACG 
CACTTCCGCG AGCAGGACGG CATCCGCAGC AAGCCCGCCG CCGATGTCAA CGTGCCCACG 
TGCTCGCTGT GTGGGAAGAC TTTCTCTTGC ATGTACACCC TCAAGCGCCA CGAGAGGACT 
CACTCGGGGG AGAAGCCCTA CACATGCACC CAGTGCGGCA AGAGCTTCCA GTACTCGCAC 
AACCTGAGCC GCCATGCCGT GGTGCACACC CGCGAGAAGC CGCACGCCTG CAAGTGGTGC 
GAGCGCAGGT TCACGCAGTC CGGGGACCTG TACAGACACA TTCGCAAGTT CCACTGTGAG 
TTGGTGAACT CCTTGTCGGT CAAAAGCGAA GCACTGAGCT TGCCTACTGT CAGAGACTGG 
ACCTTAGAAG ATAGCTCTCA AGAACTTTGG AAATAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

ZBTB18 ( XM_017000060.1 ) cDNA ORF clone, Homo sapiens(human) -> XP_016855549.1 Homo sapiens zinc finger and BTB domain containing 18 (ZBTB18), transcript variant X1, mRNA.

Price & Availability↑

CloneID	OHu00433
Clone ID Related Accession (Same CDS sequence)	NM_006352.4 , NM_001278196.1 , XM_017000060.1 , XM_005273006.2
Accession Version	XM_017000060.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1569bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-05
Organism	Homo sapiens(human)
Product	zinc finger and BTB domain-containing protein 18 isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000001.11) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Updated annotation Annotation Name :: Homo sapiens Updated Annotation Release 109.20191205 Annotation Version :: 109.20191205 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.3 Annotation Method :: Best-placed RefSeq; propagated RefSeq model Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGGAGTTTC CAGACCATAG TAGACATTTG CTACAGTGTC TGAGCGAGCA GAGACACCAG 
GGTTTTCTTT GTGACTGCAC TGTTCTGGTG GGAGATGCCC AGTTCCGAGC GCACCGAGCT 
GTACTGGCTT CATGCAGCAT GTATTTCCAC CTCTTTTACA AGGACCAGCT GGACAAAAGA 
GACATTGTTC ATCTGAACAG CGACATTGTT ACAGCCCCCG CTTTCGCTCT CCTGCTTGAA 
TTCATGTATG AAGGGAAACT CCAGTTCAAA GACTTGCCCA TTGAAGACGT GCTAGCAGCT 
GCCAGTTATC TCCACATGTA TGACATTGTC AAAGTCTGCA AAAAGAAGCT GAAAGAGAAA 
GCCACCACGG AGGCAGACAG CACCAAAAAG GAAGAAGATG CTTCAAGTTG TTCGGACAAA 
GTCGAGAGTC TCTCCGATGG CAGCAGCCAC ATAGCAGGCG ATTTGCCCAG TGATGAAGAT 
GAAGGAGAAG ATGAAAAATT GAACATCCTG CCCAGCAAAA GGGACTTGGC GGCCGAGCCT 
GGGAACATGT GGATGCGATT GCCCTCAGAC TCAGCAGGCA TCCCCCAGGC TGGCGGAGAG 
GCAGAGCCAC ACGCCACAGC AGCTGGAAAA ACAGTAGCCA GCCCCTGCAG CTCAACAGAG 
TCTTTGTCCC AGAGGTCTGT CACCTCCGTG AGGGATTCGG CAGATGTTGA CTGTGTGCTG 
GACCTGTCTG TCAAGTCCAG CCTTTCAGGA GTTGAAAATC TGAACAGCTC TTATTTCTCT 
TCACAGGACG TGCTGAGAAG CAACCTGGTG CAGGTGAAGG TGGAGAAAGA GGCTTCCTGT 
GATGAGAGTG ATGTTGGCAC TAATGACTAT GACATGGAAC ATAGCACTGT GAAAGAAAGT 
GTGAGCACTA ATAACAGGGT ACAGTATGAG CCGGCCCATC TGGCTCCCCT GAGGGAGGAC 
TCGGTCTTGA GGGAGCTGGA CCGGGAGGAC AAAGCCAGTG ATGATGAGAT GATGACCCCA 
GAGAGCGAGC GTGTCCAGGT GGAGGGAGGC ATGGAGAGCA GTCTGCTCCC CTACGTCTCC 
AACATCCTGA GCCCCGCGGG CCAGATCTTC ATGTGCCCCC TGTGCAACAA GGTCTTCCCC 
AGCCCCCACA TCCTGCAGAT CCACCTGAGC ACGCACTTCC GCGAGCAGGA CGGCATCCGC 
AGCAAGCCCG CCGCCGATGT CAACGTGCCC ACGTGCTCGC TGTGTGGGAA GACTTTCTCT 
TGCATGTACA CCCTCAAGCG CCACGAGAGG ACTCACTCGG GGGAGAAGCC CTACACATGC 
ACCCAGTGCG GCAAGAGCTT CCAGTACTCG CACAACCTGA GCCGCCATGC CGTGGTGCAC 
ACCCGCGAGA AGCCGCACGC CTGCAAGTGG TGCGAGCGCA GGTTCACGCA GTCCGGGGAC 
CTGTACAGAC ACATTCGCAA GTTCCACTGT GAGTTGGTGA ACTCCTTGTC GGTCAAAAGC 
GAAGCACTGA GCTTGCCTAC TGTCAGAGAC TGGACCTTAG AAGATAGCTC TCAAGAACTT 
TGGAAATAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_016855549.1
CDS	2231..3799
Translation	MEFPDHSRHLLQCLSEQRHQGFLCDCTVLVGDAQFRAHRAVLASCSMYFHLFYKDQLDKRDIVHLNSDIVTAPAFALLLEFMYEGKLQFKDLPIEDVLAAASYLHMYDIVKVCKKKLKEKATTEADSTKKEEDASSCSDKVESLSDGSSHIAGDLPSDEDEGEDEKLNILPSKRDLAAEPGNMWMRLPSDSAGIPQAGGEAEPHATAAGKTVASPCSSTESLSQRSVTSVRDSADVDCVLDLSVKSSLSGVENLNSSYFSSQDVLRSNLVQVKVEKEASCDESDVGTNDYDMEHSTVKESVSTNNRVQYEPAHLAPLREDSVLRELDREDKASDDEMMTPESERVQVEGGMESSLLPYVSNILSPAGQIFMCPLCNKVFPSPHILQIHLSTHFREQDGIRSKPAADVNVPTCSLCGKTFSCMYTLKRHERTHSGEKPYTCTQCGKSFQYSHNLSRHAVVHTREKPHACKWCERRFTQSGDLYRHIRKFHCELVNSLSVKSEALSLPTVRDWTLEDSSQELWK

Target ORF information:

RefSeq Version	XM_017000060.1
Organism	Homo sapiens(human)
Definition	Homo sapiens zinc finger and BTB domain containing 18 (ZBTB18), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_017000060.1

ORF Insert Sequence:

ATGGAGTTTC CAGACCATAG TAGACATTTG CTACAGTGTC TGAGCGAGCA GAGACACCAG 
GGTTTTCTTT GTGACTGCAC TGTTCTGGTG GGAGATGCCC AGTTCCGAGC GCACCGAGCT 
GTACTGGCTT CATGCAGCAT GTATTTCCAC CTCTTTTACA AGGACCAGCT GGACAAAAGA 
GACATTGTTC ATCTGAACAG CGACATTGTT ACAGCCCCCG CTTTCGCTCT CCTGCTTGAA 
TTCATGTATG AAGGGAAACT CCAGTTCAAA GACTTGCCCA TTGAAGACGT GCTAGCAGCT 
GCCAGTTATC TCCACATGTA TGACATTGTC AAAGTCTGCA AAAAGAAGCT GAAAGAGAAA 
GCCACCACGG AGGCAGACAG CACCAAAAAG GAAGAAGATG CTTCAAGTTG TTCGGACAAA 
GTCGAGAGTC TCTCCGATGG CAGCAGCCAC ATAGCAGGCG ATTTGCCCAG TGATGAAGAT 
GAAGGAGAAG ATGAAAAATT GAACATCCTG CCCAGCAAAA GGGACTTGGC GGCCGAGCCT 
GGGAACATGT GGATGCGATT GCCCTCAGAC TCAGCAGGCA TCCCCCAGGC TGGCGGAGAG 
GCAGAGCCAC ACGCCACAGC AGCTGGAAAA ACAGTAGCCA GCCCCTGCAG CTCAACAGAG 
TCTTTGTCCC AGAGGTCTGT CACCTCCGTG AGGGATTCGG CAGATGTTGA CTGTGTGCTG 
GACCTGTCTG TCAAGTCCAG CCTTTCAGGA GTTGAAAATC TGAACAGCTC TTATTTCTCT 
TCACAGGACG TGCTGAGAAG CAACCTGGTG CAGGTGAAGG TGGAGAAAGA GGCTTCCTGT 
GATGAGAGTG ATGTTGGCAC TAATGACTAT GACATGGAAC ATAGCACTGT GAAAGAAAGT 
GTGAGCACTA ATAACAGGGT ACAGTATGAG CCGGCCCATC TGGCTCCCCT GAGGGAGGAC 
TCGGTCTTGA GGGAGCTGGA CCGGGAGGAC AAAGCCAGTG ATGATGAGAT GATGACCCCA 
GAGAGCGAGC GTGTCCAGGT GGAGGGAGGC ATGGAGAGCA GTCTGCTCCC CTACGTCTCC 
AACATCCTGA GCCCCGCGGG CCAGATCTTC ATGTGCCCCC TGTGCAACAA GGTCTTCCCC 
AGCCCCCACA TCCTGCAGAT CCACCTGAGC ACGCACTTCC GCGAGCAGGA CGGCATCCGC 
AGCAAGCCCG CCGCCGATGT CAACGTGCCC ACGTGCTCGC TGTGTGGGAA GACTTTCTCT 
TGCATGTACA CCCTCAAGCG CCACGAGAGG ACTCACTCGG GGGAGAAGCC CTACACATGC 
ACCCAGTGCG GCAAGAGCTT CCAGTACTCG CACAACCTGA GCCGCCATGC CGTGGTGCAC 
ACCCGCGAGA AGCCGCACGC CTGCAAGTGG TGCGAGCGCA GGTTCACGCA GTCCGGGGAC 
CTGTACAGAC ACATTCGCAA GTTCCACTGT GAGTTGGTGA ACTCCTTGTC GGTCAAAAGC 
GAAGCACTGA GCTTGCCTAC TGTCAGAGAC TGGACCTTAG AAGATAGCTC TCAAGAACTT 
TGGAAATAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

ZBTB18 ( XM_005273006.2 ) cDNA ORF clone, Homo sapiens(human) -> XP_005273063.1 Homo sapiens zinc finger and BTB domain containing 18 (ZBTB18), transcript variant X2, mRNA.

Price & Availability↑

CloneID	OHu00433
Clone ID Related Accession (Same CDS sequence)	NM_006352.4 , NM_001278196.1 , XM_017000060.1 , XM_005273006.2
Accession Version	XM_005273006.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1569bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-05
Organism	Homo sapiens(human)
Product	zinc finger and BTB domain-containing protein 18 isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000001.11) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Mar 12, 2015 this sequence version replaced XM_005273006.1. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Updated annotation Annotation Name :: Homo sapiens Updated Annotation Release 109.20191205 Annotation Version :: 109.20191205 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.3 Annotation Method :: Best-placed RefSeq; propagated RefSeq model Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGGAGTTTC CAGACCATAG TAGACATTTG CTACAGTGTC TGAGCGAGCA GAGACACCAG 
GGTTTTCTTT GTGACTGCAC TGTTCTGGTG GGAGATGCCC AGTTCCGAGC GCACCGAGCT 
GTACTGGCTT CATGCAGCAT GTATTTCCAC CTCTTTTACA AGGACCAGCT GGACAAAAGA 
GACATTGTTC ATCTGAACAG CGACATTGTT ACAGCCCCCG CTTTCGCTCT CCTGCTTGAA 
TTCATGTATG AAGGGAAACT CCAGTTCAAA GACTTGCCCA TTGAAGACGT GCTAGCAGCT 
GCCAGTTATC TCCACATGTA TGACATTGTC AAAGTCTGCA AAAAGAAGCT GAAAGAGAAA 
GCCACCACGG AGGCAGACAG CACCAAAAAG GAAGAAGATG CTTCAAGTTG TTCGGACAAA 
GTCGAGAGTC TCTCCGATGG CAGCAGCCAC ATAGCAGGCG ATTTGCCCAG TGATGAAGAT 
GAAGGAGAAG ATGAAAAATT GAACATCCTG CCCAGCAAAA GGGACTTGGC GGCCGAGCCT 
GGGAACATGT GGATGCGATT GCCCTCAGAC TCAGCAGGCA TCCCCCAGGC TGGCGGAGAG 
GCAGAGCCAC ACGCCACAGC AGCTGGAAAA ACAGTAGCCA GCCCCTGCAG CTCAACAGAG 
TCTTTGTCCC AGAGGTCTGT CACCTCCGTG AGGGATTCGG CAGATGTTGA CTGTGTGCTG 
GACCTGTCTG TCAAGTCCAG CCTTTCAGGA GTTGAAAATC TGAACAGCTC TTATTTCTCT 
TCACAGGACG TGCTGAGAAG CAACCTGGTG CAGGTGAAGG TGGAGAAAGA GGCTTCCTGT 
GATGAGAGTG ATGTTGGCAC TAATGACTAT GACATGGAAC ATAGCACTGT GAAAGAAAGT 
GTGAGCACTA ATAACAGGGT ACAGTATGAG CCGGCCCATC TGGCTCCCCT GAGGGAGGAC 
TCGGTCTTGA GGGAGCTGGA CCGGGAGGAC AAAGCCAGTG ATGATGAGAT GATGACCCCA 
GAGAGCGAGC GTGTCCAGGT GGAGGGAGGC ATGGAGAGCA GTCTGCTCCC CTACGTCTCC 
AACATCCTGA GCCCCGCGGG CCAGATCTTC ATGTGCCCCC TGTGCAACAA GGTCTTCCCC 
AGCCCCCACA TCCTGCAGAT CCACCTGAGC ACGCACTTCC GCGAGCAGGA CGGCATCCGC 
AGCAAGCCCG CCGCCGATGT CAACGTGCCC ACGTGCTCGC TGTGTGGGAA GACTTTCTCT 
TGCATGTACA CCCTCAAGCG CCACGAGAGG ACTCACTCGG GGGAGAAGCC CTACACATGC 
ACCCAGTGCG GCAAGAGCTT CCAGTACTCG CACAACCTGA GCCGCCATGC CGTGGTGCAC 
ACCCGCGAGA AGCCGCACGC CTGCAAGTGG TGCGAGCGCA GGTTCACGCA GTCCGGGGAC 
CTGTACAGAC ACATTCGCAA GTTCCACTGT GAGTTGGTGA ACTCCTTGTC GGTCAAAAGC 
GAAGCACTGA GCTTGCCTAC TGTCAGAGAC TGGACCTTAG AAGATAGCTC TCAAGAACTT 
TGGAAATAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_005273063.1
CDS	131..1699
Translation	MEFPDHSRHLLQCLSEQRHQGFLCDCTVLVGDAQFRAHRAVLASCSMYFHLFYKDQLDKRDIVHLNSDIVTAPAFALLLEFMYEGKLQFKDLPIEDVLAAASYLHMYDIVKVCKKKLKEKATTEADSTKKEEDASSCSDKVESLSDGSSHIAGDLPSDEDEGEDEKLNILPSKRDLAAEPGNMWMRLPSDSAGIPQAGGEAEPHATAAGKTVASPCSSTESLSQRSVTSVRDSADVDCVLDLSVKSSLSGVENLNSSYFSSQDVLRSNLVQVKVEKEASCDESDVGTNDYDMEHSTVKESVSTNNRVQYEPAHLAPLREDSVLRELDREDKASDDEMMTPESERVQVEGGMESSLLPYVSNILSPAGQIFMCPLCNKVFPSPHILQIHLSTHFREQDGIRSKPAADVNVPTCSLCGKTFSCMYTLKRHERTHSGEKPYTCTQCGKSFQYSHNLSRHAVVHTREKPHACKWCERRFTQSGDLYRHIRKFHCELVNSLSVKSEALSLPTVRDWTLEDSSQELWK

Target ORF information:

RefSeq Version	XM_005273006.2
Organism	Homo sapiens(human)
Definition	Homo sapiens zinc finger and BTB domain containing 18 (ZBTB18), transcript variant X2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_005273006.2

ORF Insert Sequence:

ATGGAGTTTC CAGACCATAG TAGACATTTG CTACAGTGTC TGAGCGAGCA GAGACACCAG 
GGTTTTCTTT GTGACTGCAC TGTTCTGGTG GGAGATGCCC AGTTCCGAGC GCACCGAGCT 
GTACTGGCTT CATGCAGCAT GTATTTCCAC CTCTTTTACA AGGACCAGCT GGACAAAAGA 
GACATTGTTC ATCTGAACAG CGACATTGTT ACAGCCCCCG CTTTCGCTCT CCTGCTTGAA 
TTCATGTATG AAGGGAAACT CCAGTTCAAA GACTTGCCCA TTGAAGACGT GCTAGCAGCT 
GCCAGTTATC TCCACATGTA TGACATTGTC AAAGTCTGCA AAAAGAAGCT GAAAGAGAAA 
GCCACCACGG AGGCAGACAG CACCAAAAAG GAAGAAGATG CTTCAAGTTG TTCGGACAAA 
GTCGAGAGTC TCTCCGATGG CAGCAGCCAC ATAGCAGGCG ATTTGCCCAG TGATGAAGAT 
GAAGGAGAAG ATGAAAAATT GAACATCCTG CCCAGCAAAA GGGACTTGGC GGCCGAGCCT 
GGGAACATGT GGATGCGATT GCCCTCAGAC TCAGCAGGCA TCCCCCAGGC TGGCGGAGAG 
GCAGAGCCAC ACGCCACAGC AGCTGGAAAA ACAGTAGCCA GCCCCTGCAG CTCAACAGAG 
TCTTTGTCCC AGAGGTCTGT CACCTCCGTG AGGGATTCGG CAGATGTTGA CTGTGTGCTG 
GACCTGTCTG TCAAGTCCAG CCTTTCAGGA GTTGAAAATC TGAACAGCTC TTATTTCTCT 
TCACAGGACG TGCTGAGAAG CAACCTGGTG CAGGTGAAGG TGGAGAAAGA GGCTTCCTGT 
GATGAGAGTG ATGTTGGCAC TAATGACTAT GACATGGAAC ATAGCACTGT GAAAGAAAGT 
GTGAGCACTA ATAACAGGGT ACAGTATGAG CCGGCCCATC TGGCTCCCCT GAGGGAGGAC 
TCGGTCTTGA GGGAGCTGGA CCGGGAGGAC AAAGCCAGTG ATGATGAGAT GATGACCCCA 
GAGAGCGAGC GTGTCCAGGT GGAGGGAGGC ATGGAGAGCA GTCTGCTCCC CTACGTCTCC 
AACATCCTGA GCCCCGCGGG CCAGATCTTC ATGTGCCCCC TGTGCAACAA GGTCTTCCCC 
AGCCCCCACA TCCTGCAGAT CCACCTGAGC ACGCACTTCC GCGAGCAGGA CGGCATCCGC 
AGCAAGCCCG CCGCCGATGT CAACGTGCCC ACGTGCTCGC TGTGTGGGAA GACTTTCTCT 
TGCATGTACA CCCTCAAGCG CCACGAGAGG ACTCACTCGG GGGAGAAGCC CTACACATGC 
ACCCAGTGCG GCAAGAGCTT CCAGTACTCG CACAACCTGA GCCGCCATGC CGTGGTGCAC 
ACCCGCGAGA AGCCGCACGC CTGCAAGTGG TGCGAGCGCA GGTTCACGCA GTCCGGGGAC 
CTGTACAGAC ACATTCGCAA GTTCCACTGT GAGTTGGTGA ACTCCTTGTC GGTCAAAAGC 
GAAGCACTGA GCTTGCCTAC TGTCAGAGAC TGGACCTTAG AAGATAGCTC TCAAGAACTT 
TGGAAATAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Epigenetic Regulation of ZBTB18 Promotes Glioblastoma Progression.
Molecular cancer research : MCR15(8)998-1011(2017 Aug)
Fedele V,Dai F,Masilamani AP,Heiland DH,Kling E,G?tjens-Sanchez AM,Ferrarese R,Platania L,Soroush D,Kim H,Nelander S,Weyerbrock A,Prinz M,Califano A,Iavarone A,Bredel M,Carro MS

A de novo nonsense mutation in ZBTB18 plus a de novo 15q13.3 microdeletion in a 6-year-old female.
American journal of medical genetics. Part A173(5)1251-1256(2017 May)
Ehmke N,Karge S,Buchmann J,Korinth D,Horn D,Reis O,H??ler F

Further evidence that de novo missense and truncating variants in ZBTB18 cause intellectual disability with variable features.
Clinical genetics91(5)697-707(2017 May)
Cohen JS,Srivastava S,Farwell Hagman KD,Shinde DN,Huether R,Darcy D,Wallerstein R,Houge G,Berland S,Monaghan KG,Poretti A,Wilson AL,Chung WK,Fatemi A

Genetic and phenotypic dissection of 1q43q44 microdeletion syndrome and neurodevelopmental phenotypes associated with mutations in ZBTB18 and HNRNPU.
Human genetics136(4)463-479(2017 Apr)
Depienne C,Nava C,Keren B,Heide S,Rastetter A,Passemard S,Chantot-Bastaraud S,Moutard ML,Agrawal PB,VanNoy G,Stoler JM,Amor DJ,Billette de Villemeur T,Doummar D,Alby C,Cormier-Daire V,Garel C,Marzin P,Scheidecker S,de Saint-Martin A,Hirsch E,Korff C,Bottani A,Faivre L,Verloes A,Orzechowski C,Burglen L,Leheup B,Roume J,Andrieux J,Sheth F,Datar C,Parker MJ,Pasquier L,Odent S,Naudion S,Delrue MA,Le Caignec C,Vincent M,Isidor B,Renaldo F,Stewart F,Toutain A,Koehler U,H?ckl B,von St?lpnagel C,Kluger G,M?ller RS,Pal D,Jonson T,Soller M,Verbeek NE,van Haelst MM,de Kovel C,Koeleman B,Monroe G,van Haaften G,,Atti?-Bitach T,Boutaud L,H?ron D,Mignot C

A systems approach reveals that the myogenesis genome network is regulated by the transcriptional repressor RP58.
Developmental cell17(6)836-48(2009 Dec)
Yokoyama S,Ito Y,Ueno-Kudoh H,Shimizu H,Uchibe K,Albini S,Mitsuoka K,Miyaki S,Kiso M,Nagai A,Hikata T,Osada T,Fukuda N,Yamashita S,Harada D,Mezzano V,Kasai M,Puri PL,Hayashizaki Y,Okado H,Hashimoto M,Asahara H

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ZBTB18 cDNA ORF clone, Homo sapiens(human)

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Target ORF information:

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ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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