| Gene Symbol | Hand |
| Entrez Gene ID | 34379 |
| Full Name | CG18144 gene product from transcript CG18144-RA |
| Synonyms | CG18144,Dhand,Dmel\CG18144,HAND,bHLHa28,dHAND,dHand,hand,hand-C |
| Gene Type | protein-coding |
| Organism | Drosophila melanogaster(fruit fly) |
| Genome |
ORF » Species Summary » Drosophila melanogaster » Hand cDNA ORF clone
| Gene Symbol | Hand |
| Entrez Gene ID | 34379 |
| Full Name | CG18144 gene product from transcript CG18144-RA |
| Synonyms | CG18144,Dhand,Dmel\CG18144,HAND,bHLHa28,dHAND,dHand,hand,hand-C |
| Gene Type | protein-coding |
| Organism | Drosophila melanogaster(fruit fly) |
| Genome |
| mRNA | Protein | Name |
|---|---|---|
| NM_135526.3 | NP_609370.2 | hand |
| Homo sapiens (human) | HAND1 | NP_004812.1 |
| Bos taurus (cattle) | HAND1 | NP_001069229.1 |
| Mus musculus (house mouse) | Hand1 | NP_032239.1 |
| Gallus gallus (chicken) | HAND1 | NP_990296.1 |
| HAND1 | XP_001111722.1 | |
| Xenopus tropicalis (tropical clawed frog) | hand1 | NP_001016743.1 |
| Pan troglodytes (chimpanzee) | HAND1 | XP_518050.2 |
| Rattus norvegicus (Norway rat) | Hand1 | NP_067603.1 |
| Drosophila melanogaster (fruit fly) | Hand | NP_609370.2 |
Gene Model Annotations for Drosophila melanogaster: Impact of High-Throughput Data.
Matthews BB, Dos Santos G, Crosby MA, Emmert DB, St Pierre SE, Gramates LS, Zhou P, Schroeder AJ, Falls K, Strelets V, Russo SM, Gelbart WM,
G3 (Bethesda, Md.)5(8)1721-36(2015 Jun)
Gene Model Annotations for Drosophila melanogaster: The Rule-Benders.
Crosby MA, Gramates LS, Dos Santos G, Matthews BB, St Pierre SE, Zhou P, Schroeder AJ, Falls K, Emmert DB, Russo SM, Gelbart WM,
G3 (Bethesda, Md.)5(8)1737-49(2015 Jun)
Sequence finishing and mapping of Drosophila melanogaster heterochromatin.
Hoskins RA, Carlson JW, Kennedy C, Acevedo D, Evans-Holm M, Frise E, Wan KH, Park S, Mendez-Lago M, Rossi F, Villasante A, Dimitri P, Karpen GH, Celniker SE
Science (New York, N.Y.)316(5831)1625-8(2007 Jun)
The Release 5.1 annotation of Drosophila melanogaster heterochromatin.
Smith CD, Shu S, Mungall CJ, Karpen GH
Science (New York, N.Y.)316(5831)1586-91(2007 Jun)
Combined evidence annotation of transposable elements in genome sequences.
Quesneville H, Bergman CM, Andrieu O, Autard D, Nouaud D, Ashburner M, Anxolabehere D
PLoS computational biology1(2)166-75(2005 Jul)
GeneRIFs: Gene References Into Functions What's a GeneRIF?
Drosophila Hand regulates the expression of numerous genes of diverse physiological relevancy, including distinct factors required for proper muscle development and function.
Title: The bHLH Transcription Factor Hand Regulates the Expression of Genes Critical to Heart and Muscle Function in Drosophila melanogaster.
Hand is essential for the internal organization, alignment, and positioning of wing heart muscle cells.
Title: The bHLH transcription factor hand is required for proper wing heart formation in Drosophila.
Data demonstrate that the absence of Hand activity causes semilethality during the early larval instars.
Title: The Drosophila Hand gene is required for remodeling of the developing adult heart and midgut during metamorphosis.
Hand is dispensable for the initial differentiation of the embryonic visceral mesoderm
Title: Hand is a direct target of the forkhead transcription factor Biniou during Drosophila visceral mesoderm differentiation.
Alk-mediated signal transduction drives the expression of the bHLH transcription factor Hand in vivo.
Title: The bHLH transcription factor Hand is regulated by Alk in the Drosophila embryonic gut.
The following Hand gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Hand cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.
| CloneID | OFa14307 | |
| Clone ID Related Accession (Same CDS sequence) | NM_135526.3 | |
| Accession Version | NM_135526.3 Latest version! | Documents for ORF clone product in default vector |
| Sequence Information | ORF Nucleotide Sequence (Length: 525bp) Protein sequence SNP |
|
| Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
| Clone information | Clone Map | MSDS |
| Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
| ORF Insert Method | CloneEZ™ Seamless cloning technology | |
| Insert Structure | linear | |
| Update Date | 2019-04-24 | |
| Organism | Drosophila melanogaster(fruit fly) | |
| Product | hand | |
| Comment | Comment: REVIEWED REFSEQ: This record has been curated by FlyBase. This record is derived from an annotated genomic sequence (NT_033779). On Jul 15, 2014 this sequence version replaced NM_135526.2. ##Genome-Annotation-Data-START## Annotation Provider :: FlyBase Annotation Status :: Full annotation Annotation Version :: Release 6.26 URL :: http://flybase.org ##Genome-Annotation-Data-END## | |
1 | ATGTTTAAGA ATTCCGTTGC CTTGACGTGC GAATACTCAA CCATGTATTA TAACTCAATT |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
| RefSeq | NP_609370.2 |
| CDS | 87..611 |
| Translation |
Target ORF information:
Target ORF information:
|
NM_135526.3 |
1 | ATGTTTAAGA ATTCCGTTGC CTTGACGTGC GAATACTCAA CCATGTATTA TAACTCAATT |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
Gene Model Annotations for Drosophila melanogaster: Impact of High-Throughput Data. |
Gene Model Annotations for Drosophila melanogaster: The Rule-Benders. |
Sequence finishing and mapping of Drosophila melanogaster heterochromatin. |
The Release 5.1 annotation of Drosophila melanogaster heterochromatin. |
Combined evidence annotation of transposable elements in genome sequences. |