CDK5 cDNA ORF clone, Bos taurus(cattle)

Gene
Clones
gRNAs

Summary

Gene Symbol	CDK5
Entrez Gene ID	281066
Full Name	cyclin dependent kinase 5
General protein information	Preferred Names cyclin dependent kinase 5 Names cyclin-dependent-like kinase 5 PDPK TPKII catalytic subunit cell division protein kinase 5 proline-directed protein kinase 33 kDa subunit serine/threonine-protein kinase PSSALRE tau protein kinase II catalytic subunit
Gene Type	protein-coding
Organism	Bos taurus(cattle)

mRNA and Protein(s)

mRNA	Protein	Name
NM_174017.2	NP_776442.1	cyclin-dependent-like kinase 5

Pathways from BioSystems

Homologies

Rattus norvegicus (Norway rat)	Cdk5	NP_543161.1
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP005772	XP_315787.4
Saccharomyces cerevisiae (baker's yeast)	PHO85	NP_015294.1
Neurospora crassa	NCU07580	XP_958274.1
Xenopus tropicalis (tropical clawed frog)	cdk5	NP_001072776.1
Homo sapiens (human)	CDK5	NP_004926.1
	CDK5	XP_001102523.1
Canis lupus familiaris (dog)	CDK5	XP_005629809.1
Bos taurus (cattle)	CDK5	NP_776442.1
Gallus gallus (chicken)	CDK5	NP_001129258.1
Eremothecium gossypii	AGOS_AGL242C	NP_986425.2
Pan troglodytes (chimpanzee)	CDK5	XP_519523.2
Mus musculus (house mouse)	Cdk5	NP_031694.1
Danio rerio (zebrafish)	cdk5	NP_571794.1
Drosophila melanogaster (fruit fly)	Cdk5	NP_477080.1
Caenorhabditis elegans (roundworm)	cdk-5	NP_499783.1
Kluyveromyces lactis	KLLA0D11990g	XP_453596.1
Schizosaccharomyces pombe (fission yeast)	pef1	NP_587921.1
Magnaporthe oryzae (rice blast fungus)	MGG_04660	XP_003713655.1

Gene Ontology
Bibliography

Related articles in PubMed

A whole-genome assembly of the domestic cow, Bos taurus.
Zimin AV, Delcher AL, Florea L, Kelley DR, Schatz MC, Puiu D, Hanrahan F, Pertea G, Van Tassell CP, Sonstegard TS, Mar?ais G, Roberts M, Subramanian P, Yorke JA, Salzberg SL
Genome biology10(4)R42(2009)

Phosphorylation of protein phosphatase 1 by cyclin-dependent protein kinase 5 during nerve growth factor-induced PC12 cell differentiation.
Li T, Chalifour LE, Paudel HK
The Journal of biological chemistry282(9)6619-28(2007 Mar)

The cdk5/p35 kinase is essential for neurite outgrowth during neuronal differentiation.
Nikolic M, Dudek H, Kwon YT, Ramos YF, Tsai LH
Genes & development10(7)816-25(1996 Apr)

A cdc2-related kinase PSSALRE/cdk5 is homologous with the 30 kDa subunit of tau protein kinase II, a proline-directed protein kinase associated with microtubule.
Kobayashi S, Ishiguro K, Omori A, Takamatsu M, Arioka M, Imahori K, Uchida T
FEBS letters335(2)171-5(1993 Dec)

Brain proline-directed protein kinase is a neurofilament kinase which displays high sequence homology to p34cdc2.
Lew J, Winkfein RJ, Paudel HK, Wang JH
The Journal of biological chemistry267(36)25922-6(1992 Dec)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

data indicate that PP1alpha is a downstream target of the NGF/Egr-1/Cdk5 pathway during NGF-induced differentiation of PC12 cells and suggest that PP1 phosphorylation promotes neuronal differentiation
Title: Phosphorylation of protein phosphatase 1 by cyclin-dependent protein kinase 5 during nerve growth factor-induced PC12 cell differentiation.

The following CDK5 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the CDK5 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OBa42306	NM_174017.2 Latest version!	Bos taurus cyclin dependent kinase 5 (CDK5), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$174.30 $249.00

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

CDK5 ( NM_174017.2 ) cDNA ORF clone, Bos taurus(cattle) -> NP_776442.1 Bos taurus cyclin dependent kinase 5 (CDK5), mRNA.

Price & Availability↑

CloneID	OBa42306
Clone ID Related Accession (Same CDS sequence)	NM_174017.2
Accession Version	NM_174017.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 879bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-10-18
Organism	Bos taurus(cattle)
Product	cyclin-dependent-like kinase 5
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from X82440.1. On Jun 3, 2003 this sequence version replaced NM_174017.1. ##Evidence-Data-START## Transcript exon combination :: X82440.1, BC120083.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMN03145412, SAMN03145413 [ECO:0000350] ##Evidence-Data-END##

ATGCAGAAAT ACGAGAAACT GGAGAAGATT GGGGAAGGCA CCTACGGAAC AGTGTTCAAG 
GCCAAAAACC GGGAGACTCA TGAGATTGTG GCTCTGAAAC GGGTGAGGCT GGATGACGAT 
GACGAGGGTG TGCCGAGTTC TGCCCTTCGG GAGATCTGCC TACTCAAGGA GCTGAAGCAC 
AAGAACATCG TCAGGCTCCA TGACGTCCTG CACAGCGACA AGAAGCTGAC GTTGGTTTTT 
GAGTTCTGCG ACCAGGACCT TAAGAAGTAT TTCGACAGCT GCAATGGTGA CCTAGATCCT 
GAAATTGTGA AGTCATTCCT CTTCCAGCTG CTGAAAGGCC TGGGCTTCTG TCACAGCCGA 
AACGTGCTGC ACAGGGACCT GAAGCCTCAG AACCTGCTCA TCAACAGGAA TGGGGAGCTG 
AAACTGGCTG ATTTTGGTTT GGCTCGCGCC TTTGGGATCC CTGTTCGCTG TTACTCAGCT 
GAGGTCGTCA CGCTGTGGTA CCGCCCACCT GATGTCCTCT TTGGGGCCAA GCTGTACTCC 
ACGTCCATCG ACATGTGGTC AGCTGGCTGC ATCTTCGCAG AGCTGGCCAA CGCTGGGCGG 
CCCCTCTTTC CTGGCAATGA TGTAGACGAC CAGCTGAAGA GGATCTTCCG ACTCCTGGGC 
ACGCCAACCG AGGAGCAGTG GCCTGCCATG ACCAAGCTGC CAGACTATAA GCCCTACCCG 
ATGTACCCGG CCACAACGTC CCTGGTGAAC GTCGTGCCCA AGCTCAACGC CACAGGGAGG 
GACCTGCTGC AGAACCTGCT CAAGTGTAAC CCGGTCCAGC GCATCTCGGC GGAGGAGGCC 
CTGCAGCATC CCTACTTCTC CGACTTCTGC CCCCCCTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_776442.1
CDS	47..925
Translation	MQKYEKLEKIGEGTYGTVFKAKNRETHEIVALKRVRLDDDDEGVPSSALREICLLKELKHKNIVRLHDVLHSDKKLTLVFEFCDQDLKKYFDSCNGDLDPEIVKSFLFQLLKGLGFCHSRNVLHRDLKPQNLLINRNGELKLADFGLARAFGIPVRCYSAEVVTLWYRPPDVLFGAKLYSTSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQWPAMTKLPDYKPYPMYPATTSLVNVVPKLNATGRDLLQNLLKCNPVQRISAEEALQHPYFSDFCPP

Target ORF information:

RefSeq Version	NM_174017.2
Organism	Bos taurus(cattle)
Definition	Bos taurus cyclin dependent kinase 5 (CDK5), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_174017.2

ORF Insert Sequence:

ATGCAGAAAT ACGAGAAACT GGAGAAGATT GGGGAAGGCA CCTACGGAAC AGTGTTCAAG 
GCCAAAAACC GGGAGACTCA TGAGATTGTG GCTCTGAAAC GGGTGAGGCT GGATGACGAT 
GACGAGGGTG TGCCGAGTTC TGCCCTTCGG GAGATCTGCC TACTCAAGGA GCTGAAGCAC 
AAGAACATCG TCAGGCTCCA TGACGTCCTG CACAGCGACA AGAAGCTGAC GTTGGTTTTT 
GAGTTCTGCG ACCAGGACCT TAAGAAGTAT TTCGACAGCT GCAATGGTGA CCTAGATCCT 
GAAATTGTGA AGTCATTCCT CTTCCAGCTG CTGAAAGGCC TGGGCTTCTG TCACAGCCGA 
AACGTGCTGC ACAGGGACCT GAAGCCTCAG AACCTGCTCA TCAACAGGAA TGGGGAGCTG 
AAACTGGCTG ATTTTGGTTT GGCTCGCGCC TTTGGGATCC CTGTTCGCTG TTACTCAGCT 
GAGGTCGTCA CGCTGTGGTA CCGCCCACCT GATGTCCTCT TTGGGGCCAA GCTGTACTCC 
ACGTCCATCG ACATGTGGTC AGCTGGCTGC ATCTTCGCAG AGCTGGCCAA CGCTGGGCGG 
CCCCTCTTTC CTGGCAATGA TGTAGACGAC CAGCTGAAGA GGATCTTCCG ACTCCTGGGC 
ACGCCAACCG AGGAGCAGTG GCCTGCCATG ACCAAGCTGC CAGACTATAA GCCCTACCCG 
ATGTACCCGG CCACAACGTC CCTGGTGAAC GTCGTGCCCA AGCTCAACGC CACAGGGAGG 
GACCTGCTGC AGAACCTGCT CAAGTGTAAC CCGGTCCAGC GCATCTCGGC GGAGGAGGCC 
CTGCAGCATC CCTACTTCTC CGACTTCTGC CCCCCCTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

A whole-genome assembly of the domestic cow, Bos taurus.
Genome biology10(4)R42(2009)
Zimin AV,Delcher AL,Florea L,Kelley DR,Schatz MC,Puiu D,Hanrahan F,Pertea G,Van Tassell CP,Sonstegard TS,Mar?ais G,Roberts M,Subramanian P,Yorke JA,Salzberg SL

Phosphorylation of protein phosphatase 1 by cyclin-dependent protein kinase 5 during nerve growth factor-induced PC12 cell differentiation.
The Journal of biological chemistry282(9)6619-28(2007 Mar)
Li T,Chalifour LE,Paudel HK

The cdk5/p35 kinase is essential for neurite outgrowth during neuronal differentiation.
Genes & development10(7)816-25(1996 Apr)
Nikolic M,Dudek H,Kwon YT,Ramos YF,Tsai LH

A cdc2-related kinase PSSALRE/cdk5 is homologous with the 30 kDa subunit of tau protein kinase II, a proline-directed protein kinase associated with microtubule.
FEBS letters335(2)171-5(1993 Dec)
Kobayashi S,Ishiguro K,Omori A,Takamatsu M,Arioka M,Imahori K,Uchida T

Brain proline-directed protein kinase is a neurofilament kinase which displays high sequence homology to p34cdc2.
The Journal of biological chemistry267(36)25922-6(1992 Dec)
Lew J,Winkfein RJ,Paudel HK,Wang JH