ERVFRD-1 cDNA ORF clone, Aotus nancymaae(Ma's night monkey)

Gene
Clones
gRNAs

Summary

Gene Symbol	ERVFRD-1
Entrez Gene ID	105708749
Full Name	endogenous retrovirus group FRD member 1, envelope
Gene Type	protein-coding
Organism	Aotus nancymaae(Ma's night monkey)
Summary	Many different endogenous retrovirus families are expressed in normal placental tissue at high levels, suggesting that endogenous retroviruses are functionally important in reproduction. This gene is part of an endogenous retrovirus provirus that has inactivating mutations in the gag and pol genes. This gene is the envelope glycoprotein gene which appears to have been selectively preserved. The gene's protein product plays a major role in placental development and trophoblast fusion. The protein has the characteristics of a typical retroviral envelope protein, including a cleavage site that separates the surface (SU) and transmembrane (TM) proteins which form a heterodimer. [provided by RefSeq, May 2015].

mRNA and Protein(s)

mRNA	Protein	Name
NM_001308485.1	NP_001295414.1	syncytin-2 precursor

Pathways from BioSystems
Gene Ontology
Bibliography

Related articles in PubMed

Identification of an envelope protein from the FRD family of human endogenous retroviruses (HERV-FRD) conferring infectivity and functional conservation among simians.
Blaise S, Ruggieri A, Dewannieux M, Cosset FL, Heidmann T
Journal of virology78(2)1050-4(2004 Jan)

Genomewide screening for fusogenic human endogenous retrovirus envelopes identifies syncytin 2, a gene conserved on primate evolution.
Blaise S, de Parseval N, B?nit L, Heidmann T
Proceedings of the National Academy of Sciences of the United States of America100(22)13013-8(2003 Oct)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The following ERVFRD-1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the ERVFRD-1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OAo09207	NM_001308485.1 Latest version!	Aotus nancymaae endogenous retrovirus group FRD member 1, envelope (ERVFRD-1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	14-16	$307.30 $439.00

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

ERVFRD-1 ( NM_001308485.1 ) cDNA ORF clone, Aotus nancymaae(Ma's night monkey) -> NP_001295414.1 Aotus nancymaae endogenous retrovirus group FRD member 1, envelope (ERVFRD-1), mRNA.

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CloneID	OAo09207
Clone ID Related Accession (Same CDS sequence)	NM_001308485.1
Accession Version	NM_001308485.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1617bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-05-04
Organism	Aotus nancymaae(Ma's night monkey)
Product	syncytin-2 precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from JYKP02043273.1. On May 7, 2015 this sequence version replaced XM_012440357.1. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. ##RefSeq-Attributes-START## endogenous retrovirus :: PMID: 14557543 ##RefSeq-Attributes-END##

ATGGGCCTGC TCCTGCTGGT TCTCATTCTT ACTCCTTTAT TAGCAGCCTA CCGCCATCCT 
GATTTCCAGT TACTGGAAAA AGCTCAGCAA CTGCTCCAAA GCACAGGATC CCCTTACTCC 
ACCAATTGCT GGTTATGTAC TAGCTCATCC ACTAAAACAC CAGGAAGAGC TTACCCAGCC 
TCGTCCAGAG ACTGGACAAC CATAGAGGCG GAATTACATA TTTCCTATCA ATGGGACCCT 
AATCTGAAAG GACTGATCAG GCCTGCAAAT AGCCTTCTTT CAAAGGTAAA GCAAGATTTC 
CCTGACATCC GCAAGGAACC TCCCATTTTC GGACCCATCT TTACTAATGT CAACTTAATA 
GGAATAGCCC CTATTTGTGT TACAGCCAAA AGGAAAGATG GAACAAATGT AGGCACTCTT 
CCAAGTACAG TCTGTAATGT TACTCTCACT GTAGATCCTA GCCAACAGAC TTATCAAAAA 
TACACCCACA ACCAATTCCA CCATCAACCA AGATTCCCCA AACCTCCAAA TATTACTTTT 
CCTCAGGGAA CTTTGCTAGA TAAATCCACC CGGTTTTGCC AGGGACGCCC AAGCTCATGC 
AGTACTCGAA ATTTCTGGTT CCAGCCTGCT GATTATAACC AATGTCTGCA AATTCCTAAC 
CTCAGCTCTA CAGCAGAATG GGTTCTGTTG GACCAAACTC GAAATTCTCT TTTTTGGGAA 
AATAAAACAA AGGGAGCTAA CCAGAGCCAA ACGCCATGCG TCCAAGTTTT AGCAGGCATG 
ACTATAGCCA CCAGCTACCT GAGCGTATCA GCAGTCTCAG AATTTTCTGG AACCTCCGTC 
ACCCCCTTAT TTAGTTTCCA TATCTCTACA TGTCTTAAAA CTCAAGGAGT CTTCTATATT 
TGTGGTCAAT CAATTCACCA ATGCCTCCCC ACCAACTGGA CTGGAACTTG TACCATAGGC 
TATGTATCCC CGGACATCTT CATAGTCCCT GGCAATCTCT CTCTTCCAAT ACCAATCTAT 
GGGAATTCCC ATTTTCCGAG GGTGAGAAGG GCTATCCATT TAATTCCCCT TCTCGTGGGA 
CTTGGCATTG TAGGCAGTGC GGGAACCGGA ATTGCTGGAA TTGCAAAAGC TTCCTTCACT 
TATAGCCAGC TTTCAAAGGA AATAGCCAAC AACATTGAGG CCATGGCTAA AACCTTAACG 
ACCGTGCAAG AACAAATCGA CTCTTTGGCA GCGGTAGTCC TCCAAAATCG TCGAGGACTA 
GACATGTTAA CGGCAGCACA GGGAGGAATT TGTTTGGCCT TAGATGAAAA ATGTTGCTTT 
TGGGTAAATC AATCAGGAAA AGTACAAGAC AACATCAGAC AACTCCTAAA TCGAGCCTCC 
ACTTTACGGG AACAAGCCAC TCAGGGCTGG TTAAATTGGG AAGGAACTTG GAAATGGTTC 
TCTTGGGTTC TTCCCTTTAC AGGCCCACTT GTTAGTCTCC TACTTTTGCT CCTTTTTGGT 
CCATGTCTCC TAAATCTAAT AACCCAATTT GTCTCCTCTC GCCTTCAGGC CACAAAGGTC 
CAGATGAAAC TCAGTAAGAG AGGCCGTCCT CGCAATAGTC AAGAGTCACC CTTCTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001295414.1
CDS	482..2098
Translation	MGLLLLVLILTPLLAAYRHPDFQLLEKAQQLLQSTGSPYSTNCWLCTSSSTKTPGRAYPASSRDWTTIEAELHISYQWDPNLKGLIRPANSLLSKVKQDFPDIRKEPPIFGPIFTNVNLIGIAPICVTAKRKDGTNVGTLPSTVCNVTLTVDPSQQTYQKYTHNQFHHQPRFPKPPNITFPQGTLLDKSTRFCQGRPSSCSTRNFWFQPADYNQCLQIPNLSSTAEWVLLDQTRNSLFWENKTKGANQSQTPCVQVLAGMTIATSYLSVSAVSEFSGTSVTPLFSFHISTCLKTQGVFYICGQSIHQCLPTNWTGTCTIGYVSPDIFIVPGNLSLPIPIYGNSHFPRVRRAIHLIPLLVGLGIVGSAGTGIAGIAKASFTYSQLSKEIANNIEAMAKTLTTVQEQIDSLAAVVLQNRRGLDMLTAAQGGICLALDEKCCFWVNQSGKVQDNIRQLLNRASTLREQATQGWLNWEGTWKWFSWVLPFTGPLVSLLLLLLFGPCLLNLITQFVSSRLQATKVQMKLSKRGRPRNSQESPF

Target ORF information:

RefSeq Version	NM_001308485.1
Organism	Aotus nancymaae(Ma's night monkey)
Definition	Aotus nancymaae endogenous retrovirus group FRD member 1, envelope (ERVFRD-1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001308485.1

ORF Insert Sequence:

ATGGGCCTGC TCCTGCTGGT TCTCATTCTT ACTCCTTTAT TAGCAGCCTA CCGCCATCCT 
GATTTCCAGT TACTGGAAAA AGCTCAGCAA CTGCTCCAAA GCACAGGATC CCCTTACTCC 
ACCAATTGCT GGTTATGTAC TAGCTCATCC ACTAAAACAC CAGGAAGAGC TTACCCAGCC 
TCGTCCAGAG ACTGGACAAC CATAGAGGCG GAATTACATA TTTCCTATCA ATGGGACCCT 
AATCTGAAAG GACTGATCAG GCCTGCAAAT AGCCTTCTTT CAAAGGTAAA GCAAGATTTC 
CCTGACATCC GCAAGGAACC TCCCATTTTC GGACCCATCT TTACTAATGT CAACTTAATA 
GGAATAGCCC CTATTTGTGT TACAGCCAAA AGGAAAGATG GAACAAATGT AGGCACTCTT 
CCAAGTACAG TCTGTAATGT TACTCTCACT GTAGATCCTA GCCAACAGAC TTATCAAAAA 
TACACCCACA ACCAATTCCA CCATCAACCA AGATTCCCCA AACCTCCAAA TATTACTTTT 
CCTCAGGGAA CTTTGCTAGA TAAATCCACC CGGTTTTGCC AGGGACGCCC AAGCTCATGC 
AGTACTCGAA ATTTCTGGTT CCAGCCTGCT GATTATAACC AATGTCTGCA AATTCCTAAC 
CTCAGCTCTA CAGCAGAATG GGTTCTGTTG GACCAAACTC GAAATTCTCT TTTTTGGGAA 
AATAAAACAA AGGGAGCTAA CCAGAGCCAA ACGCCATGCG TCCAAGTTTT AGCAGGCATG 
ACTATAGCCA CCAGCTACCT GAGCGTATCA GCAGTCTCAG AATTTTCTGG AACCTCCGTC 
ACCCCCTTAT TTAGTTTCCA TATCTCTACA TGTCTTAAAA CTCAAGGAGT CTTCTATATT 
TGTGGTCAAT CAATTCACCA ATGCCTCCCC ACCAACTGGA CTGGAACTTG TACCATAGGC 
TATGTATCCC CGGACATCTT CATAGTCCCT GGCAATCTCT CTCTTCCAAT ACCAATCTAT 
GGGAATTCCC ATTTTCCGAG GGTGAGAAGG GCTATCCATT TAATTCCCCT TCTCGTGGGA 
CTTGGCATTG TAGGCAGTGC GGGAACCGGA ATTGCTGGAA TTGCAAAAGC TTCCTTCACT 
TATAGCCAGC TTTCAAAGGA AATAGCCAAC AACATTGAGG CCATGGCTAA AACCTTAACG 
ACCGTGCAAG AACAAATCGA CTCTTTGGCA GCGGTAGTCC TCCAAAATCG TCGAGGACTA 
GACATGTTAA CGGCAGCACA GGGAGGAATT TGTTTGGCCT TAGATGAAAA ATGTTGCTTT 
TGGGTAAATC AATCAGGAAA AGTACAAGAC AACATCAGAC AACTCCTAAA TCGAGCCTCC 
ACTTTACGGG AACAAGCCAC TCAGGGCTGG TTAAATTGGG AAGGAACTTG GAAATGGTTC 
TCTTGGGTTC TTCCCTTTAC AGGCCCACTT GTTAGTCTCC TACTTTTGCT CCTTTTTGGT 
CCATGTCTCC TAAATCTAAT AACCCAATTT GTCTCCTCTC GCCTTCAGGC CACAAAGGTC 
CAGATGAAAC TCAGTAAGAG AGGCCGTCCT CGCAATAGTC AAGAGTCACC CTTCTAA