| Gene Symbol | SFTPD |
| Entrez Gene ID | 397198 |
| Full Name | surfactant protein D |
| Synonyms | PSP-D,SP-D |
| Gene Type | protein-coding |
| Organism | Sus scrofa(pig) |
| Genome |
ORF » Species Summary » Sus scrofa » SFTPD cDNA ORF clone
| Gene Symbol | SFTPD |
| Entrez Gene ID | 397198 |
| Full Name | surfactant protein D |
| Synonyms | PSP-D,SP-D |
| Gene Type | protein-coding |
| Organism | Sus scrofa(pig) |
| Genome |
| mRNA | Protein | Name |
|---|---|---|
| XM_005671145.2 | XP_005671202.1 | pulmonary surfactant-associated protein D isoform X1 |
| XM_013983376.2 | XP_013838830.1 | pulmonary surfactant-associated protein D isoform X2 |
| XM_013983376.1 | XP_013838830.1 | pulmonary surfactant-associated protein D isoform X2 |
| NM_214110.1 | NP_999275.1 | pulmonary surfactant-associated protein D precursor |
| XM_005671145.3 | XP_005671202.1 | pulmonary surfactant-associated protein D isoform X1 |
The number and position of N-linked glycosylation sites in the hemagglutinin determine differential recognition of seasonal and 2009 pandemic H1N1 influenza virus by porcine surfactant protein D.
Hillaire ML, van Eijk M, Nieuwkoop NJ, Vogelzang-van Trierum SE, Fouchier RA, Osterhaus AD, Haagsman HP, Rimmelzwaan GF
Virus research169(1)301-5(2012 Oct)
The presence and activity of SP-D in porcine coronary endothelial cells depend on Akt/PI3K, Erk and nitric oxide and decrease after multiple passaging.
Lee MY, S?rensen GL, Holmskov U, Vanhoutte PM
Molecular immunology46(6)1050-7(2009 Mar)
Expression sites of the collectin SP-D suggest its importance in first line host defence: power of combining in situ hybridisation, RT-PCR and immunohistochemistry.
Her?as MV, Hogenkamp A, van Asten AJ, Tersteeg MH, van Eijk M, Haagsman HP
Molecular immunology44(13)3324-32(2007 Jul)
Interactions of influenza A virus with sialic acids present on porcine surfactant protein D.
van Eijk M, White MR, Batenburg JJ, Vaandrager AB, van Golde LM, Haagsman HP, Hartshorn KL
American journal of respiratory cell and molecular biology30(6)871-9(2004 Jun)
Porcine lung surfactant protein D: complementary DNA cloning, chromosomal localization, and tissue distribution.
van Eijk M, Haagsman HP, Skinner T, Archibald A, Reid KB, Lawson PR, Archibold A
Journal of immunology (Baltimore, Md. : 1950)164(3)1442-50(2000 Feb)
GeneRIFs: Gene References Into Functions What's a GeneRIF?
The authors demonstrated that the number and position of glycosylation sites determine viral susceptibility to the neutralizing activity of porcine SP-D.
Title: The number and position of N-linked glycosylation sites in the hemagglutinin determine differential recognition of seasonal and 2009 pandemic H1N1 influenza virus by porcine surfactant protein D.
The presence of SP-D in endothelial cells which is NO-, PI(3)K/Akt- and Erk-dependent is demonstrated. It suggests a protective role of SP-D in these cells.
Title: The presence and activity of SP-D in porcine coronary endothelial cells depend on Akt/PI3K, Erk and nitric oxide and decrease after multiple passaging.
The importance of SP-D in innate immunity is underlined by its expression at the potential ports of entry of pathogens: lung, tongue, intestinal tract, thymus, skin, gall bladder, lacrimal gland, esophagus, stomach, kidney, liver, prostate and spleen.
Title: Expression sites of the collectin SP-D suggest its importance in first line host defence: power of combining in situ hybridisation, RT-PCR and immunohistochemistry.
Data show that interactions of surfactant protein D (pSP-D) with influenza A virus mediated by the N-linked carbohydrate moiety in pSP-D depend on the terminal sialic acids present on this moiety.
Title: Interactions of influenza A virus with sialic acids present on porcine surfactant protein D.
The following SFTPD gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the SFTPD cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.
| CloneID | OSe30499 | |
| Clone ID Related Accession (Same CDS sequence) | XM_013983376.2 , XM_013983376.1 , NM_214110.1 | |
| Accession Version | NM_214110.1 Latest version! | Documents for ORF clone product in default vector |
| Sequence Information | ORF Nucleotide Sequence (Length: 1137bp) Protein sequence SNP |
|
| Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
| Clone information | Clone Map | MSDS |
| Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
| ORF Insert Method | CloneEZ™ Seamless cloning technology | |
| Insert Structure | linear | |
| Update Date | 2019-10-19 | |
| Organism | Sus scrofa(pig) | |
| Product | pulmonary surfactant-associated protein D precursor | |
| Comment | Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from AF132496.2. ##Evidence-Data-START## Transcript exon combination :: AF132496.2 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965831, SAMEA1970063 [ECO:0000348] ##Evidence-Data-END## | |
1 | ATGCTTCTCC TCCCTCTCTC CGTGCTGATC CTGCTCACAC AGCCCCCGAG GTCACTGGGA |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
| RefSeq | NP_999275.1 |
| CDS | 44..1180 |
| Translation |
Target ORF information:
Target ORF information:
|
NM_214110.1 |
1 | ATGCTTCTCC TCCCTCTCTC CGTGCTGATC CTGCTCACAC AGCCCCCGAG GTCACTGGGA |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
| CloneID | OSe22369 | |
| Clone ID Related Accession (Same CDS sequence) | XM_005671145.2 , XM_005671145.3 | |
| Accession Version | XM_005671145.2 | Documents for ORF clone product in default vector |
| Sequence Information | ORF Nucleotide Sequence (Length: 1161bp) Protein sequence SNP |
|
| Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
| Clone information | Clone Map | MSDS |
| Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
| ORF Insert Method | CloneEZ™ Seamless cloning technology | |
| Insert Structure | linear | |
| Update Date | 2015-09-10 | |
| Organism | Sus scrofa(Pig) | |
| Product | pulmonary surfactant-associated protein D isoform X1 | |
| Comment | MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NW_003612030.1) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Sep 11, 2015 this sequence version replaced XM_005671145.1. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Sus scrofa Annotation Release 105 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 6.4 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## | |
1 | ATGGGATCAG CGGCGCGTCT GGACATGCTT CTCCTCCCTC TCTCCGTGCT GATCCTGCTC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
| RefSeq | XP_005671202.1 |
| CDS | 314..1474 |
| Translation |
Target ORF information:
Target ORF information:
|
XM_005671145.2 |
1 | ATGGGATCAG CGGCGCGTCT GGACATGCTT CTCCTCCCTC TCTCCGTGCT GATCCTGCTC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
| CloneID | OSe22369 | |
| Clone ID Related Accession (Same CDS sequence) | XM_005671145.2 , XM_005671145.3 | |
| Accession Version | XM_005671145.3 Latest version! | Documents for ORF clone product in default vector |
| Sequence Information | ORF Nucleotide Sequence (Length: 1161bp) Protein sequence SNP |
|
| Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
| Clone information | Clone Map | MSDS |
| Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
| ORF Insert Method | CloneEZ™ Seamless cloning technology | |
| Insert Structure | linear | |
| Update Date | 2017-05-12 | |
| Organism | Sus scrofa(pig) | |
| Product | pulmonary surfactant-associated protein D isoform X1 | |
| Comment | Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_010456.5) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On May 13, 2017 this sequence version replaced XM_005671145.2. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Sus scrofa Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.4 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## | |
1 | ATGGGATCAG CGGCGCGTCT GGACATGCTT CTCCTCCCTC TCTCCGTGCT GATCCTGCTC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
| RefSeq | XP_005671202.1 |
| CDS | 238..1398 |
| Translation |
Target ORF information:
Target ORF information:
|
XM_005671145.3 |
1 | ATGGGATCAG CGGCGCGTCT GGACATGCTT CTCCTCCCTC TCTCCGTGCT GATCCTGCTC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
| CloneID | OSe30499 | |
| Clone ID Related Accession (Same CDS sequence) | XM_013983376.2 , XM_013983376.1 , NM_214110.1 | |
| Accession Version | XM_013983376.2 Latest version! | Documents for ORF clone product in default vector |
| Sequence Information | ORF Nucleotide Sequence (Length: 1137bp) Protein sequence SNP |
|
| Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
| Clone information | Clone Map | MSDS |
| Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
| ORF Insert Method | CloneEZ™ Seamless cloning technology | |
| Insert Structure | linear | |
| Update Date | 2017-05-12 | |
| Organism | Sus scrofa(pig) | |
| Product | pulmonary surfactant-associated protein D isoform X2 | |
| Comment | Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_010456.5) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On May 13, 2017 this sequence version replaced XM_013983376.1. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Sus scrofa Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.4 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## | |
1 | ATGCTTCTCC TCCCTCTCTC CGTGCTGATC CTGCTCACAC AGCCCCCGAG GTCACTGGGA |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
| RefSeq | XP_013838830.1 |
| CDS | 91..1227 |
| Translation |
Target ORF information:
Target ORF information:
|
XM_013983376.2 |
1 | ATGCTTCTCC TCCCTCTCTC CGTGCTGATC CTGCTCACAC AGCCCCCGAG GTCACTGGGA |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
| CloneID | OSe30499 | |
| Clone ID Related Accession (Same CDS sequence) | XM_013983376.2 , XM_013983376.1 , NM_214110.1 | |
| Accession Version | XM_013983376.1 | Documents for ORF clone product in default vector |
| Sequence Information | ORF Nucleotide Sequence (Length: 1137bp) Protein sequence SNP |
|
| Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
| Clone information | Clone Map | MSDS |
| Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
| ORF Insert Method | CloneEZ™ Seamless cloning technology | |
| Insert Structure | linear | |
| Update Date | 2015-09-10 | |
| Organism | Sus scrofa(Pig) | |
| Product | pulmonary surfactant-associated protein D isoform X2 | |
| Comment | MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NW_003612030.1) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Sus scrofa Annotation Release 105 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 6.4 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## | |
1 | ATGCTTCTCC TCCCTCTCTC CGTGCTGATC CTGCTCACAC AGCCCCCGAG GTCACTGGGA |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
| RefSeq | XP_013838830.1 |
| CDS | 299..1435 |
| Translation |
Target ORF information:
Target ORF information:
|
XM_013983376.1 |
1 | ATGCTTCTCC TCCCTCTCTC CGTGCTGATC CTGCTCACAC AGCCCCCGAG GTCACTGGGA |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
The number and position of N-linked glycosylation sites in the hemagglutinin determine differential recognition of seasonal and 2009 pandemic H1N1 influenza virus by porcine surfactant protein D. |
The presence and activity of SP-D in porcine coronary endothelial cells depend on Akt/PI3K, Erk and nitric oxide and decrease after multiple passaging. |
Expression sites of the collectin SP-D suggest its importance in first line host defence: power of combining in situ hybridisation, RT-PCR and immunohistochemistry. |
Interactions of influenza A virus with sialic acids present on porcine surfactant protein D. |
Porcine lung surfactant protein D: complementary DNA cloning, chromosomal localization, and tissue distribution. |