Slc22a4 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Slc22a4
Entrez Gene ID	64037
Full Name	solute carrier family 22 member 4
Synonyms	Octn1
General protein information	Preferred Names solute carrier family 22 member 4 Names solute carrier family 22 member 4 organic cation transporter OCTN1 organic cation/carnitine transporter 1 solute carrier family 22 (organic cation transporter), member 4 solute carrier family 22 (organic cation/zwitterion transporter), member 4
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 10 Map Location: 10q22
Summary	mediates Na(+)-independent and pH-dependent transport of the prototypical organic cation tetraethylammonium [RGD, Feb 2006].

mRNA and Protein(s)

mRNA	Protein	Name
NM_022270.1	NP_071606.1	solute carrier family 22 member 4

Pathways from BioSystems

Homologies

	LOC710179	XP_002804554.1
Canis lupus familiaris (dog)	SLC22A4	XP_005626572.1
Homo sapiens (human)	SLC22A4	NP_003050.2
Pan troglodytes (chimpanzee)	SLC22A4	XP_001163062.1
Bos taurus (cattle)	SLC22A4	NP_001193918.1
Mus musculus (house mouse)	Slc22a4	NP_062661.1
Rattus norvegicus (Norway rat)	Slc22a4	NP_071606.1
Danio rerio (zebrafish)	LOC100000685	XP_005170394.1
Gallus gallus (chicken)	SLC22A4	NP_001139603.1

Gene Ontology
Bibliography

Related articles in PubMed

Acetylcholine and acetylcarnitine transport in peritoneum: Role of the SLC22A4 (OCTN1) transporter.
Pochini L, Scalise M, Di Silvestre S, Belviso S, Pandolfi A, Arduini A, Bonomini M, Indiveri C
Biochimica et biophysica acta1858(4)653-60(2016 Apr)

Membrane transporters as mediators of Cisplatin effects and side effects.
Ciarimboli G
Scientifica2012473829(2012)

Expression and localization of carnitine/organic cation transporter OCTN1 and OCTN2 in ocular epithelium.
Garrett Q, Xu S, Simmons PA, Vehige J, Flanagan JL, Willcox MD
Investigative ophthalmology & visual science49(11)4844-9(2008 Nov)

Functional characterization of ergothioneine transport by rat organic cation/carnitine transporter Octn1 (slc22a4).
Nakamura T, Yoshida K, Yabuuchi H, Maeda T, Tamai I
Biological & pharmaceutical bulletin31(8)1580-4(2008 Aug)

Transport of organic cations across the blood-testis barrier.
Maeda T, Goto A, Kobayashi D, Tamai I
Molecular pharmaceutics4(4)600-7(2007 Jul-Aug)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

the results obtained by the pointed out experimental model demonstrate that the organic cation transporter OCTN1 is expressed in peritoneum and is localized in mesothelial cells
Title: Acetylcholine and acetylcarnitine transport in peritoneum: Role of the SLC22A4 (OCTN1) transporter.

rat Octn1 is important by transporting anti-oxidant ergothioneine in PC12 cells
Title: Functional characterization of ergothioneine transport by rat organic cation/carnitine transporter Octn1 (slc22a4).

We conclude that PPARalpha agonists increase carnitine concentrations in livers of rats and cells by an increased uptake of carnitine into the cell but not by an increased carnitine biosynthesis.
Title: PPARalpha agonists up-regulate organic cation transporters in rat liver cells.

The following Slc22a4 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Slc22a4 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa42683	NM_022270.1 Latest version!	Rattus norvegicus solute carrier family 22 member 4 (Slc22a4), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$307.30 $439.00

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Slc22a4 ( NM_022270.1 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_071606.1 Rattus norvegicus solute carrier family 22 member 4 (Slc22a4), mRNA.

Price & Availability↑

CloneID	ORa42683
Clone ID Related Accession (Same CDS sequence)	NM_022270.1
Accession Version	NM_022270.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1662bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-08-03
Organism	Rattus norvegicus(Norway rat)
Product	solute carrier family 22 member 4
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from AF169831.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AF169831.1 [ECO:0000332] ##Evidence-Data-END##

ATGAGGGACT ATGACGAGGT GATAGCCTTC CTGGGCGATT GGGGGCCCTT CCAGCGCCTT 
ATCTTCTTCC TGCTCAGCGC CAGCATCATC CCCAATGGCT TCAATGGTAT GTCAGTCGTG 
TTCCTGGCGG GGACCCCGGA GCATCGTTGC CTTGTGCCTC ACACCGTGAA CTTGAGCAGC 
GCGTGGCGCA ACCACAGCAT CCCCTTGGAA ACGAAGGACG GACGACAGGT GCCTCAAAGC 
TGCCGCCGCT ACCGACTGGC CACCATCGCC AACTTCTCTG CGCTGGGGCT GGAGCCCGGA 
CTGGATGTAG ATCTGGAGCA GCTGGAGCAA GAGAGCTGCC TGGATGGCTG GGAGTACAGC 
AAGGACGTCT TCCTGTCCAC CATCGTGACA GAGTGGAATC TGGTGTGTGA GGATGACTGG 
AAGACACCCC TCACCACCTC CCTGTTCTTC GTAGGCGTTC TCTGTGGCTC CTTCGTGTCT 
GGGCAGCTGT CAGACAGGTT CGGCAGGAAG AAAGTCCTCT TTGCCACCAT GGCTGTGCAG 
ACTGGATTCA GCTTCGTGCA GATTTTCTCA ACCAACTGGG AGATGTTTAC TGTGTTATTT 
GCCATCGTGG GCATGGGCCA AATCTCCAAC TATGTGGTGG CCTTCATACT CGGGACCGAA 
ATCCTGAGCA AGTCGGTTCG CATCCTCTTC TCCACGTTGG GAGTCTGTAC ATTTTTTGCC 
ATCGGCTACA TGGTGCTGCC GCTGTTTGCA TACTTCATCC GAGACTGGAG GATGCTGCTG 
CTGGCACTGA CACTGCCTGG GCTGTTCTGT GTCCCCCTGT GGTGGTTTAT TCCAGAGTCT 
CCCCGGTGGC TGATATCCCA GAGGAGATTT GAAGAGGCAG AACAGATCAT CCAGAAAGCC 
GCAAAGATGA ATGGCATCAT GGCACCAGCA GTGATATTTG ATCCTCTGGA GCTACAGGAG 
CTAAACTCCT TGAAGCAGCA GAAAGTCTTC ATTCTGGACC TGTTCAAGAC TCGGAACATT 
GCCACAATAA CAGTGATGTC TGTGATGCTG TGGATGCTAA CCTCAGTGGG TTACTTTGCT 
CTGTCTCTCA ATGTTCCTAA TTTGCACGGA GATGTCTACC TGAACTGCTT CCTCTCTGGC 
CTGATTGAAG TTCCAGCTTA TTTCACAGCC TGGCTGCTAC TTCGAACCCT GCCTCGGAGA 
TATATTATAG CTGGGGTGCT GTTCTGGGGA GGAGGTGTGC TTCTCTTGGT CCAAGTGGTA 
CCTGAAGATT ACAACTTTGT GTCCATTGGC CTGGTGATGC TGGGGAAATT TGGGGTCACC 
TCTGCCTTCT CCATGCTGTA CGTCTTCACA GCGGAGCTCT ACCCAACCCT GGTCAGGAAC 
ATGGCTGTGG GCATCACCTC CATGGCCTCG AGGGTGGGCA GCATCATTGC CCCCTATTTC 
GTGTACCTGG GTGCTTATAA CCGACTCCTG CCCTACATCC TCATGGGCAG TCTGACTGTC 
CTCATTGGAA TCATCACACT TTTTTTCCCT GAGAGTTTTG GAGTGACTCT ACCAGAGAAC 
TTGGAGCAGA TGCAGAAAGT CAGAGGGTTC AGATGTGGGA AAAAATCAAC AGTCTCCATG 
GACAGAGAAG AAAACCCCAA GGTTCTAATA ACTGCATTCT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_071606.1
CDS	72..1733
Translation	MRDYDEVIAFLGDWGPFQRLIFFLLSASIIPNGFNGMSVVFLAGTPEHRCLVPHTVNLSSAWRNHSIPLETKDGRQVPQSCRRYRLATIANFSALGLEPGLDVDLEQLEQESCLDGWEYSKDVFLSTIVTEWNLVCEDDWKTPLTTSLFFVGVLCGSFVSGQLSDRFGRKKVLFATMAVQTGFSFVQIFSTNWEMFTVLFAIVGMGQISNYVVAFILGTEILSKSVRILFSTLGVCTFFAIGYMVLPLFAYFIRDWRMLLLALTLPGLFCVPLWWFIPESPRWLISQRRFEEAEQIIQKAAKMNGIMAPAVIFDPLELQELNSLKQQKVFILDLFKTRNIATITVMSVMLWMLTSVGYFALSLNVPNLHGDVYLNCFLSGLIEVPAYFTAWLLLRTLPRRYIIAGVLFWGGGVLLLVQVVPEDYNFVSIGLVMLGKFGVTSAFSMLYVFTAELYPTLVRNMAVGITSMASRVGSIIAPYFVYLGAYNRLLPYILMGSLTVLIGIITLFFPESFGVTLPENLEQMQKVRGFRCGKKSTVSMDREENPKVLITAF

Target ORF information:

RefSeq Version	NM_022270.1
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus solute carrier family 22 member 4 (Slc22a4), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_022270.1

ORF Insert Sequence:

ATGAGGGACT ATGACGAGGT GATAGCCTTC CTGGGCGATT GGGGGCCCTT CCAGCGCCTT 
ATCTTCTTCC TGCTCAGCGC CAGCATCATC CCCAATGGCT TCAATGGTAT GTCAGTCGTG 
TTCCTGGCGG GGACCCCGGA GCATCGTTGC CTTGTGCCTC ACACCGTGAA CTTGAGCAGC 
GCGTGGCGCA ACCACAGCAT CCCCTTGGAA ACGAAGGACG GACGACAGGT GCCTCAAAGC 
TGCCGCCGCT ACCGACTGGC CACCATCGCC AACTTCTCTG CGCTGGGGCT GGAGCCCGGA 
CTGGATGTAG ATCTGGAGCA GCTGGAGCAA GAGAGCTGCC TGGATGGCTG GGAGTACAGC 
AAGGACGTCT TCCTGTCCAC CATCGTGACA GAGTGGAATC TGGTGTGTGA GGATGACTGG 
AAGACACCCC TCACCACCTC CCTGTTCTTC GTAGGCGTTC TCTGTGGCTC CTTCGTGTCT 
GGGCAGCTGT CAGACAGGTT CGGCAGGAAG AAAGTCCTCT TTGCCACCAT GGCTGTGCAG 
ACTGGATTCA GCTTCGTGCA GATTTTCTCA ACCAACTGGG AGATGTTTAC TGTGTTATTT 
GCCATCGTGG GCATGGGCCA AATCTCCAAC TATGTGGTGG CCTTCATACT CGGGACCGAA 
ATCCTGAGCA AGTCGGTTCG CATCCTCTTC TCCACGTTGG GAGTCTGTAC ATTTTTTGCC 
ATCGGCTACA TGGTGCTGCC GCTGTTTGCA TACTTCATCC GAGACTGGAG GATGCTGCTG 
CTGGCACTGA CACTGCCTGG GCTGTTCTGT GTCCCCCTGT GGTGGTTTAT TCCAGAGTCT 
CCCCGGTGGC TGATATCCCA GAGGAGATTT GAAGAGGCAG AACAGATCAT CCAGAAAGCC 
GCAAAGATGA ATGGCATCAT GGCACCAGCA GTGATATTTG ATCCTCTGGA GCTACAGGAG 
CTAAACTCCT TGAAGCAGCA GAAAGTCTTC ATTCTGGACC TGTTCAAGAC TCGGAACATT 
GCCACAATAA CAGTGATGTC TGTGATGCTG TGGATGCTAA CCTCAGTGGG TTACTTTGCT 
CTGTCTCTCA ATGTTCCTAA TTTGCACGGA GATGTCTACC TGAACTGCTT CCTCTCTGGC 
CTGATTGAAG TTCCAGCTTA TTTCACAGCC TGGCTGCTAC TTCGAACCCT GCCTCGGAGA 
TATATTATAG CTGGGGTGCT GTTCTGGGGA GGAGGTGTGC TTCTCTTGGT CCAAGTGGTA 
CCTGAAGATT ACAACTTTGT GTCCATTGGC CTGGTGATGC TGGGGAAATT TGGGGTCACC 
TCTGCCTTCT CCATGCTGTA CGTCTTCACA GCGGAGCTCT ACCCAACCCT GGTCAGGAAC 
ATGGCTGTGG GCATCACCTC CATGGCCTCG AGGGTGGGCA GCATCATTGC CCCCTATTTC 
GTGTACCTGG GTGCTTATAA CCGACTCCTG CCCTACATCC TCATGGGCAG TCTGACTGTC 
CTCATTGGAA TCATCACACT TTTTTTCCCT GAGAGTTTTG GAGTGACTCT ACCAGAGAAC 
TTGGAGCAGA TGCAGAAAGT CAGAGGGTTC AGATGTGGGA AAAAATCAAC AGTCTCCATG 
GACAGAGAAG AAAACCCCAA GGTTCTAATA ACTGCATTCT GA