Plvap cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Plvap
Entrez Gene ID	56765
Full Name	plasmalemma vesicle associated protein
Synonyms	Pv1
General protein information	Preferred Names plasmalemma vesicle associated protein Names plasmalemma vesicle-associated protein PV-1 gp68 plasmalemma vesicle protein 1
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 16 Map Location: 16p14
Summary	integral membrane protein associated with vesicles; protein highly expressed in the caveolae in lung epithelium [RGD, Feb 2006].

mRNA and Protein(s)

mRNA	Protein	Name
NM_020086.1	NP_064471.1	plasmalemma vesicle-associated protein

Pathways from BioSystems

Homologies

Mus musculus (house mouse)	Plvap	NP_115774.2
Rattus norvegicus (Norway rat)	Plvap	NP_064471.1
Pan troglodytes (chimpanzee)	PLVAP	XP_512490.3
Bos taurus (cattle)	PLVAP	NP_001030430.1
Homo sapiens (human)	PLVAP	NP_112600.1
Canis lupus familiaris (dog)	PLVAP	XP_541953.3

Gene Ontology
Bibliography

Related articles in PubMed

Lack of endothelial diaphragms in fenestrae and caveolae of mutant Plvap-deficient mice.
Herrnberger L, Seitz R, Kuespert S, B?sl MR, Fuchshofer R, Tamm ER
Histochemistry and cell biology138(5)709-24(2012 Nov)

Brain-endocrine interactions: a microvascular route in the mediobasal hypothalamus.
Ciofi P, Garret M, Lapirot O, Lafon P, Loyens A, Pr?vot V, Levine JE
Endocrinology150(12)5509-19(2009 Dec)

The prototype endothelial marker PAL-E is a leukocyte trafficking molecule.
Keuschnigg J, Henttinen T, Auvinen K, Karikoski M, Salmi M, Jalkanen S
Blood114(2)478-84(2009 Jul)

Proteomic analysis of exosomes from human neural stem cells by flow field-flow fractionation and nanoflow liquid chromatography-tandem mass spectrometry.
Kang D, Oh S, Ahn SM, Lee BH, Moon MH
Journal of proteome research7(8)3475-80(2008 Aug)

Developmental regulation of PV-1 in rat lung: association with the nuclear envelope and limited colocalization with Cav-1.
Hnasko R, Ben-Jonathan N
American journal of physiology. Lung cellular and molecular physiology288(2)L275-84(2005 Feb)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Data show that PV-1 was detected exclusively over highly permeable regions of the brain by in situ hybridization.
Title: Brain-endocrine interactions: a microvascular route in the mediobasal hypothalamus.

PV-1 is developmentally regulated in the rat lung and shows a divergent intracellular localization, with a limited caveolae/Cav-1 colocalization in cultured endothelial cells.
Title: Developmental regulation of PV-1 in rat lung: association with the nuclear envelope and limited colocalization with Cav-1.

tested the role of PV1 in the structure of the diaphragms and demonstrated that multiple PV1 homodimers reside in close proximity within the same diaphragm.
Title: Multiple PV1 dimers reside in the same stomatal or fenestral diaphragm.

The following Plvap gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Plvap cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa04671	NM_020086.1 Latest version!	Rattus norvegicus plasmalemma vesicle associated protein (Plvap), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$223.30 $319.00

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Plvap ( NM_020086.1 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_064471.1 Rattus norvegicus plasmalemma vesicle associated protein (Plvap), mRNA.

Price & Availability↑

CloneID	ORa04671
Clone ID Related Accession (Same CDS sequence)	NM_020086.1
Accession Version	NM_020086.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1317bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-24
Organism	Rattus norvegicus(Norway rat)
Product	plasmalemma vesicle-associated protein
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from AF154831.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC070900.1, AF154831.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMD00052296, SAMD00052297 [ECO:0000350] ##Evidence-Data-END##

ATGGGGCTCT CCATGGACCG CAGCCCGTAC TCCCGCACGG GGGACCGGGA TCGCGGCTGC 
TGGTACTACC TGCGCTATTT CTTCCTCTTC GTGTCGCTCA TCCAGTTCCT CATCATCCTG 
GGCCTGGTCC TCTTCATGAT CTATGGTAAT GTGCACGCCA CCACCGAGTC CAGTCTGCGG 
GCCACGGAGA TCCGCGCCGA CAACCTATAC AGCCAGGTGG TGGGACTGTC GGCCGCACAG 
GCTAACCTGA GCAAACAGCT GAACATCAGC ACCCTCGTCA AGGACACCGT CATGCAGCAG 
CTGCTGACCA CGCGGCGCGA GGTGGAGCGC ATCAACGCCA GCTTCCGCCA GTGCCAAGGC 
GACCTGATCA CCTACATAAA CTATAATCGG TTCATCGCCG CTATCATCCT GAGCGAGAAG 
CAGTGCCAGG AACAGCTGAA GGAGGGCAAC AAGACCTGCG AAGCCTTGCT CTTCAAGCTG 
GGAGAGAAGG TTAAGACACT GGAGATGGAG GTGGTCAAGG AGAAGGCGGT GTGCTCCAAA 
GACAAGGACA GCCTGCTGGC AGGAAAGCGG CAGGCGGAAA TGCAGCAGGA GGCCTGTGGC 
AAAGCGCGAG AGCAGCAAAA GCAGGACCAG CAGGTGACCG AGGAGCAACT GCGCAAGGTG 
CAGTCCCTGT GCCTCCCACT GGACCAGGAG AAGTTCCAGG CGGACGTGCT GAACGTGTGG 
CGGGATTCGC TGGTCTACCG TTCCCTGGAT AATATAGGCT ACCACTACTC GCTGATGCCG 
GAGTTCTCGT CCCTCCGCCG AACATGCGAG AGCCTGCCCG GGATCATGAC CACCAAGGTA 
GAAGAGCTGG CGCGCGGGTT GCGCGCGGGC ATTGAGCGCG TGACCCGTGA AAATGGAGAG 
CTGCGACGCC AGAAGCTGGA GCTGGAGCGC GCGATACAGG GCGAGCGGGA GGCGCGGACG 
CGCGCCGGGA CCGAGGCGCA GGCTCGAGAG ACCCAGCTAC GGACGGAGTG CGCGCGCCAG 
ACACAGCTGG CTCTGGAGGA GAAGGCAGCG CTGCGGACAC AGCGGGACGA CCTGGAGCGC 
CAGCTGGAGG CGCGGAAGCG GGAGCTGGAG CAACTGCGCA CCGAGGTGGA TGTGCGCATT 
AGCGCTCTGG ACACCTGCGT CAAGGCCAAG TCGCTGCCAG CCATCCAGCC GAGACTCCCA 
GGTCCACCCC CCAACCCTCC ACCCATTGAT CCAGCTAGCC TGGAGGAATT CAAGAAAAGG 
ATCCTAGAGT CGCAGCGGCC CCCTCTAGTC AACCCTGCTG TCCCACCCAG TGGCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_064471.1
CDS	25..1341
Translation	MGLSMDRSPYSRTGDRDRGCWYYLRYFFLFVSLIQFLIILGLVLFMIYGNVHATTESSLRATEIRADNLYSQVVGLSAAQANLSKQLNISTLVKDTVMQQLLTTRREVERINASFRQCQGDLITYINYNRFIAAIILSEKQCQEQLKEGNKTCEALLFKLGEKVKTLEMEVVKEKAVCSKDKDSLLAGKRQAEMQQEACGKAREQQKQDQQVTEEQLRKVQSLCLPLDQEKFQADVLNVWRDSLVYRSLDNIGYHYSLMPEFSSLRRTCESLPGIMTTKVEELARGLRAGIERVTRENGELRRQKLELERAIQGEREARTRAGTEAQARETQLRTECARQTQLALEEKAALRTQRDDLERQLEARKRELEQLRTEVDVRISALDTCVKAKSLPAIQPRLPGPPPNPPPIDPASLEEFKKRILESQRPPLVNPAVPPSG

Target ORF information:

RefSeq Version	NM_020086.1
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus plasmalemma vesicle associated protein (Plvap), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_020086.1

ORF Insert Sequence:

ATGGGGCTCT CCATGGACCG CAGCCCGTAC TCCCGCACGG GGGACCGGGA TCGCGGCTGC 
TGGTACTACC TGCGCTATTT CTTCCTCTTC GTGTCGCTCA TCCAGTTCCT CATCATCCTG 
GGCCTGGTCC TCTTCATGAT CTATGGTAAT GTGCACGCCA CCACCGAGTC CAGTCTGCGG 
GCCACGGAGA TCCGCGCCGA CAACCTATAC AGCCAGGTGG TGGGACTGTC GGCCGCACAG 
GCTAACCTGA GCAAACAGCT GAACATCAGC ACCCTCGTCA AGGACACCGT CATGCAGCAG 
CTGCTGACCA CGCGGCGCGA GGTGGAGCGC ATCAACGCCA GCTTCCGCCA GTGCCAAGGC 
GACCTGATCA CCTACATAAA CTATAATCGG TTCATCGCCG CTATCATCCT GAGCGAGAAG 
CAGTGCCAGG AACAGCTGAA GGAGGGCAAC AAGACCTGCG AAGCCTTGCT CTTCAAGCTG 
GGAGAGAAGG TTAAGACACT GGAGATGGAG GTGGTCAAGG AGAAGGCGGT GTGCTCCAAA 
GACAAGGACA GCCTGCTGGC AGGAAAGCGG CAGGCGGAAA TGCAGCAGGA GGCCTGTGGC 
AAAGCGCGAG AGCAGCAAAA GCAGGACCAG CAGGTGACCG AGGAGCAACT GCGCAAGGTG 
CAGTCCCTGT GCCTCCCACT GGACCAGGAG AAGTTCCAGG CGGACGTGCT GAACGTGTGG 
CGGGATTCGC TGGTCTACCG TTCCCTGGAT AATATAGGCT ACCACTACTC GCTGATGCCG 
GAGTTCTCGT CCCTCCGCCG AACATGCGAG AGCCTGCCCG GGATCATGAC CACCAAGGTA 
GAAGAGCTGG CGCGCGGGTT GCGCGCGGGC ATTGAGCGCG TGACCCGTGA AAATGGAGAG 
CTGCGACGCC AGAAGCTGGA GCTGGAGCGC GCGATACAGG GCGAGCGGGA GGCGCGGACG 
CGCGCCGGGA CCGAGGCGCA GGCTCGAGAG ACCCAGCTAC GGACGGAGTG CGCGCGCCAG 
ACACAGCTGG CTCTGGAGGA GAAGGCAGCG CTGCGGACAC AGCGGGACGA CCTGGAGCGC 
CAGCTGGAGG CGCGGAAGCG GGAGCTGGAG CAACTGCGCA CCGAGGTGGA TGTGCGCATT 
AGCGCTCTGG ACACCTGCGT CAAGGCCAAG TCGCTGCCAG CCATCCAGCC GAGACTCCCA 
GGTCCACCCC CCAACCCTCC ACCCATTGAT CCAGCTAGCC TGGAGGAATT CAAGAAAAGG 
ATCCTAGAGT CGCAGCGGCC CCCTCTAGTC AACCCTGCTG TCCCACCCAG TGGCTGA