Hexim1 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Hexim1
Entrez Gene ID	498008
Full Name	hexamethylene bis-acetamide inducible 1
Synonyms	Clp-1,Clp1
General protein information	Preferred Names hexamethylene bis-acetamide inducible 1 Names protein HEXIM1 cardiac lineage protein 1
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 10 Map Location: 10q32.1

mRNA and Protein(s)

mRNA	Protein	Name
NM_001025136.1	NP_001020307.1	protein HEXIM1

Pathways from BioSystems

Homologies

	HEXIM1	XP_001115260.1
Pan troglodytes (chimpanzee)	HEXIM1	XP_003953030.1
Canis lupus familiaris (dog)	HEXIM1	XP_005624429.1
Mus musculus (house mouse)	Hexim1	NP_620092.1
Gallus gallus (chicken)	HEXIM1	XP_003642831.1
Bos taurus (cattle)	HEXIM1	NP_001069649.1
Homo sapiens (human)	HEXIM1	NP_006451.1
Rattus norvegicus (Norway rat)	Hexim1	NP_001020307.1

Gene Ontology
Bibliography

Related articles in PubMed

HEXIM1 and NEAT1 Long Non-coding RNA Form a Multi-subunit Complex that Regulates DNA-Mediated Innate Immune Response.
Morchikh M, Cribier A, Raffel R, Amraoui S, Cau J, Severac D, Dubois E, Schwartz O, Bennasser Y, Benkirane M
Molecular cell67(3)387-399.e5(2017 Aug)

Identification of HEXIM1 as a positive regulator of p53.
Lew QJ, Chia YL, Chu KL, Lam YT, Gurumurthy M, Xu S, Lam KP, Cheong N, Chao SH
The Journal of biological chemistry287(43)36443-54(2012 Oct)

Specificity of Hexim1 and Hexim2 complex formation with cyclin T1/T2, importin alpha and 7SK snRNA.
Czudnochowski N, Vollmuth F, Baumann S, Vogel-Bachmayr K, Geyer M
Journal of molecular biology395(1)28-41(2010 Jan)

Ablation of the CLP-1 gene leads to down-regulation of the HAND1 gene and abnormality of the left ventricle of the heart and fetal death.
Huang F, Wagner M, Siddiqui MA
Mechanisms of development121(6)559-72(2004 Jun)

Inhibition of P-TEFb (CDK9/Cyclin T) kinase and RNA polymerase II transcription by the coordinated actions of HEXIM1 and 7SK snRNA.
Yik JH, Chen R, Nishimura R, Jennings JL, Link AJ, Zhou Q
Molecular cell12(4)971-82(2003 Oct)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The following Hexim1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Hexim1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa42537	NM_001025136.1 Latest version!	Rattus norvegicus HEXIM P-TEFb complex subunit 1 (Hexim1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$223.30 $319.00

ORF Online Only Promotion

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Hexim1 ( NM_001025136.1 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_001020307.1 Rattus norvegicus HEXIM P-TEFb complex subunit 1 (Hexim1), mRNA.

Price & Availability↑

CloneID	ORa42537
Clone ID Related Accession (Same CDS sequence)	NM_001025136.1
Accession Version	NM_001025136.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1071bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-11-15
Organism	Rattus norvegicus(Norway rat)
Product	protein HEXIM1
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC087133.1. On Jul 1, 2005 this sequence version replaced XM_573204.1. ##Evidence-Data-START## Transcript exon combination :: BC087133.1 [ECO:0000332] ##Evidence-Data-END##

ATGGCTGAGC CACTCTTGTC AGAACATCAA CACCAGCCTC AAACTAGCAA CTGTACAGGT 
GCTGCTGTTG TCCATGAGGA GCAGAACTCT GAGCGCCCCC CAAGCGCGGA GGAACGGGTG 
CCTAAGGAGG ACAGTAGGTG GCAATCGAGA GCGTCCTTGC AGTCGGGTAG CCGTCCAGGG 
CAGGAGGGAG ACGGGGGCCT GAAGCACCAG CTGCCCCCAT TGCAGACGAA TGCCTGTCCA 
GAATTGAGCT GCTTGGAAAA GGGCGAGAAG GGCCAGAATG GGGAGGACTT ATCCACTGGC 
GGTGCCTCGC CTTCGGCGGA GGGGGAGCCG ATGTCAGAGT CCCTCGTGCA ACCAGGTCAT 
GACTCGGAGG CTACTAAGCT GGAGGCTCCT GTCGCTGGAG TAGAGGAGCC ATGGGGACAG 
CAACAGAGAC AGCTGGGCAA GAAAAAACAC CGGAGACGCC CCTCCAAGAA GAAGCGACAT 
TGGAAGCCCT ATTACAAGCT GACTTGGGAG GAGAAGAAAA AGTTCGACGA GAAGCAAAGC 
CTGCGAGCTT CGCGAGTTCG AGCCGAGATG TTCGCCAAGG GCCAGCCGGT TGCGCCCTAT 
AACACCACGC AGTTCCTCAT GGATGACCAT GATCAGGAGG AGCCTGATCT CAAAACCGGC 
CTTTACCCTA AGCGGGCAGC CGCCAAATCC GACGACACCA GCGATGAGGA TTTCGTGGAA 
GAAGCTGGTG AGGAAGACGG AGGCAGCGAT GGCATGGGAG GGGACGGCAG CGAGTTTCTG 
CAGCGGGACT TTTCCGAGAC TTACGAGCGG TACCACGCCG AGAGCCTGCA GAACATGAGC 
AAGCAGGAGC TCATCAAAGA GTACCTGGAG CTGGAGAAGT GCCTCTCCCG CAAGGAGGAC 
GAAAATAACC GGCTGCGGTT GGAAAGCAAG CGGTTGGGTG GCGTCGATGC GCGAGTGCGG 
GAGCTGGAGC TAGAGCTGGA CCGACTGCGC GCCGAGAACC GCCAGCTGCT GACCGAAAAC 
GAACTGCACC GGCAGCAGGA GCGAGCGCCT CCTTCCAAGT TCGGCGACTA G

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001020307.1
CDS	660..1730
Translation	MAEPLLSEHQHQPQTSNCTGAAVVHEEQNSERPPSAEERVPKEDSRWQSRASLQSGSRPGQEGDGGLKHQLPPLQTNACPELSCLEKGEKGQNGEDLSTGGASPSAEGEPMSESLVQPGHDSEATKLEAPVAGVEEPWGQQQRQLGKKKHRRRPSKKKRHWKPYYKLTWEEKKKFDEKQSLRASRVRAEMFAKGQPVAPYNTTQFLMDDHDQEEPDLKTGLYPKRAAAKSDDTSDEDFVEEAGEEDGGSDGMGGDGSEFLQRDFSETYERYHAESLQNMSKQELIKEYLELEKCLSRKEDENNRLRLESKRLGGVDARVRELELELDRLRAENRQLLTENELHRQQERAPPSKFGD

Target ORF information:

RefSeq Version	NM_001025136.1
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus HEXIM P-TEFb complex subunit 1 (Hexim1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001025136.1

ORF Insert Sequence:

ATGGCTGAGC CACTCTTGTC AGAACATCAA CACCAGCCTC AAACTAGCAA CTGTACAGGT 
GCTGCTGTTG TCCATGAGGA GCAGAACTCT GAGCGCCCCC CAAGCGCGGA GGAACGGGTG 
CCTAAGGAGG ACAGTAGGTG GCAATCGAGA GCGTCCTTGC AGTCGGGTAG CCGTCCAGGG 
CAGGAGGGAG ACGGGGGCCT GAAGCACCAG CTGCCCCCAT TGCAGACGAA TGCCTGTCCA 
GAATTGAGCT GCTTGGAAAA GGGCGAGAAG GGCCAGAATG GGGAGGACTT ATCCACTGGC 
GGTGCCTCGC CTTCGGCGGA GGGGGAGCCG ATGTCAGAGT CCCTCGTGCA ACCAGGTCAT 
GACTCGGAGG CTACTAAGCT GGAGGCTCCT GTCGCTGGAG TAGAGGAGCC ATGGGGACAG 
CAACAGAGAC AGCTGGGCAA GAAAAAACAC CGGAGACGCC CCTCCAAGAA GAAGCGACAT 
TGGAAGCCCT ATTACAAGCT GACTTGGGAG GAGAAGAAAA AGTTCGACGA GAAGCAAAGC 
CTGCGAGCTT CGCGAGTTCG AGCCGAGATG TTCGCCAAGG GCCAGCCGGT TGCGCCCTAT 
AACACCACGC AGTTCCTCAT GGATGACCAT GATCAGGAGG AGCCTGATCT CAAAACCGGC 
CTTTACCCTA AGCGGGCAGC CGCCAAATCC GACGACACCA GCGATGAGGA TTTCGTGGAA 
GAAGCTGGTG AGGAAGACGG AGGCAGCGAT GGCATGGGAG GGGACGGCAG CGAGTTTCTG 
CAGCGGGACT TTTCCGAGAC TTACGAGCGG TACCACGCCG AGAGCCTGCA GAACATGAGC 
AAGCAGGAGC TCATCAAAGA GTACCTGGAG CTGGAGAAGT GCCTCTCCCG CAAGGAGGAC 
GAAAATAACC GGCTGCGGTT GGAAAGCAAG CGGTTGGGTG GCGTCGATGC GCGAGTGCGG 
GAGCTGGAGC TAGAGCTGGA CCGACTGCGC GCCGAGAACC GCCAGCTGCT GACCGAAAAC 
GAACTGCACC GGCAGCAGGA GCGAGCGCCT CCTTCCAAGT TCGGCGACTA G

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

HEXIM1 and NEAT1 Long Non-coding RNA Form a Multi-subunit Complex that Regulates DNA-Mediated Innate Immune Response.
Molecular cell67(3)387-399.e5(2017 Aug)
Morchikh M,Cribier A,Raffel R,Amraoui S,Cau J,Severac D,Dubois E,Schwartz O,Bennasser Y,Benkirane M

Identification of HEXIM1 as a positive regulator of p53.
The Journal of biological chemistry287(43)36443-54(2012 Oct)
Lew QJ,Chia YL,Chu KL,Lam YT,Gurumurthy M,Xu S,Lam KP,Cheong N,Chao SH

Specificity of Hexim1 and Hexim2 complex formation with cyclin T1/T2, importin alpha and 7SK snRNA.
Journal of molecular biology395(1)28-41(2010 Jan)
Czudnochowski N,Vollmuth F,Baumann S,Vogel-Bachmayr K,Geyer M

Ablation of the CLP-1 gene leads to down-regulation of the HAND1 gene and abnormality of the left ventricle of the heart and fetal death.
Mechanisms of development121(6)559-72(2004 Jun)
Huang F,Wagner M,Siddiqui MA

Inhibition of P-TEFb (CDK9/Cyclin T) kinase and RNA polymerase II transcription by the coordinated actions of HEXIM1 and 7SK snRNA.
Molecular cell12(4)971-82(2003 Oct)
Yik JH,Chen R,Nishimura R,Jennings JL,Link AJ,Zhou Q