HEXIM1 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	HEXIM1
Entrez Gene ID	10614
Full Name	hexamethylene bisacetamide inducible 1
Synonyms	CLP1,EDG1,HIS1,MAQ1
General protein information	Preferred Names hexamethylene bisacetamide inducible 1 Names protein HEXIM1 HMBA-inducible cardiac lineage protein 1 estrogen down-regulated gene 1 protein hexamethylene bis-acetamide inducible 1 hexamethylene bis-acetamide-inducible protein 1 hexamethylene bisacetamide-inducible protein hexamethylene-bis-acetamide-inducible transcript 1 hexamthylene bis-acetamide inducible 1 menage a quatre 1 menage a quatre protein 1
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 17 Map Location: 17q21.31
Summary	Expression of this gene is induced by hexamethylene-bis-acetamide in vascular smooth muscle cells. This gene has no introns. [provided by RefSeq, Jul 2008].
Disorder MIM:	607328

mRNA and Protein(s)

mRNA	Protein	Name
NM_006460.3	NP_006451.1	protein HEXIM1
NM_006460.2	NP_006451.1	protein HEXIM1

Pathways from BioSystems

Homologies

	HEXIM1	XP_001115260.1
Pan troglodytes (chimpanzee)	HEXIM1	XP_003953030.1
Canis lupus familiaris (dog)	HEXIM1	XP_005624429.1
Mus musculus (house mouse)	Hexim1	NP_620092.1
Gallus gallus (chicken)	HEXIM1	XP_003642831.1
Bos taurus (cattle)	HEXIM1	NP_001069649.1
Homo sapiens (human)	HEXIM1	NP_006451.1
Rattus norvegicus (Norway rat)	Hexim1	NP_001020307.1

Gene Ontology
Bibliography

Related articles in PubMed

Hexim1, an RNA-controlled protein hub.
Michels AA, Bensaude O
Transcription1-16(2018 Jan)

HEXIM1 and NEAT1 Long Non-coding RNA Form a Multi-subunit Complex that Regulates DNA-Mediated Innate Immune Response.
Morchikh M, Cribier A, Raffel R, Amraoui S, Cau J, Severac D, Dubois E, Schwartz O, Bennasser Y, Benkirane M
Molecular cell67(3)387-399.e5(2017 Aug)

Architecture of the human interactome defines protein communities and disease networks.
Huttlin EL, Bruckner RJ, Paulo JA, Cannon JR, Ting L, Baltier K, Colby G, Gebreab F, Gygi MP, Parzen H, Szpyt J, Tam S, Zarraga G, Pontano-Vaites L, Swarup S, White AE, Schweppe DK, Rad R, Erickson BK, Obar RA, Guruharsha KG, Li K, Artavanis-Tsakonas S, Gygi SP, Harper JW
Nature545(7655)505-509(2017 05)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Identify a HEXIM1-containing ribonuclear protein complex composed also of DNA-PK, paraspeckle subunits, and the long non-coding RNA (lncRNA) NEAT1, which acts as a key nuclear regulator of DNA-mediated activation of innate immune response through the cGAS-STING pathway.
Title: HEXIM1 and NEAT1 Long Non-coding RNA Form a Multi-subunit Complex that Regulates DNA-Mediated Innate Immune Response.

HSP70 activator shows similar activity as HMBA and 4a1 to induce HEXIM1 expression, suggesting that HMBA and 4a1 might be putative HSP70 activators
Title: HMBA is a putative HSP70 activator stimulating HEXIM1 expression that is down-regulated by estrogen.

Our results demonstrated that HEXIM1 exhibited the most consistent response to BET inhibitors in all of the settings examined, including tumors and surrogate tissues.
Title: HEXIM1 as a Robust Pharmacodynamic Marker for Monitoring Target Engagement of BET Family Bromodomain Inhibitors in Tumors and Surrogate Tissues.

HMBA and derivative HMBA4a1 induce HEXIM1 activity, targeting several signaling pathways critical in tumorigenesis and metastasis.
Title: Induction of HEXIM1 activities by HMBA derivative 4a1: Functional consequences and mechanism.

Results show that HEXIM1 is a tumor suppressor in melanoma that responds to nucleotide stress by inhibiting transcription elongation of tumorigenic genes and stabilizing mRNA transcripts of other tumor suppressor genes.
Title: Stress from Nucleotide Depletion Activates the Transcriptional Regulator HEXIM1 to Suppress Melanoma.

The following HEXIM1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the HEXIM1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu11455	NM_006460.3 Latest version!	Homo sapiens HEXIM P-TEFb complex subunit 1 (HEXIM1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
View Old Accession Versions >>
OHu11455	NM_006460.2	Homo sapiens HEXIM P-TEFb complex subunit 1 (HEXIM1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

HEXIM1 ( NM_006460.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_006451.1 Homo sapiens HEXIM P-TEFb complex subunit 1 (HEXIM1), mRNA.

Price & Availability↑

CloneID	OHu11455
Clone ID Related Accession (Same CDS sequence)	NM_006460.3 , NM_006460.2
Accession Version	NM_006460.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1080bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-19
Organism	Homo sapiens(human)
Product	protein HEXIM1
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AC142472.2. On Aug 2, 2019 this sequence version replaced NM_006460.2. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript is intronless :: AB021179.1, SRR7346977.1616100.1 [ECO:0000345] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGGCCGAGC CATTCTTGTC AGAATATCAA CACCAGCCTC AAACTAGCAA CTGTACAGGT 
GCTGCTGCTG TCCAGGAAGA GCTGAACCCT GAGCGCCCCC CAGGCGCGGA GGAGCGGGTG 
CCCGAGGAGG ACAGTAGGTG GCAATCGAGA GCGTTCCCCC AGTTGGGTGG CCGTCCGGGG 
CCGGAGGGGG AAGGGAGCCT GGAATCCCAA CCACCTCCCT TGCAGACCCA GGCCTGTCCA 
GAATCTAGCT GCCTGAGAGA GGGCGAGAAG GGCCAGAATG GGGACGACTC GTCCGCTGGC 
GGCGACTTCC CGCCGCCGGC AGAAGTGGAA CCGACGCCCG AGGCCGAGCT GCTCGCCCAG 
CCTTGTCATG ACTCCGAGGC CAGTAAGTTG GGGGCTCCTG CCGCAGGGGG CGAAGAGGAG 
TGGGGACAGC AGCAGAGACA GCTGGGGAAG AAAAAACATA GGAGACGCCC GTCCAAGAAG 
AAGCGGCATT GGAAACCGTA CTACAAGCTG ACCTGGGAAG AGAAGAAAAA GTTCGACGAG 
AAACAGAGCC TTCGAGCTTC AAGGATCCGA GCCGAGATGT TCGCCAAGGG CCAGCCGGTC 
GCGCCCTATA ACACCACGCA GTTCCTCATG GATGATCACG ACCAGGAGGA GCCGGATCTC 
AAAACCGGCC TGTACTCCAA GCGGGCCGCC GCCAAATCCG ACGACACCAG CGATGACGAC 
TTCATGGAAG AAGGGGGTGA GGAGGATGGG GGCAGCGATG GGATGGGAGG GGACGGCAGC 
GAGTTTCTGC AGCGGGACTT CTCGGAGACG TACGAGCGGT ACCACACGGA GAGCCTGCAG 
AACATGAGCA AGCAGGAGCT CATCAAGGAG TACCTGGAAC TGGAGAAGTG CCTCTCGCGC 
ATGGAGGACG AGAACAACCG GCTGCGGCTG GAGAGCAAGC GGCTGGGTGG CGACGACGCG 
CGTGTGCGGG AGCTGGAGCT GGAGCTGGAC CGGCTGCGCG CCGAGAACCT CCAGCTGCTG 
ACCGAGAACG AACTGCACCG GCAGCAGGAG CGAGCGCCGC TTTCCAAGTT TGGAGACTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_006451.1
CDS	717..1796
Translation	MAEPFLSEYQHQPQTSNCTGAAAVQEELNPERPPGAEERVPEEDSRWQSRAFPQLGGRPGPEGEGSLESQPPPLQTQACPESSCLREGEKGQNGDDSSAGGDFPPPAEVEPTPEAELLAQPCHDSEASKLGAPAAGGEEEWGQQQRQLGKKKHRRRPSKKKRHWKPYYKLTWEEKKKFDEKQSLRASRIRAEMFAKGQPVAPYNTTQFLMDDHDQEEPDLKTGLYSKRAAAKSDDTSDDDFMEEGGEEDGGSDGMGGDGSEFLQRDFSETYERYHTESLQNMSKQELIKEYLELEKCLSRMEDENNRLRLESKRLGGDDARVRELELELDRLRAENLQLLTENELHRQQERAPLSKFGD

Target ORF information:

RefSeq Version	NM_006460.3
Organism	Homo sapiens(human)
Definition	Homo sapiens HEXIM P-TEFb complex subunit 1 (HEXIM1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_006460.3

ORF Insert Sequence:

ATGGCCGAGC CATTCTTGTC AGAATATCAA CACCAGCCTC AAACTAGCAA CTGTACAGGT 
GCTGCTGCTG TCCAGGAAGA GCTGAACCCT GAGCGCCCCC CAGGCGCGGA GGAGCGGGTG 
CCCGAGGAGG ACAGTAGGTG GCAATCGAGA GCGTTCCCCC AGTTGGGTGG CCGTCCGGGG 
CCGGAGGGGG AAGGGAGCCT GGAATCCCAA CCACCTCCCT TGCAGACCCA GGCCTGTCCA 
GAATCTAGCT GCCTGAGAGA GGGCGAGAAG GGCCAGAATG GGGACGACTC GTCCGCTGGC 
GGCGACTTCC CGCCGCCGGC AGAAGTGGAA CCGACGCCCG AGGCCGAGCT GCTCGCCCAG 
CCTTGTCATG ACTCCGAGGC CAGTAAGTTG GGGGCTCCTG CCGCAGGGGG CGAAGAGGAG 
TGGGGACAGC AGCAGAGACA GCTGGGGAAG AAAAAACATA GGAGACGCCC GTCCAAGAAG 
AAGCGGCATT GGAAACCGTA CTACAAGCTG ACCTGGGAAG AGAAGAAAAA GTTCGACGAG 
AAACAGAGCC TTCGAGCTTC AAGGATCCGA GCCGAGATGT TCGCCAAGGG CCAGCCGGTC 
GCGCCCTATA ACACCACGCA GTTCCTCATG GATGATCACG ACCAGGAGGA GCCGGATCTC 
AAAACCGGCC TGTACTCCAA GCGGGCCGCC GCCAAATCCG ACGACACCAG CGATGACGAC 
TTCATGGAAG AAGGGGGTGA GGAGGATGGG GGCAGCGATG GGATGGGAGG GGACGGCAGC 
GAGTTTCTGC AGCGGGACTT CTCGGAGACG TACGAGCGGT ACCACACGGA GAGCCTGCAG 
AACATGAGCA AGCAGGAGCT CATCAAGGAG TACCTGGAAC TGGAGAAGTG CCTCTCGCGC 
ATGGAGGACG AGAACAACCG GCTGCGGCTG GAGAGCAAGC GGCTGGGTGG CGACGACGCG 
CGTGTGCGGG AGCTGGAGCT GGAGCTGGAC CGGCTGCGCG CCGAGAACCT CCAGCTGCTG 
ACCGAGAACG AACTGCACCG GCAGCAGGAG CGAGCGCCGC TTTCCAAGTT TGGAGACTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

HEXIM1 ( NM_006460.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_006451.1 Homo sapiens HEXIM P-TEFb complex subunit 1 (HEXIM1), mRNA.

Price & Availability↑

CloneID	OHu11455
Clone ID Related Accession (Same CDS sequence)	NM_006460.3 , NM_006460.2
Accession Version	NM_006460.2	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1080bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-05-03
Organism	Homo sapiens(human)
Product	protein HEXIM1
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AL562001.2, AI092623.1, CV810471.1, BQ777682.1, CA448958.1, BX111838.1, BC006460.1, AC142472.2, AB021179.1, CA946973.1, DB539383.1 and AW881781.1. On Jul 7, 2005 this sequence version replaced NM_006460.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGGCCGAGC CATTCTTGTC AGAATATCAA CACCAGCCTC AAACTAGCAA CTGTACAGGT 
GCTGCTGCTG TCCAGGAAGA GCTGAACCCT GAGCGCCCCC CAGGCGCGGA GGAGCGGGTG 
CCCGAGGAGG ACAGTAGGTG GCAATCGAGA GCGTTCCCCC AGTTGGGTGG CCGTCCGGGG 
CCGGAGGGGG AAGGGAGCCT GGAATCCCAA CCACCTCCCT TGCAGACCCA GGCCTGTCCA 
GAATCTAGCT GCCTGAGAGA GGGCGAGAAG GGCCAGAATG GGGACGACTC GTCCGCTGGC 
GGCGACTTCC CGCCGCCGGC AGAAGTGGAA CCGACGCCCG AGGCCGAGCT GCTCGCCCAG 
CCTTGTCATG ACTCCGAGGC CAGTAAGTTG GGGGCTCCTG CCGCAGGGGG CGAAGAGGAG 
TGGGGACAGC AGCAGAGACA GCTGGGGAAG AAAAAACATA GGAGACGCCC GTCCAAGAAG 
AAGCGGCATT GGAAACCGTA CTACAAGCTG ACCTGGGAAG AGAAGAAAAA GTTCGACGAG 
AAACAGAGCC TTCGAGCTTC AAGGATCCGA GCCGAGATGT TCGCCAAGGG CCAGCCGGTC 
GCGCCCTATA ACACCACGCA GTTCCTCATG GATGATCACG ACCAGGAGGA GCCGGATCTC 
AAAACCGGCC TGTACTCCAA GCGGGCCGCC GCCAAATCCG ACGACACCAG CGATGACGAC 
TTCATGGAAG AAGGGGGTGA GGAGGATGGG GGCAGCGATG GGATGGGAGG GGACGGCAGC 
GAGTTTCTGC AGCGGGACTT CTCGGAGACG TACGAGCGGT ACCACACGGA GAGCCTGCAG 
AACATGAGCA AGCAGGAGCT CATCAAGGAG TACCTGGAAC TGGAGAAGTG CCTCTCGCGC 
ATGGAGGACG AGAACAACCG GCTGCGGCTG GAGAGCAAGC GGCTGGGTGG CGACGACGCG 
CGTGTGCGGG AGCTGGAGCT GGAGCTGGAC CGGCTGCGCG CCGAGAACCT CCAGCTGCTG 
ACCGAGAACG AACTGCACCG GCAGCAGGAG CGAGCGCCGC TTTCCAAGTT TGGAGACTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_006451.1
CDS	1875..2954
Translation	MAEPFLSEYQHQPQTSNCTGAAAVQEELNPERPPGAEERVPEEDSRWQSRAFPQLGGRPGPEGEGSLESQPPPLQTQACPESSCLREGEKGQNGDDSSAGGDFPPPAEVEPTPEAELLAQPCHDSEASKLGAPAAGGEEEWGQQQRQLGKKKHRRRPSKKKRHWKPYYKLTWEEKKKFDEKQSLRASRIRAEMFAKGQPVAPYNTTQFLMDDHDQEEPDLKTGLYSKRAAAKSDDTSDDDFMEEGGEEDGGSDGMGGDGSEFLQRDFSETYERYHTESLQNMSKQELIKEYLELEKCLSRMEDENNRLRLESKRLGGDDARVRELELELDRLRAENLQLLTENELHRQQERAPLSKFGD

Target ORF information:

RefSeq Version	NM_006460.2
Organism	Homo sapiens(human)
Definition	Homo sapiens HEXIM P-TEFb complex subunit 1 (HEXIM1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_006460.2

ORF Insert Sequence:

ATGGCCGAGC CATTCTTGTC AGAATATCAA CACCAGCCTC AAACTAGCAA CTGTACAGGT 
GCTGCTGCTG TCCAGGAAGA GCTGAACCCT GAGCGCCCCC CAGGCGCGGA GGAGCGGGTG 
CCCGAGGAGG ACAGTAGGTG GCAATCGAGA GCGTTCCCCC AGTTGGGTGG CCGTCCGGGG 
CCGGAGGGGG AAGGGAGCCT GGAATCCCAA CCACCTCCCT TGCAGACCCA GGCCTGTCCA 
GAATCTAGCT GCCTGAGAGA GGGCGAGAAG GGCCAGAATG GGGACGACTC GTCCGCTGGC 
GGCGACTTCC CGCCGCCGGC AGAAGTGGAA CCGACGCCCG AGGCCGAGCT GCTCGCCCAG 
CCTTGTCATG ACTCCGAGGC CAGTAAGTTG GGGGCTCCTG CCGCAGGGGG CGAAGAGGAG 
TGGGGACAGC AGCAGAGACA GCTGGGGAAG AAAAAACATA GGAGACGCCC GTCCAAGAAG 
AAGCGGCATT GGAAACCGTA CTACAAGCTG ACCTGGGAAG AGAAGAAAAA GTTCGACGAG 
AAACAGAGCC TTCGAGCTTC AAGGATCCGA GCCGAGATGT TCGCCAAGGG CCAGCCGGTC 
GCGCCCTATA ACACCACGCA GTTCCTCATG GATGATCACG ACCAGGAGGA GCCGGATCTC 
AAAACCGGCC TGTACTCCAA GCGGGCCGCC GCCAAATCCG ACGACACCAG CGATGACGAC 
TTCATGGAAG AAGGGGGTGA GGAGGATGGG GGCAGCGATG GGATGGGAGG GGACGGCAGC 
GAGTTTCTGC AGCGGGACTT CTCGGAGACG TACGAGCGGT ACCACACGGA GAGCCTGCAG 
AACATGAGCA AGCAGGAGCT CATCAAGGAG TACCTGGAAC TGGAGAAGTG CCTCTCGCGC 
ATGGAGGACG AGAACAACCG GCTGCGGCTG GAGAGCAAGC GGCTGGGTGG CGACGACGCG 
CGTGTGCGGG AGCTGGAGCT GGAGCTGGAC CGGCTGCGCG CCGAGAACCT CCAGCTGCTG 
ACCGAGAACG AACTGCACCG GCAGCAGGAG CGAGCGCCGC TTTCCAAGTT TGGAGACTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Hexim1, an RNA-controlled protein hub.
Transcription1-16(2018 Jan)
Michels AA,Bensaude O

HEXIM1 and NEAT1 Long Non-coding RNA Form a Multi-subunit Complex that Regulates DNA-Mediated Innate Immune Response.
Molecular cell67(3)387-399.e5(2017 Aug)
Morchikh M,Cribier A,Raffel R,Amraoui S,Cau J,Severac D,Dubois E,Schwartz O,Bennasser Y,Benkirane M

Architecture of the human interactome defines protein communities and disease networks.
Nature545(7655)505-509(2017 05)
Huttlin EL,Bruckner RJ,Paulo JA,Cannon JR,Ting L,Baltier K,Colby G,Gebreab F,Gygi MP,Parzen H,Szpyt J,Tam S,Zarraga G,Pontano-Vaites L,Swarup S,White AE,Schweppe DK,Rad R,Erickson BK,Obar RA,Guruharsha KG,Li K,Artavanis-Tsakonas S,Gygi SP,Harper JW

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HEXIM1 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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